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A7BJC4

- IOLA_BACNA

UniProt

A7BJC4 - IOLA_BACNA

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Protein
Methylmalonate semialdehyde dehydrogenase [acylating]
Gene
iolA
Organism
Bacillus subtilis subsp. natto
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively By similarity.UniRule annotation

Catalytic activityi

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.UniRule annotation
2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei284 – 2841Nucleophile By similarity
Binding sitei382 – 3821NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi176 – 1805NAD By similarity

GO - Molecular functioni

  1. malonate-semialdehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. methylmalonate-semialdehyde dehydrogenase (acylating) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. inositol catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00076; UER00148.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylmalonate semialdehyde dehydrogenase [acylating] (EC:1.2.1.27)
Short name:
MMSA dehydrogenase
Short name:
MMSDH
Short name:
MSDH
Alternative name(s):
Malonate semialdehyde dehydrogenase [acetylating] (EC:1.2.1.18)
Short name:
MSA dehydrogenase
Gene namesi
Name:iolA
OrganismiBacillus subtilis subsp. natto
Taxonomic identifieri86029 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487Methylmalonate semialdehyde dehydrogenase [acylating]UniRule annotation
PRO_0000352332Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA7BJC4.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_01670. IolA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
IPR023510. MeMal-semiAld_DH_GmP_bac.
[Graphical view]
PANTHERiPTHR11699:SF27. PTHR11699:SF27. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7BJC4-1 [UniParc]FASTAAdd to Basket

« Hide

MAEIRKLKNY INGEWVESKT DQYEDVVNPA TKEVLCQVPI STKEDIDYAA    50
QTAAEAFETW SKVAVPRRAR ILFNFQQLLS QHKEELAHLI TIENGKNTKE 100
ALGEVGRGIE NVEFAAGAPS LMMGDSLASI ATDVEAANYR YPIGVVGGIA 150
PFNFPMMVPC WMFPMAIALG NTFILKPSER TPLLTEKLVE LFEKAGLPKG 200
VFNVVYGAHD VVNGILEHPE IKAISFVGSK PVGEYVYKKG SEHLKRVQSL 250
TGAKNHTIVL NDANLEDTVT NIVGAAFGSA GERCMACAVV TVEEGIADEF 300
MAKLQEKVAD IKIGNGLDDG VFLGPVIRED NKKRTLSYIE KGLEEGARLV 350
CDGRENVSDD GYFVGPTIFD NVTTEMTIWK DEIFAPVLSV IRVKNLKEAI 400
EIANKSEFAN GACLFTSNSN AIRYFRENID AGMLGINLGV PAPMAFFPFS 450
GWKSSFFGTL HANGKDSVDF YTRKKVVTAR FPAPDFN 487
Length:487
Mass (Da):53,461
Last modified:October 14, 2008 - v2
Checksum:iABB479387DF2B49C
GO

Sequence cautioni

The sequence BAF74776.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB304464 Genomic DNA. Translation: BAF74776.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB304464 Genomic DNA. Translation: BAF74776.1 . Different initiation.

3D structure databases

ProteinModelPortali A7BJC4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00076 ; UER00148 .

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_01670. IolA.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
IPR023510. MeMal-semiAld_DH_GmP_bac.
[Graphical view ]
PANTHERi PTHR11699:SF27. PTHR11699:SF27. 1 hit.
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01722. MMSDH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Determination and characterization of IS4Bsu1-insertion loci and identification of a new insertion sequence element of the IS256 family in a natto starter."
    Kimura K., Itoh Y.
    Biosci. Biotechnol. Biochem. 71:2458-2464(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Miyagino.

Entry informationi

Entry nameiIOLA_BACNA
AccessioniPrimary (citable) accession number: A7BJC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 14, 2008
Last modified: June 11, 2014
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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