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Protein

YjeF N-terminal domain-containing protein 3

Gene

YJEFN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in spermiogenesis and oogenesis.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
YjeF N-terminal domain-containing protein 3
Short name:
YjeF_N3
Short name:
hYjeF_N3
Gene namesi
Name:YJEFN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24785. YJEFN3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164727608.

Polymorphism and mutation databases

BioMutaiYJEFN3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299YjeF N-terminal domain-containing protein 3PRO_0000348461Add
BLAST

Proteomic databases

PaxDbiA6XGL0.
PeptideAtlasiA6XGL0.
PRIDEiA6XGL0.

PTM databases

iPTMnetiA6XGL0.
PhosphoSiteiA6XGL0.

Expressioni

Tissue specificityi

Expressed in theca cells in ovary and in Leydig cells in testis (at protein level). Also expressed in brain and mammary gland.1 Publication

Gene expression databases

BgeeiA6XGL0.
CleanExiHS_YJEFN3.
ExpressionAtlasiA6XGL0. baseline and differential.
GenevisibleiA6XGL0. HS.

Organism-specific databases

HPAiHPA060789.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000426964.

Structurei

3D structure databases

ProteinModelPortaliA6XGL0.
SMRiA6XGL0. Positions 70-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 287214YjeF N-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 YjeF N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2585. Eukaryota.
COG0062. LUCA.
GeneTreeiENSGT00390000007227.
HOGENOMiHOG000174236.
HOVERGENiHBG058276.
InParanoidiA6XGL0.
OMAiFTTQCEK.
OrthoDBiEOG71K63V.
PhylomeDBiA6XGL0.
TreeFamiTF300197.

Family and domain databases

Gene3Di3.40.50.10260. 1 hit.
InterProiIPR004443. YjeF_N_dom.
IPR032976. YJEFN_prot_eukaryotes.
[Graphical view]
PANTHERiPTHR13232. PTHR13232. 1 hit.
PfamiPF03853. YjeF_N. 1 hit.
[Graphical view]
SUPFAMiSSF64153. SSF64153. 1 hit.
TIGRFAMsiTIGR00197. yjeF_nterm. 1 hit.
PROSITEiPS51385. YJEF_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6XGL0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSAAGPDPS EAPEERHFLR ALELQPPLAD MGRAELSSNA TTSLVQRRKQ
60 70 80 90 100
AWGRQSWLEQ IWNAGPVCQS TAEAAALERE LLEDYRFGRQ QLVELCGHAS
110 120 130 140 150
AVAVTKAFPL PALSRKQRTV LVVCGPEQNG AVGLVCARHL RVFEYEPTIF
160 170 180 190 200
YPTRSLDLLH RDLTTQCEKM DIPFLSYLPT EVQLINEAYG LVVDAVLGPG
210 220 230 240 250
VEPGEVGGPC TRALATLKLL SIPLVSLDIP SGWDAETGSD SEDGLRPDVL
260 270 280 290
VSLAAPKRCA GRFSGRHHFV AGRFVPDDVR RKFALRLPGY TGTDCVAAL
Length:299
Mass (Da):32,585
Last modified:August 21, 2007 - v1
Checksum:i5B708900DEBF6CCE
GO
Isoform 2 (identifier: A6XGL0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-69: Missing.

Note: No experimental confirmation available.
Show »
Length:249
Mass (Da):26,954
Checksum:iFD5FD182C01B2B1C
GO

Sequence cautioni

The sequence BC020948 differs from that shown. Reason: Frameshift at position 200. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti293 – 2931T → A in BC020948 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti213 – 2131A → T.
Corresponds to variant rs58031491 [ dbSNP | Ensembl ].
VAR_061989

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei20 – 6950Missing in isoform 2. 1 PublicationVSP_035170Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ778080 mRNA. Translation: ABI63344.1.
DQ778079 mRNA. Translation: ABI63349.1.
AC011448 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84827.1.
BC020948 mRNA. No translation available.
CCDSiCCDS42530.1. [A6XGL0-1]
CCDS54236.1. [A6XGL0-2]
RefSeqiNP_001177257.1. NM_001190328.1. [A6XGL0-2]
NP_940939.2. NM_198537.3. [A6XGL0-1]
UniGeneiHs.729508.

