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Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi566Zinc; catalyticPROSITE-ProRule annotation1
Active sitei567PROSITE-ProRule annotation1
Metal bindingi570Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi573Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:oct1
ORF Names:SS1G_01296
OrganismiSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
Taxonomic identifieri665079 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeSclerotinia
Proteomesi
  • UP000001312 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:SS1G_01296

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionSequence analysisAdd BLAST27
ChainiPRO_000033859428 – 785Mitochondrial intermediate peptidaseAdd BLAST758

Structurei

3D structure databases

ProteinModelPortaliA7E7L8
SMRiA7E7L8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi283 – 287Poly-Ala5

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiA7E7L8
KOiK01410
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7E7L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKAVMPRPW VCSRCVKRQI QSSRGLATAS TQYREPRPVP TDHSAPGAKH
60 70 80 90 100
DDRTLRQIFD SPDFWADFSQ SSKQSYYRPG VGLFQNRYLV NPQGFEVFAN
110 120 130 140 150
TSLRKAQRIV DKVLKASTVE EYRHVARDLD RLSDLLCRVI DLSDFVRATH
160 170 180 190 200
PNAAIQAAAS RAYAKMFEYM NILNTTTGLD KQLEVAMGTP EIVAGWTEEE
210 220 230 240 250
VVVADILKKD FAKSAIDLPR AQREKFVALS QEISEIGPDF VDYMTPAKSY
260 270 280 290 300
LTFESSKLKG MDPVLVREHT TWGQTKIPTI GGAAAAAIRT VQNEEVRREI
310 320 330 340 350
FMATRTASRN TVHKLEELMR KRAELAKLSR YESYSQLALG DKMAKSPASV
360 370 380 390 400
TQFLEALAKD NNKIVQGEVS ELLKFKFSNP NASSPGLQPW DKDYYMSRIL
410 420 430 440 450
ASVRSHSRNS DFLSAYFSLG TVMQGLSRLF TRLYGVRLAP HETMPGETWN
460 470 480 490 500
SDVRRLDVIS ETDGHVAVLY CDLFSRPGKS PNPAHFTLRC SREITTAELE
510 520 530 540 550
EASMLSQNGL FKTDEEAAND GMATSKSSGV LKQLPTIALI CDFVTMSGKS
560 570 580 590 600
SRPALLSFNE VQTLFHEMGH AIHSILGRTS LQNVSGTRCA TDFAELPSVL
610 620 630 640 650
MEHFAADPSV LSLFARHYET DQQLPYEMVA EKLALDKRFE GSDTENQIIL
660 670 680 690 700
SMLDLAYHSD LPLSPTFNST EIYHSLQQKH GALPVDPPGT CWQGFFGHLF
710 720 730 740 750
GYGSTYYSYL FDRVLARRIW QVVFQGGEAG GSVHRGNGEK MKEEVLKWGG
760 770 780
GRDPWKCLAG VLDDGRVENG DEKAMAIVGS WGVKE
Length:785
Mass (Da):87,723
Last modified:June 10, 2008 - v2
Checksum:i22354DF6D7047D4F
GO

Sequence cautioni

The sequence EDN96370 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476622 Genomic DNA Translation: EDN96370.1 Different initiation.
RefSeqiXP_001597102.1, XM_001597052.1

Genome annotation databases

GeneIDi5493674
KEGGissl:SS1G_01296

Similar proteinsi

Entry informationi

Entry nameiPMIP_SCLS1
AccessioniPrimary (citable) accession number: A7E7L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: March 28, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health