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Protein

Trimeric intracellular cation channel type A

Gene

Tmem38a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei122Phosphatidylinositol 4,5-bisphosphate (PIP2)By similarity1
Binding sitei126Phosphatidylinositol 4,5-bisphosphate (PIP2)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Trimeric intracellular cation channel type A
Short name:
TRIC-A
Short name:
TRICA
Alternative name(s):
27 kDa sarcoplasmic reticulum protein
SPR-27
Transmembrane protein 38A
Gene namesi
Name:Tmem38aBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307901. Tmem38a.

Subcellular locationi

  • Sarcoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
  • Nucleus membrane By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18LumenalCuratedAdd BLAST18
Transmembranei19 – 39Helical;Name=1Sequence analysisAdd BLAST21
Topological domaini40 – 51CytoplasmicCuratedAdd BLAST12
Transmembranei52 – 72Helical;Name=2Sequence analysisAdd BLAST21
Topological domaini73 – 85LumenalCuratedAdd BLAST13
Transmembranei86 – 106Helical;Name=3Sequence analysisAdd BLAST21
Topological domaini107 – 143CytoplasmicCuratedAdd BLAST37
Transmembranei144 – 164Helical;Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 177LumenalCuratedAdd BLAST13
Transmembranei178 – 198Helical;Name=5Sequence analysisAdd BLAST21
Topological domaini199 – 208CytoplasmicCurated10
Transmembranei209 – 229Helical;Name=6Sequence analysisAdd BLAST21
Topological domaini230 – 233LumenalCurated4
Transmembranei234 – 254Helical;Name=7Sequence analysisAdd BLAST21
Topological domaini255 – 297CytoplasmicCuratedAdd BLAST43

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Nucleus, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094661 – 297Trimeric intracellular cation channel type AAdd BLAST297

Proteomic databases

PaxDbiA6ZIQ8.
PRIDEiA6ZIQ8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011912.

Interactioni

Subunit structurei

Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059284.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi135 – 142His-richSequence analysis8

Sequence similaritiesi

Belongs to the TMEM38 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3944. Eukaryota.
ENOG410XQ0P. LUCA.
HOGENOMiHOG000037929.
HOVERGENiHBG059853.
InParanoidiA6ZIQ8.
PhylomeDBiA6ZIQ8.

Family and domain databases

InterProiView protein in InterPro
IPR007866. TRIC_channel.
PANTHERiPTHR12454. PTHR12454. 1 hit.
PfamiView protein in Pfam
PF05197. TRIC. 1 hit.

Sequencei

Sequence statusi: Complete.

A6ZIQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLISSLSLG ELALSFSRVP LFPVFDLSYF IVSIIYLKYE PGSVELSRRH
60 70 80 90 100
PVASWLCAML HCFGSYILAD LLLGEPIIDY FSNSSSILLA SGVWYLIFFC
110 120 130 140 150
PLDLFYKCVC FLPVKLIFVA MKEVVRVRKI AVGIHHAHHY HHGWFIMIAT
160 170 180 190 200
GWVKGSGVAL LSNLEQLLRG VWKPETNEIL HMSFPTKASL YGAILFTLQQ
210 220 230 240 250
TRWLPVSKAS LIFVFTMFMV SCKVFLTATH SHSSPFDVLE GYICPVLFGA
260 270 280 290
TWGGDHHHDN HGAPHGMGLG TQHSGLPAKA KEELSEGFRK KKTKKAD
Length:297
Mass (Da):33,276
Last modified:August 21, 2007 - v1
Checksum:iAEC3C1ED6542A12D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF690436 mRNA. Translation: ABR68564.1.
RefSeqiNP_001093645.1. NM_001100175.1.
UniGeneiRn.162265.

Genome annotation databases

GeneIDi306327.
KEGGirno:306327.
UCSCiRGD:1307901. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTM38A_RAT
AccessioniPrimary (citable) accession number: A6ZIQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 21, 2007
Last modified: July 5, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families