A7E283 (A7E283_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA ligase RuleBase RU000617
EC=6.5.1.1 RuleBase RU000617

Gene names

Name:	lig4 ZFIN ZDB-GENE-070820-10
ORF Names:	zgc:165595 EMBL AAI50237.1 ZFIN ZDB-GENE-070820-10

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAI50237.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	909 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617
Sequence similarities	Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196

Ontologies

Keywords
Biological process	DNA damage DNA recombination RuleBase RU000617 DNA repair RuleBase RU000617 DNA replication RuleBase RU000617
Ligand	ATP-binding RuleBase RU000617 Nucleotide-binding
Molecular function	Ligase RuleBase RU000617
Gene Ontology (GO)
Biological process	DNA ligation involved in DNA repair Inferred from electronic annotation. Source: InterPro DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA ligase (ATP) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A7E283 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 561B62BD63C97BD0	FASTA	909	103,642
	10 20 30 40 50 60 MESVSKSDAK PQAFVAAQVP FIHLCTVLEK IQKTKLRPDK SKILKEFIDS WRNFHAALHK 70 80 90 100 110 120 DNPDTADSFY AAMRLIVPSF ERERMAYGIK ENMLAKLYIE VLGLPKNGDE ANKLLNYRAP 130 140 150 160 170 180 TTSQGEAGDF ALMAYFVLKK RCTSQGNLSI KEVNDFLGSV ATNNASKQKD QVKKSLLHLI 190 200 210 220 230 240 TQSSALEQKW LIRMILKDMK LGISKETVLQ VFHPDAPEFY NVTTDLNKVC RQLHDPSVSL 250 260 270 280 290 300 SEVSIDLFSA FKPMLAAVAN IRQIEKQMGN RPFYIETKLD GERIQLHKAG DVYKYYTRNS 310 320 330 340 350 360 YEYTQQFGAS PLEGSLTPYI HTVFSPHVVN CILDGEMMAY NPKTETFMQK GSKFDIKRLV 370 380 390 400 410 420 DDSDLQTCFC VFDVLLINNQ KFGKEPLKKR YESLETVFSP IKGRIHLVSK SEGRTMQEVV 430 440 450 460 470 480 NSLNEAIDNR EEGIMVKDPM SIYKPDKRGE GWLKIKPEYV DGLMDELDLL IVGGYWGKGR 490 500 510 520 530 540 RSGMLSHFLC AVAEVPSPGE KPTVFHTLCR IGSGYTLKEL YDLGVKLAKH WKVYNKNNPP 550 560 570 580 590 600 AAILCGTEKP EVYIEPRNSV ILQVKAAEIV TSEMYKTDCT LRFPRIERIR EDKEWHQCMT 610 620 630 640 650 660 LDDLNQFRSK ASGKLASRHL NIHEDQPEKK KRKIVAKPKK TIGVIDHFKS QDLSKVAKET 670 680 690 700 710 720 DMFEEVEFCV INGDDEHSKA ELEKGVARCG GIVVQNPGKD TYCAIAAVQN MRVKNLISSD 730 740 750 760 770 780 QHDVVWATWL LECLENKQVI PWQPRHMIHM SPSTREHFAK EYDQYGDSYY VDTSEQQLRD 790 800 810 820 830 840 VIERISSAEV KSLSVAQIEA ENAWDDLPTS IFRPYSAYFD RCADIGDPKS VICGTCLDTR 850 860 870 880 890 900 ALEFRFHGGK VVEKLKEGIS HVVVEDMKRA LDLKTLRRLH AKKFKIVHES WVTDSIKAGH VKDEIDYLI

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary EMBL AAI50237.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC150236 mRNA. Translation: AAI50237.1.
IPI	IPI00860741.
RefSeq	NP_001096593.1. NM_001103123.1.
UniGene	Dr.94394.
3D structure databases
ProteinModelPortal	A7E283.
ModBase	Search...
Protein-protein interaction databases
STRING	A7E283.
Proteomic databases
PRIDE	A7E283.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	569525.
KEGG	dre:569525.
Organism-specific databases
CTD	3981.
ZFIN	ZDB-GENE-070820-10. lig4.
Phylogenomic databases
eggNOG	fiNOG11212.
GeneTree	ENSGT00600000084443.
HOGENOM	HBG356988.
HOVERGEN	HBG005516.
OrthoDB	EOG4Q58NP.
Gene expression databases
Bgee	A7E283.
Family and domain databases
InterPro	IPR001357. BRCT. IPR000977. DNA_ligase_ATP-dep. IPR012309. DNA_ligase_ATP-dep_C. IPR012310. DNA_ligase_ATP-dep_cent. IPR016059. DNA_ligase_ATP-dep_CS. IPR012308. DNA_ligase_ATP-dep_N. IPR021536. DNA_ligase_IV. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. [Graphical view]
Gene3D	G3DSA:1.10.3260.10. DNA_ligase_ATP-dep_N. 1 hit. G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K10777.
Pfam	PF00533. BRCT. 1 hit. PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. PF11411. DNA_ligase_IV. 1 hit. [Graphical view]
SMART	SM00292. BRCT. 2 hits. [Graphical view]
SUPFAM	SSF52113. BRCT. 2 hits. SSF50249. Nucleic_acid_OB. 1 hit. SSF117018. SSF117018. 1 hit.
TIGRFAMs	TIGR00574. Dnl1. 1 hit.
PROSITE	PS50172. BRCT. 2 hits. PS00697. DNA_LIGASE_A1. 1 hit. PS00333. DNA_LIGASE_A2. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A7E283_DANRE

Accession

Primary (citable) accession number: A7E283

Entry history

Integrated into UniProtKB/TrEMBL:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	November 16, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)