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Protein

Anion exchange protein

Gene

Slc4a4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange proteinUniRule annotation
Gene namesi
Name:Slc4a4Imported
Synonyms:slc4a4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1927555. Slc4a4.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei460 – 483HelicalUniRule annotationAdd BLAST24
Transmembranei495 – 524HelicalUniRule annotationAdd BLAST30
Transmembranei544 – 562HelicalUniRule annotationAdd BLAST19
Transmembranei717 – 739HelicalUniRule annotationAdd BLAST23
Transmembranei768 – 788HelicalUniRule annotationAdd BLAST21
Transmembranei809 – 833HelicalUniRule annotationAdd BLAST25
Transmembranei869 – 888HelicalUniRule annotationAdd BLAST20
Transmembranei895 – 914HelicalUniRule annotationAdd BLAST20
Transmembranei946 – 977HelicalUniRule annotationAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000060961.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121744.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 378Band_3_cytoInterPro annotationAdd BLAST241
Domaini427 – 946HCO3_cotranspInterPro annotationAdd BLAST520

Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
HOVERGENiHBG004326.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequencei

Sequence statusi: Complete.

A7E1Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDEAVLDRG ASFLKHVCDE EEVEGHHTIY IGVHVPKSYR RRRRHKRKAG
60 70 80 90 100
HKEKKEKERI SENYSDKSDV ENADESSSSI LKPLISPAAE RIRFILGEED
110 120 130 140 150
DSPAPPQLFT ELDELLAVDG QEMEWKETAR WIKFEEKVEQ GGERWSKPHV
160 170 180 190 200
ATLSLHSLFE LRTCMEKGSI MLDREASSLP QLVEMIADHQ IETGLLKPDL
210 220 230 240 250
KDKVTYTLLR KHRHQTKKSN LRSLADIGKT VSSASSPAMT HRNLTSSSLN
260 270 280 290 300
DISDKPEKDQ LKNKFMKKLP RDAEASNVLV GEVDFLDTPF IAFVRLQQAV
310 320 330 340 350
MLGALTEVPV PTRFLFILLG PKGKAKSYHE IGRAIATLMS DEVFHDIAYK
360 370 380 390 400
AKDRHDLIAG IDEFLDEVIV LPPGEWDPTI RIEPPKSLPS SDKRKNMYSG
410 420 430 440 450
GENVQMNGDT PHDGGHGGGG HGDCEELQRT GRFCGGLIKD IKRKAPFFAS
460 470 480 490 500
DFYDALNIQA LSAILFIYLA TVTNAITFGG LLGDATDNMQ GVLESFLGTA
510 520 530 540 550
VSGAIFCLFA GQPLTILSST GPVLVFERLL FNFSKDHNFD YLEFRLWIGL
560 570 580 590 600
WSAFMCLVLV ATDASFLVQY FTRFTEEGFS SLISFIFIYD AFKKMIKLAD
610 620 630 640 650
YYPINSDFKV GYNTHFSCAC LPPDPVNLSV SNDTTLAPED LPTISSTDMY
660 670 680 690 700
HNVTFDWAYL SKKECVKYGG KLVGNNCDFV PDITLMSFIL FLGTYTSSMA
710 720 730 740 750
MKKFKTSRYF PTTARKLISD FAIILSILIF CVIDALVGVD TPKLIVPSEF
760 770 780 790 800
KPTSPNRGWF VPPFGGNPWW VCLAAAIPAL LVTILIFMDQ QITAVIVNRK
810 820 830 840 850
EHKLKKGAGY HLDLFWVAIL MVVCSFMALP WYVAATVISI AHIDSLKMET
860 870 880 890 900
ETSAPGEQPK FLGVREQRVT GTLVFILTGL SVFMAPILKF IPMPVLYGVF
910 920 930 940 950
LYMGVASLNG VQFMDRLKLL LMPLKHQPDF IYLRHVPLRR VHLFTFLQVL
960 970 980 990 1000
CLALLWILKS TVAAIIFPVM ILALVAVRKG MDYLFSQHDL SFLDDVIPEK
1010 1020 1030 1040 1050
DKKKKEDEKK KKKKKGSLDS DNDDSDCPYS EKVPSIKIPM DIMEQQPFLS
1060 1070
DNKPLDRERS STFLERHTSC
Length:1,070
Mass (Da):120,465
Last modified:January 15, 2008 - v1
Checksum:iA17124475438F69A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140492 Genomic DNA. No translation available.
AC162690 Genomic DNA. No translation available.
AC165240 Genomic DNA. No translation available.
BC148292 mRNA. Translation: AAI48293.2.
HQ204220 mRNA. Translation: ADN95183.1.
RefSeqiNP_001184076.1. NM_001197147.1.
UniGeneiMm.41044.

Genome annotation databases

EnsembliENSMUST00000113218; ENSMUSP00000108844; ENSMUSG00000060961.
GeneIDi54403.
UCSCiuc012dyc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140492 Genomic DNA. No translation available.
AC162690 Genomic DNA. No translation available.
AC165240 Genomic DNA. No translation available.
BC148292 mRNA. Translation: AAI48293.2.
HQ204220 mRNA. Translation: ADN95183.1.
RefSeqiNP_001184076.1. NM_001197147.1.
UniGeneiMm.41044.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121744.

Protocols and materials databases

DNASUi54403.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113218; ENSMUSP00000108844; ENSMUSG00000060961.
GeneIDi54403.
UCSCiuc012dyc.1. mouse.

Organism-specific databases

CTDi8671.
MGIiMGI:1927555. Slc4a4.

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
HOVERGENiHBG004326.

Miscellaneous databases

ChiTaRSiSlc4a4. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060961.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA7E1Z5_MOUSE
AccessioniPrimary (citable) accession number: A7E1Z5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 5, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.