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Protein

Alcohol dehydrogenase 4

Gene

ADH4

Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reduces acetaldehyde to ethanol during glucose fermentation. Specific for ethanol. Shows drastically reduced activity towards primary alcohols from 4 carbon atoms upward. Isomers of aliphatic alcohol, as well as secondary alcohols and glycerol are not used at all (By similarity).By similarity

Miscellaneous

While ADH4 is expressed at only low levels in laboratory strains, it is often highly expressed in brewing strains.

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarity, Fe2+By similarityNote: Zinc. May bind iron when zinc levels are limiting.By similarity

Enzyme regulationi

Inhibited by EDTA.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 4 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase IV
Short name:
ADHIV
Gene namesi
Name:ADH4
Synonyms:ZRG5
ORF Names:SCY_1818
OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Taxonomic identifieri307796 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000007060 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003450891 – 382Alcohol dehydrogenase 4Add BLAST382

Proteomic databases

PRIDEiA6ZTT5.

Expressioni

Inductioni

Induced by transcription factor ZAP1 in response to zinc deficiency.By similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliA6ZTT5.
SMRiA6ZTT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG092C28AS.

Family and domain databases

InterProiView protein in InterPro
IPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
PfamiView protein in Pfam
PF00465. Fe-ADH. 1 hit.
PROSITEiView protein in PROSITE
PS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A6ZTT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVTGFYIP PISFFGEGAL EETADYIKNK DYKKALIVTD PGIAAIGLSG
60 70 80 90 100
RVQKMLEERG LNVAIYDKTQ PNPNIANVTA GLKVLKEQNS EIVVSIGGGS
110 120 130 140 150
AHDNAKAIAL LATNGGEIGD YEGVNQSKKA ALPLFAINTT AGTASEMTRF
160 170 180 190 200
TIISNEEKKI KMAIIDNNVT PAVAVNDPST MFGLPPALTA ATGLDALTHC
210 220 230 240 250
IEAYVSTASN PITDACALKG IDLINESLVA AYKDGKDKKA RTDMCYAEYL
260 270 280 290 300
AGMAFNNASL GYVHALAHQL GGFYHLPHGV CNAVLLPHVQ EANMQCPKAK
310 320 330 340 350
KRLGEIALHF GASQEDPEET IKALHVLNRT MNIPRNLKEL GVKTEDFEIL
360 370 380
AEHAMHDACH LTNPVQFTKE QVVAIIKKAY EY
Length:382
Mass (Da):41,084
Last modified:July 22, 2008 - v2
Checksum:iAC6E77B78D6B9AA8
GO

Sequence cautioni

The sequence EDN61873 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFW02000099 Genomic DNA. Translation: EDN61873.1. Different initiation.

Genome annotation databases

EnsemblFungiiEDN61873; EDN61873; SCY_1818.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADH4_YEAS7
AccessioniPrimary (citable) accession number: A6ZTT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: March 15, 2017
This is version 37 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families