Reviewed, UniProtKB/Swiss-Prot A7F0W2 (ATG1_SCLS1)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase ATG1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	ATG1
ORF Names:	SS1G_11231

Organism

Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum) [Complete proteome]

Taxonomic identifier

665079 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Leotiomycetes › Helotiales › Sclerotiniaceae › Sclerotinia

Protein attributes

Sequence length	951 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 951	951	Serine/threonine-protein kinase ATG1		PRO_0000317798
Regions
	Domain	22 – 327	306	Protein kinase
	Nucleotide binding	28 – 36	9	ATP By similarity
Sites
	Active site	165	1	Proton acceptor By similarity
	Binding site	51	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7F0W2-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: AE638003453D730F	FASTA	951	104,696
	10 20 30 40 50 60 MASKTPSSSS SRRPRNVGVG SFTINEEIGK GSFATVYRGT HVPSGSLVAI KSVNLGRLNK 70 80 90 100 110 120 KLKDNLYVEI EILKSLHHPH IVALMDCRES TSHIHLMMEY CELGDLSYFI KKRDKLADNP 130 140 150 160 170 180 SLFDMIRKYP MPVDGGLNQV VVRHFFKQLS SAMEFLRDRD FVHRDVKPQN LLLIPSPDWM 190 200 210 220 230 240 AKSKNGPEAM KASKESIVPM VGINSLPMLK LADFGFARSL PSTSLAETLC GSPLYMAPEI 250 260 270 280 290 300 LRYEKYDARA DLWSIGTVLY EMMTGKPPFR AANHVELLRK IEQNEDEIRF PSKTVFSRDL 310 320 330 340 350 360 KDIARRFLKK RPEDRITFPE YFAHPVVTGP IPGLVGEDLP KEIITPSRSP EASVARHPSL 370 380 390 400 410 420 RERQRENPTP KPVETTYESL IARDIGEQAP RSPHIEANQP VEIPGHKSGR PGSRDRPSAI 430 440 450 460 470 480 SAATAPNVDT LPRQRDRTER HYAPIGRPVS RKPSYDEQAN LPVQEEIRSS DSITEAEQDV 490 500 510 520 530 540 RDAREYVLVE KKAVEVNAFA DEMAASPRLA HANHIPKQPT RRHTSMGAPN STSGAVAVPP 550 560 570 580 590 600 SRAVQKAQGN TRPDTSSARN SYGSYGKTGS SPSTASAIAK ALQGASVRVF GVSWSPTLIG 610 620 630 640 650 660 KGPSPQQLYN PYPAYPTPNT GFIGDARPID EDQRVVNVIE DSATRSDVVY GFAEVKYRQL 670 680 690 700 710 720 IPLAPSMNHG LGGPNNEKVG DAMDEDDGLT VEAIVNLSEE ALVLYVKSLS LLSKSMDIAG 730 740 750 760 770 780 AWWLRKNRGG VISGGHTPGS DSSSAVQAGN RINGAVQWVR TRFNEVLEKA ELVRLKLVEA 790 800 810 820 830 840 QKRLPEDHPG HPSNHATASK IVGGSSTTDG VVLSSGITAE KLMYDRALEM SRTAAINELA 850 860 870 880 890 900 NEDLPGCEIS YTTAIRMLEA VLENDEELIP RKRSPSLRED KEKCDGGEVN GINFGDRKDV 910 920 930 940 950 LKVLQMIRTR LHVLKKKMAV IARHQSMPPP SSPRHSHSGG TTPTIANTPP H

References

[1]

"Annotation of the Sclerotinia sclerotiorum 1980 genome." Birren B.W., Galagan J.E., Lander E.S., Devon K., Nusbaum C., Cuomo C., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K., Pushparaj V. , DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Yandava C., Kodira C.D., Zeng Q., Alvarado L., O'Leary S., Dickman M.B., Kohn L., Rollins J. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476637 Genomic DNA. Translation: EDN95354.1.
RefSeq	XP_001587989.1.
3D structure databases
SMR	A7F0W2. Positions 15-330.
ModBase	Search...
Genome annotation databases
GeneID	5483860.
KEGG	ssl:SS1G_11231.
Phylogenomic databases
OrthoDB	EOG98D2C4.
Family and domain databases
InterPro	IPR020636. Ca/CaM-dep_prot_kinase-like. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR020656. Ser/Thr_prot_kinase_ATG1. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
PANTHER	PTHR22982. Ca/CaM-dep_prot_kinase-like. 1 hit. PTHR22982:SF39. Ser/Thr_prot_kinase_ATG1. 1 hit.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_SCLS1

Accession

Primary (citable) accession number: A7F0W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 11, 2007
Last modified:	January 19, 2010
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)