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Protein

Gremlin

Gene

GREM1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
GremlinUniRule annotation
Gene namesi
Name:GREM1Imported
ORF Names:hCG_1811964Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000166923.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26537

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_501421245925 – 184GremlinUniRule annotationAdd BLAST160

Expressioni

Gene expression databases

BgeeiENSG00000166923

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 183CTCKInterPro annotationAdd BLAST88

Sequence similaritiesi

Belongs to the DAN family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410IG3Z Eukaryota
ENOG4111HEF LUCA
HOVERGENiHBG051837
OMAiRVKECRC
OrthoDBiEOG091G0GL9

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR004133 DAN
IPR017159 Gremlin-1/2
PfamiView protein in Pfam
PF03045 DAN, 1 hit
PIRSFiPIRSF037254 Gremlin_precursor, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit

Sequencei

Sequence statusi: Complete.

A6XAA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTAYTVGA LLLLLGTLLP AAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP
60 70 80 90 100
QQPGSRNRGR GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK
110 120 130 140 150
QTIHEEGCNS RTIINRFCYG QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT
160 170 180
TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS IDLD
Length:184
Mass (Da):20,697
Last modified:August 21, 2007 - v1
Checksum:i4B588598DE12C47E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH015087 Genomic DNA Translation: AAZ29612.1
AK312265 mRNA Translation: BAG35196.1
CH471125 Genomic DNA Translation: EAW92268.1
RefSeqiNP_037504.1, NM_013372.6
UniGeneiHs.40098

Genome annotation databases

GeneIDi26585
KEGGihsa:26585

Similar proteinsi

Entry informationi

Entry nameiA6XAA7_HUMAN
AccessioniPrimary (citable) accession number: A6XAA7
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: April 25, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health