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A6YVI1

- A6YVI1_HUMAN

UniProt

A6YVI1 - A6YVI1_HUMAN

Protein

Cytochrome b

Gene

CYTB

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.UniRule annotation

    Cofactori

    Binds 2 heme groups non-covalently.UniRule annotation

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW
    3. oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. respiratory electron transport chain Source: InterPro

    Keywords - Biological processi

    Electron transport, Respiratory chainUniRule annotation, Transport

    Keywords - Ligandi

    HemeUniRule annotation, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome bUniRule annotation
    Gene namesi
    Name:CYTBImported
    Encoded oniMitochondrionImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrion Source: UniProtKB-KW
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, MitochondrionUniRule annotationImported

    Expressioni

    Gene expression databases

    BgeeiA6YVI1.

    Structurei

    3D structure databases

    ProteinModelPortaliA6YVI1.
    SMRiA6YVI1. Positions 1-378.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome b family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG017694.

    Family and domain databases

    Gene3Di1.20.810.10. 1 hit.
    InterProiIPR005798. Cyt_b/b6_C.
    IPR005797. Cyt_b/b6_N.
    IPR027387. Cytb/b6-like.
    IPR016174. Di-haem_cyt_TM.
    [Graphical view]
    PfamiPF00032. Cytochrom_B_C. 1 hit.
    PF13631. Cytochrom_B_N_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF81342. SSF81342. 1 hit.
    SSF81648. SSF81648. 1 hit.
    PROSITEiPS51003. CYTB_CTER. 1 hit.
    PS51002. CYTB_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6YVI1-1 [UniParc]FASTAAdd to Basket

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    MTPMRKTNPL MKLINHSFID LPTPSNISAW WNFGSLLGAC LILQITTGLF    50
    LAMHYSPDAS TAFSSIAHIT RDVNYGWIIR YLHANGASMF FICLFLHIGR 100
    GLYYGSFLYS ETWNIGIILL LATMATAFMG YVLPWGQMSF WGATVITNLL 150
    SAIPYIGTDL VQWIWGGYSV DSPTLTRFFT FHFILPFIIA ALATLHLLFL 200
    HETGSNNPLG ITSHSDKITF HPYYTIKDAL GLLLFLLSLM TLTLFSPDLL 250
    GDPDNYTLAN PLNTPPHIKP EWYFLFAYTI LRSVPNKLGG VLALLLSILI 300
    LAMIPILHMS KQQSMMFRPL SQSLYWLLAA DLLILTWIGG QPVSYPFTII 350
    GQVASVLYFT TILILMPTIS LIENKMLK 378
    Length:378
    Mass (Da):42,460
    Last modified:August 21, 2007 - v1
    Checksum:i720C262E54980879
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF657287 Genomic DNA. Translation: ABR93711.1.
    EF657438 Genomic DNA. Translation: ABR95669.1.
    EF657500 Genomic DNA. Translation: ABR96473.1.
    EF657579 Genomic DNA. Translation: ABR97498.1.
    EF657648 Genomic DNA. Translation: ABR98394.1.
    EF657704 Genomic DNA. Translation: ABR99121.1.
    EF657705 Genomic DNA. Translation: ABR99134.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF657287 Genomic DNA. Translation: ABR93711.1 .
    EF657438 Genomic DNA. Translation: ABR95669.1 .
    EF657500 Genomic DNA. Translation: ABR96473.1 .
    EF657579 Genomic DNA. Translation: ABR97498.1 .
    EF657648 Genomic DNA. Translation: ABR98394.1 .
    EF657704 Genomic DNA. Translation: ABR99121.1 .
    EF657705 Genomic DNA. Translation: ABR99134.1 .

    3D structure databases

    ProteinModelPortali A6YVI1.
    SMRi A6YVI1. Positions 1-378.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG017694.

    Miscellaneous databases

    NextBioi 35462946.

    Gene expression databases

    Bgeei A6YVI1.

    Family and domain databases

    Gene3Di 1.20.810.10. 1 hit.
    InterProi IPR005798. Cyt_b/b6_C.
    IPR005797. Cyt_b/b6_N.
    IPR027387. Cytb/b6-like.
    IPR016174. Di-haem_cyt_TM.
    [Graphical view ]
    Pfami PF00032. Cytochrom_B_C. 1 hit.
    PF13631. Cytochrom_B_N_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81342. SSF81342. 1 hit.
    SSF81648. SSF81648. 1 hit.
    PROSITEi PS51003. CYTB_CTER. 1 hit.
    PS51002. CYTB_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups."
      Herrnstadt C., Elson J.L., Fahy E., Preston G., Turnbull D.M., Anderson C., Ghosh S.S., Olefsky J.M., Beal M.F., Davis R.E., Howell N.
      Am. J. Hum. Genet. 70:1152-1171(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MTDNA15Imported, MTDNA286Imported, MTDNA341Imported, MTDNA412Imported, MTDNA475Imported, MTDNA525Imported and MTDNA526Imported.
    2. Herrnstadt C., Fahy E., Preston G., Anderson C., Ghosh S.S., Davis R.E., Howell N.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MTDNA15Imported, MTDNA286Imported, MTDNA341Imported, MTDNA412Imported, MTDNA475Imported, MTDNA525Imported and MTDNA526Imported.
    3. HmtDB
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MTDNA15Imported, MTDNA286Imported, MTDNA341Imported, MTDNA412Imported, MTDNA475Imported, MTDNA525Imported and MTDNA526Imported.

    Entry informationi

    Entry nameiA6YVI1_HUMAN
    AccessioniPrimary (citable) accession number: A6YVI1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.