ID A7AQS0_BABBO Unreviewed; 281 AA. AC A7AQS0; DT 11-SEP-2007, integrated into UniProtKB/TrEMBL. DT 11-SEP-2007, sequence version 1. DT 24-JAN-2024, entry version 90. DE RecName: Full=Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial {ECO:0000256|RuleBase:RU361237}; DE EC=1.3.5.1 {ECO:0000256|RuleBase:RU361237}; GN ORFNames=BBOV_IV005280 {ECO:0000313|EMBL:BAN64773.1, GN ECO:0000313|EMBL:EDO06889.1}; OS Babesia bovis. OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida; OC Babesiidae; Babesia. OX NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO06889.1, ECO:0000313|Proteomes:UP000002173}; RN [1] {ECO:0000313|EMBL:EDO06889.1, ECO:0000313|Proteomes:UP000002173} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO06889.1}; RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148; RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S., RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D., RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H., RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr., RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F., RA Nene V.M.; RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan RT hemoprotozoa."; RL PLoS Pathog. 3:1401-1413(2007). RN [2] {ECO:0000313|EMBL:EDO06889.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO06889.1}; RA Nene V.; RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:BAN64773.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Texas {ECO:0000313|EMBL:BAN64773.1}; RX PubMed=25124460; DOI=10.1186/1471-2164-15-678; RA Yamagishi J., Wakaguri H., Yokoyama N., Yamashita R., Suzuki Y., Xuan X., RA Igarashi I.; RT "The Babesia bovis gene and promoter model: an update from full-length EST RT analysis."; RL BMC Genomics 15:678-678(2014). RN [4] {ECO:0000313|Proteomes:UP000002173} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=33294524; DOI=10.1016/j.dib.2020.106533; RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R., RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.; RT "Transcriptome dataset of Babesia bovis life stages within vertebrate and RT invertebrate hosts."; RL Data Brief 33:106533-106533(2020). RN [5] {ECO:0000313|Proteomes:UP000002173} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=33069745; RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R., RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.; RT "Comparative analysis of gene expression between Babesia bovis blood stages RT and kinetes allowed by improved genome annotation."; RL Int. J. Parasitol. 51:123-136(2021). CC -!- FUNCTION: Iron-sulfur protein (IP) subunit of succinate dehydrogenase CC (SDH) that is involved in complex II of the mitochondrial electron CC transport chain and is responsible for transferring electrons from CC succinate to ubiquinone (coenzyme Q). {ECO:0000256|RuleBase:RU361237}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a quinone + succinate = a quinol + fumarate; CC Xref=Rhea:RHEA:40523, ChEBI:CHEBI:24646, ChEBI:CHEBI:29806, CC ChEBI:CHEBI:30031, ChEBI:CHEBI:132124; CC Evidence={ECO:0000256|RuleBase:RU361237}; CC -!- COFACTOR: CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; CC Evidence={ECO:0000256|RuleBase:RU361237}; CC Note=Binds 1 [2Fe-2S] cluster. {ECO:0000256|RuleBase:RU361237}; CC -!- COFACTOR: CC Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137; CC Evidence={ECO:0000256|RuleBase:RU361237}; CC Note=Binds 1 [3Fe-4S] cluster. {ECO:0000256|RuleBase:RU361237}; CC -!