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Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78SubstrateBy similarity1
Binding sitei123SubstrateBy similarity1
Binding sitei124Substrate; via amide nitrogenBy similarity1
Binding sitei125SubstrateBy similarity1
Binding sitei183SubstrateBy similarity1
Active sitei184Proton donorSequence analysis1
Binding sitei247SubstrateBy similarity1
Active sitei283NucleophileSequence analysis1
Binding sitei349SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:SS1G_10842
OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Taxonomic identifieri665079 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
Proteomesi
  • UP000001312 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:SS1G_10842

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000039524120 – 984Probable beta-galactosidase CAdd BLAST965

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi253 ↔ 300By similarity
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi462N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi516N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi599N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi673N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi716N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi756N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi860N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi870N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA7EZS5

Structurei

3D structure databases

ProteinModelPortaliA7EZS5
SMRiA7EZS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiA7EZS5
OMAiEFEGGWF
OrthoDBiEOG092C0SLI

Family and domain databases

Gene3Di2.102.20.10, 1 hit
2.60.120.260, 2 hits
2.60.390.10, 1 hit
InterProiView protein in InterPro
IPR018954 Betagal_dom2
IPR037110 Betagal_dom2_sf
IPR025972 BetaGal_dom3
IPR036833 BetaGal_dom3_sf
IPR025300 BetaGal_jelly_roll_dom
IPR008979 Galactose-bd-like_sf
IPR031330 Gly_Hdrlase_35_cat
IPR001944 Glycoside_Hdrlase_35
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR23421 PTHR23421, 1 hit
PfamiView protein in Pfam
PF10435 BetaGal_dom2, 1 hit
PF13363 BetaGal_dom3, 1 hit
PF13364 BetaGal_dom4_5, 2 hits
PF01301 Glyco_hydro_35, 1 hit
PRINTSiPR00742 GLHYDRLASE35
SMARTiView protein in SMART
SM01029 BetaGal_dom2, 1 hit
SUPFAMiSSF117100 SSF117100, 1 hit
SSF49785 SSF49785, 2 hits
SSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7EZS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLNIFTTL CLLLWSGAAT NDGLTDVVEW DPYSLTINGD RVFIYSAEFH
60 70 80 90 100
YQRMPVPELW LDIFQKFRAN GFNTISVYFF WSYHEASKGS FDFETSGKNV
110 120 130 140 150
QRVLDYAKEA GIYVIARAGP YCNAETSAGG LALWGSDGSM GTLRTNNAAY
160 170 180 190 200
YQSWQPWIKE IGAILAKNQV TNGGPVILNQ VENELQETVH SATNTLVLYM
210 220 230 240 250
EQLETAFRAA GITVPFSHNE KGQRSQSWST DYENVGGAVN VYGLDSYPGG
260 270 280 290 300
LSCTNSNSGF SVVRNYYQWF SNYSYTQPSY FPEFEGGYFT PWGGSFYDEC
310 320 330 340 350
QSELDPSFPD VYYKNNIGQR TTLMSLYMAW GGTNWGHSAA PVVYTSYDYA
360 370 380 390 400
APLRETRQIR DKLSQTKLIG LFTRVSTDLL KTDMIGNGTG HSVSSTGIWS
410 420 430 440 450
WVLRNPDTQA GFTVVQQASS GSRASVTFDV YLNTSLGAVT ASDVNLNGRQ
460 470 480 490 500
SKILVTDYNF GNHTLLYASS DILTYGTFDV DVLVFYLEQG QIGQFALKTT
510 520 530 540 550
SKLTYQVYGN SVFAANSSST STSQTFTYTQ GAGQTVVQFS DGALVYLLDQ
560 570 580 590 600
PSAWKFWAPP TTSNPQVKPN EQIFVLGPYL VRNASISSGV AQIFGDNDNA
610 620 630 640 650
TTIEVYAGSS LTSIVWNGVS LSATKTKYGS YSASLPGTES RVISLPSLTN
660 670 680 690 700
WESANSLPEK ETSYDDSKWT VCNKTTTLSP IAPLTLPVLF SSDYGFYTGQ
710 720 730 740 750
KIYRGYFDGL TYTSINITCS GGLAFGWSAW LNGVLIGGNT GVATATTTNA
760 770 780 790 800
VLDLTNFTSV IKSENNLVTV VVDYHGHDET STAKGVENPR GILGAFLVPK
810 820 830 840 850
PSASTGFKLW KIQGNAGGSA NIDPVRGPMN EGGFYGERVG WHLPSSPSLP
860 870 880 890 900
SDSTPLIGLN TSGISFYTTN FTLALDSDLD VPLGIKLSAP AGTIARVMFW
910 920 930 940 950
INGYQYGKYV PHIGPQTVFP IPPGIINNQG SNKLALSLWA MTDAGARLTD
960 970 980
VELVSYGVYE SGFGFDRDWS YLQPGWDEGR LAYA
Length:984
Mass (Da):107,521
Last modified:September 11, 2007 - v1
Checksum:i8DD71B799E922286
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476636 Genomic DNA Translation: EDN94967.1
RefSeqiXP_001588395.1, XM_001588345.1

Genome annotation databases

GeneIDi5484283
KEGGissl:SS1G_10842

Similar proteinsi

Entry informationi

Entry nameiBGALC_SCLS1
AccessioniPrimary (citable) accession number: A7EZS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health