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Protein

Myosin-7B

Gene

MYH7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in muscle contraction.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi177 – 1848ATPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-7B
Alternative name(s):
Antigen MLAA-21
Myosin cardiac muscle beta chain
Myosin heavy chain 7B, cardiac muscle beta isoform
Slow A MYH14
Gene namesi
Name:MYH7B
Synonyms:KIAA1512
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15906. MYH7B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Thick filament

Pathology & Biotechi

Organism-specific databases

MalaCardsiMYH7B.
Orphaneti54260. Left ventricular noncompaction.
PharmGKBiPA31375.

Polymorphism and mutation databases

BioMutaiMYH7B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19411941Myosin-7BPRO_0000349312Add
BLAST

Proteomic databases

EPDiA7E2Y1.
MaxQBiA7E2Y1.
PaxDbiA7E2Y1.
PRIDEiA7E2Y1.

PTM databases

iPTMnetiA7E2Y1.
SwissPalmiA7E2Y1.

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver.1 Publication

Developmental stagei

Found in fetal liver and brain.1 Publication

Gene expression databases

BgeeiA7E2Y1.
CleanExiHS_MYH7B.
ExpressionAtlasiA7E2Y1. baseline and differential.
GenevisibleiA7E2Y1. HS.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SMYD1Q8NB122EBI-2880253,EBI-8463848

Protein-protein interaction databases

BioGridi121681. 28 interactions.
IntActiA7E2Y1. 17 interactions.
MINTiMINT-8417697.
STRINGi9606.ENSP00000262873.

Structurei

3D structure databases

ProteinModelPortaliA7E2Y1.
SMRiA7E2Y1. Positions 3-848, 857-968, 1180-1249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 785702Myosin motorAdd
BLAST
Domaini788 – 81730IQPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni662 – 68423Actin-bindingBy similarityAdd
BLAST
Regioni764 – 77815Actin-bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili846 – 19351090Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
HOVERGENiHBG004704.
InParanoidiA7E2Y1.
KOiK10352.
OrthoDBiEOG7RBZ7G.
PhylomeDBiA7E2Y1.
TreeFamiTF314375.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A7E2Y1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDVSELGES ARYLRQGYQE MTKVHTIPWD GKKRVWVPDE QDAYVEAEVK
60 70 80 90 100
SEATGGRVTV ETKDQKVLMV REAELQPMNP PRFDLLEDMA MMTHLNEASV
110 120 130 140 150
LHNLRQRYAR WMIYTYSGLF CVTINPYKWL PVYTASVVAA YKGKRRSDSP
160 170 180 190 200
PHIYAVADNA YNDMLRNRDN QSMLITGESG AGKTVNTKRV IQYFAIVAAL
210 220 230 240 250
GDGPGKKAQF LATKTGGTLE DQIIEANPAM EAFGNAKTLR NDNSSRFGKF
260 270 280 290 300
IRIHFGPSGK LASADIDSYL LEKSRVIFQL PGERSYHVYY QILSGRKPEL
310 320 330 340 350
QDMLLLSMNP YDYHFCSQGV ITVDNMNDGE ELIATDHAMD ILGFSVDEKC
360 370 380 390 400
ACYKIVGALL HFGNMKFKQK QREEQAEADG TESADKAAYL MGVSSGDLLK
410 420 430 440 450
GLLHPRVRVG NEYVTKGQSV EQVVFAVGAL AKATYDRLFR WLVSRINQTL
460 470 480 490 500
DTKLPRQFFI GVLDIAGFEI FEFNSFEQLC INFTNEKLQQ FFNQHMFVLE
510 520 530 540 550
QEEYKREGID WVFIDFGLDL QPCIDLIEKP LGILSILEEE CMFPKASDAS
560 570 580 590 600
FRAKLYDNHA GKSPNFQQPR PDKKRKYQAH FEVVHYAGVV PYSIVGWLEK
610 620 630 640 650
NKDPLNETVV PIFQKSQNRL LATLYENYAG SCSTEPPKSG VKEKRKKAAS
660 670 680 690 700
FQTVSQLHKE NLNKLMTNLR ATQPHFVRCI VPNENKTPGV MDAFLVLHQL
710 720 730 740 750
RCNGVLEGIR ICRQGFPNRL LYTDFRQRYR ILNPSAIPDD TFMDSRKATE
760 770 780 790 800
KLLGSLDLDH TQYQFGHTKV FFKAGLLGVL EELRDQRLAK VLTLLQARSR
810 820 830 840 850
GRLMRLEYQR LLGGRDALFT IQWNIRAFNA VKNWSWMKLF FKMKPLLRSA
860 870 880 890 900
QAEEELAALR AELRGLRGAL AAAEAKRQEL EETHVSITQE KNDLALQLQA
910 920 930 940 950
EQDNLADAEE RCHLLIKSKV QLEGKVKELS ERLEDEEEVN ADLAARRRKL
960 970 980 990 1000
EDECTELKKD IDDLKLTLAK AEKEKQATEN KVKNLTEEMA ALDESVARLT
1010 1020 1030 1040 1050
KEKKALQEAH QQALGDLQAE EDRVSALTKA KLRLEQQVED LECSLEQEKK
1060 1070 1080 1090 1100
LRMDTERAKR KLEGDLKLTQ ESVADAAQDK QQLEEKLKKK DSELSQLSLR
1110 1120 1130 1140 1150
VEDEQLLGAQ MQKKIKELQA RAEELEEELE AERAARARVE KQRAEAAREL
1160 1170 1180 1190 1200
EELSERLEEA GGASAGQREG CRKREAELGR LRRELEEAAL RHEATVAALR
1210 1220 1230 1240 1250
RKQAEGAAEL GEQVDSLQRV RQKLEKEKSE LRMEVDDLAA NVETLTRAKA
1260 1270 1280 1290 1300
SAEKLCRTYE DQLSEAKIKV EELQRQLADA STQRGRLQTE SGELSRLLEE
1310 1320 1330 1340 1350
KECLISQLSR GKALAAQSLE ELRRQLEEES KAKSALAHAV QALRHDCDLL
1360 1370 1380 1390 1400
REQHEEEAEA QAELQRLLSK ANAEVAQWRS KYEADAIQRT EELEEAKKKL
1410 1420 1430 1440 1450
ALRLQEAEEG VEAANAKCSS LEKAKLRLQT ESEDVTLELE RATSAAAALD
1460 1470 1480 1490 1500
KKQRHLERAL EERRRQEEEM QRELEAAQRE SRGLGTELFR LRHGHEEALE
1510 1520 1530 1540 1550
ALETLKRENK NLQEEISDLT DQVSLSGKSI QELEKTKKAL EGEKSEIQAA
1560 1570 1580 1590 1600
LEEAEGALEL EETKTLRIQL ELSQVKAEVD RKLAEKDEEC ANLRRNHQRA
1610 1620 1630 1640 1650
VESLQASLDA ETRARNEALR LKKKMEGDLN DLELQLGHAT RQATEAQAAT
1660 1670 1680 1690 1700
RLMQAQLKEE QAGRDEEQRL AAELHEQAQA LERRASLLAA ELEELRAALE
1710 1720 1730 1740 1750
QGERSRRLAE QELLEATERL NLLHSQNTGL LNQKKKLEAD LAQLSGEVEE
1760 1770 1780 1790 1800
AAQERREAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KTLEQTVREL
1810 1820 1830 1840 1850
QARLEEAEQA ALRGGKKQVQ KLEAKVRELE AELDAEQKKH AEALKGVRKH
1860 1870 1880 1890 1900
ERRVKELAYQ AEEDRKNLAR MQDLVDKLQS KVKSYKRQFE EAEQQANTNL
1910 1920 1930 1940
AKYRKAQHEL DDAEERADMA ETQANKLRAR TRDALGPKHK E
Length:1,941
Mass (Da):221,388
Last modified:January 11, 2011 - v3
Checksum:i73644B656C383EBD
GO
Isoform 2 (identifier: A7E2Y1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-1941: Missing.

