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Protein

Malonate-semialdehyde dehydrogenase

Gene

iolA

Organism
Bacillus subtilis subsp. natto
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.UniRule annotation

Catalytic activityi

3-oxopropanoate + CoA + NAD+ = acetyl-CoA + CO2 + NADH.UniRule annotation
2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.UniRule annotation

Pathwayi: myo-inositol degradation into acetyl-CoA

This protein is involved in step 7 of the subpathway that synthesizes acetyl-CoA from myo-inositol.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 5-deoxy-glucuronate isomerase (iolB)
  5. no protein annotated in this organism
  6. no protein annotated in this organism
  7. Malonate-semialdehyde dehydrogenase (iolA)
This subpathway is part of the pathway myo-inositol degradation into acetyl-CoA, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from myo-inositol, the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei284NucleophileUniRule annotation1
Binding sitei382NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi176 – 180NADUniRule annotation5

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00076; UER00148.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.-UniRule annotation)
Short name:
MSA dehydrogenaseUniRule annotation
Alternative name(s):
Methylmalonate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.27UniRule annotation)
Short name:
MMSA dehydrogenaseUniRule annotation
Short name:
MSDHUniRule annotation
Gene namesi
Name:iolAUniRule annotation
OrganismiBacillus subtilis subsp. natto
Taxonomic identifieri86029 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003523321 – 487Malonate-semialdehyde dehydrogenaseAdd BLAST487

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA7BJC4.
SMRiA7BJC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family. IolA subfamily.UniRule annotation

Family and domain databases

CDDicd07085. ALDH_F6_MMSDH. 1 hit.
Gene3Di3.40.605.10. 1 hit.
HAMAPiMF_01670. IolA. 1 hit.
InterProiView protein in InterPro
IPR016161. Ald_DH/histidinol_DH.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
IPR034322. MeMal-semiAld_DH_cyt.
IPR023510. MeMal-semiAld_DH_GmP_bac.
PANTHERiPTHR43866. PTHR43866. 1 hit.
PTHR43866:SF1. PTHR43866:SF1. 1 hit.
PfamiView protein in Pfam
PF00171. Aldedh. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiView protein in PROSITE
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.

Sequencei

Sequence statusi: Complete.

A7BJC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIRKLKNY INGEWVESKT DQYEDVVNPA TKEVLCQVPI STKEDIDYAA
60 70 80 90 100
QTAAEAFETW SKVAVPRRAR ILFNFQQLLS QHKEELAHLI TIENGKNTKE
110 120 130 140 150
ALGEVGRGIE NVEFAAGAPS LMMGDSLASI ATDVEAANYR YPIGVVGGIA
160 170 180 190 200
PFNFPMMVPC WMFPMAIALG NTFILKPSER TPLLTEKLVE LFEKAGLPKG
210 220 230 240 250
VFNVVYGAHD VVNGILEHPE IKAISFVGSK PVGEYVYKKG SEHLKRVQSL
260 270 280 290 300
TGAKNHTIVL NDANLEDTVT NIVGAAFGSA GERCMACAVV TVEEGIADEF
310 320 330 340 350
MAKLQEKVAD IKIGNGLDDG VFLGPVIRED NKKRTLSYIE KGLEEGARLV
360 370 380 390 400
CDGRENVSDD GYFVGPTIFD NVTTEMTIWK DEIFAPVLSV IRVKNLKEAI
410 420 430 440 450
EIANKSEFAN GACLFTSNSN AIRYFRENID AGMLGINLGV PAPMAFFPFS
460 470 480
GWKSSFFGTL HANGKDSVDF YTRKKVVTAR FPAPDFN
Length:487
Mass (Da):53,461
Last modified:October 14, 2008 - v2
Checksum:iABB479387DF2B49C
GO

Sequence cautioni

The sequence BAF74776 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB304464 Genomic DNA. Translation: BAF74776.1. Different initiation.
RefSeqiWP_014481419.1. NZ_CP014471.1.

Similar proteinsi

Entry informationi

Entry nameiIOLA_BACNA
AccessioniPrimary (citable) accession number: A7BJC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 14, 2008
Last modified: August 30, 2017
This is version 44 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families