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Protein

Golgin subfamily A member 8A

Gene

GOLGA8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in maintaining Golgi structure.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 8A
Alternative name(s):
88 kDa Golgi matrix protein
Short name:
GM88
GM88 autoantigen
Gene namesi
Name:GOLGA8A
Synonyms:KIAA0855
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:31972. GOLGA8A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiGOLGA8A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Golgin subfamily A member 8APRO_0000190070Add
BLAST

Proteomic databases

PaxDbiA7E2F4.
PRIDEiA7E2F4.

PTM databases

iPTMnetiA7E2F4.
PhosphoSiteiA7E2F4.

Expressioni

Gene expression databases

BgeeiENSG00000175265.
CleanExiHS_GOLGA8A.
GenevisibleiA7E2F4. HS.

Organism-specific databases

HPAiHPA051808.

Interactioni

Protein-protein interaction databases

BioGridi116657. 2 interactions.
IntActiA7E2F4. 1 interaction.
STRINGi9606.ENSP00000352111.

Structurei

3D structure databases

ProteinModelPortaliA7E2F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni519 – 631113Golgi-targeting domainBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili110 – 468359Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the GOLGA8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4725. Eukaryota.
ENOG410ZIE4. LUCA.
GeneTreeiENSGT00530000062932.
HOVERGENiHBG051752.
InParanoidiA7E2F4.
OMAiHIGELEW.
OrthoDBiEOG091G0DDT.
PhylomeDBiA7E2F4.
TreeFamiTF316990.

Family and domain databases

InterProiIPR024858. Golgin_A.
[Graphical view]
PfamiPF15070. GOLGA2L5. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A7E2F4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPVDGEERK SEGSDTEGDR TSPCAVSSAT LKDLEVGGSG RRCSDPAGQP
60 70 80 90 100
SNLLPQRGLG APLPAETAHT QPSPNDRSLY LSPKSSSASS SLHARQSPCQ
110 120 130 140 150
EQAAVLNSRS IKISRLNDTI KSLKQQKKQV EHQLEEEKKA NNEKQKAERE
160 170 180 190 200
LEGQIQRLNT EKKKLNTDLY HMKHSLRYFE EESKDLAGRL QRSSQRIGEL
210 220 230 240 250
EWSLCAVAAT QKKKPDGFSS RSKALLKRQL EQSIREQILL KGHVTQLKES
260 270 280 290 300
LKEVQLERDQ YAEQIKGERA QWQQRMRKMS QEVCTLKEEK KHDTHRVEEL
310 320 330 340 350
ERSLSRLKNQ MAEPLPPDAP AVSSEVELQD LRKELERVAG ELQAQVENNQ
360 370 380 390 400
CISLLNRGQK ERLREQEERL QEQQERLRER EKRLQQLAEP QSDLEELKHE
410 420 430 440 450
NKSALQLEQQ VKELQEKLGQ VMETLTSAEK EPEAAVPASG TGGESSGLMD
460 470 480 490 500
LLEEKADLRE HVEKLELGFI QYRRERCHQK VHRLLTEPGD SAKDASPGGG
510 520 530 540 550
HHQAGPGQGG EEGEAAGAAG DGVAACGSYS EGHGKFLAAA RNPAAEPSPG
560 570 580 590 600
APAPQELGAA DKHGDLCEAS LTNSVEPAQG EAREGSSQDN PTAQPVVQLL
610 620 630
GEMQDHQEHP GLGSNCCVPC FCWAWLPRRR R
Length:631
Mass (Da):70,117
Last modified:March 8, 2011 - v3
Checksum:i521BE39BFFBC6842
GO
Isoform 2 (identifier: A7E2F4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: MLPVDGEERK...NDRSLYLSPK → MAEETGQSKL...ASGGCHSSEA

Show »
Length:603
Mass (Da):67,264
Checksum:iE31466F22DCAC0E4
GO

Sequence cautioni

The sequence AAI44610 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI50330 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI52411 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA74878 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH18214 differs from that shown.Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951R → P in AAH93673 (PubMed:15489334).Curated
Sequence conflicti380 – 3801R → Q in AAH93673 (PubMed:15489334).Curated
Sequence conflicti422 – 4221M → T in AAH93673 (PubMed:15489334).Curated
Sequence conflicti596 – 5961V → I in AAF28463 (Ref. 1) Curated
Sequence conflicti596 – 5961V → I in BAA74878 (PubMed:10048485).Curated
Sequence conflicti596 – 5961V → I in AAI44610 (PubMed:15489334).Curated
Sequence conflicti596 – 5961V → I in AAI50330 (PubMed:15489334).Curated
Sequence conflicti596 – 5961V → I in AAI52411 (PubMed:15489334).Curated
Sequence conflicti596 – 5961V → I in CAH18214 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti480 – 4801K → N.4 Publications
Corresponds to variant rs347880 [ dbSNP | Ensembl ].
VAR_064650
Natural varianti530 – 5301S → N.4 Publications
Corresponds to variant rs238639 [ dbSNP | Ensembl ].
VAR_064651
Natural varianti541 – 5411R → Q.4 Publications
Corresponds to variant rs347879 [ dbSNP | Ensembl ].
VAR_064652

