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A7AP03

- A7AP03_BABBO

UniProt

A7AP03 - A7AP03_BABBO

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Protein

Isocitrate dehydrogenase [NADP]

Gene

BBOV_III007260

Organism
Babesia bovis
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201SubstrateUniRule annotation
Binding sitei125 – 1251NADP
Binding sitei152 – 1521SubstrateUniRule annotation
Binding sitei175 – 1751SubstrateUniRule annotation
Sitei182 – 1821Critical for catalysisUniRule annotation
Sitei254 – 2541Critical for catalysisUniRule annotation
Metal bindingi294 – 2941Magnesium or manganeseUniRule annotation
Binding sitei302 – 3021NADP
Metal bindingi317 – 3171Magnesium or manganeseUniRule annotation
Binding sitei370 – 3701NADP; via amide nitrogen and carbonyl oxygen

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi118 – 1203NADP
Nucleotide bindingi352 – 3576NADP

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:BBOV_III007260Imported
OrganismiBabesia bovisImported
Taxonomic identifieri5865 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaBabesiidaeBabesia
ProteomesiUP000002173: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiPiroplasmaDB:BBOV_III007260.

Structurei

3D structure databases

ProteinModelPortaliA7AP03.
SMRiA7AP03. Positions 53-445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 1437Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

InParanoidiA7AP03.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7AP03-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQRPFLALSY LCSFVRRSGS TDQAFRRLST SAGFRVDRDN SSTMAKIQVK
60 70 80 90 100
NPIVELDGDE MTRVMWSSVK EKLILPYVDI PLLYYDLSLP NRDATDDKVT
110 120 130 140 150
FEAAEAIKQV GIGVKCATIT PDEARLKEFG LKRMYRSPNG TIRNILDGTV
160 170 180 190 200
FRSPILTKTV PAYIPGWKKP IIIGRHAFGD QYNATDIKIP GAGTLELVFT
210 220 230 240 250
PADGGPTQAY KVTDFKGPGV ALSMFNVDQS IRGFARACFT YALDVKMPLY
260 270 280 290 300
MSTKNTILKS YDGRFKDIFQ QMYDDEFRPL FEAAGIFYEH RLIDDMVAYA
310 320 330 340 350
CKSEGGFVWA CKNYDGDVQS DIVSQAYGSL ALMSSVLYSS DGKSFLAEAA
360 370 380 390 400
HGTVTRHFRV HQKGGSTSTN SIATIVAWAR ALEKRGLADG NDALVEFGRK
410 420 430 440
LERAPVEAVD AGYYTKDLAI AIHGPQATDY LDTESFMDKV KEFLEK
Length:446
Mass (Da):49,602
Last modified:September 11, 2007 - v1
Checksum:i263686E2A04B9C0F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAXT01000001 Genomic DNA. Translation: EDO08287.1.
RefSeqiXP_001611855.1. XM_001611805.1.

Genome annotation databases

GeneIDi5480106.
KEGGibbo:BBOV_III007260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAXT01000001 Genomic DNA. Translation: EDO08287.1 .
RefSeqi XP_001611855.1. XM_001611805.1.

3D structure databases

ProteinModelPortali A7AP03.
SMRi A7AP03. Positions 53-445.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5480106.
KEGGi bbo:BBOV_III007260.

Organism-specific databases

EuPathDBi PiroplasmaDB:BBOV_III007260.

Phylogenomic databases

InParanoidi A7AP03.
KOi K00031.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T2BoImported.

Entry informationi

Entry nameiA7AP03_BABBO
AccessioniPrimary (citable) accession number: A7AP03
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3