Genome annotation databases

EnsembliENST00000436027; ENSP00000398520; ENSG00000250067. [A6XGL0-2]
ENST00000514277; ENSP00000426964; ENSG00000250067. [A6XGL0-1]
GeneIDi374887.
KEGGihsa:374887.
UCSCiuc002nmt.3. human. [A6XGL0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ778080 mRNA. Translation: ABI63344.1.
DQ778079 mRNA. Translation: ABI63349.1.
AC011448 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84827.1.
BC020948 mRNA. No translation available.
CCDSiCCDS42530.1. [A6XGL0-1]
CCDS54236.1. [A6XGL0-2]
RefSeqiNP_001177257.1. NM_001190328.1. [A6XGL0-2]
NP_940939.2. NM_198537.3. [A6XGL0-1]
UniGeneiHs.729508.

3D structure databases

ProteinModelPortaliA6XGL0.
SMRiA6XGL0. Positions 70-299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000426964.

PTM databases

iPTMnetiA6XGL0.
PhosphoSiteiA6XGL0.

Polymorphism and mutation databases

BioMutaiYJEFN3.

Proteomic databases

PaxDbiA6XGL0.
PeptideAtlasiA6XGL0.
PRIDEiA6XGL0.

Protocols and materials databases

DNASUi374887.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436027; ENSP00000398520; ENSG00000250067. [A6XGL0-2]
ENST00000514277; ENSP00000426964; ENSG00000250067. [A6XGL0-1]
GeneIDi374887.
KEGGihsa:374887.
UCSCiuc002nmt.3. human. [A6XGL0-1]

Organism-specific databases

CTDi374887.
GeneCardsiYJEFN3.
H-InvDBHIX0014943.
HGNCiHGNC:24785. YJEFN3.
HPAiHPA060789.
neXtProtiNX_A6XGL0.
PharmGKBiPA164727608.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2585. Eukaryota.
COG0062. LUCA.
GeneTreeiENSGT00390000007227.
HOGENOMiHOG000174236.
HOVERGENiHBG058276.
InParanoidiA6XGL0.
OMAiFTTQCEK.
OrthoDBiEOG71K63V.
PhylomeDBiA6XGL0.
TreeFamiTF300197.

Miscellaneous databases

GenomeRNAii374887.
PROiA6XGL0.

Gene expression databases

BgeeiA6XGL0.
CleanExiHS_YJEFN3.
ExpressionAtlasiA6XGL0. baseline and differential.
GenevisibleiA6XGL0. HS.

Family and domain databases

Gene3Di3.40.50.10260. 1 hit.
InterProiIPR004443. YjeF_N_dom.
IPR032976. YJEFN_prot_eukaryotes.
[Graphical view]
PANTHERiPTHR13232. PTHR13232. 1 hit.
PfamiPF03853. YjeF_N. 1 hit.
[Graphical view]
SUPFAMiSSF64153. SSF64153. 1 hit.
TIGRFAMsiTIGR00197. yjeF_nterm. 1 hit.
PROSITEiPS51385. YJEF_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A computer system platform used to predict novel genes and some proteins similar to apolipoprotein a1 binding protein."
    Yu Z., Zheng Z., Tang T., Fu Y.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis."
    Rudolph C., Sigruener A., Hartmann A., Orso E., Bals-Pratsch M., Gronwald W., Seifert B., Kalbitzer H.R., Verdorfer I., Luetjens C.M., Ortmann O., Bornstein S.R., Schmitz G.
    Horm. Metab. Res. 39:322-335(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiYJEN3_HUMAN
AccessioniPrimary (citable) accession number: A6XGL0
Secondary accession number(s): A6XGK9, Q4G1C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 21, 2007
Last modified: July 6, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.