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Protein

Mu-conotoxin cal12b

Gene
N/A
Organism
Californiconus californicus (California cone) (Conus californicus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods (tested on squid giant-fiber-lobe neurons) with an inhibitor constant (Ki) of 15 nmol/l, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation. Has no effect on sodium channels of the two gastropod S.luhuanus and A.californica (which are not natural prey).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Mu-conotoxin cal12b
Alternative name(s):
Conotoxin Cal 12.1.1b
Conotoxin CalTx 12.1.1B
OrganismiCaliforniconus californicus (California cone) (Conus californicus)
Taxonomic identifieri1736779 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeCaliforniconus

Organism-specific databases

ConoServeri794. Cal12.1.1b precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000039226420 – 421 PublicationAdd BLAST23
PeptideiPRO_000039226543 – 87Mu-conotoxin cal12bAdd BLAST45

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 58Curated
Disulfide bondi53 ↔ 70By similarity
Modified residuei596'-bromotryptophan1 Publication1
Disulfide bondi60 ↔ 75By similarity
Modified residuei654-hydroxyproline1 Publication1
Disulfide bondi69 ↔ 81By similarity
Modified residuei796'-bromotryptophan1 Publication1
Modified residuei806'-bromotryptophan1 Publication1
Modified residuei824-hydroxyproline1 Publication1
Modified residuei866'-bromotryptophan1 Publication1

Keywords - PTMi

Bromination, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

SMRiA6YR21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XII (C-C-C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR004214. Conotoxin.
PfamiView protein in Pfam
PF02950. Conotoxin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6YR21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTCVLVVL LLLLPYGDLI TNNYIRGAAR KVTPWRRNLK TRDVCDSLVG
60 70 80
GHCIHNGCWC DQDAPHGNCC DTDGCTAAWW CPGTKWD
Length:87
Mass (Da):9,720
Last modified:August 21, 2007 - v1
Checksum:iDAC89CC6F30C6C6F
GO

Mass spectrometryi

Molecular mass is 5194 Da from positions 43 - 87. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF644175 mRNA. Translation: ABR92945.1.

Similar proteinsi

Entry informationi

Entry nameiCOC1B_CONCL
AccessioniPrimary (citable) accession number: A6YR21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: August 21, 2007
Last modified: November 22, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families