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A6ZZS7

- RGT1_YEAS7

UniProt

A6ZZS7 - RGT1_YEAS7

Protein

Glucose transport transcription regulator RGT1

Gene

RGT1

Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose. In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator. In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription. Binds the consensus binding site sequence 5'-CGGANNA-3', of which multiple copies are present in all HXT promoters regulated by RGT1 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi47 – 7630Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose transport transcription regulator RGT1
    Alternative name(s):
    Restores glucose transport protein 1
    Gene namesi
    Name:RGT1
    ORF Names:SCY_3337
    OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)
    Taxonomic identifieri307796 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000007060: Unassembled WGS sequence

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11701170Glucose transport transcription regulator RGT1PRO_0000408019Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei202 – 2021PhosphoserineBy similarity
    Modified residuei205 – 2051PhosphoserineBy similarity
    Modified residuei208 – 2081PhosphoserineBy similarity
    Modified residuei229 – 2291PhosphoserineBy similarity
    Modified residuei283 – 2831PhosphoserineBy similarity
    Modified residuei284 – 2841PhosphoserineBy similarity
    Modified residuei410 – 4101PhosphoserineBy similarity
    Modified residuei414 – 4141PhosphoserineBy similarity
    Modified residuei1130 – 11301PhosphoserineBy similarity

    Post-translational modificationi

    Glucose-induced phosphorylation regulates the DNA-binding activity. Hyperphosphorylation in cells growing on high levels of glucose does prevents DNA-binding and dephosphorylation restores DNA-binding ability By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliA6ZZS7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi107 – 13731Asn-richAdd
    BLAST
    Compositional biasi301 – 39797Gln-richAdd
    BLAST
    Compositional biasi423 – 44018Asn-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the EDS1/RGT1 family.Curated
    Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    OrthoDBiEOG7KWSRX.

    Family and domain databases

    Gene3Di4.10.240.10. 1 hit.
    InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view]
    PfamiPF00172. Zn_clus. 1 hit.
    [Graphical view]
    SMARTiSM00066. GAL4. 1 hit.
    [Graphical view]
    SUPFAMiSSF57701. SSF57701. 1 hit.
    PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6ZZS7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNELNTVSTN SSDSTKNGGT SNSPDDMDSA AAASHAIKKR TKASRACDQC     50
    RKKKIKCDYK DEKGVCSNCQ RNGDRCSFDR VPLKRGPSKG YTRSTSHPRT 100
    NEIQDHNNSR SYNTFDNSNN TLNNNTGNSG DNGINSNTVP STPSRSNSVL 150
    LPPLTQYIPQ VGGIPPSFQN PAIQSTMPAG NIGQQQFWKV PYHEFQHQRK 200
    GSIDSLQSDI SVRTLNPNEQ LSYNTVQQSP ITNKHTNDSG NANGSVTGSG 250
    SASGSGGYWS FIRTSGLLAP TDDHNGEQTR RSSSIPSLLR NTSNSLLLGG 300
    QPQLPPPQQQ SQPQAHQQKL QQGQNPYSYS QFSQQQPYNP SISSFGQFAA 350
    NGFHSRQGSV ASEAMSPSAP AMFTSTSTNP VNVAQQTQRP QGQQVPQFSS 400
    ELDGNKRRQS APVSVTLSTD RLNGNENNNG EINNNNGSNN SGSSKDTSQH 450
    SQESVTTPAA LEASSPGSTP QRSTKKRRKS YVSKKTKPKR DSSISITSKD 500
    SAHPMTTSST IAYGQISDVD LIDTYYEFIH VGFPIIPLNK TTLTSDLLLV 550
    NTQPISNIHE VNSYVILWFR NSLELLVRVA LKQKPGGKFF DNIVGVALSP 600
    SNDNNKAGFT TATARDDAEK TRRDSHNEVQ DTLEVQSVFI AALNECFQKI 650
    VDIHPKFREN NDQISPKIKV IYLSTFILLN YILAFVGYDN SFVLGMSVTI 700
    FNEFKLYKLL LFPEPDVNDV KAPVDEEANT GNGNTKTSEF EIGSESAGHM 750
    NPSNSPNSMD ENISHYSVLF KRLYVLLSVF DSLQSCAFGG PKLLNISIQG 800
    STERFFSNDL GSKWCLEQSQ LRLKSVLQSL KLGELMSELT RNRISMNGNR 850
    KPGFDITNSS SLLSEYVETQ PLSVAQLFCK LLIGKHNFIN CLLSLYDSEA 900
    GVYSDLTLDL SSKIADSLCS LISIILQVLT LILRLNPTNS IDFNYRPPNP 950
    PANNPTVQEG PSAMGSSPVA GNLNAAPPSE GNPDFYKKLL GLKQDTGTIL 1000
    SDLCRGIISP FAIAILHEVY NITELVKQMP TSLISIMMTA TTTQNTQDTK 1050
    KSQDLVMKLS NSMNEVVQIT SVLTMIKPFK IFEHELNKPI MSLTGGLSST 1100
    TRNDVMWPKS GQGLRESSVM KTLLDERRTS GTQPTTAPVA AEESRLENVA 1150
    LENFVSIGWK LLDDSELGWY 1170
    Length:1,170
    Mass (Da):128,228
    Last modified:September 11, 2007 - v1
    Checksum:i53892AB766314AE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFW02000152 Genomic DNA. Translation: EDN59870.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFW02000152 Genomic DNA. Translation: EDN59870.1 .

    3D structure databases

    ProteinModelPortali A6ZZS7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7KWSRX.

    Family and domain databases

    Gene3Di 4.10.240.10. 1 hit.
    InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view ]
    Pfami PF00172. Zn_clus. 1 hit.
    [Graphical view ]
    SMARTi SM00066. GAL4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57701. SSF57701. 1 hit.
    PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YJM789.

    Entry informationi

    Entry nameiRGT1_YEAS7
    AccessioniPrimary (citable) accession number: A6ZZS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3