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A7EQZ1

- DAPB_SCLS1

UniProt

A7EQZ1 - DAPB_SCLS1

Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei768 – 7681Charge relay systemBy similarity
    Active sitei845 – 8451Charge relay systemBy similarity
    Active sitei878 – 8781Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:dapB
    ORF Names:SS1G_07744
    OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
    Taxonomic identifieri665079 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
    ProteomesiUP000001312: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 921921Probable dipeptidyl-aminopeptidase BPRO_0000412162Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi822 – 8221N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi665079.A7EQZ1.

    Structurei

    3D structure databases

    ProteinModelPortaliA7EQZ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 109109CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini131 – 921791VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei110 – 13021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1506.
    KOiK01282.
    OMAiETKFWYQ.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7EQZ1-1 [UniParc]FASTAAdd to Basket

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    MAGHTEENAQ LLSTEQESVS RHSSDSAAST ASTTSLVFDR IGERVAANRS    50
    EKSMMVTPKF PPRGEMAYAD DEHTQIHLDE EEEKDYDLED SAFLTNGATN 100
    KSVDKKLRKL IWIVGGVFIG AWVLALFIFL GKQAYKHSSE IPHDPQATSS 150
    RGNGKKVTMD QVMGGQWRAT KHSISWIAGA NGEDGLLLEQ GSAGKDYLIV 200
    EDVRTQNPET VGTLDRMTLM KDGSFTVAGR SLYPSKVYPS KDLKKVLVAT 250
    DVQSNWRHSF YAKYWIFDVE SQTAEPLDPV DLDGRVQLAS WSPKSDAIVF 300
    TRDNNMYLRK LSSPTVIQIT TDGGPEFFYG VPDWVYEEEV FAGASATWWD 350
    DSGKYIAFLR TNESEVPEYP IQYFVSRPSG KEPLPGEENY PEVREIKYPK 400
    AGAPNPTVDL LFYDIFKAEV FEVTIAGGFE PKNLLITEVV WAGSTGKALI 450
    RETNRESDIL RVVLVDVVAR EGKTVRYTDI NKLDGGWFEV SEDTRYIPAD 500
    PANGRPHDGY IDTIIHENYD HLGYFTPMDN PEPILLTSGN WEVVQAPSAV 550
    DLKNNLVYFV STKESPITRQ VYSVKLDGTD MKAITDTSNE GYYGASFSKG 600
    AGYVLLNYNG PGIPWQKVIS TPSNGNQYTH TIEENKGLAE MAKKHDLPIL 650
    IYQTVTIDGF ELQVVERRPP HFNPKKKYPV LFYLYGGPGS QTVSKSFNVD 700
    FESYIASNLG YIVVTVDGRG TGFIGRKART IIRGNIGHYE ARDQIETAKI 750
    WASKKYVDAS RMAIWGWSYG GFMTLKTLEE DAGETFSYGM AVAPVTDWRF 800
    YDSIYTERYM HTPQHNPGGY DNTSISNVEA LSKNVRFLVM HGVADDNVHM 850
    QNTLTLLDKL DLAGVENYDV HVFPDSDHSI YFHNANRIVY DKLNNWLINA 900
    FNGEWLRTAN AVPLQIDAAK V 921
    Length:921
    Mass (Da):103,235
    Last modified:September 11, 2007 - v1
    Checksum:i5425BDA802477FD3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476630 Genomic DNA. Translation: EDN91883.1.
    RefSeqiXP_001591119.1. XM_001591069.1.

    Genome annotation databases

    GeneIDi5487167.
    KEGGissl:SS1G_07744.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476630 Genomic DNA. Translation: EDN91883.1 .
    RefSeqi XP_001591119.1. XM_001591069.1.

    3D structure databases

    ProteinModelPortali A7EQZ1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 665079.A7EQZ1.

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5487167.
    KEGGi ssl:SS1G_07744.

    Phylogenomic databases

    eggNOGi COG1506.
    KOi K01282.
    OMAi ETKFWYQ.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
      Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
      , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
      PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 18683 / 1980 / Ss-1.

    Entry informationi

    Entry nameiDAPB_SCLS1
    AccessioniPrimary (citable) accession number: A7EQZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3