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A7EYY7

- KEX1_SCLS1

UniProt

A7EYY7 - KEX1_SCLS1

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Protein
Pheromone-processing carboxypeptidase kex1
Gene
kex1, SS1G_10553
Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei186 – 1861 By similarity
Active sitei389 – 3891 By similarity
Active sitei451 – 4511 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:SS1G_10553
OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Taxonomic identifieri665079 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
ProteomesiUP000001312: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 522492Lumenal Reviewed prediction
Add
BLAST
Transmembranei523 – 54321Helical; Reviewed prediction
Add
BLAST
Topological domaini544 – 64299Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 642612Pheromone-processing carboxypeptidase kex1
PRO_0000411945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi440 – 4401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi448 – 4481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi500 – 5001N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi665079.A7EYY7.

Structurei

3D structure databases

ProteinModelPortaliA7EYY7.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
KOiK01288.
OMAiNCESILQ.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7EYY7-1 [UniParc]FASTAAdd to Basket

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MRSLTTKTSS ALLTVWGLLS VSLMPSVGQA DKTAGDYFVH SLPGAPAGPL    50
LKMHAGHIEV TPEHHGNIFF WHFQNRHIAN KQRTVIWLNG GPGCSSEDGA 100
LMEIGPYRVK DGSNGPKLEY NPGSWDEFAN VMFVDNPVGT GFSFVDSDSY 150
IHDLPEMADQ FVQFLEKWFA LFPEYEHDDL YLAGESYAGQ HIPYITKAIL 200
ERNKKPDAKH KWPVKGMLIG NGWISPVEQY MSYLPFAYEK GLVKKDSEKA 250
KKLESQQAIC TKMLNENGGR DKVDNSQCEQ ILQEILSTTQ SKGSDGNMQC 300
YNMYDVRLKD SYPSCGMNWP PDLVNVTPYL RRSDVVAALH ISPEKRTGWT 350
ECNGAVGSAF RAANSKPSIQ ILPELLAEVP TILFSGAEDL ICNHIGTEEL 400
ISNMEWNGGK GFELGSGTWA PRRDWEFEGE PAGFWQEARN LTYVLFYNSS 450
HMVPFDYARR TRDMLDRFMK VDIASIGGAP TDSRIDGEKG LETSVGGHPN 500
STAAAEAEEE RLEAAKWNAY YKSGEIVLVI VVIAASAWGY YIWRERRQRA 550
GYAGIFGGDT PMALAGARSG SRGAAGLEDF RNKRNARDVE AADFDESELD 600
ELHVRSPTDD MDRDRYSVGS ASDDESIGKR NGNGKGKEKS YS 642
Length:642
Mass (Da):71,339
Last modified:September 11, 2007 - v1
Checksum:iD074077567B63989
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476636 Genomic DNA. Translation: EDN94679.1.
RefSeqiXP_001588107.1. XM_001588057.1.

Genome annotation databases

GeneIDi5484474.
KEGGissl:SS1G_10553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476636 Genomic DNA. Translation: EDN94679.1 .
RefSeqi XP_001588107.1. XM_001588057.1.

3D structure databases

ProteinModelPortali A7EYY7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 665079.A7EYY7.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5484474.
KEGGi ssl:SS1G_10553.

Phylogenomic databases

eggNOGi COG2939.
KOi K01288.
OMAi NCESILQ.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
    Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
    , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
    PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 18683 / 1980 / Ss-1.

Entry informationi

Entry nameiKEX1_SCLS1
AccessioniPrimary (citable) accession number: A7EYY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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