Show »
Length:176
Mass (Da):20,442
Checksum:i91A61F7A24A55CA2
GO
Isoform 3 (identifier: A7E2Y1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1767: Missing.
     1768-1769: DA → MP

Note: No experimental confirmation available.
Show »
Length:174
Mass (Da):20,273
Checksum:i58BEBBCBC47DE8AF
GO

Sequence cautioni

The sequence AAI51243.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA96036.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI19310.2 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI43047.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti937 – 9371E → G in AAH07808 (PubMed:15489334).Curated
Sequence conflicti1858 – 18581A → V in AAQ93060 (PubMed:15755502).Curated
Sequence conflicti1861 – 18611A → T in AAQ93060 (PubMed:15755502).Curated
Sequence conflicti1897 – 18971N → S in AAQ93060 (PubMed:15755502).Curated
Sequence conflicti1931 – 19311T → S in AAQ93060 (PubMed:15755502).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281P → T.
Corresponds to variant rs17092199 [ dbSNP | Ensembl ].
VAR_046359
Natural varianti459 – 4591F → Y.
Corresponds to variant rs754511 [ dbSNP | Ensembl ].
VAR_046360
Natural varianti738 – 7381P → S.
Corresponds to variant rs3746442 [ dbSNP | Ensembl ].
VAR_046361
Natural varianti965 – 9651K → E.2 Publications
Corresponds to variant rs2425015 [ dbSNP | Ensembl ].
VAR_054814
Natural varianti1510 – 15101K → N.
Corresponds to variant rs3746435 [ dbSNP | Ensembl ].
VAR_046362
Natural varianti1539 – 15391A → V.
Corresponds to variant rs6060147 [ dbSNP | Ensembl ].
VAR_046363
Natural varianti1656 – 16561Q → R.
Corresponds to variant rs6060148 [ dbSNP | Ensembl ].
VAR_046364
Natural varianti1875 – 18751V → E.
Corresponds to variant rs7273482 [ dbSNP | Ensembl ].
VAR_046365

