SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A6ZRW3

- TOM70_YEAS7

UniProt

A6ZRW3 - TOM70_YEAS7

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Mitochondrial import receptor subunit TOM70
Gene
TOM70, MAS70, OMP1, SCY_4674
Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore By similarity.

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. intracellular protein transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM70
Alternative name(s):
70 kDa mitochondrial outer membrane protein
Translocase of outer membrane 70 kDa subunit
Gene namesi
Name:TOM70
Synonyms:MAS70, OMP1
ORF Names:SCY_4674
OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Taxonomic identifieri307796 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000007060: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Mitochondrial intermembrane Reviewed prediction
Transmembranei11 – 3020Helical; Reviewed prediction
Add
BLAST
Topological domaini31 – 617587Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Mitochondrial import receptor subunit TOM70
PRO_0000378319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Forms part of the TOM (translocase of outer membrane) complex that consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70) By similarity. In the complex interacts with TOM22 By similarity. Interacts with TOM37 By similarity.

Structurei

3D structure databases

ProteinModelPortaliA6ZRW3.
SMRiA6ZRW3. Positions 94-607.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati99 – 13234TPR 1
Add
BLAST
Repeati134 – 16532TPR 2
Add
BLAST
Repeati281 – 31535TPR 3
Add
BLAST
Repeati363 – 39634TPR 4
Add
BLAST
Repeati397 – 43034TPR 5
Add
BLAST
Repeati432 – 46433TPR 6
Add
BLAST
Repeati465 – 49834TPR 7
Add
BLAST
Repeati505 – 54137TPR 8
Add
BLAST
Repeati542 – 57534TPR 9
Add
BLAST

Sequence similaritiesi

Belongs to the Tom70 family.
Contains 9 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7R839F.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR005687. Tom70.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
TIGRFAMsiTIGR00990. 3a0801s09. 1 hit.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6ZRW3-1 [UniParc]FASTAAdd to Basket

« Hide

MKSFITRNKT AILATVAATG TAIGAYYYYN QLQQQQQRGK KNTINKDEKK    50
DTKDSQKETE GAKKSTAPSN PPIYPVSSNG EPDFSNKANF TAEEKDKYAL 100
ALKDKGNQFF RNKKYDDAIK YYNWALELKE DPVFYSNLSA CYVSVGDLKK 150
VVEMSTKALE LKPDYSKVLL RRASANEGLG KFADAMFDLS VLSLNGDFND 200
ASIEPMLERN LNKQAMSKLK EKFGDIDTAT ATPTELSTQP AKERKDKQEN 250
LPSVTSMASF FGIFKPELTF ANYDESNEAD KELMNGLSNL YKRSPESYDK 300
ADESFTKAAR LFEEQLDKNN EDEKLKEKLA ISLEHTGIFK FLKNDPLGAH 350
EDIKKAIELF PRVNSYIYMA LIMADRNDST EYYNYFDKAL KLDSNNSSVY 400
YHRGQMNFIL QNYDQAGKDF DKAKELDPEN IFPYIQLACL AYRENKFDDC 450
ETLFSEAKRK FPEAPEVPNF FAEILTDKND FDKALKQYDL AIELENKLDG 500
IYVGIAPLVG KATLLTRNPT VENFIEATNL LEKASKLDPR SEQAKIGLAQ 550
MKLQQEDIDE AITLFEESAD LARTMEEKLQ AITFAEAAKV QQRIRSDPVL 600
AKKIQETLAK LREQGLM 617
Length:617
Mass (Da):70,123
Last modified:September 11, 2007 - v1
Checksum:i664B8FC32CCE39A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF125227 Genomic DNA. Translation: ABN58636.1.
AAFW02000067 Genomic DNA. Translation: EDN62695.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF125227 Genomic DNA. Translation: ABN58636.1 .
AAFW02000067 Genomic DNA. Translation: EDN62695.1 .

3D structure databases

ProteinModelPortali A6ZRW3.
SMRi A6ZRW3. Positions 94-607.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7R839F.

Miscellaneous databases

NextBioi 979768.

Family and domain databases

Gene3Di 1.25.40.10. 3 hits.
InterProi IPR005687. Tom70.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF00515. TPR_1. 2 hits.
[Graphical view ]
SMARTi SM00028. TPR. 6 hits.
[Graphical view ]
TIGRFAMsi TIGR00990. 3a0801s09. 1 hit.
PROSITEi PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast."
    Sinha H., David L., Pascon R.C., Clauder-Muenster S., Krishnakumar S., Nguyen M., Shi G., Dean J., Davis R.W., Oefner P.J., McCusker J.H., Steinmetz L.M.
    Genetics 180:1661-1670(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJM789.

Entry informationi

Entry nameiTOM70_YEAS7
AccessioniPrimary (citable) accession number: A6ZRW3
Secondary accession number(s): B0KZR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi