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A6ZRW3

- TOM70_YEAS7

UniProt

A6ZRW3 - TOM70_YEAS7

Protein

Mitochondrial import receptor subunit TOM70

Gene

TOM70

Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore By similarity.By similarity

    GO - Molecular functioni

    1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. intracellular protein transport Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial import receptor subunit TOM70
    Alternative name(s):
    70 kDa mitochondrial outer membrane protein
    Translocase of outer membrane 70 kDa subunit
    Gene namesi
    Name:TOM70
    Synonyms:MAS70, OMP1
    ORF Names:SCY_4674
    OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)
    Taxonomic identifieri307796 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000007060: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 617617Mitochondrial import receptor subunit TOM70PRO_0000378319Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei174 – 1741PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Forms part of the TOM (translocase of outer membrane) complex that consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70). In the complex interacts with TOM22. Interacts with TOM37.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA6ZRW3.
    SMRiA6ZRW3. Positions 94-607.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010Mitochondrial intermembraneSequence Analysis
    Topological domaini31 – 617587CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3020HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati99 – 13234TPR 1Add
    BLAST
    Repeati134 – 16532TPR 2Add
    BLAST
    Repeati281 – 31535TPR 3Add
    BLAST
    Repeati363 – 39634TPR 4Add
    BLAST
    Repeati397 – 43034TPR 5Add
    BLAST
    Repeati432 – 46433TPR 6Add
    BLAST
    Repeati465 – 49834TPR 7Add
    BLAST
    Repeati505 – 54137TPR 8Add
    BLAST
    Repeati542 – 57534TPR 9Add
    BLAST

    Sequence similaritiesi

    Belongs to the Tom70 family.Curated
    Contains 9 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG7R839F.

    Family and domain databases

    Gene3Di1.25.40.10. 3 hits.
    InterProiIPR005687. Tom70.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF00515. TPR_1. 2 hits.
    [Graphical view]
    SMARTiSM00028. TPR. 6 hits.
    [Graphical view]
    TIGRFAMsiTIGR00990. 3a0801s09. 1 hit.
    PROSITEiPS50005. TPR. 6 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6ZRW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSFITRNKT AILATVAATG TAIGAYYYYN QLQQQQQRGK KNTINKDEKK    50
    DTKDSQKETE GAKKSTAPSN PPIYPVSSNG EPDFSNKANF TAEEKDKYAL 100
    ALKDKGNQFF RNKKYDDAIK YYNWALELKE DPVFYSNLSA CYVSVGDLKK 150
    VVEMSTKALE LKPDYSKVLL RRASANEGLG KFADAMFDLS VLSLNGDFND 200
    ASIEPMLERN LNKQAMSKLK EKFGDIDTAT ATPTELSTQP AKERKDKQEN 250
    LPSVTSMASF FGIFKPELTF ANYDESNEAD KELMNGLSNL YKRSPESYDK 300
    ADESFTKAAR LFEEQLDKNN EDEKLKEKLA ISLEHTGIFK FLKNDPLGAH 350
    EDIKKAIELF PRVNSYIYMA LIMADRNDST EYYNYFDKAL KLDSNNSSVY 400
    YHRGQMNFIL QNYDQAGKDF DKAKELDPEN IFPYIQLACL AYRENKFDDC 450
    ETLFSEAKRK FPEAPEVPNF FAEILTDKND FDKALKQYDL AIELENKLDG 500
    IYVGIAPLVG KATLLTRNPT VENFIEATNL LEKASKLDPR SEQAKIGLAQ 550
    MKLQQEDIDE AITLFEESAD LARTMEEKLQ AITFAEAAKV QQRIRSDPVL 600
    AKKIQETLAK LREQGLM 617
    Length:617
    Mass (Da):70,123
    Last modified:September 11, 2007 - v1
    Checksum:i664B8FC32CCE39A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF125227 Genomic DNA. Translation: ABN58636.1.
    AAFW02000067 Genomic DNA. Translation: EDN62695.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF125227 Genomic DNA. Translation: ABN58636.1 .
    AAFW02000067 Genomic DNA. Translation: EDN62695.1 .

    3D structure databases

    ProteinModelPortali A6ZRW3.
    SMRi A6ZRW3. Positions 94-607.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7R839F.

    Miscellaneous databases

    NextBioi 979768.

    Family and domain databases

    Gene3Di 1.25.40.10. 3 hits.
    InterProi IPR005687. Tom70.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF00515. TPR_1. 2 hits.
    [Graphical view ]
    SMARTi SM00028. TPR. 6 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00990. 3a0801s09. 1 hit.
    PROSITEi PS50005. TPR. 6 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast."
      Sinha H., David L., Pascon R.C., Clauder-Muenster S., Krishnakumar S., Nguyen M., Shi G., Dean J., Davis R.W., Oefner P.J., McCusker J.H., Steinmetz L.M.
      Genetics 180:1661-1670(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YJM789.

    Entry informationi

    Entry nameiTOM70_YEAS7
    AccessioniPrimary (citable) accession number: A6ZRW3
    Secondary accession number(s): B0KZR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3