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A6ZZS7

- RGT1_YEAS7

UniProt

A6ZZS7 - RGT1_YEAS7

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Protein

Glucose transport transcription regulator RGT1

Gene
RGT1, SCY_3337
Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose. In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator. In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription. Binds the consensus binding site sequence 5'-CGGANNA-3', of which multiple copies are present in all HXT promoters regulated by RGT1 By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi47 – 7630Zn(2)-C6 fungal-typeAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose transport transcription regulator RGT1
Alternative name(s):
Restores glucose transport protein 1
Gene namesi
Name:RGT1
ORF Names:SCY_3337
OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Taxonomic identifieri307796 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000007060: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11701170Glucose transport transcription regulator RGT1PRO_0000408019Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei202 – 2021Phosphoserine By similarity
Modified residuei205 – 2051Phosphoserine By similarity
Modified residuei208 – 2081Phosphoserine By similarity
Modified residuei229 – 2291Phosphoserine By similarity
Modified residuei283 – 2831Phosphoserine By similarity
Modified residuei284 – 2841Phosphoserine By similarity
Modified residuei410 – 4101Phosphoserine By similarity
Modified residuei414 – 4141Phosphoserine By similarity
Modified residuei1130 – 11301Phosphoserine By similarity

Post-translational modificationi

Glucose-induced phosphorylation regulates the DNA-binding activity. Hyperphosphorylation in cells growing on high levels of glucose does prevents DNA-binding and dephosphorylation restores DNA-binding ability By similarity.

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliA6ZZS7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi107 – 13731Asn-richAdd
BLAST
Compositional biasi301 – 39797Gln-richAdd
BLAST
Compositional biasi423 – 44018Asn-richAdd
BLAST

Sequence similaritiesi

Belongs to the EDS1/RGT1 family.

Phylogenomic databases

OrthoDBiEOG7KWSRX.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6ZZS7-1 [UniParc]FASTAAdd to Basket

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MNELNTVSTN SSDSTKNGGT SNSPDDMDSA AAASHAIKKR TKASRACDQC     50
RKKKIKCDYK DEKGVCSNCQ RNGDRCSFDR VPLKRGPSKG YTRSTSHPRT 100
NEIQDHNNSR SYNTFDNSNN TLNNNTGNSG DNGINSNTVP STPSRSNSVL 150
LPPLTQYIPQ VGGIPPSFQN PAIQSTMPAG NIGQQQFWKV PYHEFQHQRK 200
GSIDSLQSDI SVRTLNPNEQ LSYNTVQQSP ITNKHTNDSG NANGSVTGSG 250
SASGSGGYWS FIRTSGLLAP TDDHNGEQTR RSSSIPSLLR NTSNSLLLGG 300
QPQLPPPQQQ SQPQAHQQKL QQGQNPYSYS QFSQQQPYNP SISSFGQFAA 350
NGFHSRQGSV ASEAMSPSAP AMFTSTSTNP VNVAQQTQRP QGQQVPQFSS 400
ELDGNKRRQS APVSVTLSTD RLNGNENNNG EINNNNGSNN SGSSKDTSQH 450
SQESVTTPAA LEASSPGSTP QRSTKKRRKS YVSKKTKPKR DSSISITSKD 500
SAHPMTTSST IAYGQISDVD LIDTYYEFIH VGFPIIPLNK TTLTSDLLLV 550
NTQPISNIHE VNSYVILWFR NSLELLVRVA LKQKPGGKFF DNIVGVALSP 600
SNDNNKAGFT TATARDDAEK TRRDSHNEVQ DTLEVQSVFI AALNECFQKI 650
VDIHPKFREN NDQISPKIKV IYLSTFILLN YILAFVGYDN SFVLGMSVTI 700
FNEFKLYKLL LFPEPDVNDV KAPVDEEANT GNGNTKTSEF EIGSESAGHM 750
NPSNSPNSMD ENISHYSVLF KRLYVLLSVF DSLQSCAFGG PKLLNISIQG 800
STERFFSNDL GSKWCLEQSQ LRLKSVLQSL KLGELMSELT RNRISMNGNR 850
KPGFDITNSS SLLSEYVETQ PLSVAQLFCK LLIGKHNFIN CLLSLYDSEA 900
GVYSDLTLDL SSKIADSLCS LISIILQVLT LILRLNPTNS IDFNYRPPNP 950
PANNPTVQEG PSAMGSSPVA GNLNAAPPSE GNPDFYKKLL GLKQDTGTIL 1000
SDLCRGIISP FAIAILHEVY NITELVKQMP TSLISIMMTA TTTQNTQDTK 1050
KSQDLVMKLS NSMNEVVQIT SVLTMIKPFK IFEHELNKPI MSLTGGLSST 1100
TRNDVMWPKS GQGLRESSVM KTLLDERRTS GTQPTTAPVA AEESRLENVA 1150
LENFVSIGWK LLDDSELGWY 1170
Length:1,170
Mass (Da):128,228
Last modified:September 11, 2007 - v1
Checksum:i53892AB766314AE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFW02000152 Genomic DNA. Translation: EDN59870.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFW02000152 Genomic DNA. Translation: EDN59870.1 .

3D structure databases

ProteinModelPortali A6ZZS7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7KWSRX.

Family and domain databases

Gene3Di 4.10.240.10. 1 hit.
InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view ]
Pfami PF00172. Zn_clus. 1 hit.
[Graphical view ]
SMARTi SM00066. GAL4. 1 hit.
[Graphical view ]
SUPFAMi SSF57701. SSF57701. 1 hit.
PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJM789.

Entry informationi

Entry nameiRGT1_YEAS7
AccessioniPrimary (citable) accession number: A6ZZS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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