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A7FD23

- A7FD23_YERP3

UniProt

A7FD23 - A7FD23_YERP3

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Protein

Acetolactate synthase

Gene

ilvB3

Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2 pyruvate = 2-acetolactate + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 magnesium ion per subunit.UniRule annotation
  • Note: Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. acetolactate synthase activity Source: UniProtKB-EC
  2. flavin adenine dinucleotide binding Source: InterPro
  3. magnesium ion binding Source: InterPro
  4. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
  2. valine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Thiamine pyrophosphateUniRule annotation

Enzyme and pathway databases

BioCyciYPSE349747:GH71-160-MONOMER.
UniPathwayiUPA00047; UER00055.
UPA00049; UER00059.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetolactate synthaseUniRule annotation (EC:2.2.1.6UniRule annotation)
Gene namesi
Name:ilvB3Imported
Ordered Locus Names:YpsIP31758_0154Imported
OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)Imported
Taxonomic identifieri349747 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000002412: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi349747.YpsIP31758_0154.

Structurei

3D structure databases

ProteinModelPortaliA7FD23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TPP enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0028.
HOGENOMiHOG000258448.
KOiK01652.
OMAiDEHENVW.
OrthoDBiEOG6KT2NW.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR012846. Acetolactate_synth_lsu.
IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00118. acolac_lg. 1 hit.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7FD23-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNGAQWVVQA LRAQGVDTVF GYPGGAIMPV YDALYDGGVE HLLCRHEQGA
60 70 80 90 100
AIAAIGYARA TGKVGVCIAT SGPGATNLIT GLADALLDSV PVIAITGQVG
110 120 130 140 150
SALIGTDAFQ EIDVLGLSLA CTKHSFLVES LDALPEIMAE AFAIATSGRP
160 170 180 190 200
GPVLIDIPKD IQLAVGELTP HLKPVEEHSV DSAAELQHAW DMLANAQKPM
210 220 230 240 250
LYVGGGVGMA QAVPALRDFI AMTGIPAVAT LKGLGAPDIA HPCYLGMLGM
260 270 280 290 300
HGTKAANFAV QDCDLLVAVG ARFDDRVTGK LNTFASKAKV IHMDIDPAEL
310 320 330 340 350
GKLRQVHVAL QGNLNVLLPA LQQPLNIQSW RDEVMALKQQ HHWRYDHPGQ
360 370 380 390 400
AIYAPLLLKQ ISERKAPETV VTTDVGQHQM WTAQHMNFTR PENFITSSGL
410 420 430 440 450
GTMGFGVPAA VGAQMARPDD MVICVSGDGS FMMNVQELGT IKRKQLPLKI
460 470 480 490 500
VLLDNQRLGM VRQWQQLFFD GRYSETNLSD NPDFITLASA FDIPGQRITR
510 520 530 540
KDQVDAALDA LFNSEGPYLL QVSIDELENV WPLVPPGAGN ETMLEKIS
Length:548
Mass (Da):58,785
Last modified:September 11, 2007 - v1
Checksum:i51C9B4D4F397D2D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA. Translation: ABS46384.1.
RefSeqiYP_001399151.1. NC_009708.1.

Genome annotation databases

EnsemblBacteriaiABS46384; ABS46384; YpsIP31758_0154.
GeneIDi5386827.
KEGGiypi:YpsIP31758_0154.
PATRICi18628798. VBIYerPse15693_0376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA. Translation: ABS46384.1 .
RefSeqi YP_001399151.1. NC_009708.1.

3D structure databases

ProteinModelPortali A7FD23.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349747.YpsIP31758_0154.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS46384 ; ABS46384 ; YpsIP31758_0154 .
GeneIDi 5386827.
KEGGi ypi:YpsIP31758_0154.
PATRICi 18628798. VBIYerPse15693_0376.

Phylogenomic databases

eggNOGi COG0028.
HOGENOMi HOG000258448.
KOi K01652.
OMAi DEHENVW.
OrthoDBi EOG6KT2NW.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00055 .
UPA00049 ; UER00059 .
BioCyci YPSE349747:GH71-160-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProi IPR012846. Acetolactate_synth_lsu.
IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view ]
Pfami PF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00118. acolac_lg. 1 hit.
PROSITEi PS00187. TPP_ENZYMES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever."
    Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J.
    PLoS Genet. 3:1508-1523(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP 31758Imported.

Entry informationi

Entry nameiA7FD23_YERP3
AccessioniPrimary (citable) accession number: A7FD23
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3