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Protein

NADPH oxidase activator 1

Gene

Noxa1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-5668599. RHO GTPases Activate NADPH Oxidases.

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH oxidase activator 1
Gene namesi
Name:Noxa1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1306687. Noxa1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003146111 – 446NADPH oxidase activator 1Add BLAST446

Proteomic databases

PaxDbiA7E3N7.
PRIDEiA7E3N7.

PTM databases

iPTMnetiA7E3N7.
PhosphoSitePlusiA7E3N7.

Expressioni

Tissue specificityi

Widely expressed. Detected in gastrum, spleen, uterus, small intestine, colon, inner ear, and brain.1 Publication

Developmental stagei

Expressed in embryonic kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000009286.

Interactioni

Subunit structurei

NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes, hence reducing its ability to activate NOX1. Interacts (via N-terminus) with SH3PXD2A and SH3PXD2B; the interaction is direct (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012375.

Structurei

3D structure databases

ProteinModelPortaliA7E3N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 38TPR 1Add BLAST32
Repeati39 – 71TPR 2Add BLAST33
Repeati73 – 105TPR 3Add BLAST33
Repeati122 – 155TPR 4Add BLAST34
Domaini287 – 367PB1PROSITE-ProRule annotationAdd BLAST81
Domaini371 – 430SH3PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 224Mediates interaction with RAC1By similarityAdd BLAST224

Domaini

The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function.By similarity
The TPR repeats mediate interaction with RAC1.By similarity

Sequence similaritiesi

Belongs to the NCF2/NOXA1 family.Curated
Contains 1 PB1 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 4 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain, TPR repeat

Phylogenomic databases

eggNOGiKOG4225. Eukaryota.
ENOG41110AD. LUCA.
GeneTreeiENSGT00530000063843.
HOGENOMiHOG000237312.
HOVERGENiHBG098043.
InParanoidiA7E3N7.
OMAiFQLERFQ.
OrthoDBiEOG091G04T7.
PhylomeDBiA7E3N7.
TreeFamiTF329087.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR000270. PB1_dom.
IPR001452. SH3_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00666. PB1. 1 hit.
SM00326. SH3. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50002. SH3. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7E3N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLGDQIRD WHRGVLAVAR EDWDSALCFF SDVREPLAKM YFNMGCVHLM
60 70 80 90 100
AGDPEAALRA FDQAVTKDTC MAVGFLQRGV ANFQLQRLQE AVSDFQLALA
110 120 130 140 150
QLRGNAAIDY TQLGLDFKLQ AWEVLYNMAS VQCQAGLWTK AANTLVEAIS
160 170 180 190 200
KRPEGAQDTL EAAMDKVQKQ VPLQLRQVPK GEVFQPPRRY LKHLEPMDFL
210 220 230 240 250
GKAKVVASVI PDDHNSDIQP QQSSQVEQAG LQSSSPVCKR VLSTRGGHMS
260 270 280 290 300
PGLWDSLLAT GGPVPGPSED SSSAEGTATK DPESLVTVTV QCHFTVPLKV
310 320 330 340 350
PRGTDLSSFR TLLSQALLQQ TQKGQFSYKA RGEDRAWVPI STEDSLQSVW
360 370 380 390 400
RNVPVSPRGL QLQCRGAWGR PVLYQVVAQY DYRAQRPEDL DFRQGDTVDV
410 420 430 440
LCEVDEAWLE GHRDGRVGIF PKCFVVPAAT CVEALPVPEP QPGEQH
Length:446
Mass (Da):49,245
Last modified:September 11, 2007 - v1
Checksum:i3463AD5FA4C38474
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03024824 Genomic DNA. No translation available.
BR000299 mRNA. Translation: FAA00366.1.
RefSeqiNP_001093641.1. NM_001100171.1.
UniGeneiRn.162651.

Genome annotation databases

EnsembliENSRNOT00000012375; ENSRNOP00000012375; ENSRNOG00000009286.
GeneIDi311793.
KEGGirno:311793.
UCSCiRGD:1306687. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03024824 Genomic DNA. No translation available.
BR000299 mRNA. Translation: FAA00366.1.
RefSeqiNP_001093641.1. NM_001100171.1.
UniGeneiRn.162651.

3D structure databases

ProteinModelPortaliA7E3N7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012375.

PTM databases

iPTMnetiA7E3N7.
PhosphoSitePlusiA7E3N7.

Proteomic databases

PaxDbiA7E3N7.
PRIDEiA7E3N7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012375; ENSRNOP00000012375; ENSRNOG00000009286.
GeneIDi311793.
KEGGirno:311793.
UCSCiRGD:1306687. rat.

Organism-specific databases

CTDi10811.
RGDi1306687. Noxa1.

Phylogenomic databases

eggNOGiKOG4225. Eukaryota.
ENOG41110AD. LUCA.
GeneTreeiENSGT00530000063843.
HOGENOMiHOG000237312.
HOVERGENiHBG098043.
InParanoidiA7E3N7.
OMAiFQLERFQ.
OrthoDBiEOG091G04T7.
PhylomeDBiA7E3N7.
TreeFamiTF329087.

Enzyme and pathway databases

ReactomeiR-RNO-5668599. RHO GTPases Activate NADPH Oxidases.

Miscellaneous databases

PROiA7E3N7.

Gene expression databases

BgeeiENSRNOG00000009286.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR000270. PB1_dom.
IPR001452. SH3_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00666. PB1. 1 hit.
SM00326. SH3. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50002. SH3. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOXA1_RAT
AccessioniPrimary (citable) accession number: A7E3N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.