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A6YVI1

- A6YVI1_HUMAN

UniProt

A6YVI1 - A6YVI1_HUMAN

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Protein

Cytochrome b

Gene

CYTB

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.UniRule annotation

Cofactori

Binds 2 heme groups non-covalently.UniRule annotation

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: InterPro

GO - Biological processi

  1. respiratory electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome bUniRule annotation
Gene namesi
Name:CYTBImported
Encoded oniMitochondrionImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

Expressioni

Gene expression databases

BgeeiA6YVI1.
ExpressionAtlasiA6YVI1. baseline.

Structurei

3D structure databases

ProteinModelPortaliA6YVI1.
SMRiA6YVI1. Positions 1-378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

HOVERGENiHBG017694.

Family and domain databases

Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6YVI1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPMRKTNPL MKLINHSFID LPTPSNISAW WNFGSLLGAC LILQITTGLF
60 70 80 90 100
LAMHYSPDAS TAFSSIAHIT RDVNYGWIIR YLHANGASMF FICLFLHIGR
110 120 130 140 150
GLYYGSFLYS ETWNIGIILL LATMATAFMG YVLPWGQMSF WGATVITNLL
160 170 180 190 200
SAIPYIGTDL VQWIWGGYSV DSPTLTRFFT FHFILPFIIA ALATLHLLFL
210 220 230 240 250
HETGSNNPLG ITSHSDKITF HPYYTIKDAL GLLLFLLSLM TLTLFSPDLL
260 270 280 290 300
GDPDNYTLAN PLNTPPHIKP EWYFLFAYTI LRSVPNKLGG VLALLLSILI
310 320 330 340 350
LAMIPILHMS KQQSMMFRPL SQSLYWLLAA DLLILTWIGG QPVSYPFTII
360 370
GQVASVLYFT TILILMPTIS LIENKMLK
Length:378
Mass (Da):42,460
Last modified:August 21, 2007 - v1
Checksum:i720C262E54980879
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF657287 Genomic DNA. Translation: ABR93711.1.
EF657438 Genomic DNA. Translation: ABR95669.1.
EF657500 Genomic DNA. Translation: ABR96473.1.
EF657579 Genomic DNA. Translation: ABR97498.1.
EF657648 Genomic DNA. Translation: ABR98394.1.
EF657704 Genomic DNA. Translation: ABR99121.1.
EF657705 Genomic DNA. Translation: ABR99134.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF657287 Genomic DNA. Translation: ABR93711.1 .
EF657438 Genomic DNA. Translation: ABR95669.1 .
EF657500 Genomic DNA. Translation: ABR96473.1 .
EF657579 Genomic DNA. Translation: ABR97498.1 .
EF657648 Genomic DNA. Translation: ABR98394.1 .
EF657704 Genomic DNA. Translation: ABR99121.1 .
EF657705 Genomic DNA. Translation: ABR99134.1 .

3D structure databases

ProteinModelPortali A6YVI1.
SMRi A6YVI1. Positions 1-378.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG017694.

Miscellaneous databases

NextBioi 35462946.

Gene expression databases

Bgeei A6YVI1.
ExpressionAtlasi A6YVI1. baseline.

Family and domain databases

Gene3Di 1.20.810.10. 1 hit.
InterProi IPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR016174. Di-haem_cyt_TM.
[Graphical view ]
Pfami PF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view ]
SUPFAMi SSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEi PS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups."
    Herrnstadt C., Elson J.L., Fahy E., Preston G., Turnbull D.M., Anderson C., Ghosh S.S., Olefsky J.M., Beal M.F., Davis R.E., Howell N.
    Am. J. Hum. Genet. 70:1152-1171(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MTDNA15Imported, MTDNA286Imported, MTDNA341Imported, MTDNA412Imported, MTDNA475Imported, MTDNA525Imported and MTDNA526Imported.
  2. Herrnstadt C., Fahy E., Preston G., Anderson C., Ghosh S.S., Davis R.E., Howell N.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MTDNA15Imported, MTDNA286Imported, MTDNA341Imported, MTDNA412Imported, MTDNA475Imported, MTDNA525Imported and MTDNA526Imported.
  3. HmtDB
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MTDNA15Imported, MTDNA286Imported, MTDNA341Imported, MTDNA412Imported, MTDNA475Imported, MTDNA525Imported and MTDNA526Imported.

Entry informationi

Entry nameiA6YVI1_HUMAN
AccessioniPrimary (citable) accession number: A6YVI1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.