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8484MLPVD…YLSPK → MAEETGQSKLAAAKKKFKEY WQRNRPGVPAAAKRNTKANG SSPETAASGGCHSSEA in isoform 2. 1 PublicationVSP_040753Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204231 mRNA. Translation: AAF28463.1.
AB020662 mRNA. Translation: BAA74878.1. Different initiation.
AC025678 Genomic DNA. No translation available.
BC093673 mRNA. Translation: AAH93673.1.
BC144609 mRNA. Translation: AAI44610.1. Different initiation.
BC150329 mRNA. Translation: AAI50330.1. Different initiation.
BC152410 mRNA. Translation: AAI52411.1. Different initiation.
CR749361 mRNA. Translation: CAH18214.1. Sequence problems.
CCDSiCCDS10038.1. [A7E2F4-3]
RefSeqiNP_851422.1. NM_181077.3. [A7E2F4-3]
UniGeneiHs.182982.
Hs.720151.

Genome annotation databases

EnsembliENST00000359187; ENSP00000352111; ENSG00000175265. [A7E2F4-3]
ENST00000432566; ENSP00000402791; ENSG00000175265. [A7E2F4-1]
GeneIDi23015.
KEGGihsa:23015.
UCSCiuc001zii.4. human. [A7E2F4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204231 mRNA. Translation: AAF28463.1.
AB020662 mRNA. Translation: BAA74878.1. Different initiation.
AC025678 Genomic DNA. No translation available.
BC093673 mRNA. Translation: AAH93673.1.
BC144609 mRNA. Translation: AAI44610.1. Different initiation.
BC150329 mRNA. Translation: AAI50330.1. Different initiation.
BC152410 mRNA. Translation: AAI52411.1. Different initiation.
CR749361 mRNA. Translation: CAH18214.1. Sequence problems.
CCDSiCCDS10038.1. [A7E2F4-3]
RefSeqiNP_851422.1. NM_181077.3. [A7E2F4-3]
UniGeneiHs.182982.
Hs.720151.

3D structure databases

ProteinModelPortaliA7E2F4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116657. 2 interactions.
IntActiA7E2F4. 1 interaction.
STRINGi9606.ENSP00000352111.

PTM databases

iPTMnetiA7E2F4.
PhosphoSiteiA7E2F4.

Polymorphism and mutation databases

BioMutaiGOLGA8A.

Proteomic databases

PaxDbiA7E2F4.
PRIDEiA7E2F4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359187; ENSP00000352111; ENSG00000175265. [A7E2F4-3]
ENST00000432566; ENSP00000402791; ENSG00000175265. [A7E2F4-1]
GeneIDi23015.
KEGGihsa:23015.
UCSCiuc001zii.4. human. [A7E2F4-1]

Organism-specific databases

CTDi23015.
GeneCardsiGOLGA8A.
H-InvDBHIX0012094.
HIX0012524.
HIX0172811.
HIX0172850.
HIX0172851.
HGNCiHGNC:31972. GOLGA8A.
HPAiHPA051808.
MIMi616180. gene.
neXtProtiNX_A7E2F4.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4725. Eukaryota.
ENOG410ZIE4. LUCA.
GeneTreeiENSGT00530000062932.
HOVERGENiHBG051752.
InParanoidiA7E2F4.
OMAiHIGELEW.
OrthoDBiEOG091G0DDT.
PhylomeDBiA7E2F4.
TreeFamiTF316990.

Miscellaneous databases

ChiTaRSiGOLGA8A. human.
GenomeRNAii23015.
PROiA7E2F4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175265.
CleanExiHS_GOLGA8A.
GenevisibleiA7E2F4. HS.

Family and domain databases

InterProiIPR024858. Golgin_A.
[Graphical view]
PfamiPF15070. GOLGA2L5. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGOG8A_HUMAN
AccessioniPrimary (citable) accession number: A7E2F4
Secondary accession number(s): A7MCY9
, B7ZMK5, O94937, Q52M46, Q68DK6, Q9NZG8, Q9NZW0, Q9NZW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 8, 2011
Last modified: September 7, 2016
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

A family of highly similar proteins (GOLGA8A, GOLGA8B, GOLGA8C, GOLGA8D, GOLGA8E, GOLGA8F, GOLGA8G) are encoded by a repeated region on chromosome 15q11-15q13. Our sequences are in agreement with HGNC nomenclature.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.