Reviewed,
UniProtKB/Swiss-Prot A6ZTT5 (ADH4_YEAS7)
Last modified
June 16, 2009.
Version 11.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Alcohol dehydrogenase 4 EC=1.1.1.1 Alternative name(s): Alcohol dehydrogenase IV Short name=ADHIV | ||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) [Complete proteome] | ||||||
| Taxonomic identifier | 307796 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 382 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Reduces acetaldehyde to ethanol during glucose fermentation. Specific for ethanol. Shows drastically reduced activity towards primary alcohols from 4 carbon atoms upward. Isomers of aliphatic alcohol, as well as secondary alcohols and glycerol are not used at all By similarity. |
| Catalytic activity | An alcohol + NAD+ = an aldehyde or ketone + NADH. |
| Cofactor | Zinc. May bind iron when zinc levels are limiting By similarity. |
| Enzyme regulation | Inhibited by EDTA By similarity. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Mitochondrion By similarity. |
| Induction | Induced by transcription factor ZAP1 in response to zinc deficiency By similarity. |
| Miscellaneous | While ADH4 is expressed at only low levels in laboratory strains, it is often highly expressed in brewing strains. |
| Sequence similarities | Belongs to the iron-containing alcohol dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Ligand | Metal-binding NAD Zinc |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 382 | 382 | Alcohol dehydrogenase 4 | PRO_0000345089 | |||
Sequences
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References
| [1] | "Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789." Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z., Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X., Jia P., Luedi P., Oefner P.J., David L. Steinmetz L.M.Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007) [PubMed: 17652520] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AAFW02000099 Genomic DNA. Translation: EDN61873.1. Different initiation. | |
3D structure databases | |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR001670. ADH_Fe. IPR018211. ADH_Fe_CS. [Graphical view] |
| Pfam | PF00465. Fe-ADH. 1 hit. [Graphical view] |
| PROSITE | PS00913. ADH_IRON_1. 1 hit. PS00060. ADH_IRON_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ADH4_YEAS7 | ||||||||
| Accession | Primary (citable) accession number: A6ZTT5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||

Clusters with


