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A7EBU5

- BGALB_SCLS1

UniProt

A7EBU5 - BGALB_SCLS1

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Protein

Probable beta-galactosidase B

Gene
lacB, SS1G_02781
Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871Substrate By similarity
Binding sitei132 – 1321Substrate By similarity
Binding sitei133 – 1331Substrate; via amide nitrogen By similarity
Binding sitei134 – 1341Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Active sitei193 – 1931Proton donor Reviewed prediction
Binding sitei262 – 2621Substrate By similarity
Active sitei305 – 3051Nucleophile Reviewed prediction
Binding sitei370 – 3701Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase B (EC:3.2.1.23)
Alternative name(s):
Lactase B
Gene namesi
Name:lacB
ORF Names:SS1G_02781
OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Taxonomic identifieri665079 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
ProteomesiUP000001312: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 1008990Probable beta-galactosidase BPRO_0000395233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi23 – 231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi108 – 1081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi208 – 2081N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi268 ↔ 321 By similarity
Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi453 – 4531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi594 – 5941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi624 – 6241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi681 – 6811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi703 – 7031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi782 – 7821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi788 – 7881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi816 – 8161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi826 – 8261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi879 – 8791N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi665079.A7EBU5.

Structurei

3D structure databases

ProteinModelPortaliA7EBU5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
OMAiYINANTS.
OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7EBU5-1 [UniParc]FASTAAdd to Basket

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MLLQSLFAWA LAIGPCIAQN STNSTWPIHN NGLTTQVEWD HYSLMVDGQR     50
FFLWSGEFHY WRIPVPELWV DVLQKVKAAG FNTFAIYTHW YFHNPNPNTL 100
DFENAAHNFT KIFDLAKELG MFVVFRPGPY VNAESNAGAF PLWLTTGAYG 150
ALRNNDERYT EAWTPFWEKV ASIVAPYQFT NGGNVLTYQI ENELGSQWRG 200
TPSNKVPNLS SVEYMEALEA SARAHGITIP FQANDPNLNS DSWSKDFYDG 250
YGSVDIYGMD SYPACWTCNL TECDSTNGAY KAFNVIDYYD HFEAISPTQP 300
SFLPEFQGGS FNPWGGPEGG CPENSPADFA NLFYRNNVGQ RVTAMSLYMI 350
YGGTNWGWLA APVVATSYDY SSPISENRMI NDKYAETKLF GHFLRVAKDL 400
TKTDRIGTGK TASTNPNVVY SEIRNPDTNA AFYVTIHKES TVGTREEFYI 450
NANTSKGAFK IPQKAASIVL NGFQSKIIVT DFNFGSHSLL YSTAEVLSHS 500
IVDDQDILAL WMPTGEAGEF VVTGAKSGSV SSCGGCSSVG FYPQGDDLLV 550
TISQSKGISV LTFDDGLRVL VMDRSFAYEF WVPVLTADPF SPANETVFVQ 600
GPSLVRSAAY SSDGSTLDLT GDNNGTSTQI QVFPPKSVSK VTWNGQVITT 650
EKTDYDSLIG SLTGPALDSL TLPTISGWKA NDSLPERLPT YDDSWWVAAD 700
HMNTSNPTKP ETLPVLYIDD YGYHVGNHLW RGRFEGSASG VYLSVTGGRA 750
FGYSAWLNGE FIGSYLGAAY PDTGKLTLSF SNVTVNSNST NILLVLQDNS 800
GHDETSEALN PRGINNATLI SSSTKNFTSW KVTGTAGKPD TAIDPVRGIL 850
SEGGLYAERL GWHLPDFDDS EWSSASPSNV SSSAGVTFYR TTVSLAIPTG 900
LDVAISFTLK ASPSNAALRV LLFVNGYQYG RFSPWIGNQV EFPVPPGILN 950
YDGDNVIGLS VWRQEEGDES MGVNVGWKVT EAFASSFEPI FDAAYLQPGW 1000
TDERLQYA 1008
Length:1,008
Mass (Da):110,685
Last modified:September 11, 2007 - v1
Checksum:i52E5C90A03793D5E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476623 Genomic DNA. Translation: EDN99923.1.
RefSeqiXP_001596561.1. XM_001596511.1.

Genome annotation databases

EnsemblFungiiEDN99923; EDN99923; SS1G_02781.
GeneIDi5492844.
KEGGissl:SS1G_02781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476623 Genomic DNA. Translation: EDN99923.1 .
RefSeqi XP_001596561.1. XM_001596511.1.

3D structure databases

ProteinModelPortali A7EBU5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 665079.A7EBU5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EDN99923 ; EDN99923 ; SS1G_02781 .
GeneIDi 5492844.
KEGGi ssl:SS1G_02781.

Phylogenomic databases

eggNOGi COG1874.
OMAi YINANTS.
OrthoDBi EOG7ZGXBD.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
    Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
    , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
    PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 18683 / 1980 / Ss-1.

Entry informationi

Entry nameiBGALB_SCLS1
AccessioniPrimary (citable) accession number: A7EBU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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