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A7A0P0

- SDC25_YEAS7

UniProt

A7A0P0 - SDC25_YEAS7

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Protein
Guanine nucleotide exchange factor SDC25
Gene
SDC25, SCD25, SCY_3564
Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Promotes the exchange of Ras-bound GDP by GTP By similarity.

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. regulation of small GTPase mediated signal transduction Source: InterPro
  4. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor SDC25
Gene namesi
Name:SDC25
Synonyms:SCD25
ORF Names:SCY_3564
OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Taxonomic identifieri307796 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000007060: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12521252Guanine nucleotide exchange factor SDC25
PRO_0000393439Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA7A0P0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 9772SH3
Add
BLAST
Domaini782 – 914133N-terminal Ras-GEF
Add
BLAST
Domaini952 – 1199248Ras-GEF
Add
BLAST

Sequence similaritiesi

Contains 1 Ras-GEF domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

OrthoDBiEOG78WM2F.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7A0P0-1 [UniParc]FASTAAdd to Basket

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MSCTASYAGM TTPVKDKEGH GIPCLQPIDV VECTYQYFTK SRNKLSLRVG     50
DLIYVLTKGS NGWWDGVLIR HSANNNNNSL ILDRGWFPPS FTRSILNELH 100
GVPDIGNELE IFQAGLNLKL ELSSNPVILS LEDFLDCCRD IEFKEQLAWS 150
PTPVHERKGC CELLYYNQDL DVYCRTLPYL PQNQVETVND YSSFPAISKI 200
AGKKMPITSS PDLFYLNDCD VVYWYDLTRL VCHYVNLTER DLLANEREKF 250
LTSLDLLTAQ ITCVYMLFRN LRLVEDSFKK TLKKLIYTLS RFSINANIWF 300
HSTPFEEREA IASQKDPERR SPLLQSILGT FQKFHFLLRL LHFLSNPNEL 350
TILPQLTPRF FKDSFNTISW NNPFLRKHLN QHMSHDLPRQ MIKAVAGASG 400
IVAENNDEIP ASKQGTSCSS ETSHHSPSAP FQRRRRGTIF SNVPGSSDES 450
DTIWSKRKKP YPLNEETLSL VRARKEQLDA KLKQMIKSAN EYLSNTANFS 500
KMLNFEMNFK TYEEVSGTIP IIDILENLDL TIYLNLRELG DENRVFDEDV 550
AIDDEDKEFL KHSLSSLSYI LSDYFNMKQY FHDVVVKFII VAQHLTLEDP 600
FVFSPMQNDL PTGYYEPMKP SSLNLDNAKD KKNGSQNTDI QEEEDEYEPD 650
PDSLILFHNL INQDSDFNDL KFFNLAHVFK KSCDDYFDVL KLSIEFVNRL 700
ILERENLLNY AARMMKNNIT ELLLRGEEGY GSYDGGETAE KSDTNAVYAD 750
SDTKDNDEWR DSQVKLPRYL QREYDSELIW GSNNRIKGGS KHALISYLTD 800
NEKKDLFFNI TFLITFRSIF TTTEFLSYLI SQYNLDPPED LCFEEYNEWV 850
TKKLIPVKCR VVEIMTTFFK QYWFPGYDEP DLATLNLDYF AQVAIKENIT 900
GSVELLKEVN QKFKHGNMQE ATAPMKTLDQ QICQEHYWGT LYSTTESILA 950
VDPVLFATQL TILEHEIYCE ITIFDCLQKI WKNKYTKSYG ASPGLNEFIS 1000
FANKLTNFIS YSIVKEADKS KRAKLLSHFI FIAEYCRKFN NFSSMTAIIS 1050
ALYSSSIYRL EKTWQAVIPQ TRDLLQSLDK LMDPKKNFIN YRSELKSLHS 1100
APCVPFFGVY LSDLTFTDSG NPDYLVLEHG LKGVHDEKKY INFNKRSRLV 1150
DILQEIIYFK KTHYDFTKDR TVIECISNSL ENIPHIEKQY QLSLIIEPKP 1200
RKKVVPNSNS NNKSQEKSRD DQTDEGKTST KKDRFSKFQL HKTKKKAPKV 1250
SK 1252
Length:1,252
Mass (Da):145,070
Last modified:April 20, 2010 - v2
Checksum:i076BCCE7C1F1EBE8
GO

Sequence cautioni

The sequence EDN59531.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFW02000167 Genomic DNA. Translation: EDN59531.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFW02000167 Genomic DNA. Translation: EDN59531.1 . Different initiation.

3D structure databases

ProteinModelPortali A7A0P0.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG78WM2F.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
InterProi IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJM789.

Entry informationi

Entry nameiSDC25_YEAS7
AccessioniPrimary (citable) accession number: A7A0P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 11, 2014
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Suppresses the CDC25-5 mutation in yeast (restores cAMP level) and has similar functions as CDC25.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi