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A7BJC4

- IOLA_BACNA

UniProt

A7BJC4 - IOLA_BACNA

Protein

Methylmalonate semialdehyde dehydrogenase [acylating]

Gene

iolA

Organism
Bacillus subtilis subsp. natto
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.UniRule annotation

    Catalytic activityi

    3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.UniRule annotation
    2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei284 – 2841NucleophileUniRule annotation
    Binding sitei382 – 3821NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi176 – 1805NADUniRule annotation

    GO - Molecular functioni

    1. malonate-semialdehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. methylmalonate-semialdehyde dehydrogenase (acylating) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. inositol catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00076; UER00148.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylmalonate semialdehyde dehydrogenase [acylating]UniRule annotation (EC:1.2.1.27UniRule annotation)
    Short name:
    MMSA dehydrogenaseUniRule annotation
    Short name:
    MMSDHUniRule annotation
    Short name:
    MSDHUniRule annotation
    Alternative name(s):
    Malonate semialdehyde dehydrogenase [acetylating]UniRule annotation (EC:1.2.1.18UniRule annotation)
    Short name:
    MSA dehydrogenaseUniRule annotation
    Gene namesi
    Name:iolAUniRule annotation
    OrganismiBacillus subtilis subsp. natto
    Taxonomic identifieri86029 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 487487Methylmalonate semialdehyde dehydrogenase [acylating]PRO_0000352332Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliA7BJC4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family. IolA subfamily.UniRule annotation

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_01670. IolA.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR010061. MeMal-semiAld_DH.
    IPR023510. MeMal-semiAld_DH_GmP_bac.
    [Graphical view]
    PANTHERiPTHR11699:SF27. PTHR11699:SF27. 1 hit.
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01722. MMSDH. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7BJC4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEIRKLKNY INGEWVESKT DQYEDVVNPA TKEVLCQVPI STKEDIDYAA    50
    QTAAEAFETW SKVAVPRRAR ILFNFQQLLS QHKEELAHLI TIENGKNTKE 100
    ALGEVGRGIE NVEFAAGAPS LMMGDSLASI ATDVEAANYR YPIGVVGGIA 150
    PFNFPMMVPC WMFPMAIALG NTFILKPSER TPLLTEKLVE LFEKAGLPKG 200
    VFNVVYGAHD VVNGILEHPE IKAISFVGSK PVGEYVYKKG SEHLKRVQSL 250
    TGAKNHTIVL NDANLEDTVT NIVGAAFGSA GERCMACAVV TVEEGIADEF 300
    MAKLQEKVAD IKIGNGLDDG VFLGPVIRED NKKRTLSYIE KGLEEGARLV 350
    CDGRENVSDD GYFVGPTIFD NVTTEMTIWK DEIFAPVLSV IRVKNLKEAI 400
    EIANKSEFAN GACLFTSNSN AIRYFRENID AGMLGINLGV PAPMAFFPFS 450
    GWKSSFFGTL HANGKDSVDF YTRKKVVTAR FPAPDFN 487
    Length:487
    Mass (Da):53,461
    Last modified:October 14, 2008 - v2
    Checksum:iABB479387DF2B49C
    GO

    Sequence cautioni

    The sequence BAF74776.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB304464 Genomic DNA. Translation: BAF74776.1. Different initiation.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB304464 Genomic DNA. Translation: BAF74776.1 . Different initiation.

    3D structure databases

    ProteinModelPortali A7BJC4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00076 ; UER00148 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_01670. IolA.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR010061. MeMal-semiAld_DH.
    IPR023510. MeMal-semiAld_DH_GmP_bac.
    [Graphical view ]
    PANTHERi PTHR11699:SF27. PTHR11699:SF27. 1 hit.
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01722. MMSDH. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Determination and characterization of IS4Bsu1-insertion loci and identification of a new insertion sequence element of the IS256 family in a natto starter."
      Kimura K., Itoh Y.
      Biosci. Biotechnol. Biochem. 71:2458-2464(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Miyagino.

    Entry informationi

    Entry nameiIOLA_BACNA
    AccessioniPrimary (citable) accession number: A7BJC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 14, 2008
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3