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Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78SubstrateBy similarity1
Binding sitei123SubstrateBy similarity1
Binding sitei124Substrate; via amide nitrogenBy similarity1
Binding sitei125SubstrateBy similarity1
Binding sitei183SubstrateBy similarity1
Active sitei184Proton donorSequence analysis1
Binding sitei247SubstrateBy similarity1
Active sitei283NucleophileSequence analysis1
Binding sitei349SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:SS1G_10842
OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Taxonomic identifieri665079 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
Proteomesi
  • UP000001312 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:SS1G_10842.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000039524120 – 984Probable beta-galactosidase CAdd BLAST965

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi253 ↔ 300By similarity
Glycosylationi272N-linked (GlcNAc...)Sequence analysis1
Glycosylationi387N-linked (GlcNAc...)Sequence analysis1
Glycosylationi433N-linked (GlcNAc...)Sequence analysis1
Glycosylationi462N-linked (GlcNAc...)Sequence analysis1
Glycosylationi516N-linked (GlcNAc...)Sequence analysis1
Glycosylationi583N-linked (GlcNAc...)Sequence analysis1
Glycosylationi599N-linked (GlcNAc...)Sequence analysis1
Glycosylationi673N-linked (GlcNAc...)Sequence analysis1
Glycosylationi716N-linked (GlcNAc...)Sequence analysis1
Glycosylationi756N-linked (GlcNAc...)Sequence analysis1
Glycosylationi860N-linked (GlcNAc...)Sequence analysis1
Glycosylationi870N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA7EZS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiA7EZS5.
OMAiPVRGPMN.
OrthoDBiEOG092C0SLI.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 3 hits.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7EZS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLNIFTTL CLLLWSGAAT NDGLTDVVEW DPYSLTINGD RVFIYSAEFH
60 70 80 90 100
YQRMPVPELW LDIFQKFRAN GFNTISVYFF WSYHEASKGS FDFETSGKNV
110 120 130 140 150
QRVLDYAKEA GIYVIARAGP YCNAETSAGG LALWGSDGSM GTLRTNNAAY
160 170 180 190 200
YQSWQPWIKE IGAILAKNQV TNGGPVILNQ VENELQETVH SATNTLVLYM
210 220 230 240 250
EQLETAFRAA GITVPFSHNE KGQRSQSWST DYENVGGAVN VYGLDSYPGG
260 270 280 290 300
LSCTNSNSGF SVVRNYYQWF SNYSYTQPSY FPEFEGGYFT PWGGSFYDEC
310 320 330 340 350
QSELDPSFPD VYYKNNIGQR TTLMSLYMAW GGTNWGHSAA PVVYTSYDYA
360 370 380 390 400
APLRETRQIR DKLSQTKLIG LFTRVSTDLL KTDMIGNGTG HSVSSTGIWS
410 420 430 440 450
WVLRNPDTQA GFTVVQQASS GSRASVTFDV YLNTSLGAVT ASDVNLNGRQ
460 470 480 490 500
SKILVTDYNF GNHTLLYASS DILTYGTFDV DVLVFYLEQG QIGQFALKTT
510 520 530 540 550
SKLTYQVYGN SVFAANSSST STSQTFTYTQ GAGQTVVQFS DGALVYLLDQ
560 570 580 590 600
PSAWKFWAPP TTSNPQVKPN EQIFVLGPYL VRNASISSGV AQIFGDNDNA
610 620 630 640 650
TTIEVYAGSS LTSIVWNGVS LSATKTKYGS YSASLPGTES RVISLPSLTN
660 670 680 690 700
WESANSLPEK ETSYDDSKWT VCNKTTTLSP IAPLTLPVLF SSDYGFYTGQ
710 720 730 740 750
KIYRGYFDGL TYTSINITCS GGLAFGWSAW LNGVLIGGNT GVATATTTNA
760 770 780 790 800
VLDLTNFTSV IKSENNLVTV VVDYHGHDET STAKGVENPR GILGAFLVPK
810 820 830 840 850
PSASTGFKLW KIQGNAGGSA NIDPVRGPMN EGGFYGERVG WHLPSSPSLP
860 870 880 890 900
SDSTPLIGLN TSGISFYTTN FTLALDSDLD VPLGIKLSAP AGTIARVMFW
910 920 930 940 950
INGYQYGKYV PHIGPQTVFP IPPGIINNQG SNKLALSLWA MTDAGARLTD
960 970 980
VELVSYGVYE SGFGFDRDWS YLQPGWDEGR LAYA
Length:984
Mass (Da):107,521
Last modified:September 11, 2007 - v1
Checksum:i8DD71B799E922286
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476636 Genomic DNA. Translation: EDN94967.1.
RefSeqiXP_001588395.1. XM_001588345.1.

Genome annotation databases

GeneIDi5484283.
KEGGissl:SS1G_10842.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476636 Genomic DNA. Translation: EDN94967.1.
RefSeqiXP_001588395.1. XM_001588345.1.

3D structure databases

ProteinModelPortaliA7EZS5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5484283.
KEGGissl:SS1G_10842.

Organism-specific databases

EuPathDBiFungiDB:SS1G_10842.

Phylogenomic databases

InParanoidiA7EZS5.
OMAiPVRGPMN.
OrthoDBiEOG092C0SLI.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 3 hits.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBGALC_SCLS1
AccessioniPrimary (citable) accession number: A7EZS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 11, 2007
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.