Reviewed, UniProtKB/Swiss-Prot A7E8H8 (KAD1_SCLS1)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 1
      Short name=AK 1
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1
    Adenylate kinase cytosolic and mitochondrial

Gene names

Name:	adk1
ORF Names:	SS1G_01606

Organism

Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum) [Complete proteome]

Taxonomic identifier

665079 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Leotiomycetes › Helotiales › Sclerotiniaceae › Sclerotinia

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Adenylate kinase 1		PRO_0000365687
Regions
	Nucleotide binding	51 – 59	9	ATP By similarity
	Nucleotide binding	74 – 103	30	AMP By similarity
Sites
	Binding site	75	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7E8H8-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 85FA5FF18627277F	FASTA	275	29,710
	10 20 30 40 50 60 MAPIGDDATQ TLHDLVNKLE SRVKELEDKL AHAAGGSAPS SSEGIRMILM GPPGAGKGTQ 70 80 90 100 110 120 APKIKEKFSC CHLATGDMLR SQVAKKTPLG REAKKIMDQG GLVSDEIVIG MIKAELETNQ 130 140 150 160 170 180 ECKGGFILDG FPRTVVQAER LDAMLSARNQ KLQHAVELQI DDSLLVSRIT GRLVHPASGR 190 200 210 220 230 240 SYHRVFNPPK AEMKDDITGE PLVSRSDDNA EALKKRLVTY HDQTAPVVGY YQKTGIWSGI 250 260 270 DASQEPGAVW KSLLGVFDKQ KAPSGSLLSK ITGRS

References

[1]

"Annotation of the Sclerotinia sclerotiorum 1980 genome." Birren B.W., Galagan J.E., Lander E.S., Devon K., Nusbaum C., Cuomo C., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K., Pushparaj V. , DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Yandava C., Kodira C.D., Zeng Q., Alvarado L., O'Leary S., Dickman M.B., Kohn L., Rollins J. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CH476622 Genomic DNA. Translation: EDN96680.1.
RefSeq	XP_001597412.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5493216.
KEGG	ssl:SS1G_01606.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_SCLS1

Accession

Primary (citable) accession number: A7E8H8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	September 11, 2007
Last modified:	September 22, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)