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Protein

Protein FAM127A

Gene

FAM127A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM127A
Alternative name(s):
Mammalian retrotransposon derived protein 8C
Gene namesi
Name:FAM127A
Synonyms:CXX1, MAR8, MAR8C, MART8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:2569. FAM127A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385908.

Polymorphism and mutation databases

BioMutaiFAM127C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Protein FAM127APRO_0000311726Add
BLAST

Proteomic databases

EPDiA6ZKI3.
MaxQBiA6ZKI3.
PaxDbiA6ZKI3.
PeptideAtlasiA6ZKI3.
PRIDEiA6ZKI3.
TopDownProteomicsiA6ZKI3.

PTM databases

iPTMnetiA6ZKI3.
PhosphoSiteiA6ZKI3.

Expressioni

Gene expression databases

BgeeiA6ZKI3.
CleanExiHS_FAM127A.
GenevisibleiA6ZKI3. HS.

Organism-specific databases

HPAiHPA042173.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEG10Q86TG73EBI-10174072,EBI-2858265
UBQLN1Q9UMX03EBI-10174072,EBI-741480
UBQLN1Q9UMX0-23EBI-10174072,EBI-10173939

Protein-protein interaction databases

BioGridi114446. 21 interactions.
IntActiA6ZKI3. 8 interactions.
STRINGi9606.ENSP00000257013.

Structurei

3D structure databases

ProteinModelPortaliA6ZKI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM127 family.Curated

Phylogenomic databases

eggNOGiENOG410IXM4. Eukaryota.
ENOG41113F5. LUCA.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
OMAiTFLITRM.
OrthoDBiEOG722JBJ.
PhylomeDBiA6ZKI3.
TreeFamiTF337843.

Family and domain databases

InterProiIPR032549. DUF4939.
IPR032567. LDOC1-rel.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6ZKI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGRVQLIKA LLALPIRPAT RRWRNPIPFP ETFDGDTDRL PEFIVQTGSY
60 70 80 90 100
MFVDENTFSS DALKVTFLIT RLTGPALQWV IPYIKKESPL LNDYRGFLAE
110
MKRVFGWEED EDF
Length:113
Mass (Da):13,171
Last modified:August 21, 2007 - v1
Checksum:i104B1C2FB5E362EA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601S → N.
Corresponds to variant rs1056977 [ dbSNP | Ensembl ].
VAR_053975

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA. Translation: CAB87958.2.
BC002385 mRNA. Translation: AAH02385.4.
BC002410 mRNA. Translation: AAH02410.4.
CCDSiCCDS43997.1.
RefSeqiNP_001071639.1. NM_001078171.1.
UniGeneiHs.522789.

Genome annotation databases

EnsembliENST00000257013; ENSP00000257013; ENSG00000134590.
GeneIDi8933.
KEGGihsa:8933.
UCSCiuc004eyd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA. Translation: CAB87958.2.
BC002385 mRNA. Translation: AAH02385.4.
BC002410 mRNA. Translation: AAH02410.4.
CCDSiCCDS43997.1.
RefSeqiNP_001071639.1. NM_001078171.1.
UniGeneiHs.522789.

3D structure databases

ProteinModelPortaliA6ZKI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114446. 21 interactions.
IntActiA6ZKI3. 8 interactions.
STRINGi9606.ENSP00000257013.

PTM databases

iPTMnetiA6ZKI3.
PhosphoSiteiA6ZKI3.

Polymorphism and mutation databases

BioMutaiFAM127C.

Proteomic databases

EPDiA6ZKI3.
MaxQBiA6ZKI3.
PaxDbiA6ZKI3.
PeptideAtlasiA6ZKI3.
PRIDEiA6ZKI3.
TopDownProteomicsiA6ZKI3.

Protocols and materials databases

DNASUi8933.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257013; ENSP00000257013; ENSG00000134590.
GeneIDi8933.
KEGGihsa:8933.
UCSCiuc004eyd.4. human.

Organism-specific databases

CTDi8933.
GeneCardsiFAM127A.
HGNCiHGNC:2569. FAM127A.
HPAiHPA042173.
MIMi300213. gene.
neXtProtiNX_A6ZKI3.
PharmGKBiPA162385908.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXM4. Eukaryota.
ENOG41113F5. LUCA.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
OMAiTFLITRM.
OrthoDBiEOG722JBJ.
PhylomeDBiA6ZKI3.
TreeFamiTF337843.

Miscellaneous databases

ChiTaRSiFAM127A. human.
GeneWikiiFAM127A.
GenomeRNAii8933.
SOURCEiSearch...

Gene expression databases

BgeeiA6ZKI3.
CleanExiHS_FAM127A.
GenevisibleiA6ZKI3. HS.

Family and domain databases

InterProiIPR032549. DUF4939.
IPR032567. LDOC1-rel.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  3. "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes."
    Brandt J., Veith A.-M., Volff J.-N.
    Cytogenet. Genome Res. 110:307-317(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals."
    Brandt J., Schrauth S., Veith A.-M., Froschauer A., Haneke T., Schultheis C., Gessler M., Leimeister C., Volff J.-N.
    Gene 345:101-111(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF127A_HUMAN
AccessioniPrimary (citable) accession number: A6ZKI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 21, 2007
Last modified: July 6, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

There seems to be two proteins that can be transcribed from FAM127A, one with a C-terminal CAAX box (AC O15255) and a smaller protein (the sequence shown here) that seems to be encoded by a multicopy gene originating from a retrotransposon.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.