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A6ZMK5

- EIF3I_YEAS7

UniProt

A6ZMK5 - EIF3I_YEAS7

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Protein
Eukaryotic translation initiation factor 3 subunit I
Gene
TIF34, SCY_4321
Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome By similarity.UniRule annotation

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
  2. regulation of translational initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit I
Short name:
eIF3i
Alternative name(s):
Eukaryotic translation initiation factor 3 39 kDa subunit homolog
Short name:
eIF-3 39 kDa subunit homolog
Gene namesi
Name:TIF34
ORF Names:SCY_4321
OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Taxonomic identifieri307796 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000007060: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
  2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Eukaryotic translation initiation factor 3 subunit IUniRule annotation
PRO_0000366904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei302 – 3021Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex By similarity.

Protein-protein interaction databases

IntActiA6ZMK5. 2 interactions.
MINTiMINT-7980995.

Structurei

3D structure databases

ProteinModelPortaliA6ZMK5.
SMRiA6ZMK5. Positions 1-342.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 4740WD 1UniRule annotation
Add
BLAST
Repeati50 – 8940WD 2UniRule annotation
Add
BLAST
Repeati149 – 19042WD 3UniRule annotation
Add
BLAST
Repeati194 – 23340WD 4UniRule annotation
Add
BLAST
Repeati291 – 33040WD 5UniRule annotation
Add
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit I family.
Contains 5 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

OrthoDBiEOG7Z95X9.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03008. eIF3i.
InterProiIPR027525. eIF3i.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6ZMK5-1 [UniParc]FASTAAdd to Basket

« Hide

MKAIKLTGHE RPLTQVKYNK EGDLLFSCSK DSSASVWYSL NGERLGTLDG    50
HTGTIWSIDV DCFTKYCVTG SADYSIKLWD VSNGQCVATW KSPVPVKRVE 100
FSPCGNYFLA ILDNVMKNPG SINIYEIERD SATHELTKVS EEPIHKIITH 150
EGLDAATVAG WSTKGKYIIA GHKDGKISKY DVSNNYEYVD SIDLHEKSIS 200
DMQFSPDLTY FITSSRDTNS FLVDVSTLQV LKKYETDCPL NTAVITPLKE 250
FIILGGGQEA KDVTTTSANE GKFEARFYHK IFEEEIGRVQ GHFGPLNTVA 300
ISPQGTSYAS GGEDGFIRLH HFEKSYFDFK YDVEKAAEAK EHMQEAN 347
Length:347
Mass (Da):38,755
Last modified:September 11, 2007 - v1
Checksum:iE6C0D0B275E87622
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFW02000021 Genomic DNA. Translation: EDN64079.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFW02000021 Genomic DNA. Translation: EDN64079.1 .

3D structure databases

ProteinModelPortali A6ZMK5.
SMRi A6ZMK5. Positions 1-342.
ModBasei Search...

Protein-protein interaction databases

IntActi A6ZMK5. 2 interactions.
MINTi MINT-7980995.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7Z95X9.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
HAMAPi MF_03008. eIF3i.
InterProi IPR027525. eIF3i.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 4 hits.
[Graphical view ]
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJM789.

Entry informationi

Entry nameiEIF3I_YEAS7
AccessioniPrimary (citable) accession number: A6ZMK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 11, 2007
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi