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A6ZUP2

- A6ZUP2_YEAS7

UniProt

A6ZUP2 - A6ZUP2_YEAS7

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Protein
Submitted name: Flavohemoglobin
Gene
YHB1, SCY_2125
Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Potassium; via pros nitrogenImported
Metal bindingi38 – 381PotassiumImported
Binding sitei44 – 441FAD
Metal bindingi85 – 851Iron (heme axial ligand); via tele nitrogenImported
Binding sitei189 – 1891FADImported
Binding sitei285 – 2851FADImported
Binding sitei390 – 3901FADImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi207 – 2104FADImported
Nucleotide bindingi223 – 2253FADImported
Nucleotide bindingi230 – 23910FADImported

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. nucleotide binding Source: UniProtKB-KW
  4. oxidoreductase activity Source: InterPro
  5. oxygen binding Source: InterPro

GO - Biological processi

  1. oxygen transport Source: InterPro
Complete GO annotation...

Keywords - Ligandi

FADImported, Flavoprotein, HemeImported, Iron, Metal-binding, Nucleotide-bindingImported, PotassiumImported

Names & Taxonomyi

Protein namesi
Submitted name:
FlavohemoglobinImported
Gene namesi
Name:YHB1Imported
ORF Names:SCY_2125Imported
OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)Imported
Taxonomic identifieri307796 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000007060: Unassembled WGS sequence

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4G1BX-ray3.00A/B/C/D1-399[»]
4G1VX-ray2.10A1-399[»]

Family & Domainsi

Phylogenomic databases

OrthoDBiEOG73Z337.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR017927. Fd_Rdtase_FAD-bd.
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00970. FAD_binding_6. 1 hit.
PF00042. Globin. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
SUPFAMiSSF46458. SSF46458. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6ZUP2-1 [UniParc]FASTAAdd to Basket

« Hide

MLAEKTRSII KATVPVLEQQ GTVITRTFYK NMLTEHTELL NIFNRTNQKV    50
GAQPNALATT VLAAAKNIDD LSVLMDHVKQ IGHKHRALQI KPEHYPIVGE 100
YLLKAIKEVL GDAATPEIIN AWGEAYQAIA DIFITVEKKM YEEALWPGWK 150
PFEITAKEYV ASDIVEFTVK PKFGSGIELE SLPITPGQYI TVNTHPIRQE 200
NQYDALRHYS LCSASTKNGL RFAVKMEAAR ENFPAGLVSE YLHKDAKVGD 250
EIKLSAPAGD FAINKELIHQ NEVPLVLLSS GVGVTPLLAM LEEQVKCNPN 300
RPIYWIQSSY DEKTQAFKKH VDELLAECAN VDKIIVHTDT EPLINAAFLK 350
EKSPAHADVY TCGSLAFMQA MIGHLKELEH RDDMIHYEPF GPKMSTVQV 399
Length:399
Mass (Da):44,660
Last modified:September 11, 2007 - v1
Checksum:i9AF1DE8280220D21
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFW02000100 Genomic DNA. Translation: EDN61819.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFW02000100 Genomic DNA. Translation: EDN61819.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4G1B X-ray 3.00 A/B/C/D 1-399 [» ]
4G1V X-ray 2.10 A 1-399 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG73Z337.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR017927. Fd_Rdtase_FAD-bd.
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
Pfami PF00970. FAD_binding_6. 1 hit.
PF00042. Globin. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view ]
SUPFAMi SSF46458. SSF46458. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEi PS51384. FAD_FR. 1 hit.
PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJM789.
  2. "Active site analysis of yeast flavohemoglobin based on its structure with a small ligand or econazole."
    El Hammi E., Warkentin E., Demmer U., Marzouki N.M., Ermler U., Baciou L.
    FEBS J. 279:4565-4575(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH FAD; HEME AND POTASSIUM.

Entry informationi

Entry nameiA6ZUP2_YEAS7
AccessioniPrimary (citable) accession number: A6ZUP2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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