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A7AP03

- A7AP03_BABBO

UniProt

A7AP03 - A7AP03_BABBO

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Protein

Isocitrate dehydrogenase [NADP]

Gene
BBOV_III007260
Organism
Babesia bovis
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201Substrate By similarityUniRule annotation
Binding sitei125 – 1251NADP By similarityUniRule annotation
Binding sitei152 – 1521Substrate By similarityUniRule annotation
Binding sitei175 – 1751Substrate By similarityUniRule annotation
Sitei182 – 1821Critical for catalysis By similarityUniRule annotation
Sitei254 – 2541Critical for catalysis By similarityUniRule annotation
Metal bindingi294 – 2941Magnesium or manganese By similarityUniRule annotation
Binding sitei302 – 3021NADP By similarityUniRule annotation
Metal bindingi317 – 3171Magnesium or manganese By similarityUniRule annotation
Binding sitei370 – 3701NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi118 – 1203NADP By similarityUniRule annotation
Nucleotide bindingi352 – 3576NADP By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:BBOV_III007260Imported
OrganismiBabesia bovis
Taxonomic identifieri5865 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaBabesiidaeBabesia
ProteomesiUP000002173: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiPiroplasmaDB:BBOV_III007260.

Structurei

3D structure databases

ProteinModelPortaliA7AP03.
SMRiA7AP03. Positions 53-445.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 1437Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7AP03-1 [UniParc]FASTAAdd to Basket

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MQRPFLALSY LCSFVRRSGS TDQAFRRLST SAGFRVDRDN SSTMAKIQVK    50
NPIVELDGDE MTRVMWSSVK EKLILPYVDI PLLYYDLSLP NRDATDDKVT 100
FEAAEAIKQV GIGVKCATIT PDEARLKEFG LKRMYRSPNG TIRNILDGTV 150
FRSPILTKTV PAYIPGWKKP IIIGRHAFGD QYNATDIKIP GAGTLELVFT 200
PADGGPTQAY KVTDFKGPGV ALSMFNVDQS IRGFARACFT YALDVKMPLY 250
MSTKNTILKS YDGRFKDIFQ QMYDDEFRPL FEAAGIFYEH RLIDDMVAYA 300
CKSEGGFVWA CKNYDGDVQS DIVSQAYGSL ALMSSVLYSS DGKSFLAEAA 350
HGTVTRHFRV HQKGGSTSTN SIATIVAWAR ALEKRGLADG NDALVEFGRK 400
LERAPVEAVD AGYYTKDLAI AIHGPQATDY LDTESFMDKV KEFLEK 446
Length:446
Mass (Da):49,602
Last modified:September 11, 2007 - v1
Checksum:i263686E2A04B9C0F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAXT01000001 Genomic DNA. Translation: EDO08287.1.
RefSeqiXP_001611855.1. XM_001611805.1.

Genome annotation databases

GeneIDi5480106.
KEGGibbo:BBOV_III007260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAXT01000001 Genomic DNA. Translation: EDO08287.1 .
RefSeqi XP_001611855.1. XM_001611805.1.

3D structure databases

ProteinModelPortali A7AP03.
SMRi A7AP03. Positions 53-445.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5480106.
KEGGi bbo:BBOV_III007260.

Organism-specific databases

EuPathDBi PiroplasmaDB:BBOV_III007260.

Phylogenomic databases

KOi K00031.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T2BoImported.

Entry informationi

Entry nameiA7AP03_BABBO
AccessioniPrimary (citable) accession number: A7AP03
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: July 9, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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