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A7EZS5

- BGALC_SCLS1

UniProt

A7EZS5 - BGALC_SCLS1

Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei78 – 781SubstrateBy similarity
    Binding sitei123 – 1231SubstrateBy similarity
    Binding sitei124 – 1241Substrate; via amide nitrogenBy similarity
    Binding sitei125 – 1251SubstrateBy similarity
    Binding sitei183 – 1831SubstrateBy similarity
    Active sitei184 – 1841Proton donorSequence Analysis
    Binding sitei247 – 2471SubstrateBy similarity
    Active sitei283 – 2831NucleophileSequence Analysis
    Binding sitei349 – 3491SubstrateBy similarity

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-galactosidase C (EC:3.2.1.23)
    Alternative name(s):
    Lactase C
    Gene namesi
    Name:lacC
    ORF Names:SS1G_10842
    OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
    Taxonomic identifieri665079 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
    ProteomesiUP000001312: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 984965Probable beta-galactosidase CPRO_0000395241Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi253 ↔ 300By similarity
    Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi583 – 5831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi599 – 5991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi673 – 6731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi716 – 7161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi756 – 7561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi860 – 8601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi870 – 8701N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi665079.A7EZS5.

    Structurei

    3D structure databases

    ProteinModelPortaliA7EZS5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 35 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1874.
    OMAiSGEFHYQ.
    OrthoDBiEOG7ZGXBD.

    Family and domain databases

    Gene3Di2.102.20.10. 1 hit.
    2.60.120.260. 2 hits.
    2.60.390.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR018954. Betagal_dom2.
    IPR025972. BetaGal_dom3.
    IPR025300. BetaGal_jelly_roll_dom.
    IPR008979. Galactose-bd-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR23421. PTHR23421. 1 hit.
    PfamiPF10435. BetaGal_dom2. 1 hit.
    PF13363. BetaGal_dom3. 1 hit.
    PF13364. BetaGal_dom4_5. 2 hits.
    PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view]
    PRINTSiPR00742. GLHYDRLASE35.
    SUPFAMiSSF117100. SSF117100. 1 hit.
    SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A7EZS5-1 [UniParc]FASTAAdd to Basket

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    MRLLNIFTTL CLLLWSGAAT NDGLTDVVEW DPYSLTINGD RVFIYSAEFH    50
    YQRMPVPELW LDIFQKFRAN GFNTISVYFF WSYHEASKGS FDFETSGKNV 100
    QRVLDYAKEA GIYVIARAGP YCNAETSAGG LALWGSDGSM GTLRTNNAAY 150
    YQSWQPWIKE IGAILAKNQV TNGGPVILNQ VENELQETVH SATNTLVLYM 200
    EQLETAFRAA GITVPFSHNE KGQRSQSWST DYENVGGAVN VYGLDSYPGG 250
    LSCTNSNSGF SVVRNYYQWF SNYSYTQPSY FPEFEGGYFT PWGGSFYDEC 300
    QSELDPSFPD VYYKNNIGQR TTLMSLYMAW GGTNWGHSAA PVVYTSYDYA 350
    APLRETRQIR DKLSQTKLIG LFTRVSTDLL KTDMIGNGTG HSVSSTGIWS 400
    WVLRNPDTQA GFTVVQQASS GSRASVTFDV YLNTSLGAVT ASDVNLNGRQ 450
    SKILVTDYNF GNHTLLYASS DILTYGTFDV DVLVFYLEQG QIGQFALKTT 500
    SKLTYQVYGN SVFAANSSST STSQTFTYTQ GAGQTVVQFS DGALVYLLDQ 550
    PSAWKFWAPP TTSNPQVKPN EQIFVLGPYL VRNASISSGV AQIFGDNDNA 600
    TTIEVYAGSS LTSIVWNGVS LSATKTKYGS YSASLPGTES RVISLPSLTN 650
    WESANSLPEK ETSYDDSKWT VCNKTTTLSP IAPLTLPVLF SSDYGFYTGQ 700
    KIYRGYFDGL TYTSINITCS GGLAFGWSAW LNGVLIGGNT GVATATTTNA 750
    VLDLTNFTSV IKSENNLVTV VVDYHGHDET STAKGVENPR GILGAFLVPK 800
    PSASTGFKLW KIQGNAGGSA NIDPVRGPMN EGGFYGERVG WHLPSSPSLP 850
    SDSTPLIGLN TSGISFYTTN FTLALDSDLD VPLGIKLSAP AGTIARVMFW 900
    INGYQYGKYV PHIGPQTVFP IPPGIINNQG SNKLALSLWA MTDAGARLTD 950
    VELVSYGVYE SGFGFDRDWS YLQPGWDEGR LAYA 984
    Length:984
    Mass (Da):107,521
    Last modified:September 11, 2007 - v1
    Checksum:i8DD71B799E922286
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476636 Genomic DNA. Translation: EDN94967.1.
    RefSeqiXP_001588395.1. XM_001588345.1.

    Genome annotation databases

    GeneIDi5484283.
    KEGGissl:SS1G_10842.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476636 Genomic DNA. Translation: EDN94967.1 .
    RefSeqi XP_001588395.1. XM_001588345.1.

    3D structure databases

    ProteinModelPortali A7EZS5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 665079.A7EZS5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5484283.
    KEGGi ssl:SS1G_10842.

    Phylogenomic databases

    eggNOGi COG1874.
    OMAi SGEFHYQ.
    OrthoDBi EOG7ZGXBD.

    Family and domain databases

    Gene3Di 2.102.20.10. 1 hit.
    2.60.120.260. 2 hits.
    2.60.390.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR018954. Betagal_dom2.
    IPR025972. BetaGal_dom3.
    IPR025300. BetaGal_jelly_roll_dom.
    IPR008979. Galactose-bd-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR23421. PTHR23421. 1 hit.
    Pfami PF10435. BetaGal_dom2. 1 hit.
    PF13363. BetaGal_dom3. 1 hit.
    PF13364. BetaGal_dom4_5. 2 hits.
    PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view ]
    PRINTSi PR00742. GLHYDRLASE35.
    SUPFAMi SSF117100. SSF117100. 1 hit.
    SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
      Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
      , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
      PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 18683 / 1980 / Ss-1.

    Entry informationi

    Entry nameiBGALC_SCLS1
    AccessioniPrimary (citable) accession number: A7EZS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3