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A7EZS5

- BGALC_SCLS1

UniProt

A7EZS5 - BGALC_SCLS1

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Protein
Probable beta-galactosidase C
Gene
lacC, SS1G_10842
Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 781Substrate By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei124 – 1241Substrate; via amide nitrogen By similarity
Binding sitei125 – 1251Substrate By similarity
Binding sitei183 – 1831Substrate By similarity
Active sitei184 – 1841Proton donor Reviewed prediction
Binding sitei247 – 2471Substrate By similarity
Active sitei283 – 2831Nucleophile Reviewed prediction
Binding sitei349 – 3491Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:SS1G_10842
OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Taxonomic identifieri665079 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
ProteomesiUP000001312: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 984965Probable beta-galactosidase C
PRO_0000395241Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi253 ↔ 300 By similarity
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi387 – 3871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi433 – 4331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi462 – 4621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi516 – 5161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi583 – 5831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi599 – 5991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi673 – 6731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi716 – 7161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi756 – 7561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi860 – 8601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi870 – 8701N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi665079.A7EZS5.

Structurei

3D structure databases

ProteinModelPortaliA7EZS5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
OMAiSGEFHYQ.
OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7EZS5-1 [UniParc]FASTAAdd to Basket

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MRLLNIFTTL CLLLWSGAAT NDGLTDVVEW DPYSLTINGD RVFIYSAEFH    50
YQRMPVPELW LDIFQKFRAN GFNTISVYFF WSYHEASKGS FDFETSGKNV 100
QRVLDYAKEA GIYVIARAGP YCNAETSAGG LALWGSDGSM GTLRTNNAAY 150
YQSWQPWIKE IGAILAKNQV TNGGPVILNQ VENELQETVH SATNTLVLYM 200
EQLETAFRAA GITVPFSHNE KGQRSQSWST DYENVGGAVN VYGLDSYPGG 250
LSCTNSNSGF SVVRNYYQWF SNYSYTQPSY FPEFEGGYFT PWGGSFYDEC 300
QSELDPSFPD VYYKNNIGQR TTLMSLYMAW GGTNWGHSAA PVVYTSYDYA 350
APLRETRQIR DKLSQTKLIG LFTRVSTDLL KTDMIGNGTG HSVSSTGIWS 400
WVLRNPDTQA GFTVVQQASS GSRASVTFDV YLNTSLGAVT ASDVNLNGRQ 450
SKILVTDYNF GNHTLLYASS DILTYGTFDV DVLVFYLEQG QIGQFALKTT 500
SKLTYQVYGN SVFAANSSST STSQTFTYTQ GAGQTVVQFS DGALVYLLDQ 550
PSAWKFWAPP TTSNPQVKPN EQIFVLGPYL VRNASISSGV AQIFGDNDNA 600
TTIEVYAGSS LTSIVWNGVS LSATKTKYGS YSASLPGTES RVISLPSLTN 650
WESANSLPEK ETSYDDSKWT VCNKTTTLSP IAPLTLPVLF SSDYGFYTGQ 700
KIYRGYFDGL TYTSINITCS GGLAFGWSAW LNGVLIGGNT GVATATTTNA 750
VLDLTNFTSV IKSENNLVTV VVDYHGHDET STAKGVENPR GILGAFLVPK 800
PSASTGFKLW KIQGNAGGSA NIDPVRGPMN EGGFYGERVG WHLPSSPSLP 850
SDSTPLIGLN TSGISFYTTN FTLALDSDLD VPLGIKLSAP AGTIARVMFW 900
INGYQYGKYV PHIGPQTVFP IPPGIINNQG SNKLALSLWA MTDAGARLTD 950
VELVSYGVYE SGFGFDRDWS YLQPGWDEGR LAYA 984
Length:984
Mass (Da):107,521
Last modified:September 11, 2007 - v1
Checksum:i8DD71B799E922286
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476636 Genomic DNA. Translation: EDN94967.1.
RefSeqiXP_001588395.1. XM_001588345.1.

Genome annotation databases

GeneIDi5484283.
KEGGissl:SS1G_10842.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476636 Genomic DNA. Translation: EDN94967.1 .
RefSeqi XP_001588395.1. XM_001588345.1.

3D structure databases

ProteinModelPortali A7EZS5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 665079.A7EZS5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5484283.
KEGGi ssl:SS1G_10842.

Phylogenomic databases

eggNOGi COG1874.
OMAi SGEFHYQ.
OrthoDBi EOG7ZGXBD.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
    Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
    , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
    PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 18683 / 1980 / Ss-1.

Entry informationi

Entry nameiBGALC_SCLS1
AccessioniPrimary (citable) accession number: A7EZS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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