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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571ZincUniRule annotation
Metal bindingi177 – 1771ZincUniRule annotation
Metal bindingi179 – 1791ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATPUniRule annotation
Nucleotide bindingi133 – 1408ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
  2. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciYPSE349747:GH71-1643-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
Alternative name(s):
GlcNAc kinaseUniRule annotation
Gene namesi
Name:nagKUniRule annotation
Ordered Locus Names:YpsIP31758_1603
OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Taxonomic identifieri349747 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000002412: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304N-acetyl-D-glucosamine kinasePRO_1000067381Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349747.YpsIP31758_1603.

Structurei

3D structure databases

ProteinModelPortaliA7FH52.
SMRiA7FH52. Positions 1-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OMAiWIGNDAD.
OrthoDBiEOG61P6P0.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7FH52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYGFDMGGT KIELGVFDEN LQRIWHKRVP TPREDYPQLL QILRDLTEEA
60 70 80 90 100
DTYCGVQGSV GIGIPGLPNA DDGTVFTANV PSAMGQPLQA DLSRLIQREV
110 120 130 140 150
RIDNDANCFA LSEAWDPEFR TYPTVLGLIL GTGVGGGLIV NGSIVSGRNH
160 170 180 190 200
ITGEFGHFRL PVDALDILGA DIPHVPCGCG HRGCIENYIS GRGFEWMYSH
210 220 230 240 250
FYQHTLPATD IIAHYAAGEP KAVAHVERFM DVLAVCLGNL LTMLDPHLVV
260 270 280 290 300
VGGGLSNFEK IYQELPKRLP AHLLRVARLP RIEKARYGDS GGVRGAAFLH

LAEK
Length:304
Mass (Da):33,302
Last modified:September 11, 2007 - v1
Checksum:i846570FFD39100BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA. Translation: ABS48486.1.
RefSeqiYP_001400580.1. NC_009708.1.

Genome annotation databases

EnsemblBacteriaiABS48486; ABS48486; YpsIP31758_1603.
GeneIDi5386543.
KEGGiypi:YpsIP31758_1603.
PATRICi18632018. VBIYerPse15693_1957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA. Translation: ABS48486.1.
RefSeqiYP_001400580.1. NC_009708.1.

3D structure databases

ProteinModelPortaliA7FH52.
SMRiA7FH52. Positions 1-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349747.YpsIP31758_1603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS48486; ABS48486; YpsIP31758_1603.
GeneIDi5386543.
KEGGiypi:YpsIP31758_1603.
PATRICi18632018. VBIYerPse15693_1957.

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OMAiWIGNDAD.
OrthoDBiEOG61P6P0.

Enzyme and pathway databases

UniPathwayiUPA00544.
BioCyciYPSE349747:GH71-1643-MONOMER.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever."
    Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J.
    PLoS Genet. 3:1508-1523(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP 31758.

Entry informationi

Entry nameiNAGK_YERP3
AccessioniPrimary (citable) accession number: A7FH52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: February 4, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.