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A6ZRW3

- TOM70_YEAS7

UniProt

A6ZRW3 - TOM70_YEAS7

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Protein

Mitochondrial import receptor subunit TOM70

Gene

TOM70

Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).By similarity

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. intracellular protein transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM70
Alternative name(s):
70 kDa mitochondrial outer membrane protein
Translocase of outer membrane 70 kDa subunit
Gene namesi
Name:TOM70
Synonyms:MAS70, OMP1
ORF Names:SCY_4674
OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Taxonomic identifieri307796 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000007060: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Mitochondrial import receptor subunit TOM70PRO_0000378319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Forms part of the TOM (translocase of outer membrane) complex that consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70). In the complex interacts with TOM22. Interacts with TOM37.By similarity

Structurei

3D structure databases

ProteinModelPortaliA6ZRW3.
SMRiA6ZRW3. Positions 94-607.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Mitochondrial intermembraneSequence Analysis
Topological domaini31 – 617587CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3020HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati99 – 13234TPR 1Add
BLAST
Repeati134 – 16532TPR 2Add
BLAST
Repeati281 – 31535TPR 3Add
BLAST
Repeati363 – 39634TPR 4Add
BLAST
Repeati397 – 43034TPR 5Add
BLAST
Repeati432 – 46433TPR 6Add
BLAST
Repeati465 – 49834TPR 7Add
BLAST
Repeati505 – 54137TPR 8Add
BLAST
Repeati542 – 57534TPR 9Add
BLAST

Sequence similaritiesi

Belongs to the Tom70 family.Curated
Contains 9 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7R839F.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR005687. Tom70.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
TIGRFAMsiTIGR00990. 3a0801s09. 1 hit.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6ZRW3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSFITRNKT AILATVAATG TAIGAYYYYN QLQQQQQRGK KNTINKDEKK
60 70 80 90 100
DTKDSQKETE GAKKSTAPSN PPIYPVSSNG EPDFSNKANF TAEEKDKYAL
110 120 130 140 150
ALKDKGNQFF RNKKYDDAIK YYNWALELKE DPVFYSNLSA CYVSVGDLKK
160 170 180 190 200
VVEMSTKALE LKPDYSKVLL RRASANEGLG KFADAMFDLS VLSLNGDFND
210 220 230 240 250
ASIEPMLERN LNKQAMSKLK EKFGDIDTAT ATPTELSTQP AKERKDKQEN
260 270 280 290 300
LPSVTSMASF FGIFKPELTF ANYDESNEAD KELMNGLSNL YKRSPESYDK
310 320 330 340 350
ADESFTKAAR LFEEQLDKNN EDEKLKEKLA ISLEHTGIFK FLKNDPLGAH
360 370 380 390 400
EDIKKAIELF PRVNSYIYMA LIMADRNDST EYYNYFDKAL KLDSNNSSVY
410 420 430 440 450
YHRGQMNFIL QNYDQAGKDF DKAKELDPEN IFPYIQLACL AYRENKFDDC
460 470 480 490 500
ETLFSEAKRK FPEAPEVPNF FAEILTDKND FDKALKQYDL AIELENKLDG
510 520 530 540 550
IYVGIAPLVG KATLLTRNPT VENFIEATNL LEKASKLDPR SEQAKIGLAQ
560 570 580 590 600
MKLQQEDIDE AITLFEESAD LARTMEEKLQ AITFAEAAKV QQRIRSDPVL
610
AKKIQETLAK LREQGLM
Length:617
Mass (Da):70,123
Last modified:September 11, 2007 - v1
Checksum:i664B8FC32CCE39A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF125227 Genomic DNA. Translation: ABN58636.1.
AAFW02000067 Genomic DNA. Translation: EDN62695.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF125227 Genomic DNA. Translation: ABN58636.1 .
AAFW02000067 Genomic DNA. Translation: EDN62695.1 .

3D structure databases

ProteinModelPortali A6ZRW3.
SMRi A6ZRW3. Positions 94-607.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7R839F.

Miscellaneous databases

NextBioi 979768.

Family and domain databases

Gene3Di 1.25.40.10. 3 hits.
InterProi IPR005687. Tom70.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF00515. TPR_1. 2 hits.
[Graphical view ]
SMARTi SM00028. TPR. 6 hits.
[Graphical view ]
TIGRFAMsi TIGR00990. 3a0801s09. 1 hit.
PROSITEi PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast."
    Sinha H., David L., Pascon R.C., Clauder-Muenster S., Krishnakumar S., Nguyen M., Shi G., Dean J., Davis R.W., Oefner P.J., McCusker J.H., Steinmetz L.M.
    Genetics 180:1661-1670(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJM789.

Entry informationi

Entry nameiTOM70_YEAS7
AccessioniPrimary (citable) accession number: A6ZRW3
Secondary accession number(s): B0KZR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3