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Protein

Zinc finger SWIM domain-containing protein 8

Gene

ZSWIM8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 208SWIM-typePROSITE-ProRule annotationAdd BLAST37

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31679-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 8
Gene namesi
Name:ZSWIM8
Synonyms:KIAA0913
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23528. ZSWIM8.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214655.
PharmGKBiPA134885317.

Polymorphism and mutation databases

BioMutaiZSWIM8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003118021 – 1837Zinc finger SWIM domain-containing protein 8Add BLAST1837

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Modified residuei53PhosphoserineBy similarity1
Modified residuei437PhosphoserineCombined sources1
Modified residuei567PhosphoserineCombined sources1
Modified residuei1139PhosphothreonineCombined sources1
Modified residuei1153PhosphoserineBy similarity1
Modified residuei1156PhosphoserineBy similarity1
Modified residuei1160PhosphoserineCombined sources1
Modified residuei1267PhosphoserineCombined sources1
Modified residuei1836PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA7E2V4.
MaxQBiA7E2V4.
PaxDbiA7E2V4.
PRIDEiA7E2V4.

PTM databases

iPTMnetiA7E2V4.
PhosphoSitePlusiA7E2V4.

Expressioni

Gene expression databases

BgeeiENSG00000214655.
CleanExiHS_KIAA0913.
ExpressionAtlasiA7E2V4. baseline and differential.
GenevisibleiA7E2V4. HS.

Organism-specific databases

HPAiHPA041244.

Interactioni

Protein-protein interaction databases

BioGridi116690. 18 interactors.
IntActiA7E2V4. 12 interactors.
MINTiMINT-2870247.
STRINGi9606.ENSP00000381693.

Structurei

3D structure databases

ProteinModelPortaliA7E2V4.
SMRiA7E2V4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi56 – 65Poly-Gly10
Compositional biasi546 – 602Gly-richAdd BLAST57
Compositional biasi1143 – 1204Ser-richAdd BLAST62
Compositional biasi1471 – 1474Poly-Ala4
Compositional biasi1493 – 1658Pro-richAdd BLAST166

