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A7EZS5

- BGALC_SCLS1

UniProt

A7EZS5 - BGALC_SCLS1

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Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 781SubstrateBy similarity
Binding sitei123 – 1231SubstrateBy similarity
Binding sitei124 – 1241Substrate; via amide nitrogenBy similarity
Binding sitei125 – 1251SubstrateBy similarity
Binding sitei183 – 1831SubstrateBy similarity
Active sitei184 – 1841Proton donorSequence Analysis
Binding sitei247 – 2471SubstrateBy similarity
Active sitei283 – 2831NucleophileSequence Analysis
Binding sitei349 – 3491SubstrateBy similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:SS1G_10842
OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Taxonomic identifieri665079 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
ProteomesiUP000001312: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 984965Probable beta-galactosidase CPRO_0000395241Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi253 ↔ 300By similarity
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi583 – 5831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi599 – 5991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi673 – 6731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi716 – 7161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi756 – 7561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi860 – 8601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi870 – 8701N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi665079.A7EZS5.

Structurei

3D structure databases

ProteinModelPortaliA7EZS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
InParanoidiA7EZS5.
OMAiSGEFHYQ.
OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7EZS5-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MRLLNIFTTL CLLLWSGAAT NDGLTDVVEW DPYSLTINGD RVFIYSAEFH
60 70 80 90 100
YQRMPVPELW LDIFQKFRAN GFNTISVYFF WSYHEASKGS FDFETSGKNV
110 120 130 140 150
QRVLDYAKEA GIYVIARAGP YCNAETSAGG LALWGSDGSM GTLRTNNAAY
160 170 180 190 200
YQSWQPWIKE IGAILAKNQV TNGGPVILNQ VENELQETVH SATNTLVLYM
210 220 230 240 250
EQLETAFRAA GITVPFSHNE KGQRSQSWST DYENVGGAVN VYGLDSYPGG
260 270 280 290 300
LSCTNSNSGF SVVRNYYQWF SNYSYTQPSY FPEFEGGYFT PWGGSFYDEC
310 320 330 340 350
QSELDPSFPD VYYKNNIGQR TTLMSLYMAW GGTNWGHSAA PVVYTSYDYA
360 370 380 390 400
APLRETRQIR DKLSQTKLIG LFTRVSTDLL KTDMIGNGTG HSVSSTGIWS
410 420 430 440 450
WVLRNPDTQA GFTVVQQASS GSRASVTFDV YLNTSLGAVT ASDVNLNGRQ
460 470 480 490 500
SKILVTDYNF GNHTLLYASS DILTYGTFDV DVLVFYLEQG QIGQFALKTT
510 520 530 540 550
SKLTYQVYGN SVFAANSSST STSQTFTYTQ GAGQTVVQFS DGALVYLLDQ
560 570 580 590 600
PSAWKFWAPP TTSNPQVKPN EQIFVLGPYL VRNASISSGV AQIFGDNDNA
610 620 630 640 650
TTIEVYAGSS LTSIVWNGVS LSATKTKYGS YSASLPGTES RVISLPSLTN
660 670 680 690 700
WESANSLPEK ETSYDDSKWT VCNKTTTLSP IAPLTLPVLF SSDYGFYTGQ
710 720 730 740 750
KIYRGYFDGL TYTSINITCS GGLAFGWSAW LNGVLIGGNT GVATATTTNA
760 770 780 790 800
VLDLTNFTSV IKSENNLVTV VVDYHGHDET STAKGVENPR GILGAFLVPK
810 820 830 840 850
PSASTGFKLW KIQGNAGGSA NIDPVRGPMN EGGFYGERVG WHLPSSPSLP
860 870 880 890 900
SDSTPLIGLN TSGISFYTTN FTLALDSDLD VPLGIKLSAP AGTIARVMFW
910 920 930 940 950
INGYQYGKYV PHIGPQTVFP IPPGIINNQG SNKLALSLWA MTDAGARLTD
960 970 980
VELVSYGVYE SGFGFDRDWS YLQPGWDEGR LAYA
Length:984
Mass (Da):107,521
Last modified:September 11, 2007 - v1
Checksum:i8DD71B799E922286
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476636 Genomic DNA. Translation: EDN94967.1.
RefSeqiXP_001588395.1. XM_001588345.1.

Genome annotation databases

GeneIDi5484283.
KEGGissl:SS1G_10842.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476636 Genomic DNA. Translation: EDN94967.1 .
RefSeqi XP_001588395.1. XM_001588345.1.

3D structure databases

ProteinModelPortali A7EZS5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 665079.A7EZS5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5484283.
KEGGi ssl:SS1G_10842.

Phylogenomic databases

eggNOGi COG1874.
InParanoidi A7EZS5.
OMAi SGEFHYQ.
OrthoDBi EOG7ZGXBD.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
    Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
    , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
    PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 18683 / 1980 / Ss-1.

Entry informationi

Entry nameiBGALC_SCLS1
AccessioniPrimary (citable) accession number: A7EZS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3