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A6ZRW3 (TOM70_YEAS7) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial import receptor subunit TOM70
Alternative name(s):
70 kDa mitochondrial outer membrane protein
Translocase of outer membrane 70 kDa subunit
Gene names
Name:TOM70
Synonyms:MAS70, OMP1
ORF Names:SCY_4674
OrganismSaccharomyces cerevisiae (strain YJM789) (Baker's yeast) [Complete proteome]
Taxonomic identifier307796 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length617 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore By similarity.

Subunit structure

Forms part of the TOM (translocase of outer membrane) complex that consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70) By similarity. In the complex interacts with TOM22 By similarity. Interacts with TOM37 By similarity.

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the Tom70 family.

Contains 9 TPR repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 617617Mitochondrial import receptor subunit TOM70
PRO_0000378319

Regions

Topological domain1 – 1010Mitochondrial intermembrane Potential
Transmembrane11 – 3020Helical; Potential
Topological domain31 – 617587Cytoplasmic Potential
Repeat99 – 13234TPR 1
Repeat134 – 16532TPR 2
Repeat281 – 31535TPR 3
Repeat363 – 39634TPR 4
Repeat397 – 43034TPR 5
Repeat432 – 46433TPR 6
Repeat465 – 49834TPR 7
Repeat505 – 54137TPR 8
Repeat542 – 57534TPR 9

Amino acid modifications

Modified residue1741Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
A6ZRW3 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 664B8FC32CCE39A2

FASTA61770,123
        10         20         30         40         50         60 
MKSFITRNKT AILATVAATG TAIGAYYYYN QLQQQQQRGK KNTINKDEKK DTKDSQKETE 

        70         80         90        100        110        120 
GAKKSTAPSN PPIYPVSSNG EPDFSNKANF TAEEKDKYAL ALKDKGNQFF RNKKYDDAIK 

       130        140        150        160        170        180 
YYNWALELKE DPVFYSNLSA CYVSVGDLKK VVEMSTKALE LKPDYSKVLL RRASANEGLG 

       190        200        210        220        230        240 
KFADAMFDLS VLSLNGDFND ASIEPMLERN LNKQAMSKLK EKFGDIDTAT ATPTELSTQP 

       250        260        270        280        290        300 
AKERKDKQEN LPSVTSMASF FGIFKPELTF ANYDESNEAD KELMNGLSNL YKRSPESYDK 

       310        320        330        340        350        360 
ADESFTKAAR LFEEQLDKNN EDEKLKEKLA ISLEHTGIFK FLKNDPLGAH EDIKKAIELF 

       370        380        390        400        410        420 
PRVNSYIYMA LIMADRNDST EYYNYFDKAL KLDSNNSSVY YHRGQMNFIL QNYDQAGKDF 

       430        440        450        460        470        480 
DKAKELDPEN IFPYIQLACL AYRENKFDDC ETLFSEAKRK FPEAPEVPNF FAEILTDKND 

       490        500        510        520        530        540 
FDKALKQYDL AIELENKLDG IYVGIAPLVG KATLLTRNPT VENFIEATNL LEKASKLDPR 

       550        560        570        580        590        600 
SEQAKIGLAQ MKLQQEDIDE AITLFEESAD LARTMEEKLQ AITFAEAAKV QQRIRSDPVL 

       610 
AKKIQETLAK LREQGLM 

« Hide

References

« Hide 'large scale' references
[1]"Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast."
Sinha H., David L., Pascon R.C., Clauder-Muenster S., Krishnakumar S., Nguyen M., Shi G., Dean J., Davis R.W., Oefner P.J., McCusker J.H., Steinmetz L.M.
Genetics 180:1661-1670(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789."
Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z., Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X., Jia P., Luedi P., Oefner P.J., David L. expand/collapse author list , Dietrich F.S., Li Y., Davis R.W., Steinmetz L.M.
Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YJM789.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF125227 Genomic DNA. Translation: ABN58636.1.
AAFW02000067 Genomic DNA. Translation: EDN62695.1.

3D structure databases

ProteinModelPortalA6ZRW3.
SMRA6ZRW3. Positions 94-607.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7R839F.

Family and domain databases

Gene3D1.25.40.10. 3 hits.
InterProIPR005687. Tom70.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamPF00515. TPR_1. 2 hits.
[Graphical view]
SMARTSM00028. TPR. 6 hits.
[Graphical view]
TIGRFAMsTIGR00990. 3a0801s09. 1 hit.
PROSITEPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio979768.

Entry information

Entry nameTOM70_YEAS7
AccessionPrimary (citable) accession number: A6ZRW3
Secondary accession number(s): B0KZR5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families