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Protein
Submitted name:

NRXN1 protein

Gene

NRXN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
NRXN1 proteinImported
Submitted name:
Neurexin-1-betaImported
Gene namesi
Name:NRXN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:8008. NRXN1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1422 – 144221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31786.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 14961471Sequence analysisPRO_5006715596Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiA7E294.

Expressioni

Gene expression databases

BgeeiA7E294.
ExpressionAtlasiA7E294. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000385142.

Structurei

3D structure databases

SMRiA7E294. Positions 279-460, 708-891, 896-1320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 217188LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini219 – 25638EGF-likeInterPro annotationAdd
BLAST
Domaini283 – 465183LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini472 – 664193LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini668 – 70538EGF-likeInterPro annotationAdd
BLAST
Domaini710 – 883174LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini897 – 1072176LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini1075 – 111238EGF-likeInterPro annotationAdd
BLAST
Domaini1118 – 1316199LAM_G_DOMAINInterPro annotationAdd
BLAST

Keywords - Domaini

EGF-like domainUniRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230481.
HOVERGENiHBG052670.
KOiK07377.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 3 hits.
PfamiPF00008. EGF. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 5 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7E294-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC
60 70 80 90 100
ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP
110 120 130 140 150
ATLLADTPVN DGAWHSVRIR RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF
160 170 180 190 200
SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQVLPVDSG
210 220 230 240 250
EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF
260 270 280 290 300
RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP
310 320 330 340 350
IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA
360 370 380 390 400
FEALVEPVNG KFNDNAWHDV KVTRNLRQVT ISVDGILTTT GYTQEDYTML
410 420 430 440 450
GSDDFFYVGG SPSTADLPGS PVSNNFMGCL KEVVYKNNDV RLELSRLAKQ
460 470 480 490 500
GDPKMKIHGV VAFKCENVAT LDPITFETPE SFISLPKWNA KKTGSISFDF
510 520 530 540 550
RTTEPNGLIL FSHGKPRHQK DAKHPQMIKV DFFAIEMLDG HLYLLLDMGS
560 570 580 590 600
GTIKIKALLK KVNDGEWYHV DFQRDGRSGT ISVNTLRTPY TAPGESEILD
610 620 630 640 650
LDDELYLGGL PENKAGLVFP TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ
660 670 680 690 700
MAEVQSTAGV KPSCSKETAK PCLSNPCKNN GMCRDGWNRY VCDCSGTGYL
710 720 730 740 750
GRSCEREATV LSYDGSMFMK IQLPVVMHTE AEDVSLRFRS QRAYGILMAT
760 770 780 790 800
TSRDSADTLR LELDAGRVKL TVNLDCIRIN CNSSKGPETL FAGYNLNDNE
810 820 830 840 850
WHTVRVVRRG KSLKLTVDDQ QAMTGQMAGD HTRLEFHNIE TGIITERRYL
860 870 880 890 900
SSVPSNFIGH LQSLTFNGMA YIDLCKNGDI DYCELNARFG FRNIIADPVT
910 920 930 940 950
FKTKSSYVAL ATLQAYTSMH LFFQFKTTSL DGLILYNSGD GNDFIVVELV
960 970 980 990 1000
KGYLHYVFDL GNGANLIKGS SNKPLNDNQW HNVMISRDTS NLHTVKIDTK
1010 1020 1030 1040 1050
ITTQITAGAR NLDLKSDLYI GGVAKETYKS LPKLVHAKEG FQGCLASVDL
1060 1070 1080 1090 1100
NGRLPDLISD ALFCNGQIER GCEGPSTTCQ EDSCSNQGVC LQQWDGFSCD
1110 1120 1130 1140 1150
CSMTSFSGPL CNDPGTTYIF SKGGGQITYK WPPNDRPSTR ADRLAIGFST
1160 1170 1180 1190 1200
VQKEAVLVRV DSSSGLGDYL ELHIHQGKIG VKFNVGTDDI AIEESNAIIN
1210 1220 1230 1240 1250
DGKYHVVRFT RSGGNATLQV DSWPVIERYP AGNNDNERLA IARQRIPYRL
1260 1270 1280 1290 1300
GRVVDEWLLD KGRQLTIFNS QATIIIGGKE QGQPFQGQLS GLYYNGLKVL
1310 1320 1330 1340 1350
NMAAENDANI AIVGNVRLVG EVPSSMTTES TATAMQSEMS TSIMETTTTL
1360 1370 1380 1390 1400
ATSTARRGKP PTKEPISQTT DDILVASAEC PSDDEDIDPC EPSSANPTRA
1410 1420 1430 1440 1450
GGREPYPGSA EVIRESSSTT GMVVGIVAAA ALCILILLYA MYKYRNRDEG
1460 1470 1480 1490
SYHVDESRNY ISNSAQSNGA VVKEKQPSSA KSSNKNKKNK DKEYYV
Length:1,496
Mass (Da):164,428
Last modified:September 11, 2007 - v1
Checksum:i8A9B5DA4D7783F9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007462 Genomic DNA. No translation available.
AC007560 Genomic DNA. No translation available.
AC007680 Genomic DNA. No translation available.
AC007682 Genomic DNA. No translation available.
AC009234 Genomic DNA. No translation available.
AC010721 Genomic DNA. No translation available.
AC068715 Genomic DNA. No translation available.
AC068725 Genomic DNA. No translation available.
AC069550 Genomic DNA. No translation available.
AC078994 Genomic DNA. No translation available.
BC150247 mRNA. Translation: AAI50248.1.
RefSeqiNP_001129131.1. NM_001135659.1.
NP_001307085.1. NM_001320156.1.
NP_001307086.1. NM_001320157.1.
NP_004792.1. NM_004801.4.
NP_620072.1. NM_138735.2.
XP_005264700.1. XM_005264643.2.
UniGeneiHs.637685.

