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A7FE74

- UPPP_YERP3

UniProt

A7FE74 - UPPP_YERP3

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, YpsIP31758_0559
Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciYPSE349747:GH71-576-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:YpsIP31758_0559
OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Taxonomic identifieri349747 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000002412: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Reviewed prediction
Add
BLAST
Transmembranei45 – 6521Helical; Reviewed prediction
Add
BLAST
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Reviewed prediction
Add
BLAST
Transmembranei153 – 17220Helical; Reviewed prediction
Add
BLAST
Transmembranei189 – 20921Helical; Reviewed prediction
Add
BLAST
Transmembranei221 – 24121Helical; Reviewed prediction
Add
BLAST
Transmembranei251 – 27121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Undecaprenyl-diphosphataseUniRule annotation
PRO_1000062821Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349747.YpsIP31758_0559.

Structurei

3D structure databases

ProteinModelPortaliA7FE74.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A7FE74-1 [UniParc]FASTAAdd to Basket

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MTDMYSLFVA FILGVVEGLT EFLPVSSTGH MIIVGELLGF TGDKAKTFEV    50
IIQLGSILAV VVVFWRRLFG LIGIHFGAVP HEGKTNGHLT LGHILLAMIP 100
AVILGLAFHD VIKALFDPKS VMYALVAGGV LLLAAEWLKP KNPKAVGLDD 150
ITYRQAFAIG CFQCLALWPG FSRSGATISG GMLVGVNRYA ASEFSFILAV 200
PMMIGASGLD LYKSLHFLTL GDLPMFAVGF ITAFIVALIA IKTFLSLIKR 250
ISFVPFAIYR FIVAAVVYWV FM 272
Length:272
Mass (Da):29,483
Last modified:September 11, 2007 - v1
Checksum:i164FC644788F2189
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000720 Genomic DNA. Translation: ABS49217.1.
RefSeqiYP_001399552.1. NC_009708.1.

Genome annotation databases

EnsemblBacteriaiABS49217; ABS49217; YpsIP31758_0559.
GeneIDi5384940.
KEGGiypi:YpsIP31758_0559.
PATRICi18629678. VBIYerPse15693_0805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000720 Genomic DNA. Translation: ABS49217.1 .
RefSeqi YP_001399552.1. NC_009708.1.

3D structure databases

ProteinModelPortali A7FE74.
ModBasei Search...

Protein-protein interaction databases

STRINGi 349747.YpsIP31758_0559.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS49217 ; ABS49217 ; YpsIP31758_0559 .
GeneIDi 5384940.
KEGGi ypi:YpsIP31758_0559.
PATRICi 18629678. VBIYerPse15693_0805.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci YPSE349747:GH71-576-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever."
    Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J.
    PLoS Genet. 3:1508-1523(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP 31758.

Entry informationi

Entry nameiUPPP_YERP3
AccessioniPrimary (citable) accession number: A7FE74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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