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A7F4H5 (CBPYA_SCLS1) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase Y homolog A

EC=3.4.16.5
Gene names
Name:cpyA
ORF Names:SS1G_12500
OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum) [Reference proteome]
Taxonomic identifier665079 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia

Protein attributes

Sequence length546 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processphytochelatin biosynthetic process

Inferred from electronic annotation. Source: EnsemblFungi

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentfungal-type vacuole

Inferred from electronic annotation. Source: EnsemblFungi

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 132115 By similarity
PRO_0000407476
Chain133 – 546414Carboxypeptidase Y homolog A
PRO_0000407477

Sites

Active site2731 By similarity
Active site4651 By similarity
Active site5231 By similarity

Amino acid modifications

Glycosylation2171N-linked (GlcNAc...) Potential
Glycosylation5121N-linked (GlcNAc...) Potential
Disulfide bond186 ↔ 426 By similarity
Disulfide bond320 ↔ 334 By similarity
Disulfide bond344 ↔ 367 By similarity
Disulfide bond351 ↔ 360 By similarity
Disulfide bond389 ↔ 396 By similarity

Sequences

Sequence LengthMass (Da)Tools
A7F4H5 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 02150015494651E2

FASTA54661,151
        10         20         30         40         50         60 
MKLLASTVLM GAAAASIAPQ QQVLKNPFQS ASKPISEAWS KSMESLNHLT DSMKDMTSEA 

        70         80         90        100        110        120 
KAVWDEVSTL FPEAMDRATF FQQPKPHTRK PDTAWDYVVK GADIQNVWVE NSKGEKEREI 

       130        140        150        160        170        180 
DGKLEKYNMR AKKVDPTKLG VDKVKQYSGY LDDEENDKHL FYWFFESRND PKNDPVVLWL 

       190        200        210        220        230        240 
NGGPGCSSLT GLFLELGPAS IDKNGKLHNN PYSWNANASV IFLDQPVNVG YSYSGGSVSN 

       250        260        270        280        290        300 
TIAAGKDVYA LLTLFFKQFP EYAKQDFHIA GESYAGHYIP VFTHEILSHK KRNINLKSVL 

       310        320        330        340        350        360 
IGNGLTDGLT QYEHYRPMAC GEGGYPAVLD SSECKAMDNA LPRCQSLIQS CYDSESVWSC 

       370        380        390        400        410        420 
VPASIYCNNA MMGPYQRTGQ NVYDIRGKCE DSSNLCYSAL GWISDYLNQA AVQKELGVEV 

       430        440        450        460        470        480 
SSYDSCNFDI NRNFLFQGDW MQPFHRLVPD ILEQIPVLIY AGDADFICNW LGNQAWTEAL 

       490        500        510        520        530        540 
EWPGQKGFNA AKTKDLQLEN GHKTGTFKSS GNFTFARIFG AGHMVPMDQP EASLDFLNKW 


LNDYTL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476641 Genomic DNA. Translation: EDN97646.1.
RefSeqXP_001586513.1. XM_001586463.1.

3D structure databases

ProteinModelPortalA7F4H5.
SMRA7F4H5. Positions 135-542.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING665079.A7F4H5.

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEDN97646; EDN97646; SS1G_12500.
GeneID5482640.
KEGGssl:SS1G_12500.

Phylogenomic databases

eggNOGCOG2939.
KOK13289.
OMAHYRPMAC.
OrthoDBEOG7XDBR1.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_SCLS1
AccessionPrimary (citable) accession number: A7F4H5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 11, 2007
Last modified: November 13, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries