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Protein

MEF2-activating motif and SAP domain-containing transcriptional regulator

Gene

MAMSTR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
MEF2-activating motif and SAP domain-containing transcriptional regulator
Alternative name(s):
MEF2-activating SAP transcriptional regulatory protein
Gene namesi
Name:MAMSTR
Synonyms:MASTR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:31160 MAMSTR

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003199801 – 430MEF2-activating motif and SAP domain-containing transcriptional regulatorAdd BLAST430

Proteomic databases

PaxDbiA7E346
PRIDEiA7E346

Expressioni

Gene expression databases

BgeeiENSBTAG00000011617

Interactioni

Subunit structurei

Interacts with MEF2C.By similarity

Structurei

3D structure databases

ProteinModelPortaliA7E346
SMRiA7E346
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 215SAPPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni224 – 430Transcription activationBy similarityAdd BLAST207

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 28MEF2-bindingBy similarityAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 171Pro-richAdd BLAST130
Compositional biasi260 – 263Poly-Pro4

Phylogenomic databases

eggNOGiENOG410II34 Eukaryota
ENOG4111CQH LUCA
GeneTreeiENSGT00390000003056
HOGENOMiHOG000082480
HOVERGENiHBG108119
InParanoidiA7E346
OMAiSGTRLWD
OrthoDBiEOG091G0IHX

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PfamiView protein in Pfam
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit
SUPFAMiSSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50800 SAP, 1 hit

Sequencei

Sequence statusi: Complete.

A7E346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLAASSQRS QIIRSKFRSV LQLRIHRRYQ DPTLSGSFTA SPVLDPDPWI
60 70 80 90 100
SAADPALALA PASPLGPAPF LFNPEVLLPE PKPCWSLKKE SPKTSQHWRE
110 120 130 140 150
PKPKGNLTYH QYIPPEPRQG YRADPQVEGS PLDPPGPPLW EGTTSQQPPP
160 170 180 190 200
RMKPTPLTPS PPGVPSPSPL PHKLELQTLK LEELTVSELR QQLRLRGLPV
210 220 230 240 250
SGTKSMLLER MRGGAPPRER PKARREDSAA GAPWPRFRPK ALGAARSACS
260 270 280 290 300
FKLSPTSHSP PPPRAVETLV TASASAPVPV ATTAQAPTPA PVPVPSSAPA
310 320 330 340 350
STALTLEEEL QEAIRRAQLL PNRGIDDILE DQVEPEDPLP AIPLDFPGSF
360 370 380 390 400
DMLSPSPDSE GLSSVFSSSL PSPTNSPSPS PRGPTDFLDW LEALSGGPSL
410 420 430
GCGPPAPSIF SADLSDSSGT RLWDLLEDPW
Length:430
Mass (Da):46,215
Last modified:February 26, 2008 - v2
Checksum:iE91D646B7AC61387
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03027484 Genomic DNA No translation available.
BC151712 mRNA Translation: AAI51713.1
RefSeqiNP_001181940.1, NM_001195011.1
XP_005219251.1, XM_005219194.2
XP_005219252.1, XM_005219195.2
XP_010813311.1, XM_010815009.2
UniGeneiBt.8440

Genome annotation databases

EnsembliENSBTAT00000015429; ENSBTAP00000015429; ENSBTAG00000011617
GeneIDi505540
KEGGibta:505540

Similar proteinsi

Entry informationi

Entry nameiMASTR_BOVIN
AccessioniPrimary (citable) accession number: A7E346
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: March 28, 2018
This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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