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A6X942 (SH24B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH2 domain-containing protein 4B
Gene names
Name:Sh2d4b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SH2 domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainSH2 domain
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A6X942-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A6X942-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-253: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431SH2 domain-containing protein 4B
PRO_0000308601

Regions

Domain325 – 41793SH2
Compositional bias92 – 223132Glu-rich

Natural variations

Alternative sequence1 – 253253Missing in isoform 2.
VSP_029013

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 091871DEC7A439EA

FASTA43151,120
        10         20         30         40         50         60 
MLQQILQDMY IDPELLAELS DVQKHILFYK MREEQLRRWR EREAWDALAQ AEGLRPAKVK 

        70         80         90        100        110        120 
RASNKHLQWL LGADGEVWVW VMGEGPGDKP YEEISEELIA ERARLQAQKE AEELWRQKEA 

       130        140        150        160        170        180 
EITKKFRDAL ANEKARILAE KWKVEMEDRK AAKILEERIH EEFKRKEEEE RRRGEEQIRL 

       190        200        210        220        230        240 
QEEQRAKELY WTLKQAQLHS QASENEEREW EEQLRRSKAA DEERSRRAQR ARDEYRRHSL 

       250        260        270        280        290        300 
RAIQKGTVAG LSTMFQELGQ NHEQEARLYH QLPDTSPPSP LTGPDRTWER PLRPLSREVI 

       310        320        330        340        350        360 
VRWFKEEQLP RRAGFERNTK SIAPWFHGII SRESAEDLLE NMTEGAFLVR VSEKIWGYTL 

       370        380        390        400        410        420 
SYRLQRGFKH FLVDASGDFY SFLGVDPNRH ATLTDLIDFH KEEIITVSGG ELLQEPCGQR 

       430 
DSPPDYHLLF E 

« Hide

Isoform 2 [UniParc].

Checksum: 062C90621B678F94
Show »

FASTA17820,725

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Thymus.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK050671 mRNA. Translation: BAC34372.1.
AK134033 mRNA. Translation: BAE21988.1.
CT025537 Genomic DNA. Translation: CAO77722.1.
CT025537 Genomic DNA. Translation: CAO77723.1.
BC138964 mRNA. Translation: AAI38965.1.
RefSeqNP_808484.2. NM_177816.3.
XP_006519203.1. XM_006519140.1.
XP_006519204.1. XM_006519141.1.
UniGeneMm.235694.

3D structure databases

ProteinModelPortalA6X942.
SMRA6X942. Positions 285-424.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA6X942.

Proteomic databases

PRIDEA6X942.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000070328; ENSMUSP00000064708; ENSMUSG00000037833. [A6X942-2]
ENSMUST00000096000; ENSMUSP00000093699; ENSMUSG00000037833. [A6X942-1]
GeneID328381.
KEGGmmu:328381.
UCSCuc007tcd.1. mouse. [A6X942-2]
uc007tce.1. mouse. [A6X942-1]

Organism-specific databases

CTD387694.
MGIMGI:1925182. Sh2d4b.

Phylogenomic databases

eggNOGNOG77708.
GeneTreeENSGT00570000079047.
HOGENOMHOG000031527.
HOVERGENHBG057918.
InParanoidB2RSQ7.
OMAVRWFKEE.
OrthoDBEOG71P2BD.
PhylomeDBA6X942.
TreeFamTF336893.

Gene expression databases

BgeeA6X942.
CleanExMM_SH2D4B.
GenevestigatorA6X942.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR000980. SH2.
[Graphical view]
PfamPF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
SMARTSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio398270.
PROA6X942.
SOURCESearch...

Entry information

Entry nameSH24B_MOUSE
AccessionPrimary (citable) accession number: A6X942
Secondary accession number(s): B2RSQ7, Q8BQI0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot