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A6ZME2

- YM084_YEAS7

UniProt

A6ZME2 - YM084_YEAS7

Protein

Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

SCY_4254

Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).By similarity

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-KW
    3. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00113; UER00528.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
    Short name:
    GFAT
    Alternative name(s):
    D-fructose-6-phosphate amidotransferase
    Hexosephosphate aminotransferase
    Gene namesi
    ORF Names:SCY_4254
    OrganismiSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)
    Taxonomic identifieri307796 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000007060: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 714714Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000377676Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA6ZME2.
    SMRiA6ZME2. Positions 347-702.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 321320Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd
    BLAST
    Domaini387 – 526140SIS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini559 – 704146SIS 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.PROSITE-ProRule annotation
    Contains 2 SIS domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    OrthoDBiEOG7034RG.

    Family and domain databases

    Gene3Di3.60.20.10. 2 hits.
    InterProiIPR017932. GATase_2_dom.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 2 hits.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6ZME2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIFGYCNF LIEKTRGEII DTLIEGLQAL EYKEYDSSGI SIQGDELKSL    50
    NIYKQTGKIS SLKEEIDLYN LNKNLPFISH CGIAHTRRAT HGGLRRANCH 100
    PHNSDPSNEF VVVHNGVITN FANLKALLVA KGYVFKSDTD TECIPKLYKH 150
    IYDTSIELGY NLDFHVLTNL VLKELEGSYG LLCTSSHFPD EVVAARKGSP 200
    LVIGVKGKTD MDVNFVEVEY LDQEEDYLKL NTQTKSSGNV LAAAPVKYNT 250
    CLRKSPPLRS QYLRNSTTST FNHGSSTETP AENGLPRPME FYLSSDCASL 300
    ARYVSKVVYL EDNDIAHIYD GELHIHCSKI GSEDFSFRTE LSKIKKGPYD 350
    NFMQKEIYEQ CETTKNVMRG RVDAFTNRVV LGGLENWLTE LRRAKRIIMI 400
    ASKASFHSCL AARPIFEELM EVPVNVELAL DFVDRNCCIF RNDVCIFVSR 450
    SGETTDTINA LNYCIKKEAV TIGVVNCSGS SISRFTHCGV HTNTGPEKGI 500
    ATTKSYTSQY IALVMIALWM SEDLVSKIER RKEIIQALTI VPSQIKEVLE 550
    LEPLIIELCD KKLKQHDTFL LLGRGYQFAS ALEGASKMKE ISYVHSESIL 600
    TNELGHRVLA VASDNPPIIA FATKDAFSPK IASCIDQIIE RKGNPIIICN 650
    KGHKIWEQDK QKGNVVTLEV PQTVDCLQGI LNVIPLQLIS YWLAIKKDIG 700
    VDLPRDSAMS APDI 714
    Length:714
    Mass (Da):79,816
    Last modified:September 11, 2007 - v1
    Checksum:i9E672D9EB22FE108
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFW02000020 Genomic DNA. Translation: EDN64472.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFW02000020 Genomic DNA. Translation: EDN64472.1 .

    3D structure databases

    ProteinModelPortali A6ZME2.
    SMRi A6ZME2. Positions 347-702.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7034RG.

    Enzyme and pathway databases

    UniPathwayi UPA00113 ; UER00528 .

    Family and domain databases

    Gene3Di 3.60.20.10. 2 hits.
    InterProi IPR017932. GATase_2_dom.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 2 hits.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YJM789.

    Entry informationi

    Entry nameiYM084_YEAS7
    AccessioniPrimary (citable) accession number: A6ZME2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3