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Protein

Acetolactate synthase

Gene

ilvB3

Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 pyruvate = 2-acetolactate + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation
  • thiamine diphosphateUniRule annotationNote: Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. acetolactate synthase activity Source: UniProtKB-EC
  2. flavin adenine dinucleotide binding Source: InterPro
  3. magnesium ion binding Source: InterPro
  4. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
  2. valine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Thiamine pyrophosphateUniRule annotation

Enzyme and pathway databases

BioCyciYPSE349747:GH71-160-MONOMER.
UniPathwayiUPA00047; UER00055.
UPA00049; UER00059.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetolactate synthaseUniRule annotation (EC:2.2.1.6UniRule annotation)
Gene namesi
Name:ilvB3Imported
Ordered Locus Names:YpsIP31758_0154Imported
OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)Imported
Taxonomic identifieri349747 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000002412 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi349747.YpsIP31758_0154.

Structurei

3D structure databases

ProteinModelPortaliA7FD23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TPP enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0028.
HOGENOMiHOG000258448.
KOiK01652.
OMAiHSWVVRD.
OrthoDBiEOG6KT2NW.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR012846. Acetolactate_synth_lsu.
IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00118. acolac_lg. 1 hit.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7FD23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGAQWVVQA LRAQGVDTVF GYPGGAIMPV YDALYDGGVE HLLCRHEQGA
60 70 80 90 100
AIAAIGYARA TGKVGVCIAT SGPGATNLIT GLADALLDSV PVIAITGQVG
110 120 130 140 150
SALIGTDAFQ EIDVLGLSLA CTKHSFLVES LDALPEIMAE AFAIATSGRP
160 170 180 190 200
GPVLIDIPKD IQLAVGELTP HLKPVEEHSV DSAAELQHAW DMLANAQKPM
210 220 230 240 250
LYVGGGVGMA QAVPALRDFI AMTGIPAVAT LKGLGAPDIA HPCYLGMLGM
260 270 280 290 300
HGTKAANFAV QDCDLLVAVG ARFDDRVTGK LNTFASKAKV IHMDIDPAEL
310 320 330 340 350
GKLRQVHVAL QGNLNVLLPA LQQPLNIQSW RDEVMALKQQ HHWRYDHPGQ
360 370 380 390 400
AIYAPLLLKQ ISERKAPETV VTTDVGQHQM WTAQHMNFTR PENFITSSGL
410 420 430 440 450
GTMGFGVPAA VGAQMARPDD MVICVSGDGS FMMNVQELGT IKRKQLPLKI
460 470 480 490 500
VLLDNQRLGM VRQWQQLFFD GRYSETNLSD NPDFITLASA FDIPGQRITR
510 520 530 540
KDQVDAALDA LFNSEGPYLL QVSIDELENV WPLVPPGAGN ETMLEKIS
Length:548
Mass (Da):58,785
Last modified:September 10, 2007 - v1
Checksum:i51C9B4D4F397D2D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA. Translation: ABS46384.1.
RefSeqiYP_001399151.1. NC_009708.1.

Genome annotation databases

EnsemblBacteriaiABS46384; ABS46384; YpsIP31758_0154.
KEGGiypi:YpsIP31758_0154.
PATRICi18628798. VBIYerPse15693_0376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA. Translation: ABS46384.1.
RefSeqiYP_001399151.1. NC_009708.1.

3D structure databases

ProteinModelPortaliA7FD23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349747.YpsIP31758_0154.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS46384; ABS46384; YpsIP31758_0154.
KEGGiypi:YpsIP31758_0154.
PATRICi18628798. VBIYerPse15693_0376.

Phylogenomic databases

eggNOGiCOG0028.
HOGENOMiHOG000258448.
KOiK01652.
OMAiHSWVVRD.
OrthoDBiEOG6KT2NW.

Enzyme and pathway databases

UniPathwayiUPA00047; UER00055.
UPA00049; UER00059.
BioCyciYPSE349747:GH71-160-MONOMER.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR012846. Acetolactate_synth_lsu.
IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00118. acolac_lg. 1 hit.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever."
    Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J.
    PLoS Genet. 3:1508-1523(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP 31758Imported.

Entry informationi

Entry nameiA7FD23_YERP3
AccessioniPrimary (citable) accession number: A7FD23
Entry historyi
Integrated into UniProtKB/TrEMBL: September 10, 2007
Last sequence update: September 10, 2007
Last modified: March 31, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.