ID   A7EBU3_SCLS1            Unreviewed;       894 AA.
AC   A7EBU3;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   24-JAN-2024, entry version 71.
DE   RecName: Full=SET domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SS1G_02779 {ECO:0000313|EMBL:EDN99921.1};
OS   Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS   (Whetzelinia sclerotiorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Sclerotinia.
OX   NCBI_TaxID=665079 {ECO:0000313|EMBL:EDN99921.1, ECO:0000313|Proteomes:UP000001312};
RN   [1] {ECO:0000313|Proteomes:UP000001312}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18683 / 1980 / Ss-1 {ECO:0000313|Proteomes:UP000001312};
RX   PubMed=21876677; DOI=.1371/journal.pgen.1002230;
RA   Amselem J., Cuomo C.A., van Kan J.A., Viaud M., Benito E.P., Couloux A.,
RA   Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA   Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.M.,
RA   Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA   Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA   Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA   Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA   Grossetete S., Guldener U., Henrissat B., Howlett B.J., Kodira C.,
RA   Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA   Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA   Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA   Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA   Zeng Q., Rollins J.A., Lebrun M.H., Dickman M.;
RT   "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT   sclerotiorum and Botrytis cinerea.";
RL   PLoS Genet. 7:E1002230-E1002230(2011).
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DR   EMBL; CH476623; EDN99921.1; -; Genomic_DNA.
DR   RefSeq; XP_001596559.1; XM_001596509.1.
DR   AlphaFoldDB; A7EBU3; -.
DR   STRING; 665079.A7EBU3; -.
DR   EnsemblFungi; EDN99921; EDN99921; SS1G_02779.
DR   GeneID; 5492842; -.
DR   KEGG; ssl:SS1G_02779; -.
DR   eggNOG; KOG1079; Eukaryota.
DR   HOGENOM; CLU_323417_0_0_1; -.
DR   InParanoid; A7EBU3; -.
DR   OMA; CQNIALQ; -.
DR   OrthoDB; 902834at2759; -.
DR   Proteomes; UP000001312; Unassembled WGS sequence.
DR   GO; GO:0035098; C:ESC/E(Z) complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0046976; F:histone H3K27 methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0031507; P:heterochromatin formation; IBA:GO_Central.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR026489; CXC_dom.
DR   InterPro; IPR045318; EZH1/2-like.
DR   InterPro; IPR048360; Ezh2-like_CXC_fung.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR   PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR   Pfam; PF21509; Ezh2-like__CXC_fung; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51633; CXC; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001312};
KW   Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT   DOMAIN          484..596
FT                   /note="CXC"
FT                   /evidence="ECO:0000259|PROSITE:PS51633"
FT   DOMAIN          611..732
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          741..894
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        758..781
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        850..884
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   894 AA;  100851 MW;  D215102BC64264DB CRC64;
     MDLHFLKSPE EETSGRLGAP GLSKENSSTS DALTQMMRQE KSMDVIKESI GTSEEAMMED
     WSLSLEALLE KRHLRTMIAL DNDTLDDDES PFISLEAPDR HVQGAIKLNI QTTKKQRTPN
     YALPIIVGDG GVERTPSYAH HTDVLRNHLT ADDKILRYVP SVVQNEEKFM NKFEKDLHGL
     YEERNDDPRE REQIYQIDRH VDVFLENMGY DYCNREALIR YYLGHKHEKL PYPMEEKRLV
     LKTLGGPLSG DELRIMGLVA EEMTAGCDID MGDVVLSKSR FKVLVEDSKD KLYKLSGNQP
     PPPERLGTMA GFSCLICHGA ACTTHGEFKN NLSDGSSEIG SPDSSSSKKS NDDHKWKRFV
     MYSSDVMRKH NARDHSNKNE NWHPEHWNTE KDTAEACGEE CYRGRTEWAN HAWTQEEESE
     LKSILLVTKP KKPCTLVDIL DKPCWQIYSK ILDLEEESSI SRSKSLQKQQ QSERAHWYDP
     AAVPRNRGLK PGWRDSTVAH MAELRAQPGP CLHEGPCRRE LNCYCVIHNL LCEQFCGCTE
     DCVRRFAGCS CRSEGLACTS DTCICFQMNR ECGDQCDTCG AIPRLRPQDR YNHELFQHGC
     QNIALQRGVN KKLILGKSPI PNAGFGLFTA EPVKKGDFIS EYTGEVISDK EADRRGVGYD
     ARRLSYLFGL NKEWVIDATR MGNKTRFINH AKSEAGGTNC FARVLFVQGE YRIEFRATRN
     ILIGEELLFD YGTSFAEIHD LNKKSGDGKG KTKGNKGTSN ESSEKKSAKN GKIGEKRKVG
     WPKGRPRPKA SKKAKVHEYG VAGPSNAHSH SRSHSNSDQG VDDDSDEMML DADSPLFPDM
     IQDSDSADET FVGKLSDVEM RDAGNGDGGD GENEDEERVR RTSRTRTVPV RYTL
//