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A7EZS5 (BGALC_SCLS1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-galactosidase C

EC=3.2.1.23
Alternative name(s):
Lactase C
Gene names
Name:lacC
ORF Names:SS1G_10842
OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum) [Reference proteome]
Taxonomic identifier665079 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia

Protein attributes

Sequence length984 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 984965Probable beta-galactosidase C
PRO_0000395241

Sites

Active site1841Proton donor Potential
Active site2831Nucleophile Potential
Binding site781Substrate By similarity
Binding site1231Substrate By similarity
Binding site1241Substrate; via amide nitrogen By similarity
Binding site1251Substrate By similarity
Binding site1831Substrate By similarity
Binding site2471Substrate By similarity
Binding site3491Substrate By similarity

Amino acid modifications

Glycosylation2721N-linked (GlcNAc...) Potential
Glycosylation3871N-linked (GlcNAc...) Potential
Glycosylation4331N-linked (GlcNAc...) Potential
Glycosylation4621N-linked (GlcNAc...) Potential
Glycosylation5161N-linked (GlcNAc...) Potential
Glycosylation5831N-linked (GlcNAc...) Potential
Glycosylation5991N-linked (GlcNAc...) Potential
Glycosylation6731N-linked (GlcNAc...) Potential
Glycosylation7161N-linked (GlcNAc...) Potential
Glycosylation7561N-linked (GlcNAc...) Potential
Glycosylation8601N-linked (GlcNAc...) Potential
Glycosylation8701N-linked (GlcNAc...) Potential
Disulfide bond253 ↔ 300 By similarity

Sequences

Sequence LengthMass (Da)Tools
A7EZS5 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 8DD71B799E922286

FASTA984107,521
        10         20         30         40         50         60 
MRLLNIFTTL CLLLWSGAAT NDGLTDVVEW DPYSLTINGD RVFIYSAEFH YQRMPVPELW 

        70         80         90        100        110        120 
LDIFQKFRAN GFNTISVYFF WSYHEASKGS FDFETSGKNV QRVLDYAKEA GIYVIARAGP 

       130        140        150        160        170        180 
YCNAETSAGG LALWGSDGSM GTLRTNNAAY YQSWQPWIKE IGAILAKNQV TNGGPVILNQ 

       190        200        210        220        230        240 
VENELQETVH SATNTLVLYM EQLETAFRAA GITVPFSHNE KGQRSQSWST DYENVGGAVN 

       250        260        270        280        290        300 
VYGLDSYPGG LSCTNSNSGF SVVRNYYQWF SNYSYTQPSY FPEFEGGYFT PWGGSFYDEC 

       310        320        330        340        350        360 
QSELDPSFPD VYYKNNIGQR TTLMSLYMAW GGTNWGHSAA PVVYTSYDYA APLRETRQIR 

       370        380        390        400        410        420 
DKLSQTKLIG LFTRVSTDLL KTDMIGNGTG HSVSSTGIWS WVLRNPDTQA GFTVVQQASS 

       430        440        450        460        470        480 
GSRASVTFDV YLNTSLGAVT ASDVNLNGRQ SKILVTDYNF GNHTLLYASS DILTYGTFDV 

       490        500        510        520        530        540 
DVLVFYLEQG QIGQFALKTT SKLTYQVYGN SVFAANSSST STSQTFTYTQ GAGQTVVQFS 

       550        560        570        580        590        600 
DGALVYLLDQ PSAWKFWAPP TTSNPQVKPN EQIFVLGPYL VRNASISSGV AQIFGDNDNA 

       610        620        630        640        650        660 
TTIEVYAGSS LTSIVWNGVS LSATKTKYGS YSASLPGTES RVISLPSLTN WESANSLPEK 

       670        680        690        700        710        720 
ETSYDDSKWT VCNKTTTLSP IAPLTLPVLF SSDYGFYTGQ KIYRGYFDGL TYTSINITCS 

       730        740        750        760        770        780 
GGLAFGWSAW LNGVLIGGNT GVATATTTNA VLDLTNFTSV IKSENNLVTV VVDYHGHDET 

       790        800        810        820        830        840 
STAKGVENPR GILGAFLVPK PSASTGFKLW KIQGNAGGSA NIDPVRGPMN EGGFYGERVG 

       850        860        870        880        890        900 
WHLPSSPSLP SDSTPLIGLN TSGISFYTTN FTLALDSDLD VPLGIKLSAP AGTIARVMFW 

       910        920        930        940        950        960 
INGYQYGKYV PHIGPQTVFP IPPGIINNQG SNKLALSLWA MTDAGARLTD VELVSYGVYE 

       970        980 
SGFGFDRDWS YLQPGWDEGR LAYA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476636 Genomic DNA. Translation: EDN94967.1.
RefSeqXP_001588395.1. XM_001588345.1.

3D structure databases

ProteinModelPortalA7EZS5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING665079.A7EZS5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5484283.
KEGGssl:SS1G_10842.

Phylogenomic databases

eggNOGCOG1874.
OMASGEFHYQ.
OrthoDBEOG7ZGXBD.

Family and domain databases

Gene3D2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSPR00742. GLHYDRLASE35.
SUPFAMSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBGALC_SCLS1
AccessionPrimary (citable) accession number: A7EZS5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries