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A7EYY7

- KEX1_SCLS1

UniProt

A7EYY7 - KEX1_SCLS1

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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei186 – 1861PROSITE-ProRule annotation
Active sitei389 – 3891PROSITE-ProRule annotation
Active sitei451 – 4511PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:SS1G_10553
OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Taxonomic identifieri665079 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
ProteomesiUP000001312: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 642612Pheromone-processing carboxypeptidase kex1PRO_0000411945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi665079.A7EYY7.

Structurei

3D structure databases

ProteinModelPortaliA7EYY7.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 522492LumenalSequence AnalysisAdd
BLAST
Topological domaini544 – 64299CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei523 – 54321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
InParanoidiA7EYY7.
KOiK01288.
OMAiNCESILQ.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7EYY7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSLTTKTSS ALLTVWGLLS VSLMPSVGQA DKTAGDYFVH SLPGAPAGPL
60 70 80 90 100
LKMHAGHIEV TPEHHGNIFF WHFQNRHIAN KQRTVIWLNG GPGCSSEDGA
110 120 130 140 150
LMEIGPYRVK DGSNGPKLEY NPGSWDEFAN VMFVDNPVGT GFSFVDSDSY
160 170 180 190 200
IHDLPEMADQ FVQFLEKWFA LFPEYEHDDL YLAGESYAGQ HIPYITKAIL
210 220 230 240 250
ERNKKPDAKH KWPVKGMLIG NGWISPVEQY MSYLPFAYEK GLVKKDSEKA
260 270 280 290 300
KKLESQQAIC TKMLNENGGR DKVDNSQCEQ ILQEILSTTQ SKGSDGNMQC
310 320 330 340 350
YNMYDVRLKD SYPSCGMNWP PDLVNVTPYL RRSDVVAALH ISPEKRTGWT
360 370 380 390 400
ECNGAVGSAF RAANSKPSIQ ILPELLAEVP TILFSGAEDL ICNHIGTEEL
410 420 430 440 450
ISNMEWNGGK GFELGSGTWA PRRDWEFEGE PAGFWQEARN LTYVLFYNSS
460 470 480 490 500
HMVPFDYARR TRDMLDRFMK VDIASIGGAP TDSRIDGEKG LETSVGGHPN
510 520 530 540 550
STAAAEAEEE RLEAAKWNAY YKSGEIVLVI VVIAASAWGY YIWRERRQRA
560 570 580 590 600
GYAGIFGGDT PMALAGARSG SRGAAGLEDF RNKRNARDVE AADFDESELD
610 620 630 640
ELHVRSPTDD MDRDRYSVGS ASDDESIGKR NGNGKGKEKS YS
Length:642
Mass (Da):71,339
Last modified:September 11, 2007 - v1
Checksum:iD074077567B63989
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476636 Genomic DNA. Translation: EDN94679.1.
RefSeqiXP_001588107.1. XM_001588057.1.

Genome annotation databases

GeneIDi5484474.
KEGGissl:SS1G_10553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476636 Genomic DNA. Translation: EDN94679.1 .
RefSeqi XP_001588107.1. XM_001588057.1.

3D structure databases

ProteinModelPortali A7EYY7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 665079.A7EYY7.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5484474.
KEGGi ssl:SS1G_10553.

Phylogenomic databases

eggNOGi COG2939.
InParanoidi A7EYY7.
KOi K01288.
OMAi NCESILQ.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
    Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
    , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
    PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 18683 / 1980 / Ss-1.

Entry informationi

Entry nameiKEX1_SCLS1
AccessioniPrimary (citable) accession number: A7EYY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3