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A6YRY8

- RSSA_SHEEP

UniProt

A6YRY8 - RSSA_SHEEP

Protein

40S ribosomal protein SA

Gene

RPSA

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei115 – 1162Cleavage; by ST3; site 1UniRule annotation
    Sitei133 – 1342Cleavage; by ST3; site 2UniRule annotation

    GO - Molecular functioni

    1. laminin receptor activity Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-HAMAP
    2. ribosomal small subunit assembly Source: UniProtKB-HAMAP
    3. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Receptor, Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein SAUniRule annotation
    Alternative name(s):
    37 kDa laminin receptor precursorUniRule annotation
    Short name:
    37LRPUniRule annotation
    37/67 kDa laminin receptorUniRule annotation
    Short name:
    LRP/LRUniRule annotation
    67 kDa laminin receptorUniRule annotation
    Short name:
    67LRUniRule annotation
    Laminin receptor 1UniRule annotation
    Short name:
    LamRUniRule annotation
    Laminin-binding protein precursor p40UniRule annotation
    Short name:
    LBP/p40UniRule annotation
    Gene namesi
    Name:RPSAUniRule annotation
    Synonyms:LAMR1
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    Cell membrane UniRule annotation. Cytoplasm UniRule annotation. Nucleus UniRule annotation
    Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosolic small ribosomal subunit Source: UniProtKB-HAMAP
    3. nucleus Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 29529440S ribosomal protein SAPRO_0000319321Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineUniRule annotation
    Modified residuei89 – 891N6-acetyllysineBy similarity
    Modified residuei139 – 1391PhosphotyrosineBy similarity

    Post-translational modificationi

    Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.UniRule annotation
    Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.UniRule annotation

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Interactioni

    Subunit structurei

    Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliA6YRY8.
    SMRiA6YRY8. Positions 9-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati230 – 2323[DE]-W-[ST] 1
    Repeati247 – 2493[DE]-W-[ST] 2
    Repeati266 – 2683[DE]-W-[ST] 3
    Repeati275 – 2773[DE]-W-[ST] 4

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni54 – 11360Interaction with PPP1R16BUniRule annotationAdd
    BLAST
    Regioni161 – 18020Laminin-bindingUniRule annotationAdd
    BLAST
    Regioni205 – 22925Laminin-bindingUniRule annotationAdd
    BLAST
    Regioni242 – 29554Laminin-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ribosomal protein S2P family.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG054466.

    Family and domain databases

    HAMAPiMF_03015. Ribosomal_S2_euk.
    MF_03016. Ribosomal_S2_laminin_receptor.
    InterProiIPR027504. 40S_ribosomal_SA.
    IPR001865. Ribosomal_S2.
    IPR018130. Ribosomal_S2_CS.
    IPR027498. Ribosomal_S2_euk.
    IPR005707. Ribosomal_S2_euk/arc.
    IPR023591. Ribosomal_S2_flav_dom.
    [Graphical view]
    PANTHERiPTHR11489. PTHR11489. 1 hit.
    PfamiPF00318. Ribosomal_S2. 1 hit.
    [Graphical view]
    PRINTSiPR00395. RIBOSOMALS2.
    SUPFAMiSSF52313. SSF52313. 1 hit.
    TIGRFAMsiTIGR01012. Sa_S2_E_A. 1 hit.
    PROSITEiPS00962. RIBOSOMAL_S2_1. 1 hit.
    PS00963. RIBOSOMAL_S2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6YRY8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN    50
    LKRTWEKLLL AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA 100
    GRFTPGTFTN QIQAAFREPR LLVVTDPRAD HQPLTEASYV NLPTIALCNT 150
    DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR EVLRMRGTIS REHPWEVMPD 200
    LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPAPEFTA AQPEVADWSE 250
    GVQVPSVPIQ QFPTEDWSAR PFTEDWSAAP TAQATEWVGT TSELS 295
    Length:295
    Mass (Da):32,885
    Last modified:August 21, 2007 - v1
    Checksum:iC6F8AF91A7458D2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF649775 mRNA. Translation: ABR57322.1.
    EF222474 mRNA. Translation: ABQ42346.1.
    RefSeqiNP_001098733.1. NM_001105263.1.
    UniGeneiOar.22928.

    Genome annotation databases

    GeneIDi100125628.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF649775 mRNA. Translation: ABR57322.1 .
    EF222474 mRNA. Translation: ABQ42346.1 .
    RefSeqi NP_001098733.1. NM_001105263.1.
    UniGenei Oar.22928.

    3D structure databases

    ProteinModelPortali A6YRY8.
    SMRi A6YRY8. Positions 9-205.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100125628.

    Phylogenomic databases

    HOVERGENi HBG054466.

    Family and domain databases

    HAMAPi MF_03015. Ribosomal_S2_euk.
    MF_03016. Ribosomal_S2_laminin_receptor.
    InterProi IPR027504. 40S_ribosomal_SA.
    IPR001865. Ribosomal_S2.
    IPR018130. Ribosomal_S2_CS.
    IPR027498. Ribosomal_S2_euk.
    IPR005707. Ribosomal_S2_euk/arc.
    IPR023591. Ribosomal_S2_flav_dom.
    [Graphical view ]
    PANTHERi PTHR11489. PTHR11489. 1 hit.
    Pfami PF00318. Ribosomal_S2. 1 hit.
    [Graphical view ]
    PRINTSi PR00395. RIBOSOMALS2.
    SUPFAMi SSF52313. SSF52313. 1 hit.
    TIGRFAMsi TIGR01012. Sa_S2_E_A. 1 hit.
    PROSITEi PS00962. RIBOSOMAL_S2_1. 1 hit.
    PS00963. RIBOSOMAL_S2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of Ovis aries laminin receptor 1."
      Qiao J., Zhao D., Li Y.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structural and functional analysis of the ovine laminin receptor gene (RPSA): Possible involvement of the LRP/LR protein in scrapie response."
      Marcos-Carcavilla A., Calvo J.H., Gonzalez C., Serrano C., Moazami-Goudarzi K., Laurent P., Bertaud M., Hayes H., Beattie A.E., Lyahyai J., Martin-Burriel I., Torres J.M., Serrano M.
      Mamm. Genome 19:92-105(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-250.

    Entry informationi

    Entry nameiRSSA_SHEEP
    AccessioniPrimary (citable) accession number: A6YRY8
    Secondary accession number(s): B0L420
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
    It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Ribosomal proteins
      Ribosomal proteins families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3