Sequence similaritiesi

Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 208SWIM-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3615. Eukaryota.
ENOG410XPG2. LUCA.
GeneTreeiENSGT00390000012572.
HOVERGENiHBG092246.
InParanoidiA7E2V4.
OMAiQQMYIQC.
OrthoDBiEOG091G00OR.
PhylomeDBiA7E2V4.
TreeFamiTF324881.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A7E2V4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELMFAEWED GERFSFEDSD RFEEDSLCSF ISEAESLCQN WRGWRKQSAG
60 70 80 90 100
PNSPTGGGGG GGSGGTRMRD GLVIPLVELS AKQVAFHIPF EVVEKVYPPV
110 120 130 140 150
PEQLQLRIAF WSFPENEEDI RLYSCLANGS ADEFQRGDQL FRMRAVKDPL
160 170 180 190 200
QIGFHLSATV VPPQMVPPKG AYNVAVMFDR CRVTSCSCTC GAGAKWCTHV
210 220 230 240 250
VALCLFRIHN ASAVCLRAPV SESLSRLQRD QLQKFAQYLI SELPQQILPT
260 270 280 290 300
AQRLLDELLS SQSTAINTVC GAPDPTAGPS ASDQSTWYLD ESTLTDNIKK
310 320 330 340 350
TLHKFCGPSP VVFSDVNSMY LSSTEPPAAA EWACLLRPLR GREPEGVWNL
360 370 380 390 400
LSIVREMFKR RDSNAAPLLE ILTDQCLTYE QITGWWYSVR TSASHSSASG
410 420 430 440 450
HTGRSNGQSE VAAHACASMC DEMVTLWRLA VLDPALSPQR RRELCTQLRQ
460 470 480 490 500
WQLKVIENVK RGQHKKTLER LFPGFRPAVE ACYFNWEEAY PLPGVTYSGT
510 520 530 540 550
DRKLALCWAR ALPSRPGASR SGGLEESRDR PRPLPTEPAV RPKEPGTKRK
560 570 580 590 600
GLGEGVPSSQ RGPRRLSAEG GDKALHKMGP GGGKAKALGG AGSGSKGSAG
610 620 630 640 650
GGSKRRLSSE DSSLEPDLAE MSLDDSSLAL GAEASTFGGF PESPPPCPLH
660 670 680 690 700
GGSRGPSTFL PEPPDTYEED GGVYFSEGPE PPTASVGPPG LLPGDVCTQD
710 720 730 740 750
DLPSTDESGN GLPKTKEAAP AVGEEDDDYQ AYYLNAQDGA GGEEEKAEGG
760 770 780 790 800
AGEEHDLFAG LKPLEQESRM EVLFACAEAL HAHGYSSEAS RLTVELAQDL
810 820 830 840 850
LANPPDLKVE PPPAKGKKNK VSTSRQTWVA TNTLSKAAFL LTVLSERPEH
860 870 880 890 900
HNLAFRVGMF ALELQRPPAS TKALEVKLAY QESEVAALLK KIPLGPSEMS
910 920 930 940 950
TMRCRAEELR EGTLCDYRPV LPLMLASFIF DVLCAPGSRP PSRNWNSETP
960 970 980 990 1000
GDEELGFEAA VAALGMKTTV SEAEHPLLCE GTRREKGDLA LALMITYKDD
1010 1020 1030 1040 1050
QAKLKKILDK LLDRESQTHK PQTLSSFYSS SRPTTASQRS PSKHGGPSAP
1060 1070 1080 1090 1100
GALQPLTSGS AGPAQPGSVA GAGPGPTEGF TEKNVPESSP HSPCEGLPSE
1110 1120 1130 1140 1150
AALTPRPEGK VPSRLALGSR GGYNGRGWGS PGRPKKKHTG MASIDSSAPE
1160 1170 1180 1190 1200
TTSDSSPTLS RRPLRGGWAP TSWGRGQDSD SISSSSSDSL GSSSSSGSRR
1210 1220 1230 1240 1250
ASASGGARAK TVEVGRYKGR RPESHAPHVP NQPSEAAAHF YFELAKTVLI
1260 1270 1280 1290 1300
KAGGNSSTSI FTHPSSSGGH QGPHRNLHLC AFEIGLYALG LHNFVSPNWL
1310 1320 1330 1340 1350
SRTYSSHVSW ITGQAMEIGS AALTILVECW DGHLTPPEVA SLADRASRAR
1360 1370 1380 1390 1400
DSNMVRAAAE LALSCLPHAH ALNPNEIQRA LVQCKEQDNL MLEKACMAVE
1410 1420 1430 1440 1450
EAAKGGGVYP EVLFEVAHQW FWLYEQTAGG SSTAREGATS CSASGIRAGG
1460 1470 1480 1490 1500
EAGRGMPEGR GGPGTEPVTV AAAAVTAAAT VVPVISVGSS LYPGPGLGHG
1510 1520 1530 1540 1550
HSPGLHPYTA LQPHLPCSPQ YLTHPAHPAH PMPHMPRPAV FPVPSSAYPQ
1560 1570 1580 1590 1600
GVHPAFLGAQ YPYSVTPPSL AATAVSFPVP SMAPITVHPY HTEPGLPLPT
1610 1620 1630 1640 1650
SVACELWGQG TVSSVHPAST FPAIQGASLP ALTTQPSPLV SGGFPPPEEE
1660 1670 1680 1690 1700
THSQPVNPHS LHHLHAAYRV GMLALEMLGR RAHNDHPNNF SRSPPYTDDV
1710 1720 1730 1740 1750
KWLLGLAAKL GVNYVHQFCV GAAKGVLSPF VLQEIVMETL QRLSPAHAHN
1760 1770 1780 1790 1800
HLRAPAFHQL VQRCQQAYMQ YIHHRLIHLT PADYDDFVNA IRSARSAFCL
1810 1820 1830
TPMGMMQFND ILQNLKRSKQ TKELWQRVSL EMATFSP
Length:1,837
Mass (Da):197,297
Last modified:September 11, 2007 - v1
Checksum:i391CF6AE25E4F8C6
GO
Isoform 2 (identifier: A7E2V4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1604-1612: CELWGQGTV → L
     1712-1837: VNYVHQFCVG...VSLEMATFSP → DRHGDAAAAE...SGIYLAFINI

Note: No experimental confirmation available.
Show »
Length:1,892
Mass (Da):201,521
Checksum:i2A3771D8E5FB1B29
GO
Isoform 3 (identifier: A7E2V4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     936-936: P → PVVSPT
     1006-1006: K → KVTASVFQ
     1604-1612: CELWGQGTV → L

Note: No experimental confirmation available.
Show »
Length:1,841
Mass (Da):197,653
Checksum:i9686990176C4841E
GO
Isoform 4 (identifier: A7E2V4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     936-936: P → PVVSPT

Note: No experimental confirmation available.
Show »
Length:1,842
Mass (Da):197,781
Checksum:i9218AB3CF6511CEB
GO
Isoform 5 (identifier: A7E2V4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1604-1612: CELWGQGTV → L

Note: No experimental confirmation available.
Show »
Length:1,829
Mass (Da):196,436
Checksum:i8AC63F718E8FD28A
GO

