A7FD00 (ARGB_YERP3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	YpsIP31758_0128

Organism

Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) [Complete proteome] [HAMAP]

Taxonomic identifier

349747 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia › Yersinia pseudotuberculosis

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP-Rule MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP-Rule MF_00082
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Acetylglutamate kinase HAMAP-Rule MF_00082		PRO_1000057543
Regions
	Nucleotide binding	181 – 186	6	ATP By similarity
	Nucleotide binding	209 – 211	3	ATP By similarity
	Region	44 – 45	2	Substrate binding By similarity
Sites
	Binding site	66	1	Substrate By similarity
	Binding site	158	1	Substrate By similarity
	Site	8	1	Transition state stabilizer By similarity
	Site	217	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7FD00 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: B0096A7285B8AA95	FASTA	258	26,987
	10 20 30 40 50 60 MMNPLVIKLG GVLLDSEEAL ERLFTALVTY REKHERPLVI MHGGGCLVDE LMKRLALPVV 70 80 90 100 110 120 KKNGLRVTPA DQIDIITGAL AGTANKTLLA WAVKHQINAV GLCLADGNTV TVTLLDAELG 130 140 150 160 170 180 HVGKAQPGSA ALVQTLLAAG YMPIISSIGI TVEGQLMNVN ADQAATALAA TLGADLILLS 190 200 210 220 230 240 DVSGILDGKG QRIAEMTAQK AEQLIAQGII TDGMVVKVNA ALDAARSLGR PVDIASWRHS 250 EQLPALFNGV PIGTRISV

References

[1]

"The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever." Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G., Fayolle C., Lindler L.E., Carniel E., Ravel J. PLoS Genet. 3:1508-1523(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IP 31758.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000720 Genomic DNA. Translation: ABS46009.1.
RefSeq	YP_001399128.1. NC_009708.1.
3D structure databases
ProteinModelPortal	A7FD00.
SMR	A7FD00. Positions 1-256.
ModBase	Search...
Protein-protein interaction databases
STRING	349747.YpsIP31758_0128.
Proteomic databases
PRIDE	A7FD00.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABS46009; ABS46009; YpsIP31758_0128.
GeneID	5385361.
KEGG	ypi:YpsIP31758_0128.
PATRIC	18628732. VBIYerPse15693_0349.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HOG000233260.
KO	K00930.
OMA	GGCLVDD.
ProtClustDB	PRK00942.
Enzyme and pathway databases
UniPathway	UPA00068; UER00107.
Family and domain databases
Gene3D	3.40.1160.10. 1 hit.
HAMAP	MF_00082_B. ArgB_B.
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_YERP3

Accession

Primary (citable) accession number: A7FD00

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 11, 2007
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program