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A6ZZS7

- RGT1_YEAS7

UniProt

A6ZZS7 - RGT1_YEAS7

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Protein

Glucose transport transcription regulator RGT1

Gene

RGT1

Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose. In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator. In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription. Binds the consensus binding site sequence 5'-CGGANNA-3', of which multiple copies are present in all HXT promoters regulated by RGT1 By similarity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi47 – 7630Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose transport transcription regulator RGT1
Alternative name(s):
Restores glucose transport protein 1
Gene namesi
Name:RGT1
ORF Names:SCY_3337
OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Taxonomic identifieri307796 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000007060: Unassembled WGS sequence

Subcellular locationi

Nucleus PROSITE-ProRule annotation. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11701170Glucose transport transcription regulator RGT1PRO_0000408019Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei202 – 2021PhosphoserineBy similarity
Modified residuei205 – 2051PhosphoserineBy similarity
Modified residuei208 – 2081PhosphoserineBy similarity
Modified residuei229 – 2291PhosphoserineBy similarity
Modified residuei283 – 2831PhosphoserineBy similarity
Modified residuei284 – 2841PhosphoserineBy similarity
Modified residuei410 – 4101PhosphoserineBy similarity
Modified residuei414 – 4141PhosphoserineBy similarity
Modified residuei1130 – 11301PhosphoserineBy similarity

Post-translational modificationi

Glucose-induced phosphorylation regulates the DNA-binding activity. Hyperphosphorylation in cells growing on high levels of glucose does prevents DNA-binding and dephosphorylation restores DNA-binding ability By similarity.By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliA6ZZS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi107 – 13731Asn-richAdd
BLAST
Compositional biasi301 – 39797Gln-richAdd
BLAST
Compositional biasi423 – 44018Asn-richAdd
BLAST

Sequence similaritiesi

Belongs to the EDS1/RGT1 family.Curated
Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

OrthoDBiEOG7KWSRX.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6ZZS7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNELNTVSTN SSDSTKNGGT SNSPDDMDSA AAASHAIKKR TKASRACDQC
60 70 80 90 100
RKKKIKCDYK DEKGVCSNCQ RNGDRCSFDR VPLKRGPSKG YTRSTSHPRT
110 120 130 140 150
NEIQDHNNSR SYNTFDNSNN TLNNNTGNSG DNGINSNTVP STPSRSNSVL
160 170 180 190 200
LPPLTQYIPQ VGGIPPSFQN PAIQSTMPAG NIGQQQFWKV PYHEFQHQRK
210 220 230 240 250
GSIDSLQSDI SVRTLNPNEQ LSYNTVQQSP ITNKHTNDSG NANGSVTGSG
260 270 280 290 300
SASGSGGYWS FIRTSGLLAP TDDHNGEQTR RSSSIPSLLR NTSNSLLLGG
310 320 330 340 350
QPQLPPPQQQ SQPQAHQQKL QQGQNPYSYS QFSQQQPYNP SISSFGQFAA
360 370 380 390 400
NGFHSRQGSV ASEAMSPSAP AMFTSTSTNP VNVAQQTQRP QGQQVPQFSS
410 420 430 440 450
ELDGNKRRQS APVSVTLSTD RLNGNENNNG EINNNNGSNN SGSSKDTSQH
460 470 480 490 500
SQESVTTPAA LEASSPGSTP QRSTKKRRKS YVSKKTKPKR DSSISITSKD
510 520 530 540 550
SAHPMTTSST IAYGQISDVD LIDTYYEFIH VGFPIIPLNK TTLTSDLLLV
560 570 580 590 600
NTQPISNIHE VNSYVILWFR NSLELLVRVA LKQKPGGKFF DNIVGVALSP
610 620 630 640 650
SNDNNKAGFT TATARDDAEK TRRDSHNEVQ DTLEVQSVFI AALNECFQKI
660 670 680 690 700
VDIHPKFREN NDQISPKIKV IYLSTFILLN YILAFVGYDN SFVLGMSVTI
710 720 730 740 750
FNEFKLYKLL LFPEPDVNDV KAPVDEEANT GNGNTKTSEF EIGSESAGHM
760 770 780 790 800
NPSNSPNSMD ENISHYSVLF KRLYVLLSVF DSLQSCAFGG PKLLNISIQG
810 820 830 840 850
STERFFSNDL GSKWCLEQSQ LRLKSVLQSL KLGELMSELT RNRISMNGNR
860 870 880 890 900
KPGFDITNSS SLLSEYVETQ PLSVAQLFCK LLIGKHNFIN CLLSLYDSEA
910 920 930 940 950
GVYSDLTLDL SSKIADSLCS LISIILQVLT LILRLNPTNS IDFNYRPPNP
960 970 980 990 1000
PANNPTVQEG PSAMGSSPVA GNLNAAPPSE GNPDFYKKLL GLKQDTGTIL
1010 1020 1030 1040 1050
SDLCRGIISP FAIAILHEVY NITELVKQMP TSLISIMMTA TTTQNTQDTK
1060 1070 1080 1090 1100
KSQDLVMKLS NSMNEVVQIT SVLTMIKPFK IFEHELNKPI MSLTGGLSST
1110 1120 1130 1140 1150
TRNDVMWPKS GQGLRESSVM KTLLDERRTS GTQPTTAPVA AEESRLENVA
1160 1170
LENFVSIGWK LLDDSELGWY
Length:1,170
Mass (Da):128,228
Last modified:September 11, 2007 - v1
Checksum:i53892AB766314AE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFW02000152 Genomic DNA. Translation: EDN59870.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFW02000152 Genomic DNA. Translation: EDN59870.1 .

3D structure databases

ProteinModelPortali A6ZZS7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7KWSRX.

Family and domain databases

Gene3Di 4.10.240.10. 1 hit.
InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view ]
Pfami PF00172. Zn_clus. 1 hit.
[Graphical view ]
SMARTi SM00066. GAL4. 1 hit.
[Graphical view ]
SUPFAMi SSF57701. SSF57701. 1 hit.
PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJM789.

Entry informationi

Entry nameiRGT1_YEAS7
AccessioniPrimary (citable) accession number: A6ZZS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3