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A7EBU5 (BGALB_SCLS1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-galactosidase B

EC=3.2.1.23
Alternative name(s):
Lactase B
Gene names
Name:lacB
ORF Names:SS1G_02781
OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum) [Reference proteome]
Taxonomic identifier665079 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia

Protein attributes

Sequence length1008 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 1008990Probable beta-galactosidase B
PRO_0000395233

Sites

Active site1931Proton donor Potential
Active site3051Nucleophile Potential
Binding site871Substrate By similarity
Binding site1321Substrate By similarity
Binding site1331Substrate; via amide nitrogen By similarity
Binding site1341Substrate By similarity
Binding site1921Substrate By similarity
Binding site2621Substrate By similarity
Binding site3701Substrate By similarity

Amino acid modifications

Glycosylation201N-linked (GlcNAc...) Potential
Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation1081N-linked (GlcNAc...) Potential
Glycosylation2081N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation4531N-linked (GlcNAc...) Potential
Glycosylation5941N-linked (GlcNAc...) Potential
Glycosylation6241N-linked (GlcNAc...) Potential
Glycosylation6811N-linked (GlcNAc...) Potential
Glycosylation7031N-linked (GlcNAc...) Potential
Glycosylation7821N-linked (GlcNAc...) Potential
Glycosylation7881N-linked (GlcNAc...) Potential
Glycosylation8161N-linked (GlcNAc...) Potential
Glycosylation8261N-linked (GlcNAc...) Potential
Glycosylation8791N-linked (GlcNAc...) Potential
Disulfide bond268 ↔ 321 By similarity

Sequences

Sequence LengthMass (Da)Tools
A7EBU5 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 52E5C90A03793D5E

FASTA1,008110,685
        10         20         30         40         50         60 
MLLQSLFAWA LAIGPCIAQN STNSTWPIHN NGLTTQVEWD HYSLMVDGQR FFLWSGEFHY 

        70         80         90        100        110        120 
WRIPVPELWV DVLQKVKAAG FNTFAIYTHW YFHNPNPNTL DFENAAHNFT KIFDLAKELG 

       130        140        150        160        170        180 
MFVVFRPGPY VNAESNAGAF PLWLTTGAYG ALRNNDERYT EAWTPFWEKV ASIVAPYQFT 

       190        200        210        220        230        240 
NGGNVLTYQI ENELGSQWRG TPSNKVPNLS SVEYMEALEA SARAHGITIP FQANDPNLNS 

       250        260        270        280        290        300 
DSWSKDFYDG YGSVDIYGMD SYPACWTCNL TECDSTNGAY KAFNVIDYYD HFEAISPTQP 

       310        320        330        340        350        360 
SFLPEFQGGS FNPWGGPEGG CPENSPADFA NLFYRNNVGQ RVTAMSLYMI YGGTNWGWLA 

       370        380        390        400        410        420 
APVVATSYDY SSPISENRMI NDKYAETKLF GHFLRVAKDL TKTDRIGTGK TASTNPNVVY 

       430        440        450        460        470        480 
SEIRNPDTNA AFYVTIHKES TVGTREEFYI NANTSKGAFK IPQKAASIVL NGFQSKIIVT 

       490        500        510        520        530        540 
DFNFGSHSLL YSTAEVLSHS IVDDQDILAL WMPTGEAGEF VVTGAKSGSV SSCGGCSSVG 

       550        560        570        580        590        600 
FYPQGDDLLV TISQSKGISV LTFDDGLRVL VMDRSFAYEF WVPVLTADPF SPANETVFVQ 

       610        620        630        640        650        660 
GPSLVRSAAY SSDGSTLDLT GDNNGTSTQI QVFPPKSVSK VTWNGQVITT EKTDYDSLIG 

       670        680        690        700        710        720 
SLTGPALDSL TLPTISGWKA NDSLPERLPT YDDSWWVAAD HMNTSNPTKP ETLPVLYIDD 

       730        740        750        760        770        780 
YGYHVGNHLW RGRFEGSASG VYLSVTGGRA FGYSAWLNGE FIGSYLGAAY PDTGKLTLSF 

       790        800        810        820        830        840 
SNVTVNSNST NILLVLQDNS GHDETSEALN PRGINNATLI SSSTKNFTSW KVTGTAGKPD 

       850        860        870        880        890        900 
TAIDPVRGIL SEGGLYAERL GWHLPDFDDS EWSSASPSNV SSSAGVTFYR TTVSLAIPTG 

       910        920        930        940        950        960 
LDVAISFTLK ASPSNAALRV LLFVNGYQYG RFSPWIGNQV EFPVPPGILN YDGDNVIGLS 

       970        980        990       1000 
VWRQEEGDES MGVNVGWKVT EAFASSFEPI FDAAYLQPGW TDERLQYA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476623 Genomic DNA. Translation: EDN99923.1.
RefSeqXP_001596561.1. XM_001596511.1.

3D structure databases

ProteinModelPortalA7EBU5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING665079.A7EBU5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEDN99923; EDN99923; SS1G_02781.
GeneID5492844.
KEGGssl:SS1G_02781.

Phylogenomic databases

eggNOGCOG1874.
OMAYINANTS.
OrthoDBEOG7ZGXBD.

Family and domain databases

Gene3D2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSPR00742. GLHYDRLASE35.
SUPFAMSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBGALB_SCLS1
AccessionPrimary (citable) accession number: A7EBU5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries