A7E3U5 (S38A7_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative sodium-coupled neutral amino acid transporter 7

Gene names

Name:	SLC38A7
Synonyms:	SNAT7

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates sodium-dependent transport of amino acids, preferentially L-glutamine By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity. Note: In neurons, located in soma and axons By similarity.
Sequence similarities	Belongs to the amino acid/polyamine transporter 2 family.

Ontologies

Keywords
Biological process	Amino-acid transport Ion transport Sodium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sodium ion transport Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	axon Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW neuronal cell body Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	L-alanine transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-asparagine transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-aspartate transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-glutamate transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-glutamine transmembrane transporter activity Inferred from sequence or structural similarity. Source: UniProtKB L-histidine transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-leucine transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-methionine transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-serine transmembrane transporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Putative sodium-coupled neutral amino acid transporter 7		PRO_0000319596
Regions
	Transmembrane	56 – 76	21	Helical; Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Transmembrane	130 – 150	21	Helical; Potential
	Transmembrane	179 – 199	21	Helical; Potential
	Transmembrane	206 – 226	21	Helical; Potential
	Transmembrane	240 – 260	21	Helical; Potential
	Transmembrane	283 – 303	21	Helical; Potential
	Transmembrane	320 – 340	21	Helical; Potential
	Transmembrane	372 – 392	21	Helical; Potential
	Transmembrane	396 – 416	21	Helical; Potential
	Transmembrane	429 – 449	21	Helical; Potential
Amino acid modifications
	Modified residue	28	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7E3U5 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: C0929D8494FAA397	FASTA	463	49,853
	10 20 30 40 50 60 MAQVSINRDL GEWGLSTDSG ERARLLQSPS VDIAPKSEGE APPGGVGGGT TSTLGAIFIV 70 80 90 100 110 120 VNACLGAGLL NFPAAFSTAG GVAAGITLQM AMLVFIISGL VILAYCSQAS NERTYQEVVW 130 140 150 160 170 180 AVCGKLTGVL CEVAIATYTF GTCIAFLIII GDQQDKIIAV MAKEPEGPGG SPWYTDRKFT 190 200 210 220 230 240 ISLTAFLFIL PLSIPREIGF QKYASFLSVV GTWYVTAIII IKYIWPDKEM TPADILNRPA 250 260 270 280 290 300 SWIAVFNAMP TICFGFQCHV SSVPVFNSMR QPEVKTWGGV VTAAMVIALA VYMGTGICGF 310 320 330 340 350 360 LTFGDAVDPD VLLSYPSEDM AVAVARAFII LSVLTSYPIL HFCGRAVIEG LWLRYQGMPV 370 380 390 400 410 420 EEDVGRERRR RVLQTLVWFL LTLLLALFIP DIGKVISVIG GLAACFIFVF PGLCLIQAKL 430 440 450 460 SEMEEVKPAS WWAMVSYGVL LVTLGAFIFG QTTANAIFVD LLA

References

[1]

"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT030716 mRNA. Translation: ABS45032.1.
IPI	IPI00714565.
RefSeq	NP_001093825.1. NM_001100355.1.
UniGene	Bt.53312.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000009438.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000009438; ENSBTAP00000009438; ENSBTAG00000007170.
GeneID	513110.
KEGG	bta:513110.
Organism-specific databases
CTD	55238.
Phylogenomic databases
eggNOG	COG0814.
GeneTree	ENSGT00700000104173.
HOGENOM	HOG000008036.
HOVERGEN	HBG055999.
InParanoid	A7E3U5.
KO	K14994.
OMA	TWGGVVT.
OrthoDB	EOG46143X.
Family and domain databases
InterPro	IPR013057. AA_transpt_TM. [Graphical view]
Pfam	PF01490. Aa_trans. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20870706.

Entry information

Entry name

S38A7_BOVIN

Accession

Primary (citable) accession number: A7E3U5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	September 11, 2007
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program