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Protein

LAS seventeen-binding protein 3

Gene

LSB3

Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
LAS seventeen-binding protein 3
Short name:
LAS17-binding protein 3
Gene namesi
Name:LSB3
ORF Names:SCY_1771
OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Taxonomic identifieri307796 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000007060 Componenti: Unassembled WGS sequence

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459LAS seventeen-binding protein 3PRO_0000345086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei227 – 2271PhosphoserineBy similarity
Modified residuei298 – 2981PhosphothreonineBy similarity
Modified residuei300 – 3001PhosphoserineBy similarity
Modified residuei303 – 3031PhosphoserineBy similarity
Modified residuei393 – 3931PhosphothreonineBy similarity
Modified residuei397 – 3971PhosphoserineBy similarity
Modified residuei402 – 4021PhosphoserineBy similarity
Modified residuei416 – 4161PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation of Ser-397 is induced 2-fold in response to mating pheromone.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with LAS17.By similarity

Structurei

3D structure databases

ProteinModelPortaliA7A261.
SMRiA7A261. Positions 368-459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini400 – 45960SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi229 – 28456Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the SH3YL1 family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

OrthoDBiEOG7X9GH6.

Family and domain databases

InterProiIPR001452. SH3_domain.
IPR007461. Ysc84_actin-binding.
[Graphical view]
PfamiPF04366. DUF500. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7A261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGINNPIPRS LKSETKKAAK ILASFVKPNQ VFGADQVIPP DVLKRAKGLA
60 70 80 90 100
IITILKAGFL FSGRAGSGVI VARLKDGTWS APSAIAMAGA GAGGMVGIEL
110 120 130 140 150
TDFVFILNTQ DAVKSFSEFG TITLGGNVSV SAGPLGRSAE AAASASAGGV
160 170 180 190 200
AAVFAYSKSK GLFAGVSVEG SAIIERREAN RKFYGDNCTA KMILSGRIRP
210 220 230 240 250
PPAVDPLFRV LESRAFNYRP SNGGRGSFDD DEDDYYDDDD YYNDIPSSFS
260 270 280 290 300
STDASSTRPN TRSTRRRAQS GSRYTFDDDD DDDDYGTGYS RNSRLAPTNS
310 320 330 340 350
GGSGGKLDDP SGASSYYASH RRSGTAQSRA RSSRNRWADD EYDDYDDDYE
360 370 380 390 400
SGYRRGNGRD RTKDREVDDL SNRFSKSRIS SASTPQTSQG RFTAPTSPST
410 420 430 440 450
SSPKAVALYS FAGEESGDLP FRKGDVITIL KKSDSQNDWW TGRVNGREGI

FPANYVELV
Length:459
Mass (Da):49,344
Last modified:July 22, 2008 - v2
Checksum:iF486C787B5771AAC
GO

Sequence cautioni

The sequence EDN59172.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFW02000176 Genomic DNA. Translation: EDN59172.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFW02000176 Genomic DNA. Translation: EDN59172.1. Sequence problems.

3D structure databases

ProteinModelPortaliA7A261.
SMRiA7A261. Positions 368-459.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiEOG7X9GH6.

Family and domain databases

InterProiIPR001452. SH3_domain.
IPR007461. Ysc84_actin-binding.
[Graphical view]
PfamiPF04366. DUF500. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJM789.

Entry informationi

Entry nameiLSB3_YEAS7
AccessioniPrimary (citable) accession number: A7A261
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: March 4, 2015
This is version 30 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.