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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei186PROSITE-ProRule annotation1
Active sitei389PROSITE-ProRule annotation1
Active sitei451PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:SS1G_10553
OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Taxonomic identifieri665079 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
Proteomesi
  • UP000001312 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:SS1G_10553.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 522LumenalSequence analysisAdd BLAST492
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Topological domaini544 – 642CytoplasmicSequence analysisAdd BLAST99

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000041194531 – 642Pheromone-processing carboxypeptidase kex1Add BLAST612

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi440N-linked (GlcNAc...)Sequence analysis1
Glycosylationi448N-linked (GlcNAc...)Sequence analysis1
Glycosylationi500N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA7EYY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiA7EYY7.
KOiK01288.
OMAiDEFANVM.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7EYY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLTTKTSS ALLTVWGLLS VSLMPSVGQA DKTAGDYFVH SLPGAPAGPL
60 70 80 90 100
LKMHAGHIEV TPEHHGNIFF WHFQNRHIAN KQRTVIWLNG GPGCSSEDGA
110 120 130 140 150
LMEIGPYRVK DGSNGPKLEY NPGSWDEFAN VMFVDNPVGT GFSFVDSDSY
160 170 180 190 200
IHDLPEMADQ FVQFLEKWFA LFPEYEHDDL YLAGESYAGQ HIPYITKAIL
210 220 230 240 250
ERNKKPDAKH KWPVKGMLIG NGWISPVEQY MSYLPFAYEK GLVKKDSEKA
260 270 280 290 300
KKLESQQAIC TKMLNENGGR DKVDNSQCEQ ILQEILSTTQ SKGSDGNMQC
310 320 330 340 350
YNMYDVRLKD SYPSCGMNWP PDLVNVTPYL RRSDVVAALH ISPEKRTGWT
360 370 380 390 400
ECNGAVGSAF RAANSKPSIQ ILPELLAEVP TILFSGAEDL ICNHIGTEEL
410 420 430 440 450
ISNMEWNGGK GFELGSGTWA PRRDWEFEGE PAGFWQEARN LTYVLFYNSS
460 470 480 490 500
HMVPFDYARR TRDMLDRFMK VDIASIGGAP TDSRIDGEKG LETSVGGHPN
510 520 530 540 550
STAAAEAEEE RLEAAKWNAY YKSGEIVLVI VVIAASAWGY YIWRERRQRA
560 570 580 590 600
GYAGIFGGDT PMALAGARSG SRGAAGLEDF RNKRNARDVE AADFDESELD
610 620 630 640
ELHVRSPTDD MDRDRYSVGS ASDDESIGKR NGNGKGKEKS YS
Length:642
Mass (Da):71,339
Last modified:September 11, 2007 - v1
Checksum:iD074077567B63989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476636 Genomic DNA. Translation: EDN94679.1.
RefSeqiXP_001588107.1. XM_001588057.1.

Genome annotation databases

GeneIDi5484474.
KEGGissl:SS1G_10553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476636 Genomic DNA. Translation: EDN94679.1.
RefSeqiXP_001588107.1. XM_001588057.1.

3D structure databases

ProteinModelPortaliA7EYY7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5484474.
KEGGissl:SS1G_10553.

Organism-specific databases

EuPathDBiFungiDB:SS1G_10553.

Phylogenomic databases

InParanoidiA7EYY7.
KOiK01288.
OMAiDEFANVM.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_SCLS1
AccessioniPrimary (citable) accession number: A7EYY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 11, 2007
Last modified: September 7, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.