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A7DZP8

- GPDM_MESAU

UniProt

A7DZP8 - GPDM_MESAU

Protein

Glycerol-3-phosphate dehydrogenase, mitochondrial

Gene

GPD2

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

    Cofactori

    FAD.By similarity

    Enzyme regulationi

    Calcium-binding enhance the activity of the enzyme.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi71 – 9929FADSequence AnalysisAdd
    BLAST
    Calcium bindingi672 – 68312PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: InterPro
    2. glycerol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Calcium, FAD, Flavoprotein, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00618; UER00674.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
    Short name:
    GPD-M
    Short name:
    GPDH-M
    Alternative name(s):
    mGPD
    Gene namesi
    Name:GPD2
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
    2. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4242MitochondrionBy similarityAdd
    BLAST
    Chaini43 – 727685Glycerol-3-phosphate dehydrogenase, mitochondrialPRO_0000355968Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei601 – 6011PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiA7DZP8.

    Structurei

    3D structure databases

    ProteinModelPortaliA7DZP8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini623 – 65836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini659 – 69436EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transit peptide

    Phylogenomic databases

    HOVERGENiHBG005897.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    [Graphical view]
    PfamiPF01266. DAO. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    PRINTSiPR01001. FADG3PDH.
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A7DZP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFQKAVKRT VLVCGGALAT VLGLSQCSHY RRKQVNLACL KAAGCHTEPV    50
    NREPPSREAQ LLTLQNTSEF DILVIGGGAT GSGCALDAVT RGLKTALVER 100
    DDFSSGTSSR STKLIHGGVR YLQKAIMKLD VEQYRMVKEA LHERANLLEI 150
    APHLSAPLPI MLPIYKWWQL PYYWVGIKLY DLVAGSNCLK SSYVLSKSRA 200
    LEHFPMLQKD KLVGAIVYYD GQHNDARMNL AIALTAARYG AATANYREVV 250
    SLLKKTDPET GKERVSGARC KDVLTGLEFD VRAKCVINAT GPFTDSVRKM 300
    DDNKAPAICQ PSAGVHIVMP GYYSPESMGL LDPATSDGRV IFFLPWENMT 350
    IAGTTDSPTK NTHHPIPSEE DINFILNEVR NYLSCDVEVR RGDVLAAWSG 400
    IRPLVIDPKS ADTQSISRNH VVDVSESGLI TIAGGKWTTY RSMAEDTVDT 450
    AIKVHNLKAG PCRTVGLFLQ GGKDWSPTLY IRLVQDYGLE SEVAQHLATT 500
    YGDKAFEVAK MAKVTGKRWP IVGVRLVSEF PYIEAEVKYG IKEYACTAVD 550
    MISRRTRLAF LNIQAAEEAL PRIVELMGRE LDWSEIRKQA ELETATKFLY 600
    YEMGSKSRSE QLTDRTEISL RPSDIERYTK RFHKFDADEK GFITIVDVQR 650
    VLENINVKID ENTLHEILSE VDLNKNGQVE LNEFLQLMSA IQKGRVSGSR 700
    LAILMKTAEE NLDRRVPIPV DRSCGGL 727
    Length:727
    Mass (Da):80,857
    Last modified:September 11, 2007 - v1
    Checksum:i89C18A4C8D0205DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM774032 mRNA. Translation: CAO79918.1.
    RefSeqiNP_001268609.1. NM_001281680.1.

    Genome annotation databases

    GeneIDi101825992.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM774032 mRNA. Translation: CAO79918.1 .
    RefSeqi NP_001268609.1. NM_001281680.1.

    3D structure databases

    ProteinModelPortali A7DZP8.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A7DZP8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101825992.

    Organism-specific databases

    CTDi 2820.

    Phylogenomic databases

    HOVERGENi HBG005897.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00674 .

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    [Graphical view ]
    Pfami PF01266. DAO. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    PRINTSi PR01001. FADG3PDH.
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hamster sperm capacitation: role of FAD linked glycerol-3-phosphate dehydrogenase."
      Venkatesh K., Shivaji S.
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
      Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
      Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiGPDM_MESAU
    AccessioniPrimary (citable) accession number: A7DZP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3