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Protein

Cytochrome b

Gene

CYTB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.UniRule annotation

Cofactori

hemeUniRule annotationNote: Binds 2 heme groups non-covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome bUniRule annotation
Gene namesi
Name:CYTBImported
Encoded oniMitochondrionImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5627HelicalUniRule annotationAdd
BLAST
Transmembranei77 – 9822HelicalUniRule annotationAdd
BLAST
Transmembranei113 – 13321HelicalUniRule annotationAdd
BLAST
Transmembranei140 – 15819HelicalUniRule annotationAdd
BLAST
Transmembranei178 – 20023HelicalUniRule annotationAdd
BLAST
Transmembranei229 – 24618HelicalUniRule annotationAdd
BLAST
Transmembranei288 – 30821HelicalUniRule annotationAdd
BLAST
Transmembranei320 – 33920HelicalUniRule annotationAdd
BLAST
Transmembranei345 – 37228HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

PTM / Processingi

Proteomic databases

PeptideAtlasiA6YVI1.

Expressioni

Gene expression databases

BgeeiENSG00000198727.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354554.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 209209CYTB_NTERInterPro annotationAdd
BLAST
Domaini210 – 378169CYTB_CTERInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytochrome b family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG4663. Eukaryota.
COG1290. LUCA.
HOVERGENiHBG017694.

Family and domain databases

CDDicd00284. Cytochrome_b_N. 1 hit.
Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR030689. Cytochrome_b.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF00033. Cytochrome_B. 1 hit.
[Graphical view]
PIRSFiPIRSF038885. COB. 1 hit.
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6YVI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPMRKTNPL MKLINHSFID LPTPSNISAW WNFGSLLGAC LILQITTGLF
60 70 80 90 100
LAMHYSPDAS TAFSSIAHIT RDVNYGWIIR YLHANGASMF FICLFLHIGR
110 120 130 140 150
GLYYGSFLYS ETWNIGIILL LATMATAFMG YVLPWGQMSF WGATVITNLL
160 170 180 190 200
SAIPYIGTDL VQWIWGGYSV DSPTLTRFFT FHFILPFIIA ALATLHLLFL
210 220 230 240 250
HETGSNNPLG ITSHSDKITF HPYYTIKDAL GLLLFLLSLM TLTLFSPDLL
260 270 280 290 300
GDPDNYTLAN PLNTPPHIKP EWYFLFAYTI LRSVPNKLGG VLALLLSILI
310 320 330 340 350
LAMIPILHMS KQQSMMFRPL SQSLYWLLAA DLLILTWIGG QPVSYPFTII
360 370
GQVASVLYFT TILILMPTIS LIENKMLK
Length:378
Mass (Da):42,460
Last modified:August 21, 2007 - v1
Checksum:i720C262E54980879
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF657287 Genomic DNA. Translation: ABR93711.1.
EF657438 Genomic DNA. Translation: ABR95669.1.
EF657500 Genomic DNA. Translation: ABR96473.1.
EF657579 Genomic DNA. Translation: ABR97498.1.
EF657648 Genomic DNA. Translation: ABR98394.1.
EF657704 Genomic DNA. Translation: ABR99121.1.
EF657705 Genomic DNA. Translation: ABR99134.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF657287 Genomic DNA. Translation: ABR93711.1.
EF657438 Genomic DNA. Translation: ABR95669.1.
EF657500 Genomic DNA. Translation: ABR96473.1.
EF657579 Genomic DNA. Translation: ABR97498.1.
EF657648 Genomic DNA. Translation: ABR98394.1.
EF657704 Genomic DNA. Translation: ABR99121.1.
EF657705 Genomic DNA. Translation: ABR99134.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354554.

Proteomic databases

PeptideAtlasiA6YVI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4663. Eukaryota.
COG1290. LUCA.
HOVERGENiHBG017694.

Gene expression databases

BgeeiENSG00000198727.

Family and domain databases

CDDicd00284. Cytochrome_b_N. 1 hit.
Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR030689. Cytochrome_b.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF00033. Cytochrome_B. 1 hit.
[Graphical view]
PIRSFiPIRSF038885. COB. 1 hit.
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA6YVI1_HUMAN
AccessioniPrimary (citable) accession number: A6YVI1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.