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A6XGL2

- A6XGL2_HUMAN

UniProt

A6XGL2 - A6XGL2_HUMAN

Protein
Submitted name:

Insulin

Gene

INS

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.SAAS annotation

    GO - Biological processi

    1. glucose metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    HormoneSAAS annotation

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolismSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    InsulinImported
    Submitted name:
    Insulin B chainImported
    Gene namesi
    Name:INSImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:6081. INS.

    Subcellular locationi

    Secreted UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    SecretedSAAS annotation

    Pathology & Biotechi

    Protein family/group databases

    Allergomei2121. Hom s Insulin.

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Interactioni

    Subunit structurei

    Heterodimer of a B chain and an A chain linked by two disulfide bonds.SAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliA6XGL2.
    SMRiA6XGL2. Positions 25-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the insulin family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000261669.
    HOVERGENiHBG006137.
    OrthoDBiEOG7TF7CG.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR004825. Insulin.
    IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    PRINTSiPR00277. INSULIN.
    PR00276. INSULINFAMLY.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6XGL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY   50
    TPKTRREAED LQGSLQPLAL EGSLQKRGIV EQCCTSICSL YQLENYCN 98
    Length:98
    Mass (Da):10,959
    Last modified:August 21, 2007 - v1
    Checksum:i6DDEDC02ED1A9CB9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC132217 Genomic DNA. No translation available.
    DQ778082 mRNA. Translation: ABI63346.1.

    Genome annotation databases

    EnsembliENST00000512523; ENSP00000424008; ENSG00000254647.
    UCSCiuc009ydg.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC132217 Genomic DNA. No translation available.
    DQ778082 mRNA. Translation: ABI63346.1 .

    3D structure databases

    ProteinModelPortali A6XGL2.
    SMRi A6XGL2. Positions 25-98.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 2121. Hom s Insulin.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000512523 ; ENSP00000424008 ; ENSG00000254647 .
    UCSCi uc009ydg.1. human.

    Organism-specific databases

    HGNCi HGNC:6081. INS.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000261669.
    HOVERGENi HBG006137.
    OrthoDBi EOG7TF7CG.

    Miscellaneous databases

    NextBioi 35462875.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR004825. Insulin.
    IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    PRINTSi PR00277. INSULIN.
    PR00276. INSULINFAMLY.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "A computer system platform used to predict novel genes."
      Yu Z., Zheng Z., Tang T., Fu Y.
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiA6XGL2_HUMAN
    AccessioniPrimary (citable) accession number: A6XGL2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3