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Protein

Fructose-bisphosphate aldolase

Gene

Aldoa

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotationSAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi1), Glucose-6-phosphate isomerase (Gpi1), Glucose-6-phosphate isomerase (Gpi1)
  3. ATP-dependent 6-phosphofructokinase, liver type (Pfkl), ATP-dependent 6-phosphofructokinase (Pfkp), ATP-dependent 6-phosphofructokinase (Pfkm), ATP-dependent 6-phosphofructokinase, platelet type (Pfkp), ATP-dependent 6-phosphofructokinase, muscle type (Pfkm)
  4. Fructose-bisphosphate aldolase (Aldoart1), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoart2), Fructose-bisphosphate aldolase (Aldoart1), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldob), Fructose-bisphosphate aldolase C (Aldoc), Fructose-bisphosphate aldolase A (Aldoa), Fructose-bisphosphate aldolase B (Aldob), Fructose-bisphosphate aldolase (Aldob)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
Biological processGlycolysisUniRule annotationSAAS annotation
LigandSchiff baseSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolaseUniRule annotationSAAS annotation (EC:4.1.2.13UniRule annotationSAAS annotation)
Gene namesi
Name:AldoaImported
ORF Names:mCG_22383Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:87994 Aldoa

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_501456577530 – 418Fructose-bisphosphate aldolaseSequence analysisAdd BLAST389

Proteomic databases

TopDownProteomicsiA6ZI44

Expressioni

Gene expression databases

BgeeiENSMUSG00000030695

Interactioni

Protein-protein interaction databases

IntActiA6ZI44, 2 interactors

Family & Domainsi

Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
GeneTreeiENSGT00390000010235
HOVERGENiHBG002386
OMAiMILKPNM
OrthoDBiEOG091G0A9T
TreeFamiTF314203

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequencei

Sequence statusi: Complete.

A6ZI44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRRPDGSS FNMTRLSLAL AFSFPPVASE QPHSELGNTQ QQTELGKEST
60 70 80 90 100
ATGTMPHPYP ALTPEQKKEL SDIAHRIVAP GKGILAADES TGSIAKRLQS
110 120 130 140 150
IGTENTEENR RFYRQLLLTA DDRVNPCIGG VILFHETLYQ KADDGRPFPQ
160 170 180 190 200
VIKSKGGVVG IKVDKGVVPL AGTNGETTTQ GLDGLSERCA QYKKDGADFA
210 220 230 240 250
KWRCVLKIGE HTPSALAIME NANVLARYAS ICQQNGIVPI VEPEILPDGD
260 270 280 290 300
HDLKRCQYVT EKVLAAVYKA LSDHHVYLEG TLLKPNMVTP GHACTQKFSN
310 320 330 340 350
EEIAMATVTA LRRTVPPAVT GVTFLSGGQS EEEASINLNA INKCPLLKPW
360 370 380 390 400
ALTFSYGRAL QASALKAWGG KKENLKAAQE EYIKRALANS LACQGKYTPS
410
GQSGAAASES LFISNHAY
Length:418
Mass (Da):45,120
Last modified:August 21, 2007 - v1
Checksum:i945DC1228901AF1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124505 Genomic DNA No translation available.
EF662059 mRNA Translation: ABR58859.1
CH466531 Genomic DNA Translation: EDL17445.1
RefSeqiNP_001170778.1, NM_001177307.1
XP_006507272.1, XM_006507209.1
UniGeneiMm.275831

Genome annotation databases

EnsembliENSMUST00000087566; ENSMUSP00000084846; ENSMUSG00000030695
GeneIDi11674
UCSCiuc009jst.2 mouse

Similar proteinsi

Entry informationi

Entry nameiA6ZI44_MOUSE
AccessioniPrimary (citable) accession number: A6ZI44
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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