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A6ZZS7 (RGT1_YEAS7) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose transport transcription regulator RGT1
Alternative name(s):
Restores glucose transport protein 1
Gene names
Name:RGT1
ORF Names:SCY_3337
OrganismSaccharomyces cerevisiae (strain YJM789) (Baker's yeast) [Complete proteome]
Taxonomic identifier307796 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length1170 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose. In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator. In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription. Binds the consensus binding site sequence 5'-CGGANNA-3', of which multiple copies are present in all HXT promoters regulated by RGT1 By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity.

Post-translational modification

Glucose-induced phosphorylation regulates the DNA-binding activity. Hyperphosphorylation in cells growing on high levels of glucose does prevents DNA-binding and dephosphorylation restores DNA-binding ability By similarity.

Sequence similarities

Belongs to the EDS1/RGT1 family.

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11701170Glucose transport transcription regulator RGT1
PRO_0000408019

Regions

DNA binding47 – 7630Zn(2)-C6 fungal-type
Compositional bias107 – 13731Asn-rich
Compositional bias301 – 39797Gln-rich
Compositional bias423 – 44018Asn-rich

Amino acid modifications

Modified residue2021Phosphoserine By similarity
Modified residue2051Phosphoserine By similarity
Modified residue2081Phosphoserine By similarity
Modified residue2291Phosphoserine By similarity
Modified residue2831Phosphoserine By similarity
Modified residue2841Phosphoserine By similarity
Modified residue4101Phosphoserine By similarity
Modified residue4141Phosphoserine By similarity
Modified residue11301Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
A6ZZS7 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 53892AB766314AE9

FASTA1,170128,228
        10         20         30         40         50         60 
MNELNTVSTN SSDSTKNGGT SNSPDDMDSA AAASHAIKKR TKASRACDQC RKKKIKCDYK 

        70         80         90        100        110        120 
DEKGVCSNCQ RNGDRCSFDR VPLKRGPSKG YTRSTSHPRT NEIQDHNNSR SYNTFDNSNN 

       130        140        150        160        170        180 
TLNNNTGNSG DNGINSNTVP STPSRSNSVL LPPLTQYIPQ VGGIPPSFQN PAIQSTMPAG 

       190        200        210        220        230        240 
NIGQQQFWKV PYHEFQHQRK GSIDSLQSDI SVRTLNPNEQ LSYNTVQQSP ITNKHTNDSG 

       250        260        270        280        290        300 
NANGSVTGSG SASGSGGYWS FIRTSGLLAP TDDHNGEQTR RSSSIPSLLR NTSNSLLLGG 

       310        320        330        340        350        360 
QPQLPPPQQQ SQPQAHQQKL QQGQNPYSYS QFSQQQPYNP SISSFGQFAA NGFHSRQGSV 

       370        380        390        400        410        420 
ASEAMSPSAP AMFTSTSTNP VNVAQQTQRP QGQQVPQFSS ELDGNKRRQS APVSVTLSTD 

       430        440        450        460        470        480 
RLNGNENNNG EINNNNGSNN SGSSKDTSQH SQESVTTPAA LEASSPGSTP QRSTKKRRKS 

       490        500        510        520        530        540 
YVSKKTKPKR DSSISITSKD SAHPMTTSST IAYGQISDVD LIDTYYEFIH VGFPIIPLNK 

       550        560        570        580        590        600 
TTLTSDLLLV NTQPISNIHE VNSYVILWFR NSLELLVRVA LKQKPGGKFF DNIVGVALSP 

       610        620        630        640        650        660 
SNDNNKAGFT TATARDDAEK TRRDSHNEVQ DTLEVQSVFI AALNECFQKI VDIHPKFREN 

       670        680        690        700        710        720 
NDQISPKIKV IYLSTFILLN YILAFVGYDN SFVLGMSVTI FNEFKLYKLL LFPEPDVNDV 

       730        740        750        760        770        780 
KAPVDEEANT GNGNTKTSEF EIGSESAGHM NPSNSPNSMD ENISHYSVLF KRLYVLLSVF 

       790        800        810        820        830        840 
DSLQSCAFGG PKLLNISIQG STERFFSNDL GSKWCLEQSQ LRLKSVLQSL KLGELMSELT 

       850        860        870        880        890        900 
RNRISMNGNR KPGFDITNSS SLLSEYVETQ PLSVAQLFCK LLIGKHNFIN CLLSLYDSEA 

       910        920        930        940        950        960 
GVYSDLTLDL SSKIADSLCS LISIILQVLT LILRLNPTNS IDFNYRPPNP PANNPTVQEG 

       970        980        990       1000       1010       1020 
PSAMGSSPVA GNLNAAPPSE GNPDFYKKLL GLKQDTGTIL SDLCRGIISP FAIAILHEVY 

      1030       1040       1050       1060       1070       1080 
NITELVKQMP TSLISIMMTA TTTQNTQDTK KSQDLVMKLS NSMNEVVQIT SVLTMIKPFK 

      1090       1100       1110       1120       1130       1140 
IFEHELNKPI MSLTGGLSST TRNDVMWPKS GQGLRESSVM KTLLDERRTS GTQPTTAPVA 

      1150       1160       1170 
AEESRLENVA LENFVSIGWK LLDDSELGWY 

« Hide

References

[1]"Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789."
Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z., Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X., Jia P., Luedi P., Oefner P.J., David L. expand/collapse author list , Dietrich F.S., Li Y., Davis R.W., Steinmetz L.M.
Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YJM789.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFW02000152 Genomic DNA. Translation: EDN59870.1.

3D structure databases

ProteinModelPortalA6ZZS7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7KWSRX.

Family and domain databases

Gene3D4.10.240.10. 1 hit.
InterProIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMSSF57701. SSF57701. 1 hit.
PROSITEPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRGT1_YEAS7
AccessionPrimary (citable) accession number: A6ZZS7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families