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Protein

MEF2-activating motif and SAP domain-containing transcriptional regulator

Gene

MAMSTR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
MEF2-activating motif and SAP domain-containing transcriptional regulator
Alternative name(s):
MEF2-activating SAP transcriptional regulatory protein
Gene namesi
Name:MAMSTR
Synonyms:MASTR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430MEF2-activating motif and SAP domain-containing transcriptional regulatorPRO_0000319980Add
BLAST

Proteomic databases

PaxDbiA7E346.
PRIDEiA7E346.

Expressioni

Gene expression databases

BgeeiENSBTAG00000011617.

Interactioni

Subunit structurei

Interacts with MEF2C.By similarity

Structurei

3D structure databases

ProteinModelPortaliA7E346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini181 – 21535SAPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni224 – 430207Transcription activationBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi12 – 2817MEF2-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 171130Pro-richAdd
BLAST
Compositional biasi260 – 2634Poly-Pro

Sequence similaritiesi

Contains 1 SAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410II34. Eukaryota.
ENOG4111CQH. LUCA.
GeneTreeiENSGT00390000003056.
HOGENOMiHOG000082480.
HOVERGENiHBG108119.
InParanoidiA7E346.
OMAiPPPRMKP.
OrthoDBiEOG091G0IHX.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR003034. SAP_dom.
[Graphical view]
PfamiPF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7E346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLAASSQRS QIIRSKFRSV LQLRIHRRYQ DPTLSGSFTA SPVLDPDPWI
60 70 80 90 100
SAADPALALA PASPLGPAPF LFNPEVLLPE PKPCWSLKKE SPKTSQHWRE
110 120 130 140 150
PKPKGNLTYH QYIPPEPRQG YRADPQVEGS PLDPPGPPLW EGTTSQQPPP
160 170 180 190 200
RMKPTPLTPS PPGVPSPSPL PHKLELQTLK LEELTVSELR QQLRLRGLPV
210 220 230 240 250
SGTKSMLLER MRGGAPPRER PKARREDSAA GAPWPRFRPK ALGAARSACS
260 270 280 290 300
FKLSPTSHSP PPPRAVETLV TASASAPVPV ATTAQAPTPA PVPVPSSAPA
310 320 330 340 350
STALTLEEEL QEAIRRAQLL PNRGIDDILE DQVEPEDPLP AIPLDFPGSF
360 370 380 390 400
DMLSPSPDSE GLSSVFSSSL PSPTNSPSPS PRGPTDFLDW LEALSGGPSL
410 420 430
GCGPPAPSIF SADLSDSSGT RLWDLLEDPW
Length:430
Mass (Da):46,215
Last modified:February 26, 2008 - v2
Checksum:iE91D646B7AC61387
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03027484 Genomic DNA. No translation available.
BC151712 mRNA. Translation: AAI51713.1.
RefSeqiNP_001181940.1. NM_001195011.1.
XP_005219251.1. XM_005219194.2.
XP_005219252.1. XM_005219195.2.
XP_010813311.1. XM_010815009.2.
UniGeneiBt.8440.

Genome annotation databases

EnsembliENSBTAT00000015429; ENSBTAP00000015429; ENSBTAG00000011617.
GeneIDi505540.
KEGGibta:505540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03027484 Genomic DNA. No translation available.
BC151712 mRNA. Translation: AAI51713.1.
RefSeqiNP_001181940.1. NM_001195011.1.
XP_005219251.1. XM_005219194.2.
XP_005219252.1. XM_005219195.2.
XP_010813311.1. XM_010815009.2.
UniGeneiBt.8440.

3D structure databases

ProteinModelPortaliA7E346.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiA7E346.
PRIDEiA7E346.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000015429; ENSBTAP00000015429; ENSBTAG00000011617.
GeneIDi505540.
KEGGibta:505540.

Organism-specific databases

CTDi284358.

Phylogenomic databases

eggNOGiENOG410II34. Eukaryota.
ENOG4111CQH. LUCA.
GeneTreeiENSGT00390000003056.
HOGENOMiHOG000082480.
HOVERGENiHBG108119.
InParanoidiA7E346.
OMAiPPPRMKP.
OrthoDBiEOG091G0IHX.

Gene expression databases

BgeeiENSBTAG00000011617.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR003034. SAP_dom.
[Graphical view]
PfamiPF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMASTR_BOVIN
AccessioniPrimary (citable) accession number: A7E346
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 7, 2016
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.