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A7A0P0

- SDC25_YEAS7

UniProt

A7A0P0 - SDC25_YEAS7

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Protein

Guanine nucleotide exchange factor SDC25

Gene

SDC25

Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Promotes the exchange of Ras-bound GDP by GTP.By similarity

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. regulation of small GTPase mediated signal transduction Source: InterPro
  4. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor SDC25
Gene namesi
Name:SDC25
Synonyms:SCD25
ORF Names:SCY_3564
OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Taxonomic identifieri307796 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000007060: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12521252Guanine nucleotide exchange factor SDC25PRO_0000393439Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA7A0P0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 9772SH3PROSITE-ProRule annotationAdd
BLAST
Domaini782 – 914133N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini952 – 1199248Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

OrthoDBiEOG78WM2F.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7A0P0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSCTASYAGM TTPVKDKEGH GIPCLQPIDV VECTYQYFTK SRNKLSLRVG
60 70 80 90 100
DLIYVLTKGS NGWWDGVLIR HSANNNNNSL ILDRGWFPPS FTRSILNELH
110 120 130 140 150
GVPDIGNELE IFQAGLNLKL ELSSNPVILS LEDFLDCCRD IEFKEQLAWS
160 170 180 190 200
PTPVHERKGC CELLYYNQDL DVYCRTLPYL PQNQVETVND YSSFPAISKI
210 220 230 240 250
AGKKMPITSS PDLFYLNDCD VVYWYDLTRL VCHYVNLTER DLLANEREKF
260 270 280 290 300
LTSLDLLTAQ ITCVYMLFRN LRLVEDSFKK TLKKLIYTLS RFSINANIWF
310 320 330 340 350
HSTPFEEREA IASQKDPERR SPLLQSILGT FQKFHFLLRL LHFLSNPNEL
360 370 380 390 400
TILPQLTPRF FKDSFNTISW NNPFLRKHLN QHMSHDLPRQ MIKAVAGASG
410 420 430 440 450
IVAENNDEIP ASKQGTSCSS ETSHHSPSAP FQRRRRGTIF SNVPGSSDES
460 470 480 490 500
DTIWSKRKKP YPLNEETLSL VRARKEQLDA KLKQMIKSAN EYLSNTANFS
510 520 530 540 550
KMLNFEMNFK TYEEVSGTIP IIDILENLDL TIYLNLRELG DENRVFDEDV
560 570 580 590 600
AIDDEDKEFL KHSLSSLSYI LSDYFNMKQY FHDVVVKFII VAQHLTLEDP
610 620 630 640 650
FVFSPMQNDL PTGYYEPMKP SSLNLDNAKD KKNGSQNTDI QEEEDEYEPD
660 670 680 690 700
PDSLILFHNL INQDSDFNDL KFFNLAHVFK KSCDDYFDVL KLSIEFVNRL
710 720 730 740 750
ILERENLLNY AARMMKNNIT ELLLRGEEGY GSYDGGETAE KSDTNAVYAD
760 770 780 790 800
SDTKDNDEWR DSQVKLPRYL QREYDSELIW GSNNRIKGGS KHALISYLTD
810 820 830 840 850
NEKKDLFFNI TFLITFRSIF TTTEFLSYLI SQYNLDPPED LCFEEYNEWV
860 870 880 890 900
TKKLIPVKCR VVEIMTTFFK QYWFPGYDEP DLATLNLDYF AQVAIKENIT
910 920 930 940 950
GSVELLKEVN QKFKHGNMQE ATAPMKTLDQ QICQEHYWGT LYSTTESILA
960 970 980 990 1000
VDPVLFATQL TILEHEIYCE ITIFDCLQKI WKNKYTKSYG ASPGLNEFIS
1010 1020 1030 1040 1050
FANKLTNFIS YSIVKEADKS KRAKLLSHFI FIAEYCRKFN NFSSMTAIIS
1060 1070 1080 1090 1100
ALYSSSIYRL EKTWQAVIPQ TRDLLQSLDK LMDPKKNFIN YRSELKSLHS
1110 1120 1130 1140 1150
APCVPFFGVY LSDLTFTDSG NPDYLVLEHG LKGVHDEKKY INFNKRSRLV
1160 1170 1180 1190 1200
DILQEIIYFK KTHYDFTKDR TVIECISNSL ENIPHIEKQY QLSLIIEPKP
1210 1220 1230 1240 1250
RKKVVPNSNS NNKSQEKSRD DQTDEGKTST KKDRFSKFQL HKTKKKAPKV

SK
Length:1,252
Mass (Da):145,070
Last modified:April 20, 2010 - v2
Checksum:i076BCCE7C1F1EBE8
GO

Sequence cautioni

The sequence EDN59531.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFW02000167 Genomic DNA. Translation: EDN59531.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFW02000167 Genomic DNA. Translation: EDN59531.1 . Different initiation.

3D structure databases

ProteinModelPortali A7A0P0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG78WM2F.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
InterProi IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJM789.

Entry informationi

Entry nameiSDC25_YEAS7
AccessioniPrimary (citable) accession number: A7A0P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Suppresses the CDC25-5 mutation in yeast (restores cAMP level) and has similar functions as CDC25.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3