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A6ZUP2

- A6ZUP2_YEAS7

UniProt

A6ZUP2 - A6ZUP2_YEAS7

Protein
Submitted name:

Flavohemoglobin

Gene

YHB1

Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441FADImported
    Metal bindingi85 – 851Iron (heme axial ligand); via tele nitrogenImported
    Binding sitei189 – 1891FADImported
    Binding sitei285 – 2851FADImported
    Binding sitei390 – 3901FADImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi207 – 2104FADImported
    Nucleotide bindingi223 – 2253FADImported
    Nucleotide bindingi230 – 23910FADImported

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. nucleotide binding Source: UniProtKB-KW
    4. oxidoreductase activity Source: InterPro
    5. oxygen binding Source: InterPro

    GO - Biological processi

    1. oxygen transport Source: InterPro

    Keywords - Ligandi

    FADImported, Flavoprotein, HemeImported, Iron, Metal-binding, Nucleotide-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    FlavohemoglobinImported
    Gene namesi
    Name:YHB1Imported
    ORF Names:SCY_2125Imported
    OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)Imported
    Taxonomic identifieri307796 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000007060: Unassembled WGS sequence

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4G1BX-ray3.00A/B/C/D1-399[»]
    4G1VX-ray2.10A1-399[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    OrthoDBiEOG73Z337.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR017927. Fd_Rdtase_FAD-bd.
    IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR008333. OxRdtase_FAD-bd_dom.
    IPR001433. OxRdtase_FAD/NAD-bd.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view]
    PfamiPF00970. FAD_binding_6. 1 hit.
    PF00042. Globin. 1 hit.
    PF00175. NAD_binding_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46458. SSF46458. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEiPS51384. FAD_FR. 1 hit.
    PS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6ZUP2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAEKTRSII KATVPVLEQQ GTVITRTFYK NMLTEHTELL NIFNRTNQKV    50
    GAQPNALATT VLAAAKNIDD LSVLMDHVKQ IGHKHRALQI KPEHYPIVGE 100
    YLLKAIKEVL GDAATPEIIN AWGEAYQAIA DIFITVEKKM YEEALWPGWK 150
    PFEITAKEYV ASDIVEFTVK PKFGSGIELE SLPITPGQYI TVNTHPIRQE 200
    NQYDALRHYS LCSASTKNGL RFAVKMEAAR ENFPAGLVSE YLHKDAKVGD 250
    EIKLSAPAGD FAINKELIHQ NEVPLVLLSS GVGVTPLLAM LEEQVKCNPN 300
    RPIYWIQSSY DEKTQAFKKH VDELLAECAN VDKIIVHTDT EPLINAAFLK 350
    EKSPAHADVY TCGSLAFMQA MIGHLKELEH RDDMIHYEPF GPKMSTVQV 399
    Length:399
    Mass (Da):44,660
    Last modified:September 11, 2007 - v1
    Checksum:i9AF1DE8280220D21
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFW02000100 Genomic DNA. Translation: EDN61819.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFW02000100 Genomic DNA. Translation: EDN61819.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4G1B X-ray 3.00 A/B/C/D 1-399 [» ]
    4G1V X-ray 2.10 A 1-399 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG73Z337.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR017927. Fd_Rdtase_FAD-bd.
    IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR008333. OxRdtase_FAD-bd_dom.
    IPR001433. OxRdtase_FAD/NAD-bd.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view ]
    Pfami PF00970. FAD_binding_6. 1 hit.
    PF00042. Globin. 1 hit.
    PF00175. NAD_binding_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46458. SSF46458. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEi PS51384. FAD_FR. 1 hit.
    PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YJM789Imported.
    2. "Active site analysis of yeast flavohemoglobin based on its structure with a small ligand or econazole."
      El Hammi E., Warkentin E., Demmer U., Marzouki N.M., Ermler U., Baciou L.
      FEBS J. 279:4565-4575(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH FAD AND HEME.

    Entry informationi

    Entry nameiA6ZUP2_YEAS7
    AccessioniPrimary (citable) accession number: A6ZUP2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3