Genome annotation databases

EnsembliENST00000625672; ENSP00000485887; ENSG00000179915.
GeneIDi9378.
KEGGihsa:9378.
UCSCiuc002rxb.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007462 Genomic DNA. No translation available.
AC007560 Genomic DNA. No translation available.
AC007680 Genomic DNA. No translation available.
AC007682 Genomic DNA. No translation available.
AC009234 Genomic DNA. No translation available.
AC010721 Genomic DNA. No translation available.
AC068715 Genomic DNA. No translation available.
AC068725 Genomic DNA. No translation available.
AC069550 Genomic DNA. No translation available.
AC078994 Genomic DNA. No translation available.
BC150247 mRNA. Translation: AAI50248.1.
RefSeqiNP_001129131.1. NM_001135659.1.
NP_001307085.1. NM_001320156.1.
NP_001307086.1. NM_001320157.1.
NP_004792.1. NM_004801.4.
NP_620072.1. NM_138735.2.
XP_005264700.1. XM_005264643.2.
UniGeneiHs.637685.

3D structure databases

SMRiA7E294. Positions 279-460, 708-891, 896-1320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000385142.

Proteomic databases

PRIDEiA7E294.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000625672; ENSP00000485887; ENSG00000179915.
GeneIDi9378.
KEGGihsa:9378.
UCSCiuc002rxb.5. human.

Organism-specific databases

CTDi9378.
HGNCiHGNC:8008. NRXN1.
PharmGKBiPA31786.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230481.
HOVERGENiHBG052670.
KOiK07377.

Miscellaneous databases

ChiTaRSiNRXN1. human.
GenomeRNAii9378.
NextBioi35134.

Gene expression databases

BgeeiA7E294.
ExpressionAtlasiA7E294. baseline and differential.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 3 hits.
PfamiPF00008. EGF. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 5 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Ensembl
    Submitted (APR-2015) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiA7E294_HUMAN
AccessioniPrimary (citable) accession number: A7E294
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.