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Protein

Fructose-bisphosphate aldolase

Gene

Aldoa

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotationSAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi1), Glucose-6-phosphate isomerase (Gpi1), Glucose-6-phosphate isomerase (Gpi1)
  3. ATP-dependent 6-phosphofructokinase, liver type (Pfkl), ATP-dependent 6-phosphofructokinase (Pfkp), ATP-dependent 6-phosphofructokinase (Pfkm), ATP-dependent 6-phosphofructokinase, platelet type (Pfkp), ATP-dependent 6-phosphofructokinase, muscle type (Pfkm)
  4. Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoart1), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoart2), Fructose-bisphosphate aldolase (Aldoart1), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldob), Fructose-bisphosphate aldolase C (Aldoc), Fructose-bisphosphate aldolase A (Aldoa), Fructose-bisphosphate aldolase B (Aldob), Fructose-bisphosphate aldolase (Aldob)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolaseUniRule annotationSAAS annotation (EC:4.1.2.13UniRule annotationSAAS annotation)
Gene namesi
Name:AldoaImported
ORF Names:mCG_22383Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:87994. Aldoa.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 418389Fructose-bisphosphate aldolaseSequence analysisPRO_5007909652Add
BLAST

Proteomic databases

TopDownProteomicsiA6ZI44.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030695.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084846.

Family & Domainsi

Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
GeneTreeiENSGT00390000010235.
HOVERGENiHBG002386.
OMAiPNMVIDG.
OrthoDBiEOG091G0A9T.
TreeFamiTF314203.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6ZI44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRRPDGSS FNMTRLSLAL AFSFPPVASE QPHSELGNTQ QQTELGKEST
60 70 80 90 100
ATGTMPHPYP ALTPEQKKEL SDIAHRIVAP GKGILAADES TGSIAKRLQS
110 120 130 140 150
IGTENTEENR RFYRQLLLTA DDRVNPCIGG VILFHETLYQ KADDGRPFPQ
160 170 180 190 200
VIKSKGGVVG IKVDKGVVPL AGTNGETTTQ GLDGLSERCA QYKKDGADFA
210 220 230 240 250
KWRCVLKIGE HTPSALAIME NANVLARYAS ICQQNGIVPI VEPEILPDGD
260 270 280 290 300
HDLKRCQYVT EKVLAAVYKA LSDHHVYLEG TLLKPNMVTP GHACTQKFSN
310 320 330 340 350
EEIAMATVTA LRRTVPPAVT GVTFLSGGQS EEEASINLNA INKCPLLKPW
360 370 380 390 400
ALTFSYGRAL QASALKAWGG KKENLKAAQE EYIKRALANS LACQGKYTPS
410
GQSGAAASES LFISNHAY
Length:418
Mass (Da):45,120
Last modified:August 21, 2007 - v1
Checksum:i945DC1228901AF1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124505 Genomic DNA. No translation available.
EF662059 mRNA. Translation: ABR58859.1.
CH466531 Genomic DNA. Translation: EDL17445.1.
RefSeqiNP_001170778.1. NM_001177307.1.
XP_006507272.1. XM_006507209.1.
UniGeneiMm.275831.

Genome annotation databases

EnsembliENSMUST00000087566; ENSMUSP00000084846; ENSMUSG00000030695.
GeneIDi11674.
UCSCiuc009jst.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124505 Genomic DNA. No translation available.
EF662059 mRNA. Translation: ABR58859.1.
CH466531 Genomic DNA. Translation: EDL17445.1.
RefSeqiNP_001170778.1. NM_001177307.1.
XP_006507272.1. XM_006507209.1.
UniGeneiMm.275831.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084846.

Proteomic databases

TopDownProteomicsiA6ZI44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087566; ENSMUSP00000084846; ENSMUSG00000030695.
GeneIDi11674.
UCSCiuc009jst.2. mouse.

Organism-specific databases

CTDi226.
MGIiMGI:87994. Aldoa.

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
GeneTreeiENSGT00390000010235.
HOVERGENiHBG002386.
OMAiPNMVIDG.
OrthoDBiEOG091G0A9T.
TreeFamiTF314203.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Miscellaneous databases

ChiTaRSiAldoa. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030695.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA6ZI44_MOUSE
AccessioniPrimary (citable) accession number: A6ZI44
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.