Sequence cautioni

The sequence AAI37250 differs from that shown. Probable cloning artifact.Curated
The sequence AAI37251 differs from that shown. Probable cloning artifact.Curated
The sequence BAA74936 differs from that shown. Aberrant splicing.Curated
The sequence BAA74936 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB14664 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03709 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti751A → D in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti762K → M in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti774F → S in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1052A → T in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1136K → M in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1165R → Q in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1184S → N in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1252A → T in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1401E → V in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1775R → S in BAB14664 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029586936P → PVVSPT in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_0295871006K → KVTASVFQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_0295901604 – 1612CELWGQGTV → L in isoform 2, isoform 3 and isoform 5. 2 Publications9
Alternative sequenceiVSP_0295911712 – 1837VNYVH…ATFSP → DRHGDAAAAESRSCPQPPAC PGLPPTGAALPAGIHAVHPP PLDSPDSCGLRRLCECDPEC PQRLLPDAHGHDAVQRHPTE PQAQQTDQGAVAAGLTRDGH LLPLSLSPLGSYTGTQACGY GGPSHRGSETWLDRSSSLSS LVAQTDSCSWAIAWGQDVSH PRSLGLGETALSGRGRWVAS GIYLAFINI in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020720 mRNA. Translation: BAA74936.2. Sequence problems.
AC022400 Genomic DNA. No translation available.
BC040726 mRNA. Translation: AAH40726.1.
BC063694 mRNA. Translation: AAH63694.1.
BC111006 mRNA. Translation: AAI11007.1.
BC117205 mRNA. Translation: AAI17206.1.
BC137249 mRNA. Translation: AAI37250.1. Sequence problems.
BC137250 mRNA. Translation: AAI37251.1. Sequence problems.
BC151206 mRNA. Translation: AAI51207.1.
AK023742 mRNA. Translation: BAB14664.1. Different initiation.
AK091621 mRNA. Translation: BAC03709.1. Sequence problems.
CCDSiCCDS44440.1. [A7E2V4-4]
CCDS60560.1. [A7E2V4-1]
RefSeqiNP_001229416.1. NM_001242487.1. [A7E2V4-1]
NP_001229417.1. NM_001242488.1. [A7E2V4-2]
NP_055852.2. NM_015037.3. [A7E2V4-4]
XP_006717788.1. XM_006717725.3. [A7E2V4-5]
UniGeneiHs.65135.

Genome annotation databases

EnsembliENST00000398706; ENSP00000381693; ENSG00000214655. [A7E2V4-4]
ENST00000605216; ENSP00000474748; ENSG00000214655. [A7E2V4-1]
GeneIDi23053.
KEGGihsa:23053.
UCSCiuc001jve.4. human. [A7E2V4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020720 mRNA. Translation: BAA74936.2. Sequence problems.
AC022400 Genomic DNA. No translation available.
BC040726 mRNA. Translation: AAH40726.1.
BC063694 mRNA. Translation: AAH63694.1.
BC111006 mRNA. Translation: AAI11007.1.
BC117205 mRNA. Translation: AAI17206.1.
BC137249 mRNA. Translation: AAI37250.1. Sequence problems.
BC137250 mRNA. Translation: AAI37251.1. Sequence problems.
BC151206 mRNA. Translation: AAI51207.1.
AK023742 mRNA. Translation: BAB14664.1. Different initiation.
AK091621 mRNA. Translation: BAC03709.1. Sequence problems.
CCDSiCCDS44440.1. [A7E2V4-4]
CCDS60560.1. [A7E2V4-1]
RefSeqiNP_001229416.1. NM_001242487.1. [A7E2V4-1]
NP_001229417.1. NM_001242488.1. [A7E2V4-2]
NP_055852.2. NM_015037.3. [A7E2V4-4]
XP_006717788.1. XM_006717725.3. [A7E2V4-5]
UniGeneiHs.65135.

3D structure databases

ProteinModelPortaliA7E2V4.
SMRiA7E2V4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116690. 18 interactors.
IntActiA7E2V4. 12 interactors.
MINTiMINT-2870247.
STRINGi9606.ENSP00000381693.

PTM databases

iPTMnetiA7E2V4.
PhosphoSitePlusiA7E2V4.

Polymorphism and mutation databases

BioMutaiZSWIM8.

Proteomic databases

EPDiA7E2V4.
MaxQBiA7E2V4.
PaxDbiA7E2V4.
PRIDEiA7E2V4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398706; ENSP00000381693; ENSG00000214655. [A7E2V4-4]
ENST00000605216; ENSP00000474748; ENSG00000214655. [A7E2V4-1]
GeneIDi23053.
KEGGihsa:23053.
UCSCiuc001jve.4. human. [A7E2V4-1]

Organism-specific databases

CTDi23053.
GeneCardsiZSWIM8.
HGNCiHGNC:23528. ZSWIM8.
HPAiHPA041244.
neXtProtiNX_A7E2V4.
OpenTargetsiENSG00000214655.
PharmGKBiPA134885317.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3615. Eukaryota.
ENOG410XPG2. LUCA.
GeneTreeiENSGT00390000012572.
HOVERGENiHBG092246.
InParanoidiA7E2V4.
OMAiQQMYIQC.
OrthoDBiEOG091G00OR.
PhylomeDBiA7E2V4.
TreeFamiTF324881.

Enzyme and pathway databases

BioCyciZFISH:G66-31679-MONOMER.

Miscellaneous databases

GenomeRNAii23053.
PROiA7E2V4.

Gene expression databases

BgeeiENSG00000214655.
CleanExiHS_KIAA0913.
ExpressionAtlasiA7E2V4. baseline and differential.
GenevisibleiA7E2V4. HS.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZSWM8_HUMAN
AccessioniPrimary (citable) accession number: A7E2V4
Secondary accession number(s): B2RP37
, O94987, Q17RS8, Q2TAB8, Q6P439, Q8IW81, Q8NB34, Q9H8F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.