A6ZMK5 (EIF3I_YEAS7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 3 subunit I
Short name=eIF3i

Alternative name(s):
Eukaryotic translation initiation factor 3 39 kDa subunit homolog
Short name=eIF-3 39 kDa subunit homolog

Gene names

Name:	TIF34
ORF Names:	SCY_4321

Organism

Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) [Complete proteome]

Taxonomic identifier

307796 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome By similarity. HAMAP-Rule MF_03008
Subunit structure	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex By similarity.
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_03008.
Sequence similarities	Belongs to the eIF-3 subunit I family. Contains 5 WD repeats.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Domain	Repeat WD repeat
Molecular function	Initiation factor
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	eukaryotic translation initiation factor 3 complex Inferred from electronic annotation. Source: InterPro
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Eukaryotic translation initiation factor 3 subunit I HAMAP-Rule MF_03008		PRO_0000366904
Regions
	Repeat	8 – 47	40	WD 1 HAMAP-Rule MF_03008
	Repeat	50 – 89	40	WD 2 HAMAP-Rule MF_03008
	Repeat	149 – 190	42	WD 3 HAMAP-Rule MF_03008
	Repeat	194 – 233	40	WD 4 HAMAP-Rule MF_03008
	Repeat	291 – 330	40	WD 5 HAMAP-Rule MF_03008
Amino acid modifications
	Modified residue	302	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6ZMK5 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: E6C0D0B275E87622	FASTA	347	38,755
	10 20 30 40 50 60 MKAIKLTGHE RPLTQVKYNK EGDLLFSCSK DSSASVWYSL NGERLGTLDG HTGTIWSIDV 70 80 90 100 110 120 DCFTKYCVTG SADYSIKLWD VSNGQCVATW KSPVPVKRVE FSPCGNYFLA ILDNVMKNPG 130 140 150 160 170 180 SINIYEIERD SATHELTKVS EEPIHKIITH EGLDAATVAG WSTKGKYIIA GHKDGKISKY 190 200 210 220 230 240 DVSNNYEYVD SIDLHEKSIS DMQFSPDLTY FITSSRDTNS FLVDVSTLQV LKKYETDCPL 250 260 270 280 290 300 NTAVITPLKE FIILGGGQEA KDVTTTSANE GKFEARFYHK IFEEEIGRVQ GHFGPLNTVA 310 320 330 340 ISPQGTSYAS GGEDGFIRLH HFEKSYFDFK YDVEKAAEAK EHMQEAN

References

[1]

"Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789." Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z., Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X., Jia P., Luedi P., Oefner P.J., David L. , Dietrich F.S., Li Y., Davis R.W., Steinmetz L.M. Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YJM789.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFW02000021 Genomic DNA. Translation: EDN64079.1.
3D structure databases
ProteinModelPortal	A6ZMK5.
SMR	A6ZMK5. Positions 1-342.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-7980995.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
HAMAP	MF_03008. eIF3i.
InterPro	IPR027525. eIF3i. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 4 hits. [Graphical view]
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EIF3I_YEAS7

Accession

Primary (citable) accession number: A6ZMK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 11, 2007
Last modified:	May 29, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program