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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei273By similarity1
Active sitei465By similarity1
Active sitei523By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:SS1G_12500
OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Taxonomic identifieri665079 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
Proteomesi
  • UP000001312 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:SS1G_12500

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040747618 – 132By similarityAdd BLAST115
ChainiPRO_0000407477133 – 546Carboxypeptidase Y homolog AAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi186 ↔ 426By similarity
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi320 ↔ 334By similarity
Disulfide bondi344 ↔ 367By similarity
Disulfide bondi351 ↔ 360By similarity
Disulfide bondi389 ↔ 396By similarity
Glycosylationi512N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiA7F4H5

Interactioni

Protein-protein interaction databases

STRINGi5180.EDN97646

Structurei

3D structure databases

ProteinModelPortaliA7F4H5
SMRiA7F4H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiA7F4H5
KOiK13289
OMAiMDNALPR
OrthoDBiEOG092C1EU7

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR008442 Propeptide_carboxypepY
IPR033124 Ser_caboxypep_his_AS
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF05388 Carbpep_Y_N, 1 hit
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7F4H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLASTVLM GAAAASIAPQ QQVLKNPFQS ASKPISEAWS KSMESLNHLT
60 70 80 90 100
DSMKDMTSEA KAVWDEVSTL FPEAMDRATF FQQPKPHTRK PDTAWDYVVK
110 120 130 140 150
GADIQNVWVE NSKGEKEREI DGKLEKYNMR AKKVDPTKLG VDKVKQYSGY
160 170 180 190 200
LDDEENDKHL FYWFFESRND PKNDPVVLWL NGGPGCSSLT GLFLELGPAS
210 220 230 240 250
IDKNGKLHNN PYSWNANASV IFLDQPVNVG YSYSGGSVSN TIAAGKDVYA
260 270 280 290 300
LLTLFFKQFP EYAKQDFHIA GESYAGHYIP VFTHEILSHK KRNINLKSVL
310 320 330 340 350
IGNGLTDGLT QYEHYRPMAC GEGGYPAVLD SSECKAMDNA LPRCQSLIQS
360 370 380 390 400
CYDSESVWSC VPASIYCNNA MMGPYQRTGQ NVYDIRGKCE DSSNLCYSAL
410 420 430 440 450
GWISDYLNQA AVQKELGVEV SSYDSCNFDI NRNFLFQGDW MQPFHRLVPD
460 470 480 490 500
ILEQIPVLIY AGDADFICNW LGNQAWTEAL EWPGQKGFNA AKTKDLQLEN
510 520 530 540
GHKTGTFKSS GNFTFARIFG AGHMVPMDQP EASLDFLNKW LNDYTL
Length:546
Mass (Da):61,151
Last modified:September 11, 2007 - v1
Checksum:i02150015494651E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476641 Genomic DNA Translation: EDN97646.1
RefSeqiXP_001586513.1, XM_001586463.1

Genome annotation databases

EnsemblFungiiEDN97646; EDN97646; SS1G_12500
GeneIDi5482640
KEGGissl:SS1G_12500

Similar proteinsi

Entry informationi

Entry nameiCBPYA_SCLS1
AccessioniPrimary (citable) accession number: A7F4H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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