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Protein

Homeobox protein ARX

Gene

Arx

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi332 – 391HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • brain development Source: RGD
  • neuron development Source: RGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ARX
Alternative name(s):
Aristaless-related homeobox
Gene namesi
Name:ArxBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1562672. Arx.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003079201 – 566Homeobox protein ARXAdd BLAST566

Proteomic databases

PRIDEiA6YP92.

Structurei

3D structure databases

ProteinModelPortaliA6YP92.
SMRiA6YP92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi534 – 547OARPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 155Ala-richSequence analysisAdd BLAST56
Compositional biasi224 – 253Glu-richSequence analysisAdd BLAST30
Compositional biasi395 – 459Pro-richSequence analysisAdd BLAST65
Compositional biasi425 – 544Ala-richSequence analysisAdd BLAST120

Sequence similaritiesi

Belongs to the paired homeobox family. Bicoid subfamily.Sequence analysis

Keywords - Domaini

Homeobox

Phylogenomic databases

HOGENOMiHOG000012381.
HOVERGENiHBG004285.
InParanoidiA6YP92.
KOiK09452.
PhylomeDBiA6YP92.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR003654. OAR_dom.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.

Sequencei

Sequence statusi: Complete.

A6YP92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL
60 70 80 90 100
PAPLASRTDQ EKAMQGSPKG SSAPFEAELH LPPKLRRLYG PGGGRLLQGA
110 120 130 140 150
AAAAAAAAAA AAAAATATGT AGPRGEVPPP PPPAARPGER QDSAGAVAAA
160 170 180 190 200
AAAAWDTLKI SQAPQVSISR SKSYRENGAP FVPPPPALDE LGGPGGVAHP
210 220 230 240 250
EERLSAASGP GSAPAAGGGT GTEEDEEELL EDEEDEDEEE ELLEDDEEEL
260 270 280 290 300
LEDDARALLK EPRRCSVATT GTVAAAAAAA AAAAAVATEG GELSPKEELL
310 320 330 340 350
LHPEDAEGKD GEDSVCLSAG SDSEEGLLKR KQRRYRTTFT SYQLEELERA
360 370 380 390 400
FQKTHYPDVF TREELAMRLD LTEARVQVWF QNRRAKWRKR EKAGAQTHPP
410 420 430 440 450
GLPFPGPLSA THPLSPYLDA SPFPPHHPAL DSAWTAAAAA AAAAFPSLPP
460 470 480 490 500
PPGSASLPPS GAPLGLSTFL GAAVFRHPAF ISPAFGRLFS TMAPLTSAST
510 520 530 540 550
AAALLRQPTP AVEGAVASGA LADPATAAAD RRASSIAALR LKAKEHAAQL
560
TQLNILPGTS TGKEVC
Length:566
Mass (Da):58,647
Last modified:August 21, 2007 - v1
Checksum:i399926C42A63B6AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF638804 mRNA. Translation: ABR27821.1.
RefSeqiNP_001093644.1. NM_001100174.1.
UniGeneiRn.22484.

Genome annotation databases

GeneIDi317268.
KEGGirno:317268.

Similar proteinsi

Entry informationi

Entry nameiARX_RAT
AccessioniPrimary (citable) accession number: A6YP92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 21, 2007
Last modified: September 27, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families