ID   TOM70_YEAS7             Reviewed;         617 AA.
AC   A6ZRW3; B0KZR5;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   24-JAN-2024, entry version 75.
DE   RecName: Full=Mitochondrial import receptor subunit TOM70;
DE   AltName: Full=70 kDa mitochondrial outer membrane protein;
DE   AltName: Full=Translocase of outer membrane 70 kDa subunit;
GN   Name=TOM70; Synonyms=MAS70, OMP1; ORFNames=SCY_4674;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=18780730; DOI=10.1534/genetics.108.092932;
RA   Sinha H., David L., Pascon R.C., Clauder-Muenster S., Krishnakumar S.,
RA   Nguyen M., Shi G., Dean J., Davis R.W., Oefner P.J., McCusker J.H.,
RA   Steinmetz L.M.;
RT   "Sequential elimination of major-effect contributors identifies additional
RT   quantitative trait loci conditioning high-temperature growth in yeast.";
RL   Genetics 180:1661-1670(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Component of the TOM (translocase of outer membrane) receptor
CC       complex responsible for the recognition and translocation of
CC       cytosolically synthesized mitochondrial preproteins. Together with
CC       TOM20 and TOM22 functions as the transit peptide receptor at the
CC       surface of the mitochondrion outer membrane and facilitates the
CC       movement of preproteins into the TOM40 translocation pore (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms part of the TOM (translocase of outer membrane) complex
CC       that consists of at least 7 different proteins (TOM5, TOM6, TOM7,
CC       TOM20, TOM22, TOM40 and TOM70). In the complex interacts with TOM22.
CC       Interacts with TOM37. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Tom70 family. {ECO:0000305}.
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DR   EMBL; EF125227; ABN58636.1; -; Genomic_DNA.
DR   EMBL; AAFW02000067; EDN62695.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZRW3; -.
DR   SMR; A6ZRW3; -.
DR   HOGENOM; CLU_017516_1_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015450; F:protein-transporting ATPase activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR005687; Tom70.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR001440; TPR_1.
DR   InterPro; IPR019734; TPR_repeat.
DR   NCBIfam; TIGR00990; 3a0801s09; 1.
DR   PANTHER; PTHR46208; MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70; 1.
DR   PANTHER; PTHR46208:SF1; MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70; 1.
DR   Pfam; PF00515; TPR_1; 1.
DR   Pfam; PF13432; TPR_16; 1.
DR   Pfam; PF14559; TPR_19; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 8.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 6.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein;
KW   Repeat; TPR repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..617
FT                   /note="Mitochondrial import receptor subunit TOM70"
FT                   /id="PRO_0000378319"
FT   TOPO_DOM        1..10
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..617
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          99..132
FT                   /note="TPR 1"
FT   REPEAT          134..165
FT                   /note="TPR 2"
FT   REPEAT          281..315
FT                   /note="TPR 3"
FT   REPEAT          363..396
FT                   /note="TPR 4"
FT   REPEAT          397..430
FT                   /note="TPR 5"
FT   REPEAT          432..464
FT                   /note="TPR 6"
FT   REPEAT          465..498
FT                   /note="TPR 7"
FT   REPEAT          505..541
FT                   /note="TPR 8"
FT   REPEAT          542..575
FT                   /note="TPR 9"
FT   REGION          36..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..61
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         174
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P07213"
SQ   SEQUENCE   617 AA;  70123 MW;  664B8FC32CCE39A2 CRC64;
     MKSFITRNKT AILATVAATG TAIGAYYYYN QLQQQQQRGK KNTINKDEKK DTKDSQKETE
     GAKKSTAPSN PPIYPVSSNG EPDFSNKANF TAEEKDKYAL ALKDKGNQFF RNKKYDDAIK
     YYNWALELKE DPVFYSNLSA CYVSVGDLKK VVEMSTKALE LKPDYSKVLL RRASANEGLG
     KFADAMFDLS VLSLNGDFND ASIEPMLERN LNKQAMSKLK EKFGDIDTAT ATPTELSTQP
     AKERKDKQEN LPSVTSMASF FGIFKPELTF ANYDESNEAD KELMNGLSNL YKRSPESYDK
     ADESFTKAAR LFEEQLDKNN EDEKLKEKLA ISLEHTGIFK FLKNDPLGAH EDIKKAIELF
     PRVNSYIYMA LIMADRNDST EYYNYFDKAL KLDSNNSSVY YHRGQMNFIL QNYDQAGKDF
     DKAKELDPEN IFPYIQLACL AYRENKFDDC ETLFSEAKRK FPEAPEVPNF FAEILTDKND
     FDKALKQYDL AIELENKLDG IYVGIAPLVG KATLLTRNPT VENFIEATNL LEKASKLDPR
     SEQAKIGLAQ MKLQQEDIDE AITLFEESAD LARTMEEKLQ AITFAEAAKV QQRIRSDPVL
     AKKIQETLAK LREQGLM
//