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A7E7L8

- PMIP_SCLS1

UniProt

A7E7L8 - PMIP_SCLS1

Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 2 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi566 – 5661Zinc; catalyticPROSITE-ProRule annotation
    Active sitei567 – 5671PROSITE-ProRule annotation
    Metal bindingi570 – 5701Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi573 – 5731Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:oct1
    ORF Names:SS1G_01296
    OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
    Taxonomic identifieri665079 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
    ProteomesiUP000001312: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2727MitochondrionSequence AnalysisAdd
    BLAST
    Chaini28 – 785758Mitochondrial intermediate peptidasePRO_0000338594Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi665079.A7E7L8.

    Structurei

    3D structure databases

    ProteinModelPortaliA7E7L8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi283 – 2875Poly-Ala

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    KOiK01410.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A7E7L8-1 [UniParc]FASTAAdd to Basket

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    MLKAVMPRPW VCSRCVKRQI QSSRGLATAS TQYREPRPVP TDHSAPGAKH    50
    DDRTLRQIFD SPDFWADFSQ SSKQSYYRPG VGLFQNRYLV NPQGFEVFAN 100
    TSLRKAQRIV DKVLKASTVE EYRHVARDLD RLSDLLCRVI DLSDFVRATH 150
    PNAAIQAAAS RAYAKMFEYM NILNTTTGLD KQLEVAMGTP EIVAGWTEEE 200
    VVVADILKKD FAKSAIDLPR AQREKFVALS QEISEIGPDF VDYMTPAKSY 250
    LTFESSKLKG MDPVLVREHT TWGQTKIPTI GGAAAAAIRT VQNEEVRREI 300
    FMATRTASRN TVHKLEELMR KRAELAKLSR YESYSQLALG DKMAKSPASV 350
    TQFLEALAKD NNKIVQGEVS ELLKFKFSNP NASSPGLQPW DKDYYMSRIL 400
    ASVRSHSRNS DFLSAYFSLG TVMQGLSRLF TRLYGVRLAP HETMPGETWN 450
    SDVRRLDVIS ETDGHVAVLY CDLFSRPGKS PNPAHFTLRC SREITTAELE 500
    EASMLSQNGL FKTDEEAAND GMATSKSSGV LKQLPTIALI CDFVTMSGKS 550
    SRPALLSFNE VQTLFHEMGH AIHSILGRTS LQNVSGTRCA TDFAELPSVL 600
    MEHFAADPSV LSLFARHYET DQQLPYEMVA EKLALDKRFE GSDTENQIIL 650
    SMLDLAYHSD LPLSPTFNST EIYHSLQQKH GALPVDPPGT CWQGFFGHLF 700
    GYGSTYYSYL FDRVLARRIW QVVFQGGEAG GSVHRGNGEK MKEEVLKWGG 750
    GRDPWKCLAG VLDDGRVENG DEKAMAIVGS WGVKE 785
    Length:785
    Mass (Da):87,723
    Last modified:June 10, 2008 - v2
    Checksum:i22354DF6D7047D4F
    GO

    Sequence cautioni

    The sequence EDN96370.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476622 Genomic DNA. Translation: EDN96370.1. Different initiation.
    RefSeqiXP_001597102.1. XM_001597052.1.

    Genome annotation databases

    EnsemblFungiiEDN96370; EDN96370; SS1G_01296.
    GeneIDi5493674.
    KEGGissl:SS1G_01296.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476622 Genomic DNA. Translation: EDN96370.1 . Different initiation.
    RefSeqi XP_001597102.1. XM_001597052.1.

    3D structure databases

    ProteinModelPortali A7E7L8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 665079.A7E7L8.

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EDN96370 ; EDN96370 ; SS1G_01296 .
    GeneIDi 5493674.
    KEGGi ssl:SS1G_01296.

    Phylogenomic databases

    eggNOGi COG0339.
    KOi K01410.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
      Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
      , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
      PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 18683 / 1980 / Ss-1.

    Entry informationi

    Entry nameiPMIP_SCLS1
    AccessioniPrimary (citable) accession number: A7E7L8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3