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 17671767Missing in isoform 3. 1 PublicationVSP_035359Add
BLAST
Alternative sequencei177 – 19411765Missing in isoform 2. 2 PublicationsVSP_035360Add
BLAST
Alternative sequencei1768 – 17692DA → MP in isoform 3. 1 PublicationVSP_035361

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288964 mRNA. Translation: AAQ93060.1.
AB040945 mRNA. Translation: BAA96036.2. Different initiation.
AK000947 mRNA. Translation: BAA91440.1.
AL133324, AL132825 Genomic DNA. Translation: CAI19310.2. Sequence problems.
AL132825, AL133324 Genomic DNA. Translation: CAI43047.2. Sequence problems.
CH471077 Genomic DNA. Translation: EAW76237.1.
BC007808 mRNA. Translation: AAH07808.1.
BC069327 mRNA. Translation: AAH69327.2.
BC069406 mRNA. Translation: AAH69406.2.
BC151242 mRNA. Translation: AAI51243.1. Different initiation.
RefSeqiNP_065935.3. NM_020884.4.
UniGeneiHs.414122.

Genome annotation databases

EnsembliENST00000262873; ENSP00000262873; ENSG00000078814.
GeneIDi57644.
KEGGihsa:57644.
UCSCiuc061wko.1. human. [A7E2Y1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288964 mRNA. Translation: AAQ93060.1.
AB040945 mRNA. Translation: BAA96036.2. Different initiation.
AK000947 mRNA. Translation: BAA91440.1.
AL133324, AL132825 Genomic DNA. Translation: CAI19310.2. Sequence problems.
AL132825, AL133324 Genomic DNA. Translation: CAI43047.2. Sequence problems.
CH471077 Genomic DNA. Translation: EAW76237.1.
BC007808 mRNA. Translation: AAH07808.1.
BC069327 mRNA. Translation: AAH69327.2.
BC069406 mRNA. Translation: AAH69406.2.
BC151242 mRNA. Translation: AAI51243.1. Different initiation.
RefSeqiNP_065935.3. NM_020884.4.
UniGeneiHs.414122.

3D structure databases

ProteinModelPortaliA7E2Y1.
SMRiA7E2Y1. Positions 3-848, 857-968, 1180-1249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121681. 28 interactions.
IntActiA7E2Y1. 17 interactions.
MINTiMINT-8417697.
STRINGi9606.ENSP00000262873.

PTM databases

iPTMnetiA7E2Y1.
SwissPalmiA7E2Y1.

Polymorphism and mutation databases

BioMutaiMYH7B.

Proteomic databases

EPDiA7E2Y1.
MaxQBiA7E2Y1.
PaxDbiA7E2Y1.
PRIDEiA7E2Y1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262873; ENSP00000262873; ENSG00000078814.
GeneIDi57644.
KEGGihsa:57644.
UCSCiuc061wko.1. human. [A7E2Y1-1]

Organism-specific databases

CTDi57644.
GeneCardsiMYH7B.
HGNCiHGNC:15906. MYH7B.
MalaCardsiMYH7B.
MIMi609928. gene.
neXtProtiNX_A7E2Y1.
Orphaneti54260. Left ventricular noncompaction.
PharmGKBiPA31375.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
HOVERGENiHBG004704.
InParanoidiA7E2Y1.
KOiK10352.
OrthoDBiEOG7RBZ7G.
PhylomeDBiA7E2Y1.
TreeFamiTF314375.

Enzyme and pathway databases

ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.

Miscellaneous databases

ChiTaRSiMYH7B. human.
GeneWikiiMYH7B.
GenomeRNAii57644.
NextBioi64370.
PROiA7E2Y1.
SOURCEiSearch...

Gene expression databases

BgeeiA7E2Y1.
CleanExiHS_MYH7B.
ExpressionAtlasiA7E2Y1. baseline and differential.
GenevisibleiA7E2Y1. HS.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Serological identification of immunogenic antigens in acute monocytic leukemia."
    Chen G., Zhang W.G., Cao X.M., Li F.Y., Liu X.P., Yao L.B.
    Leuk. Res. 29:503-509(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), SUBCELLULAR LOCATION, VARIANT GLU-965.
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLU-965.
    Tissue: Skin.
  7. "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family."
    Desjardins P.R., Burkman J.M., Shrager J.B., Allmond L.A., Stedman H.H.
    Mol. Biol. Evol. 19:375-393(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiMYH7B_HUMAN
AccessioniPrimary (citable) accession number: A7E2Y1
Secondary accession number(s): Q5JVW7
, Q6NT44, Q6NT57, Q6WG75, Q96I57, Q9NWE2, Q9P216
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 11, 2011
Last modified: May 11, 2016
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Expression does not vary in normal patients compared to patients with acute monocytic leukemia.
The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.

Caution

This protein sequence has been named 'Slow A' MYH14, but it also appears also as 'Slow B' MYH15 within the reference.1 Publication
Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.