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Protein

SH2 domain-containing protein 4B

Gene

Sh2d4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 4B
Gene namesi
Name:Sh2d4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1925182 Sh2d4b

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003086011 – 431SH2 domain-containing protein 4BAdd BLAST431

Proteomic databases

PaxDbiA6X942
PRIDEiA6X942

PTM databases

PhosphoSitePlusiA6X942

Expressioni

Gene expression databases

BgeeiENSMUSG00000037833
CleanExiMM_SH2D4B
GenevisibleiA6X942 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093699

Structurei

3D structure databases

ProteinModelPortaliA6X942
SMRiA6X942
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini325 – 417SH2PROSITE-ProRule annotationAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi92 – 223Glu-richAdd BLAST132

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IEFY Eukaryota
ENOG410XPPJ LUCA
GeneTreeiENSGT00570000079047
HOGENOMiHOG000031527
HOVERGENiHBG057918
InParanoidiA6X942
OMAiQILHDMY
OrthoDBiEOG091G08HG
PhylomeDBiA6X942
TreeFamiTF336893

Family and domain databases

CDDicd10351 SH2_SH2D4B, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR035839 SH2D4B_SH2
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6X942-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQQILQDMY IDPELLAELS DVQKHILFYK MREEQLRRWR EREAWDALAQ
60 70 80 90 100
AEGLRPAKVK RASNKHLQWL LGADGEVWVW VMGEGPGDKP YEEISEELIA
110 120 130 140 150
ERARLQAQKE AEELWRQKEA EITKKFRDAL ANEKARILAE KWKVEMEDRK
160 170 180 190 200
AAKILEERIH EEFKRKEEEE RRRGEEQIRL QEEQRAKELY WTLKQAQLHS
210 220 230 240 250
QASENEEREW EEQLRRSKAA DEERSRRAQR ARDEYRRHSL RAIQKGTVAG
260 270 280 290 300
LSTMFQELGQ NHEQEARLYH QLPDTSPPSP LTGPDRTWER PLRPLSREVI
310 320 330 340 350
VRWFKEEQLP RRAGFERNTK SIAPWFHGII SRESAEDLLE NMTEGAFLVR
360 370 380 390 400
VSEKIWGYTL SYRLQRGFKH FLVDASGDFY SFLGVDPNRH ATLTDLIDFH
410 420 430
KEEIITVSGG ELLQEPCGQR DSPPDYHLLF E
Length:431
Mass (Da):51,120
Last modified:August 21, 2007 - v1
Checksum:i091871DEC7A439EA
GO
Isoform 2 (identifier: A6X942-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-253: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):20,725
Checksum:i062C90621B678F94
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0290131 – 253Missing in isoform 2. 1 PublicationAdd BLAST253

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050671 mRNA Translation: BAC34372.1
AK134033 mRNA Translation: BAE21988.1
CT025537 Genomic DNA No translation available.
BC138964 mRNA Translation: AAI38965.1
CCDSiCCDS26955.1 [A6X942-1]
RefSeqiNP_808484.2, NM_177816.3 [A6X942-1]
XP_017171549.1, XM_017316060.1 [A6X942-2]
UniGeneiMm.235694

Genome annotation databases

EnsembliENSMUST00000070328; ENSMUSP00000064708; ENSMUSG00000037833 [A6X942-2]
ENSMUST00000096000; ENSMUSP00000093699; ENSMUSG00000037833 [A6X942-1]
GeneIDi328381
KEGGimmu:328381
UCSCiuc007tcd.1 mouse [A6X942-2]
uc007tce.1 mouse [A6X942-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSH24B_MOUSE
AccessioniPrimary (citable) accession number: A6X942
Secondary accession number(s): B2RSQ7, Q8BQI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health