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A7AP03 (A7AP03_BABBO) Unreviewed, UniProtKB/TrEMBL

Last modified October 16, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
ORF Names:BBOV_III007260 EMBL EDO08287.1
OrganismBabesia bovis [Reference proteome]
Taxonomic identifier5865 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaBabesiidaeBabesia

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding118 – 1203NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding352 – 3576NADP By similarity PIRSR PIRSR000108-4
Region137 – 1437Substrate binding By similarity

Sites

Metal binding2941Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding3171Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site1201Substrate By similarity
Binding site1251NADP By similarity PIRSR PIRSR000108-4
Binding site1521Substrate By similarity
Binding site1751Substrate By similarity
Binding site3021NADP By similarity PIRSR PIRSR000108-4
Binding site3701NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1821Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2541Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
A7AP03 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 263686E2A04B9C0F

FASTA44649,602
        10         20         30         40         50         60 
MQRPFLALSY LCSFVRRSGS TDQAFRRLST SAGFRVDRDN SSTMAKIQVK NPIVELDGDE 

        70         80         90        100        110        120 
MTRVMWSSVK EKLILPYVDI PLLYYDLSLP NRDATDDKVT FEAAEAIKQV GIGVKCATIT 

       130        140        150        160        170        180 
PDEARLKEFG LKRMYRSPNG TIRNILDGTV FRSPILTKTV PAYIPGWKKP IIIGRHAFGD 

       190        200        210        220        230        240 
QYNATDIKIP GAGTLELVFT PADGGPTQAY KVTDFKGPGV ALSMFNVDQS IRGFARACFT 

       250        260        270        280        290        300 
YALDVKMPLY MSTKNTILKS YDGRFKDIFQ QMYDDEFRPL FEAAGIFYEH RLIDDMVAYA 

       310        320        330        340        350        360 
CKSEGGFVWA CKNYDGDVQS DIVSQAYGSL ALMSSVLYSS DGKSFLAEAA HGTVTRHFRV 

       370        380        390        400        410        420 
HQKGGSTSTN SIATIVAWAR ALEKRGLADG NDALVEFGRK LERAPVEAVD AGYYTKDLAI 

       430        440 
AIHGPQATDY LDTESFMDKV KEFLEK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAXT01000001 Genomic DNA. Translation: EDO08287.1.
RefSeqXP_001611855.1. XM_001611805.1.

3D structure databases

ProteinModelPortalA7AP03.
SMRA7AP03. Positions 53-445.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5480106.
KEGGbbo:BBOV_III007260.

Organism-specific databases

EuPathDBPiroplasmaDB:BBOV_III007260.

Phylogenomic databases

KOK00031.
ProtClustDBPTZ00435.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7AP03_BABBO
AccessionPrimary (citable) accession number: A7AP03
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: October 16, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)