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Protein

Homeobox protein ARX

Gene

Arx

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi332 – 39160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ARX
Alternative name(s):
Aristaless-related homeobox
Gene namesi
Name:ArxBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1562672. Arx.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Homeobox protein ARXPRO_0000307920Add
BLAST

Proteomic databases

PRIDEiA6YP92.

Structurei

3D structure databases

ProteinModelPortaliA6YP92.
SMRiA6YP92. Positions 331-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi534 – 54714OARPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi100 – 15556Ala-richSequence analysisAdd
BLAST
Compositional biasi224 – 25330Glu-richSequence analysisAdd
BLAST
Compositional biasi395 – 45965Pro-richSequence analysisAdd
BLAST
Compositional biasi425 – 544120Ala-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the paired homeobox family. Bicoid subfamily.Sequence analysis
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOGENOMiHOG000012381.
HOVERGENiHBG004285.
InParanoidiA6YP92.
KOiK09452.
PhylomeDBiA6YP92.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6YP92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL
60 70 80 90 100
PAPLASRTDQ EKAMQGSPKG SSAPFEAELH LPPKLRRLYG PGGGRLLQGA
110 120 130 140 150
AAAAAAAAAA AAAAATATGT AGPRGEVPPP PPPAARPGER QDSAGAVAAA
160 170 180 190 200
AAAAWDTLKI SQAPQVSISR SKSYRENGAP FVPPPPALDE LGGPGGVAHP
210 220 230 240 250
EERLSAASGP GSAPAAGGGT GTEEDEEELL EDEEDEDEEE ELLEDDEEEL
260 270 280 290 300
LEDDARALLK EPRRCSVATT GTVAAAAAAA AAAAAVATEG GELSPKEELL
310 320 330 340 350
LHPEDAEGKD GEDSVCLSAG SDSEEGLLKR KQRRYRTTFT SYQLEELERA
360 370 380 390 400
FQKTHYPDVF TREELAMRLD LTEARVQVWF QNRRAKWRKR EKAGAQTHPP
410 420 430 440 450
GLPFPGPLSA THPLSPYLDA SPFPPHHPAL DSAWTAAAAA AAAAFPSLPP
460 470 480 490 500
PPGSASLPPS GAPLGLSTFL GAAVFRHPAF ISPAFGRLFS TMAPLTSAST
510 520 530 540 550
AAALLRQPTP AVEGAVASGA LADPATAAAD RRASSIAALR LKAKEHAAQL
560
TQLNILPGTS TGKEVC
Length:566
Mass (Da):58,647
Last modified:August 21, 2007 - v1
Checksum:i399926C42A63B6AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF638804 mRNA. Translation: ABR27821.1.
RefSeqiNP_001093644.1. NM_001100174.1.
UniGeneiRn.22484.

Genome annotation databases

GeneIDi317268.
KEGGirno:317268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF638804 mRNA. Translation: ABR27821.1.
RefSeqiNP_001093644.1. NM_001100174.1.
UniGeneiRn.22484.

3D structure databases

ProteinModelPortaliA6YP92.
SMRiA6YP92. Positions 331-393.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA6YP92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi317268.
KEGGirno:317268.

Organism-specific databases

CTDi170302.
RGDi1562672. Arx.

Phylogenomic databases

HOGENOMiHOG000012381.
HOVERGENiHBG004285.
InParanoidiA6YP92.
KOiK09452.
PhylomeDBiA6YP92.

Miscellaneous databases

PROiA6YP92.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARX_RAT
AccessioniPrimary (citable) accession number: A6YP92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 21, 2007
Last modified: June 8, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.