Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A6YRY8 (RSSA_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
40S ribosomal protein SA
Alternative name(s):
37 kDa laminin receptor precursor
Short name=37LRP
37/67 kDa laminin receptor
Short name=LRP/LR
67 kDa laminin receptor
Short name=67LR
Laminin receptor 1
Short name=LamR
Laminin-binding protein precursor p40
Short name=LBP/p40
Gene names
Name:RPSA
Synonyms:LAMR1
OrganismOvis aries (Sheep) [Reference proteome]
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA By similarity. HAMAP-Rule MF_03016

Subunit structure

Monomer (37LRP) and homodimer (67LR) By similarity. Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21 By similarity. Interacts with several laminins including at least LAMB1 By similarity. Interacts with MDK By similarity. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B By similarity. HAMAP-Rule MF_03016

Subcellular location

Cell membrane By similarity. Cytoplasm By similarity. Nucleus By similarity. Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane By similarity. HAMAP-Rule MF_03016

Post-translational modification

Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association By similarity. HAMAP-Rule MF_03016

Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions By similarity. HAMAP-Rule MF_03016

Miscellaneous

This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.

Sequence similarities

Belongs to the ribosomal protein S2P family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 29529440S ribosomal protein SA HAMAP-Rule MF_03016
PRO_0000319321

Regions

Repeat230 – 2323[DE]-W-[ST] 1 HAMAP-Rule MF_03016
Repeat247 – 2493[DE]-W-[ST] 2 HAMAP-Rule MF_03016
Repeat266 – 2683[DE]-W-[ST] 3 HAMAP-Rule MF_03016
Repeat275 – 2773[DE]-W-[ST] 4 HAMAP-Rule MF_03016
Region54 – 11360Interaction with PPP1R16B By similarity
Region161 – 18020Laminin-binding By similarity
Region205 – 22925Laminin-binding By similarity
Region242 – 29554Laminin-binding By similarity

Sites

Site115 – 1162Cleavage; by ST3; site 1 By similarity
Site133 – 1342Cleavage; by ST3; site 2 By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue891N6-acetyllysine By similarity
Modified residue1391Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
A6YRY8 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: C6F8AF91A7458D2B

FASTA29532,885
        10         20         30         40         50         60 
MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN LKRTWEKLLL 

        70         80         90        100        110        120 
AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA GRFTPGTFTN QIQAAFREPR 

       130        140        150        160        170        180 
LLVVTDPRAD HQPLTEASYV NLPTIALCNT DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR 

       190        200        210        220        230        240 
EVLRMRGTIS REHPWEVMPD LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPAPEFTA 

       250        260        270        280        290 
AQPEVADWSE GVQVPSVPIQ QFPTEDWSAR PFTEDWSAAP TAQATEWVGT TSELS 

« Hide

References

[1]"Cloning and sequence analysis of Ovis aries laminin receptor 1."
Qiao J., Zhao D., Li Y.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structural and functional analysis of the ovine laminin receptor gene (RPSA): Possible involvement of the LRP/LR protein in scrapie response."
Marcos-Carcavilla A., Calvo J.H., Gonzalez C., Serrano C., Moazami-Goudarzi K., Laurent P., Bertaud M., Hayes H., Beattie A.E., Lyahyai J., Martin-Burriel I., Torres J.M., Serrano M.
Mamm. Genome 19:92-105(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-250.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF649775 mRNA. Translation: ABR57322.1.
EF222474 mRNA. Translation: ABQ42346.1.
RefSeqNP_001098733.1. NM_001105263.1.
UniGeneOar.22928.

3D structure databases

ProteinModelPortalA6YRY8.
SMRA6YRY8. Positions 9-205.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100125628.

Phylogenomic databases

HOVERGENHBG054466.

Family and domain databases

HAMAPMF_03015. Ribosomal_S2_euk.
MF_03016. Ribosomal_S2_laminin_receptor.
InterProIPR027504. 40S_ribosomal_SA.
IPR001865. Ribosomal_S2.
IPR018130. Ribosomal_S2_CS.
IPR027498. Ribosomal_S2_euk.
IPR005707. Ribosomal_S2_euk/arc.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view]
PANTHERPTHR11489. PTHR11489. 1 hit.
PfamPF00318. Ribosomal_S2. 1 hit.
[Graphical view]
PRINTSPR00395. RIBOSOMALS2.
SUPFAMSSF52313. SSF52313. 1 hit.
TIGRFAMsTIGR01012. Sa_S2_E_A. 1 hit.
PROSITEPS00962. RIBOSOMAL_S2_1. 1 hit.
PS00963. RIBOSOMAL_S2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRSSA_SHEEP
AccessionPrimary (citable) accession number: A6YRY8
Secondary accession number(s): B0L420
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries