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A7E3U5 (S38A7_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative sodium-coupled neutral amino acid transporter 7
Alternative name(s):
Solute carrier family 38 member 7
Gene names
Name:SLC38A7
Synonyms:SNAT7
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates sodium-dependent transport of amino acids, preferentially L-glutamine By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity. Note: In neurons, located in soma and axons By similarity.

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.

Ontologies

Keywords
   Biological processAmino-acid transport
Ion transport
Sodium transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-alpha-amino acid transmembrane transport

Inferred from sequence or structural similarity. Source: GOC

sodium ion transport

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentaxon

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuronal cell body

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionL-alanine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-amino acid transmembrane transporter activity

Inferred from sequence or structural similarity. Source: UniProtKB

L-asparagine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-aspartate transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-glutamate transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-glutamine transmembrane transporter activity

Inferred from sequence or structural similarity. Source: UniProtKB

L-histidine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-leucine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-methionine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-serine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 463463Putative sodium-coupled neutral amino acid transporter 7
PRO_0000319596

Regions

Transmembrane56 – 7621Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane179 – 19921Helical; Potential
Transmembrane206 – 22621Helical; Potential
Transmembrane240 – 26021Helical; Potential
Transmembrane283 – 30321Helical; Potential
Transmembrane320 – 34021Helical; Potential
Transmembrane372 – 39221Helical; Potential
Transmembrane396 – 41621Helical; Potential
Transmembrane429 – 44921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A7E3U5 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: C0929D8494FAA397

FASTA46349,853
        10         20         30         40         50         60 
MAQVSINRDL GEWGLSTDSG ERARLLQSPS VDIAPKSEGE APPGGVGGGT TSTLGAIFIV 

        70         80         90        100        110        120 
VNACLGAGLL NFPAAFSTAG GVAAGITLQM AMLVFIISGL VILAYCSQAS NERTYQEVVW 

       130        140        150        160        170        180 
AVCGKLTGVL CEVAIATYTF GTCIAFLIII GDQQDKIIAV MAKEPEGPGG SPWYTDRKFT 

       190        200        210        220        230        240 
ISLTAFLFIL PLSIPREIGF QKYASFLSVV GTWYVTAIII IKYIWPDKEM TPADILNRPA 

       250        260        270        280        290        300 
SWIAVFNAMP TICFGFQCHV SSVPVFNSMR QPEVKTWGGV VTAAMVIALA VYMGTGICGF 

       310        320        330        340        350        360 
LTFGDAVDPD VLLSYPSEDM AVAVARAFII LSVLTSYPIL HFCGRAVIEG LWLRYQGMPV 

       370        380        390        400        410        420 
EEDVGRERRR RVLQTLVWFL LTLLLALFIP DIGKVISVIG GLAACFIFVF PGLCLIQAKL 

       430        440        450        460 
SEMEEVKPAS WWAMVSYGVL LVTLGAFIFG QTTANAIFVD LLA 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT030716 mRNA. Translation: ABS45032.1.
RefSeqNP_001093825.1. NM_001100355.1.
XP_005218601.1. XM_005218544.1.
XP_005218602.1. XM_005218545.1.
UniGeneBt.53312.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000009438.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000009438; ENSBTAP00000009438; ENSBTAG00000007170.
GeneID513110.
KEGGbta:513110.

Organism-specific databases

CTD55238.

Phylogenomic databases

eggNOGCOG0814.
GeneTreeENSGT00710000106751.
HOGENOMHOG000008036.
HOVERGENHBG055999.
InParanoidA7E3U5.
KOK14994.
OMATWGGVVT.
OrthoDBEOG769ZJG.
TreeFamTF328787.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20870706.

Entry information

Entry nameS38A7_BOVIN
AccessionPrimary (citable) accession number: A7E3U5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families