Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Trimeric intracellular cation channel type A

Gene

Tmem38a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Trimeric intracellular cation channel type A
Short name:
TRIC-A
Short name:
TRICA
Alternative name(s):
27 kDa sarcoplasmic reticulum protein
SPR-27
Transmembrane protein 38A
Gene namesi
Name:Tmem38aBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307901. Tmem38a.

Subcellular locationi

  • Sarcoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
  • Nucleus membrane By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151LumenalSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Topological domaini73 – 8513CytoplasmicSequence analysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Topological domaini107 – 14337CytoplasmicSequence analysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence analysisAdd
BLAST
Topological domaini165 – 20844LumenalSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST
Topological domaini230 – 29768CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Trimeric intracellular cation channel type APRO_0000309466Add
BLAST

Proteomic databases

PaxDbiA6ZIQ8.
PRIDEiA6ZIQ8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011912.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059284.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 1428His-richSequence analysis

Domaini

The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore (By similarity).By similarity

Sequence similaritiesi

Belongs to the TMEM38 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3944. Eukaryota.
ENOG410XQ0P. LUCA.
HOGENOMiHOG000037929.
HOVERGENiHBG059853.
InParanoidiA6ZIQ8.
PhylomeDBiA6ZIQ8.

Family and domain databases

InterProiIPR007866. TRIC_channel.
[Graphical view]
PANTHERiPTHR12454. PTHR12454. 1 hit.
PfamiPF05197. TRIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6ZIQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLISSLSLG ELALSFSRVP LFPVFDLSYF IVSIIYLKYE PGSVELSRRH
60 70 80 90 100
PVASWLCAML HCFGSYILAD LLLGEPIIDY FSNSSSILLA SGVWYLIFFC
110 120 130 140 150
PLDLFYKCVC FLPVKLIFVA MKEVVRVRKI AVGIHHAHHY HHGWFIMIAT
160 170 180 190 200
GWVKGSGVAL LSNLEQLLRG VWKPETNEIL HMSFPTKASL YGAILFTLQQ
210 220 230 240 250
TRWLPVSKAS LIFVFTMFMV SCKVFLTATH SHSSPFDVLE GYICPVLFGA
260 270 280 290
TWGGDHHHDN HGAPHGMGLG TQHSGLPAKA KEELSEGFRK KKTKKAD
Length:297
Mass (Da):33,276
Last modified:August 21, 2007 - v1
Checksum:iAEC3C1ED6542A12D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF690436 mRNA. Translation: ABR68564.1.
RefSeqiNP_001093645.1. NM_001100175.1.
UniGeneiRn.162265.

Genome annotation databases

GeneIDi306327.
KEGGirno:306327.
UCSCiRGD:1307901. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF690436 mRNA. Translation: ABR68564.1.
RefSeqiNP_001093645.1. NM_001100175.1.
UniGeneiRn.162265.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059284.

Proteomic databases

PaxDbiA6ZIQ8.
PRIDEiA6ZIQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi306327.
KEGGirno:306327.
UCSCiRGD:1307901. rat.

Organism-specific databases

CTDi79041.
RGDi1307901. Tmem38a.

Phylogenomic databases

eggNOGiKOG3944. Eukaryota.
ENOG410XQ0P. LUCA.
HOGENOMiHOG000037929.
HOVERGENiHBG059853.
InParanoidiA6ZIQ8.
PhylomeDBiA6ZIQ8.

Miscellaneous databases

PROiA6ZIQ8.

Gene expression databases

BgeeiENSRNOG00000011912.

Family and domain databases

InterProiIPR007866. TRIC_channel.
[Graphical view]
PANTHERiPTHR12454. PTHR12454. 1 hit.
PfamiPF05197. TRIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM38A_RAT
AccessioniPrimary (citable) accession number: A6ZIQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.