ID   A7EFC7_SCLS1            Unreviewed;       763 AA.
AC   A7EFC7;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   27-MAR-2024, entry version 96.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SS1G_04018 {ECO:0000313|EMBL:EDO01543.1};
OS   Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS   (Whetzelinia sclerotiorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Sclerotinia.
OX   NCBI_TaxID=665079 {ECO:0000313|EMBL:EDO01543.1, ECO:0000313|Proteomes:UP000001312};
RN   [1] {ECO:0000313|Proteomes:UP000001312}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18683 / 1980 / Ss-1 {ECO:0000313|Proteomes:UP000001312};
RX   PubMed=21876677; DOI=.1371/journal.pgen.1002230;
RA   Amselem J., Cuomo C.A., van Kan J.A., Viaud M., Benito E.P., Couloux A.,
RA   Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA   Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.M.,
RA   Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA   Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA   Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA   Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA   Grossetete S., Guldener U., Henrissat B., Howlett B.J., Kodira C.,
RA   Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA   Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA   Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA   Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA   Zeng Q., Rollins J.A., Lebrun M.H., Dickman M.;
RT   "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT   sclerotiorum and Botrytis cinerea.";
RL   PLoS Genet. 7:E1002230-E1002230(2011).
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; CH476625; EDO01543.1; -; Genomic_DNA.
DR   RefSeq; XP_001594211.1; XM_001594161.1.
DR   AlphaFoldDB; A7EFC7; -.
DR   STRING; 665079.A7EFC7; -.
DR   EnsemblFungi; EDO01543; EDO01543; SS1G_04018.
DR   GeneID; 5491160; -.
DR   KEGG; ssl:SS1G_04018; -.
DR   eggNOG; KOG1083; Eukaryota.
DR   HOGENOM; CLU_004379_1_0_1; -.
DR   InParanoid; A7EFC7; -.
DR   OMA; YSSKCVC; -.
DR   OrthoDB; 950362at2759; -.
DR   Proteomes; UP000001312; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046975; F:histone H3K36 methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR22884:SF512; N-METHYLTRANSFERASE (ASH1), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G06480)-RELATED; 1.
DR   PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR   Pfam; PF17907; AWS; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001312};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          389..436
FT                   /note="AWS"
FT                   /evidence="ECO:0000259|PROSITE:PS51215"
FT   DOMAIN          453..560
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          568..584
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          159..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          713..747
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          211..238
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   763 AA;  84107 MW;  25B63E417DD3DF16 CRC64;
     MGASSRSSTK HEITRAPSSE SINTAITVDD TSNLDSSSTP PTSIGDNVSV TSATTKPEPA
     ADEVSIASEP MDRRSQRVRA KVGTYNVKIL SGTAVHAPKK FLKNNGALDN ETRRQTISGG
     DLEGALGSIN TSTSSIGKSV QKLVSEGIDA LDLSWPVKKL PKSSSDNSLP GSPKITARKE
     DLSRRKSLRS TPSETAAELT KKISFLGKRS RKEMEGGLQK AKRELRNLAD TKEYAKIETE
     PVVLEVWSNG KLVPKESARK KKKAEEAQAS EPEPIKALTK KAAQGRKEKA WLTKGLYAGQ
     DPANLDWFKS SGNAKSAFRW TGKPNKALPL PLWNGQRLLH VGRDFKLPFD ICAPLPPGQP
     KPTEWYKTSH NRFIGEAGTM WKKSSLFDSF FSKCICKPDT GCDEDCQNRI MLYECDDTNC
     GAGRDNCTNR AFAELFNRRK GNSFRKGGNK YEIGVEVIKT ADRGYGVRSN RCFNANQIIV
     EYTGEIITED ECDRRMNEDY KDNENMIIDA TRGSIARFVN HSCRPNCRMV KWIVEGKPRM
     ALFAGDNPIM TGDELTYDYN FDPFSAKNVQ ACRCGSDNCR GVLGPRPKDQ KVTKATTIKE
     VVKAGIKAGK RKLQQMIGDD EDDDDVQILK KRKTKAATGV KRSISTATTN VANTVKKSVS
     SRLLNARHAV GSNKKTIKVS QATAGPLKTY GKKQMKLSSS RTSLTIVSPE KNLKAKDTTQ
     RESVTKSLVR NVRSSRRSSV SDDGNESTIR VVTVFEEDVE EED
//