A6ZRL6 (SQS1_YEAS7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein SQS1

Alternative name(s):
Squelch of splicing suppression protein 1

Gene names

Name:	SQS1
ORF Names:	SCY_4577

Organism

Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) [Complete proteome]

Taxonomic identifier

307796 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	767 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be involved in splicing since overexpression antagonizes the suppression of splicing defects by SPP382 mutants By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the SQS1 family. Contains 1 G-patch domain. Contains 1 R3H domain.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Cytoplasm Nucleus
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 767	767	Protein SQS1		PRO_0000325003
Regions
	Domain	594 – 656	63	R3H
	Domain	720 – 767	48	G-patch
Amino acid modifications
	Modified residue	105	1	Phosphoserine By similarity
	Modified residue	106	1	Phosphoserine By similarity
	Modified residue	217	1	Phosphoserine By similarity
	Modified residue	255	1	Phosphoserine By similarity
	Modified residue	334	1	Phosphoserine By similarity
	Modified residue	343	1	Phosphoserine By similarity
	Modified residue	345	1	Phosphoserine By similarity
	Modified residue	372	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6ZRL6 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 0DC6EEA57B2475B2	FASTA	767	86,940
	10 20 30 40 50 60 MAKRHSHYQG SRRRHARGSN SKKAGRGNAK GIQGRKIKKK PTPTNSWHNS SIPLGEGDLD 70 80 90 100 110 120 DVGADFNPGR AFISPKTIED YYFGRDAKSR SMKMGGLRPG NRYDSSTDLQ AGRAAFRKRP 130 140 150 160 170 180 MQFVKAKEVY DPSHNMIQKL RAKNETKNSE EIVEREADVF EEPGKMTSDV EYINNEDSEN 190 200 210 220 230 240 EDDDSQNSPS TDHSLSSNES KVEDGDLFFV DEEAQQSPDL TKIKRVCIEE IARPREVAIE 250 260 270 280 290 300 FDPILTIGKV ELSVSEGNES KEISVDVPNK GNKTYHPFAG YISNVLHGMH TSDSDNDELD 310 320 330 340 350 360 YEIETENNSE PLYESSASSE VDQGFNYVGQ RHNSRADNNL LPSPSPQLTE DIKCLSINGT 370 380 390 400 410 420 KTFEGNNDNL SSPASEELEF GFKEEDFVIN TNDIVVSNIR MGGVDNSYYL RCYRLLGDYD 430 440 450 460 470 480 FHWIDQDLLT DFVVDELGLP EDRLPAYLNF IKNSLIPKIE PAEPTYSDIP ISDSSDEGDS 490 500 510 520 530 540 YEGDSYEDDE DMASSVVHSD IEEGLDDLIA YTLKHDTERF KTFETKSLET KGKGKKKKLL 550 560 570 580 590 600 IDDALALDTE TLETLQSKFS KRIETKAKKR KAKEDFIDQE NRNSNDMLKK YPYGLHIQNI 610 620 630 640 650 660 KDEFESFLSR NNDRLTFPPL DPHGNKTVMK IAKHYNMKSS KIGKANHTSV VVEKIKKTKW 670 680 690 700 710 720 SSPNYSLIDQ LMRQRPVFMR IDIRRPREEQ AAFERTKTIR GKFHVKEGEI VGQNAPEIGN 730 740 750 760 ENIGRRMLEK LGWKSGEGLG IQGNKGISEP IFAKIKKNRS GLRHSES

References

[1]

"Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789." Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z., Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X., Jia P., Luedi P., Oefner P.J., David L. , Dietrich F.S., Li Y., Davis R.W., Steinmetz L.M. Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YJM789.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFW02000067 Genomic DNA. Translation: EDN62598.1.
3D structure databases
ProteinModelPortal	A6ZRL6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000467. G_patch_dom. [Graphical view]
Pfam	PF01585. G-patch. 1 hit. [Graphical view]
SMART	SM00443. G_patch. 1 hit. [Graphical view]
PROSITE	PS50174. G_PATCH. 1 hit. PS51061. R3H. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SQS1_YEAS7

Accession

Primary (citable) accession number: A6ZRL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	September 11, 2007
Last modified:	April 18, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program