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A7E2Z2

- EZH1_BOVIN

UniProt

A7E2Z2 - EZH1_BOVIN

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Protein

Histone-lysine N-methyltransferase EZH1

Gene
EZH1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. histone methyltransferase activity (H3-K27 specific) Source: Ensembl

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase EZH1 (EC:2.1.1.43)
Alternative name(s):
Enhancer of zeste homolog 1
Gene namesi
Name:EZH1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

Nucleus By similarity
Note: Colocalizes with trimethylated 'Lys-27' of histone H3 By similarity.

GO - Cellular componenti

  1. ESC/E(Z) complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747Histone-lysine N-methyltransferase EZH1PRO_0000363956Add
BLAST

Interactioni

Subunit structurei

Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2/EED-EZH1 is less abundant than the PRC2/EED-EZH2 complex, has weak methyltransferase activity and compacts chromatin in the absence of the methyltransferase cofactor S-adenosyl-L-methionine (SAM) By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029222.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini504 – 606103CXCAdd
BLAST
Domaini613 – 728116SETAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi524 – 60582Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 CXC domain.
Contains 1 SET domain.

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00740000115009.
HOGENOMiHOG000008176.
HOVERGENiHBG002453.
InParanoidiA7E2Z2.
KOiK17451.
OMAiSTQVYNY.
OrthoDBiEOG7VB2DR.
TreeFamiTF314509.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A7E2Z2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDIPNPPTSK CITYWKRKVK SEYMRLRQLK RLQANMGAKA LYVANFAKVQ    50
EKTQILNEEW KKLRVQPVQL MKPVSGHPFL KKCTIESIFP GFASQHMLMR 100
SLNTVALVPI MYSWSPLQQN FMVEDETVLC NIPYMGDEVK EEDETFIEEL 150
INNYDGKVHG EEEMIPGSVL ISDAVFLELV DALNQYSDED EEGHNDTSDG 200
KQDDSKEDLP VTRKRKRHAI EGSKKSSKKQ FPNDMIFSAI ASMFPENGVP 250
DDMKERYREL TEMSDPNALP PQCTPNIDGP NAKSVQREQS LHSFHTLFCR 300
RCFKYDCFLH PFHATPNVYK RKNKEIKIEP EPCGTDCFLL LEGAKEYAML 350
HNPRSKCSGR RRRRHHVVNA SCSNTSASAV AETKEGDSDR DTGNDWASSS 400
SEANSRCQTP TKQKASPAPP QLCVVEAPSE PVEWTGAEES LFRVFHGTYF 450
NNFCSIARLL GTKTCKQVFQ FAVKESLILK LPTDELMNPS QKKKRKHRLW 500
AAHCRKIQLK KDNSSTQVYN YQPCDHPDRP CDSTCPCIMT QNFCEKFCQC 550
NPDCQNRFPG CRCKTQCNTK QCPCYLAVRE CDPDLCLTCG ASEHWDCKVV 600
SCKNCSIQRG LKKHLLLAPS DVAGWGTFIK ESVQKNEFIS EYCGELISQD 650
EADRRGKVYD KYMSSFLFNL NNDFVVDATR KGNKIRFANH SVNPNCYAKV 700
VMVNGDHRIG IFAKRAIQAG EELFFDYRYS QADALKYVGI ERETDVL 747
Length:747
Mass (Da):85,285
Last modified:February 10, 2009 - v2
Checksum:iA40D3D08F63CA155
GO
Isoform 2 (identifier: A7E2Z2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     700-747: VVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVL → AKITDLKA

Note: No experimental confirmation available.

Show »
Length:707
Mass (Da):80,639
Checksum:i3A925BD51154C096
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei700 – 74748VVMVN…ETDVL → AKITDLKA in isoform 2. VSP_036369Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151626 mRNA. Translation: AAI51627.1.
RefSeqiNP_001095621.1. NM_001102151.2. [A7E2Z2-2]
XP_005220793.1. XM_005220736.1. [A7E2Z2-1]
UniGeneiBt.21818.

Genome annotation databases

EnsembliENSBTAT00000029222; ENSBTAP00000029222; ENSBTAG00000021918. [A7E2Z2-2]
GeneIDi533087.
KEGGibta:533087.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151626 mRNA. Translation: AAI51627.1 .
RefSeqi NP_001095621.1. NM_001102151.2. [A7E2Z2-2 ]
XP_005220793.1. XM_005220736.1. [A7E2Z2-1 ]
UniGenei Bt.21818.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000029222.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000029222 ; ENSBTAP00000029222 ; ENSBTAG00000021918 . [A7E2Z2-2 ]
GeneIDi 533087.
KEGGi bta:533087.

Organism-specific databases

CTDi 2145.

Phylogenomic databases

eggNOGi COG2940.
GeneTreei ENSGT00740000115009.
HOGENOMi HOG000008176.
HOVERGENi HBG002453.
InParanoidi A7E2Z2.
KOi K17451.
OMAi STQVYNY.
OrthoDBi EOG7VB2DR.
TreeFami TF314509.

Miscellaneous databases

NextBioi 20875906.

Family and domain databases

InterProi IPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiEZH1_BOVIN
AccessioniPrimary (citable) accession number: A7E2Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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