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A6YRY8

- RSSA_SHEEP

UniProt

A6YRY8 - RSSA_SHEEP

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Protein
40S ribosomal protein SA
Gene
RPSA, LAMR1
Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei115 – 1162Cleavage; by ST3; site 1 By similarity
Sitei133 – 1342Cleavage; by ST3; site 2 By similarity

GO - Molecular functioni

  1. laminin receptor activity Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell adhesion Source: UniProtKB-HAMAP
  2. ribosomal small subunit assembly Source: UniProtKB-HAMAP
  3. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Receptor, Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein SA
Alternative name(s):
37 kDa laminin receptor precursor
Short name:
37LRP
37/67 kDa laminin receptor
Short name:
LRP/LR
67 kDa laminin receptor
Short name:
67LR
Laminin receptor 1
Short name:
LamR
Laminin-binding protein precursor p40
Short name:
LBP/p40
Gene namesi
Name:RPSA
Synonyms:LAMR1
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Unplaced

Subcellular locationi

Cell membrane By similarity. Cytoplasm By similarity. Nucleus By similarity
Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosolic small ribosomal subunit Source: UniProtKB-HAMAP
  3. nucleus Source: UniProtKB-SubCell
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 29529440S ribosomal protein SAUniRule annotation
PRO_0000319321Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei89 – 891N6-acetyllysine By similarity
Modified residuei139 – 1391Phosphotyrosine By similarity

Post-translational modificationi

Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association By similarity.UniRule annotation
Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions By similarity.UniRule annotation

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Monomer (37LRP) and homodimer (67LR) By similarity. Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21 By similarity. Interacts with several laminins including at least LAMB1 By similarity. Interacts with MDK By similarity. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA6YRY8.
SMRiA6YRY8. Positions 9-205.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati230 – 2323[DE]-W-[ST] 1UniRule annotation
Repeati247 – 2493[DE]-W-[ST] 2UniRule annotation
Repeati266 – 2683[DE]-W-[ST] 3UniRule annotation
Repeati275 – 2773[DE]-W-[ST] 4UniRule annotation

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 11360Interaction with PPP1R16B By similarity
Add
BLAST
Regioni161 – 18020Laminin-binding By similarity
Add
BLAST
Regioni205 – 22925Laminin-binding By similarity
Add
BLAST
Regioni242 – 29554Laminin-binding By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG054466.

Family and domain databases

HAMAPiMF_03015. Ribosomal_S2_euk.
MF_03016. Ribosomal_S2_laminin_receptor.
InterProiIPR027504. 40S_ribosomal_SA.
IPR001865. Ribosomal_S2.
IPR018130. Ribosomal_S2_CS.
IPR027498. Ribosomal_S2_euk.
IPR005707. Ribosomal_S2_euk/arc.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view]
PANTHERiPTHR11489. PTHR11489. 1 hit.
PfamiPF00318. Ribosomal_S2. 1 hit.
[Graphical view]
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
TIGRFAMsiTIGR01012. Sa_S2_E_A. 1 hit.
PROSITEiPS00962. RIBOSOMAL_S2_1. 1 hit.
PS00963. RIBOSOMAL_S2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6YRY8-1 [UniParc]FASTAAdd to Basket

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MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN    50
LKRTWEKLLL AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA 100
GRFTPGTFTN QIQAAFREPR LLVVTDPRAD HQPLTEASYV NLPTIALCNT 150
DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR EVLRMRGTIS REHPWEVMPD 200
LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPAPEFTA AQPEVADWSE 250
GVQVPSVPIQ QFPTEDWSAR PFTEDWSAAP TAQATEWVGT TSELS 295
Length:295
Mass (Da):32,885
Last modified:August 21, 2007 - v1
Checksum:iC6F8AF91A7458D2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF649775 mRNA. Translation: ABR57322.1.
EF222474 mRNA. Translation: ABQ42346.1.
RefSeqiNP_001098733.1. NM_001105263.1.
UniGeneiOar.22928.

Genome annotation databases

GeneIDi100125628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF649775 mRNA. Translation: ABR57322.1 .
EF222474 mRNA. Translation: ABQ42346.1 .
RefSeqi NP_001098733.1. NM_001105263.1.
UniGenei Oar.22928.

3D structure databases

ProteinModelPortali A6YRY8.
SMRi A6YRY8. Positions 9-205.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100125628.

Phylogenomic databases

HOVERGENi HBG054466.

Family and domain databases

HAMAPi MF_03015. Ribosomal_S2_euk.
MF_03016. Ribosomal_S2_laminin_receptor.
InterProi IPR027504. 40S_ribosomal_SA.
IPR001865. Ribosomal_S2.
IPR018130. Ribosomal_S2_CS.
IPR027498. Ribosomal_S2_euk.
IPR005707. Ribosomal_S2_euk/arc.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view ]
PANTHERi PTHR11489. PTHR11489. 1 hit.
Pfami PF00318. Ribosomal_S2. 1 hit.
[Graphical view ]
PRINTSi PR00395. RIBOSOMALS2.
SUPFAMi SSF52313. SSF52313. 1 hit.
TIGRFAMsi TIGR01012. Sa_S2_E_A. 1 hit.
PROSITEi PS00962. RIBOSOMAL_S2_1. 1 hit.
PS00963. RIBOSOMAL_S2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence analysis of Ovis aries laminin receptor 1."
    Qiao J., Zhao D., Li Y.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structural and functional analysis of the ovine laminin receptor gene (RPSA): Possible involvement of the LRP/LR protein in scrapie response."
    Marcos-Carcavilla A., Calvo J.H., Gonzalez C., Serrano C., Moazami-Goudarzi K., Laurent P., Bertaud M., Hayes H., Beattie A.E., Lyahyai J., Martin-Burriel I., Torres J.M., Serrano M.
    Mamm. Genome 19:92-105(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-250.

Entry informationi

Entry nameiRSSA_SHEEP
AccessioniPrimary (citable) accession number: A6YRY8
Secondary accession number(s): B0L420
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi