A6YRY8 (RSSA_SHEEP) Reviewed, UniProtKB/Swiss-Prot
Last modified March 19, 2014. Version 36. History...
Names and origin
|Protein names||Recommended name:|
40S ribosomal protein SA
37 kDa laminin receptor precursor
37/67 kDa laminin receptor
67 kDa laminin receptor
Laminin receptor 1
Laminin-binding protein precursor p40
|Organism||Ovis aries (Sheep) [Complete proteome]|
|Taxonomic identifier||9940 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis|
|Sequence length||295 AA.|
|Sequence processing||The displayed sequence is further processed into a mature form.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA By similarity. HAMAP-Rule MF_03016
Monomer (37LRP) and homodimer (67LR) By similarity. Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21 By similarity. Interacts with several laminins including at least LAMB1 By similarity. Interacts with MDK By similarity. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B By similarity. HAMAP-Rule MF_03016
Cell membrane By similarity. Cytoplasm By similarity. Nucleus By similarity. Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane By similarity. HAMAP-Rule MF_03016
Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association By similarity. HAMAP-Rule MF_03016
Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions By similarity. HAMAP-Rule MF_03016
This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.
Belongs to the ribosomal protein S2P family.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Initiator methionine||1||1||Removed By similarity|
|Chain||2 – 295||294||40S ribosomal protein SA HAMAP-Rule MF_03016||PRO_0000319321|
|Repeat||230 – 232||3||[DE]-W-[ST] 1 HAMAP-Rule MF_03016|
|Repeat||247 – 249||3||[DE]-W-[ST] 2 HAMAP-Rule MF_03016|
|Repeat||266 – 268||3||[DE]-W-[ST] 3 HAMAP-Rule MF_03016|
|Repeat||275 – 277||3||[DE]-W-[ST] 4 HAMAP-Rule MF_03016|
|Region||54 – 113||60||Interaction with PPP1R16B By similarity|
|Region||161 – 180||20||Laminin-binding By similarity|
|Region||205 – 229||25||Laminin-binding By similarity|
|Region||242 – 295||54||Laminin-binding By similarity|
|Site||115 – 116||2||Cleavage; by ST3; site 1 By similarity|
|Site||133 – 134||2||Cleavage; by ST3; site 2 By similarity|
Amino acid modifications
|Modified residue||2||1||N-acetylserine By similarity|
|Modified residue||52||1||N6-acetyllysine By similarity|
|Modified residue||89||1||N6-acetyllysine By similarity|
|Modified residue||139||1||Phosphotyrosine By similarity|
|||"Cloning and sequence analysis of Ovis aries laminin receptor 1."|
Qiao J., Zhao D., Li Y.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
|||"Structural and functional analysis of the ovine laminin receptor gene (RPSA): Possible involvement of the LRP/LR protein in scrapie response."|
Marcos-Carcavilla A., Calvo J.H., Gonzalez C., Serrano C., Moazami-Goudarzi K., Laurent P., Bertaud M., Hayes H., Beattie A.E., Lyahyai J., Martin-Burriel I., Torres J.M., Serrano M.
Mamm. Genome 19:92-105(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-250.
|EF649775 mRNA. Translation: ABR57322.1.|
EF222474 mRNA. Translation: ABQ42346.1.
|RefSeq||NP_001098733.1. NM_001105263.1. |
3D structure databases
|SMR||A6YRY8. Positions 9-205. |
Protocols and materials databases
Genome annotation databases
Family and domain databases
|HAMAP||MF_03015. Ribosomal_S2_euk. |
|InterPro||IPR027504. 40S_ribosomal_SA. |
|PANTHER||PTHR11489. PTHR11489. 1 hit. |
|Pfam||PF00318. Ribosomal_S2. 1 hit. |
|PRINTS||PR00395. RIBOSOMALS2. |
|SUPFAM||SSF52313. SSF52313. 1 hit. |
|TIGRFAMs||TIGR01012. Sa_S2_E_A. 1 hit. |
|PROSITE||PS00962. RIBOSOMAL_S2_1. 1 hit. |
PS00963. RIBOSOMAL_S2_2. 1 hit.
|Accession||Primary (citable) accession number: A6YRY8|
Secondary accession number(s): B0L420
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|