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A7F4H5

- CBPYA_SCLS1

UniProt

A7F4H5 - CBPYA_SCLS1

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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei273 – 2731By similarity
Active sitei465 – 4651By similarity
Active sitei523 – 5231By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. phytochelatin biosynthetic process Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:SS1G_12500
OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Taxonomic identifieri665079 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
ProteomesiUP000001312: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. fungal-type vacuole Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 132115By similarityPRO_0000407476Add
BLAST
Chaini133 – 546414Carboxypeptidase Y homolog APRO_0000407477Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi186 ↔ 426By similarity
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi320 ↔ 334By similarity
Disulfide bondi344 ↔ 367By similarity
Disulfide bondi351 ↔ 360By similarity
Disulfide bondi389 ↔ 396By similarity
Glycosylationi512 – 5121N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi665079.A7F4H5.

Structurei

3D structure databases

ProteinModelPortaliA7F4H5.
SMRiA7F4H5. Positions 135-542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
InParanoidiA7F4H5.
KOiK13289.
OMAiWPGQKEY.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7F4H5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLASTVLM GAAAASIAPQ QQVLKNPFQS ASKPISEAWS KSMESLNHLT
60 70 80 90 100
DSMKDMTSEA KAVWDEVSTL FPEAMDRATF FQQPKPHTRK PDTAWDYVVK
110 120 130 140 150
GADIQNVWVE NSKGEKEREI DGKLEKYNMR AKKVDPTKLG VDKVKQYSGY
160 170 180 190 200
LDDEENDKHL FYWFFESRND PKNDPVVLWL NGGPGCSSLT GLFLELGPAS
210 220 230 240 250
IDKNGKLHNN PYSWNANASV IFLDQPVNVG YSYSGGSVSN TIAAGKDVYA
260 270 280 290 300
LLTLFFKQFP EYAKQDFHIA GESYAGHYIP VFTHEILSHK KRNINLKSVL
310 320 330 340 350
IGNGLTDGLT QYEHYRPMAC GEGGYPAVLD SSECKAMDNA LPRCQSLIQS
360 370 380 390 400
CYDSESVWSC VPASIYCNNA MMGPYQRTGQ NVYDIRGKCE DSSNLCYSAL
410 420 430 440 450
GWISDYLNQA AVQKELGVEV SSYDSCNFDI NRNFLFQGDW MQPFHRLVPD
460 470 480 490 500
ILEQIPVLIY AGDADFICNW LGNQAWTEAL EWPGQKGFNA AKTKDLQLEN
510 520 530 540
GHKTGTFKSS GNFTFARIFG AGHMVPMDQP EASLDFLNKW LNDYTL
Length:546
Mass (Da):61,151
Last modified:September 11, 2007 - v1
Checksum:i02150015494651E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476641 Genomic DNA. Translation: EDN97646.1.
RefSeqiXP_001586513.1. XM_001586463.1.

Genome annotation databases

EnsemblFungiiEDN97646; EDN97646; SS1G_12500.
GeneIDi5482640.
KEGGissl:SS1G_12500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476641 Genomic DNA. Translation: EDN97646.1 .
RefSeqi XP_001586513.1. XM_001586463.1.

3D structure databases

ProteinModelPortali A7F4H5.
SMRi A7F4H5. Positions 135-542.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 665079.A7F4H5.

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EDN97646 ; EDN97646 ; SS1G_12500 .
GeneIDi 5482640.
KEGGi ssl:SS1G_12500.

Phylogenomic databases

eggNOGi COG2939.
InParanoidi A7F4H5.
KOi K13289.
OMAi WPGQKEY.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
    Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
    , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
    PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 18683 / 1980 / Ss-1.

Entry informationi

Entry nameiCBPYA_SCLS1
AccessioniPrimary (citable) accession number: A7F4H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3