- COFACTOR: CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; CC Evidence={ECO:0000256|RuleBase:RU361237}; CC Note=Binds 1 [4Fe-4S] cluster. {ECO:0000256|RuleBase:RU361237}; CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; fumarate CC from succinate (eukaryal route): step 1/1. CC {ECO:0000256|ARBA:ARBA00004788, ECO:0000256|RuleBase:RU361237}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|ARBA:ARBA00004443, ECO:0000256|RuleBase:RU361237}; CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004443, CC ECO:0000256|RuleBase:RU361237}; Matrix side CC {ECO:0000256|ARBA:ARBA00004443, ECO:0000256|RuleBase:RU361237}. CC -!- SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase CC iron-sulfur protein family. {ECO:0000256|ARBA:ARBA00009433, CC ECO:0000256|RuleBase:RU361237}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK440979; BAN64773.1; -; mRNA. DR EMBL; AAXT01000002; EDO06889.1; -; Genomic_DNA. DR RefSeq; XP_001610457.1; XM_001610407.1. DR STRING; 5865.A7AQS0; -. DR EnsemblProtists; EDO06889; EDO06889; BBOV_IV005280. DR GeneID; 5478691; -. DR KEGG; bbo:BBOV_IV005280; -. DR VEuPathDB; PiroplasmaDB:BBOV_IV005280; -. DR eggNOG; KOG3049; Eukaryota. DR UniPathway; UPA00223; UER01006. DR Proteomes; UP000002173; Unassembled WGS sequence. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. DR GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro. DR GO; GO:0102040; F:fumarate reductase (menaquinone); IEA:UniProtKB-EC. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. DR Gene3D; 3.10.20.30; -; 1. DR Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1. DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf. DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type. DR InterPro; IPR006058; 2Fe2S_fd_BS. DR InterPro; IPR017896; 4Fe4S_Fe-S-bd. DR InterPro; IPR017900; 4Fe4S_Fe_S_CS. DR InterPro; IPR012675; Beta-grasp_dom_sf. DR InterPro; IPR009051; Helical_ferredxn. DR InterPro; IPR004489; Succ_DH/fum_Rdtase_Fe-S. DR InterPro; IPR025192; Succ_DH/fum_Rdtase_N. DR NCBIfam; TIGR00384; dhsB; 1. DR PANTHER; PTHR11921:SF29; SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL; 1. DR PANTHER; PTHR11921; SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN; 1. DR Pfam; PF13085; Fer2_3; 1. DR Pfam; PF13534; Fer4_17; 1. DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1. DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1. DR PROSITE; PS00197; 2FE2S_FER_1; 1. DR PROSITE; PS51085; 2FE2S_FER_2; 1. DR PROSITE; PS00198; 4FE4S_FER_1; 1. DR PROSITE; PS51379; 4FE4S_FER_2; 1. PE 2: Evidence at transcript level; KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714, ECO:0000256|RuleBase:RU361237}; KW 3Fe-4S {ECO:0000256|ARBA:ARBA00023291, ECO:0000256|RuleBase:RU361237}; KW 4Fe-4S {ECO:0000256|RuleBase:RU361237}; KW Iron {ECO:0000256|RuleBase:RU361237}; KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU361237}; KW Membrane {ECO:0000256|RuleBase:RU361237}; KW Metal-binding {ECO:0000256|RuleBase:RU361237}; KW Mitochondrion {ECO:0000256|RuleBase:RU361237}; KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU361237}; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, KW ECO:0000313|EMBL:EDO06889.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000002173}; KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}. FT DOMAIN 19..113 FT /note="2Fe-2S ferredoxin-type" FT /evidence="ECO:0000259|PROSITE:PS51085" FT DOMAIN 157..187 FT /note="4Fe-4S ferredoxin-type" FT /evidence="ECO:0000259|PROSITE:PS51379" SQ SEQUENCE 281 AA; 31625 MW; 94FE46F7DE0A1AE3 CRC64; MSVCNYGLIR RCARRLSANG VTFSVFRYSP ESGKRPRMQS YKVDTAACGP MILDALIKIK NEQDSTLSFR RSCREGICGS CAMNVNGENC LACLRSIESC TNQGNSVEIQ PLPGMYVLRD LVADMTNFYE QYRTVQPWLK RKTPKSGEAE FLQSREDRAL LDGMYECILC ACCTTSCPSY WWNPEHYIGP AALMQAYRWI EDSRDEYTVE RMVDVNDSMK LYRCHGILNC TRACPKGLDP AKAISKLKAK VEASADDTWR SIAASEYAKN NQTPLGGGDK Q //