Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei186 – 1861PROSITE-ProRule annotation
Active sitei389 – 3891PROSITE-ProRule annotation
Active sitei451 – 4511PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:SS1G_10553
OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Taxonomic identifieri665079 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
ProteomesiUP000001312 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:SS1G_10553.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 522492LumenalSequence AnalysisAdd
BLAST
Transmembranei523 – 54321HelicalSequence AnalysisAdd
BLAST
Topological domaini544 – 64299CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 642612Pheromone-processing carboxypeptidase kex1PRO_0000411945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi665079.A7EYY7.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
InParanoidiA7EYY7.
KOiK01288.
OMAiDEFANVM.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7EYY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLTTKTSS ALLTVWGLLS VSLMPSVGQA DKTAGDYFVH SLPGAPAGPL
60 70 80 90 100
LKMHAGHIEV TPEHHGNIFF WHFQNRHIAN KQRTVIWLNG GPGCSSEDGA
110 120 130 140 150
LMEIGPYRVK DGSNGPKLEY NPGSWDEFAN VMFVDNPVGT GFSFVDSDSY
160 170 180 190 200
IHDLPEMADQ FVQFLEKWFA LFPEYEHDDL YLAGESYAGQ HIPYITKAIL
210 220 230 240 250
ERNKKPDAKH KWPVKGMLIG NGWISPVEQY MSYLPFAYEK GLVKKDSEKA
260 270 280 290 300
KKLESQQAIC TKMLNENGGR DKVDNSQCEQ ILQEILSTTQ SKGSDGNMQC
310 320 330 340 350
YNMYDVRLKD SYPSCGMNWP PDLVNVTPYL RRSDVVAALH ISPEKRTGWT
360 370 380 390 400
ECNGAVGSAF RAANSKPSIQ ILPELLAEVP TILFSGAEDL ICNHIGTEEL
410 420 430 440 450
ISNMEWNGGK GFELGSGTWA PRRDWEFEGE PAGFWQEARN LTYVLFYNSS
460 470 480 490 500
HMVPFDYARR TRDMLDRFMK VDIASIGGAP TDSRIDGEKG LETSVGGHPN
510 520 530 540 550
STAAAEAEEE RLEAAKWNAY YKSGEIVLVI VVIAASAWGY YIWRERRQRA
560 570 580 590 600
GYAGIFGGDT PMALAGARSG SRGAAGLEDF RNKRNARDVE AADFDESELD
610 620 630 640
ELHVRSPTDD MDRDRYSVGS ASDDESIGKR NGNGKGKEKS YS
Length:642
Mass (Da):71,339
Last modified:September 11, 2007 - v1
Checksum:iD074077567B63989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476636 Genomic DNA. Translation: EDN94679.1.
RefSeqiXP_001588107.1. XM_001588057.1.

Genome annotation databases

GeneIDi5484474.
KEGGissl:SS1G_10553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476636 Genomic DNA. Translation: EDN94679.1.
RefSeqiXP_001588107.1. XM_001588057.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi665079.A7EYY7.

Protein family/group databases

MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5484474.
KEGGissl:SS1G_10553.

Organism-specific databases

EuPathDBiFungiDB:SS1G_10553.

Phylogenomic databases

eggNOGiCOG2939.
InParanoidiA7EYY7.
KOiK01288.
OMAiDEFANVM.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
    Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
    , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
    PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 18683 / 1980 / Ss-1.

Entry informationi

Entry nameiKEX1_SCLS1
AccessioniPrimary (citable) accession number: A7EYY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 11, 2007
Last modified: April 29, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.