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A7F4H5

- CBPYA_SCLS1

UniProt

A7F4H5 - CBPYA_SCLS1

Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei273 – 2731By similarity
    Active sitei465 – 4651By similarity
    Active sitei523 – 5231By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. phytochelatin biosynthetic process Source: EnsemblFungi

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:cpyA
    ORF Names:SS1G_12500
    OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
    Taxonomic identifieri665079 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
    ProteomesiUP000001312: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. fungal-type vacuole Source: EnsemblFungi

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 132115By similarityPRO_0000407476Add
    BLAST
    Chaini133 – 546414Carboxypeptidase Y homolog APRO_0000407477Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi186 ↔ 426By similarity
    Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi320 ↔ 334By similarity
    Disulfide bondi344 ↔ 367By similarity
    Disulfide bondi351 ↔ 360By similarity
    Disulfide bondi389 ↔ 396By similarity
    Glycosylationi512 – 5121N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Protein-protein interaction databases

    STRINGi665079.A7F4H5.

    Structurei

    3D structure databases

    ProteinModelPortaliA7F4H5.
    SMRiA7F4H5. Positions 135-542.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2939.
    KOiK13289.
    OMAiWPGQKEY.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A7F4H5-1 [UniParc]FASTAAdd to Basket

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    MKLLASTVLM GAAAASIAPQ QQVLKNPFQS ASKPISEAWS KSMESLNHLT    50
    DSMKDMTSEA KAVWDEVSTL FPEAMDRATF FQQPKPHTRK PDTAWDYVVK 100
    GADIQNVWVE NSKGEKEREI DGKLEKYNMR AKKVDPTKLG VDKVKQYSGY 150
    LDDEENDKHL FYWFFESRND PKNDPVVLWL NGGPGCSSLT GLFLELGPAS 200
    IDKNGKLHNN PYSWNANASV IFLDQPVNVG YSYSGGSVSN TIAAGKDVYA 250
    LLTLFFKQFP EYAKQDFHIA GESYAGHYIP VFTHEILSHK KRNINLKSVL 300
    IGNGLTDGLT QYEHYRPMAC GEGGYPAVLD SSECKAMDNA LPRCQSLIQS 350
    CYDSESVWSC VPASIYCNNA MMGPYQRTGQ NVYDIRGKCE DSSNLCYSAL 400
    GWISDYLNQA AVQKELGVEV SSYDSCNFDI NRNFLFQGDW MQPFHRLVPD 450
    ILEQIPVLIY AGDADFICNW LGNQAWTEAL EWPGQKGFNA AKTKDLQLEN 500
    GHKTGTFKSS GNFTFARIFG AGHMVPMDQP EASLDFLNKW LNDYTL 546
    Length:546
    Mass (Da):61,151
    Last modified:September 11, 2007 - v1
    Checksum:i02150015494651E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476641 Genomic DNA. Translation: EDN97646.1.
    RefSeqiXP_001586513.1. XM_001586463.1.

    Genome annotation databases

    EnsemblFungiiEDN97646; EDN97646; SS1G_12500.
    GeneIDi5482640.
    KEGGissl:SS1G_12500.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476641 Genomic DNA. Translation: EDN97646.1 .
    RefSeqi XP_001586513.1. XM_001586463.1.

    3D structure databases

    ProteinModelPortali A7F4H5.
    SMRi A7F4H5. Positions 135-542.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 665079.A7F4H5.

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EDN97646 ; EDN97646 ; SS1G_12500 .
    GeneIDi 5482640.
    KEGGi ssl:SS1G_12500.

    Phylogenomic databases

    eggNOGi COG2939.
    KOi K13289.
    OMAi WPGQKEY.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
      Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
      , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
      PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 18683 / 1980 / Ss-1.

    Entry informationi

    Entry nameiCBPYA_SCLS1
    AccessioniPrimary (citable) accession number: A7F4H5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3