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A7ECT7 (A7ECT7_SCLS1) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific RuleBase RU271113

EC=2.1.1.43 RuleBase RU271113
Alternative name(s):
Histone H3-K79 methyltransferase RuleBase RU271113
Gene names
ORF Names:SS1G_03126 EMBL EDO00653.1
OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum) [Reference proteome]
Taxonomic identifier665079 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity. RuleBase RU271113

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. RuleBase RU271113

Enzyme regulation

Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3 By similarity. RuleBase RU271113

Subcellular location

Nucleus By similarity RuleBase RU271113.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity. RuleBase RU271113

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. RuleBase RU271113

Contains 1 DOT1 domain. RuleBase RU271113

Ontologies

Sequences

Sequence LengthMass (Da)Tools
A7ECT7 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: F2DD1270E4E296DD

FASTA40345,269
        10         20         30         40         50         60 
MSLNFGQKNL TIKPVVPKYK IETIKVPKQS PRPILPTRTS SNNLRTGAPA TKVADARGRL 

        70         80         90        100        110        120 
AISTSNSGAG KKRKEREISG SRGVGKNSNL KARRSPSQRP LQTDSEEDEE TRIPAKRAKS 

       130        140        150        160        170        180 
ENVELDLGRS LKDQKAFSSD AADNQGSKCK MIHAADVMMT KHRAKRGEKV CDRKKEEGEA 

       190        200        210        220        230        240 
VYLRYPSVRR MERYQLISEG EVIDPGEEEL INPYDEIPKI AEIVKDEYLT EEQAAEFQHP 

       250        260        270        280        290        300 
ETGIIRKINK ATNNITWTLA NKHKKPYDKA KLKELLVEFR NAVEVYNDAL GTLTKNGSLA 

       310        320        330        340        350        360 
HNLDNKHSLS SKLLKMVLQQ VYDRAVSPQV ELTREYQNGT DYVYGELTFP FISRILKEDT 

       370        380        390        400 
HMKSDQVFID LGSGVGNVVI HAALQVGCES WGCEIMENCC LQP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476624 Genomic DNA. Translation: EDO00653.1.
RefSeqXP_001595038.1. XM_001594988.1.

3D structure databases

ProteinModelPortalA7ECT7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING665079.A7ECT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEDO00653; EDO00653; SS1G_03126.
GeneID5492104.
KEGGssl:SS1G_03126.

Phylogenomic databases

eggNOGNOG294902.
KOK11427.
OMAATNNITW.
OrthoDBEOG7KH9VN.

Family and domain databases

InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7ECT7_SCLS1
AccessionPrimary (citable) accession number: A7ECT7
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)