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A6X942

- SH24B_MOUSE

UniProt

A6X942 - SH24B_MOUSE

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Protein

SH2 domain-containing protein 4B

Gene
Sh2d4b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 4B
Gene namesi
Name:Sh2d4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1925182. Sh2d4b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431SH2 domain-containing protein 4BPRO_0000308601Add
BLAST

Proteomic databases

PRIDEiA6X942.

PTM databases

PhosphoSiteiA6X942.

Expressioni

Gene expression databases

BgeeiA6X942.
CleanExiMM_SH2D4B.
GenevestigatoriA6X942.

Structurei

3D structure databases

ProteinModelPortaliA6X942.
SMRiA6X942. Positions 285-424.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini325 – 41793SH2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi92 – 223132Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG77708.
GeneTreeiENSGT00570000079047.
HOGENOMiHOG000031527.
HOVERGENiHBG057918.
InParanoidiB2RSQ7.
OMAiVRWFKEE.
OrthoDBiEOG71P2BD.
PhylomeDBiA6X942.
TreeFamiTF336893.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A6X942-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLQQILQDMY IDPELLAELS DVQKHILFYK MREEQLRRWR EREAWDALAQ    50
AEGLRPAKVK RASNKHLQWL LGADGEVWVW VMGEGPGDKP YEEISEELIA 100
ERARLQAQKE AEELWRQKEA EITKKFRDAL ANEKARILAE KWKVEMEDRK 150
AAKILEERIH EEFKRKEEEE RRRGEEQIRL QEEQRAKELY WTLKQAQLHS 200
QASENEEREW EEQLRRSKAA DEERSRRAQR ARDEYRRHSL RAIQKGTVAG 250
LSTMFQELGQ NHEQEARLYH QLPDTSPPSP LTGPDRTWER PLRPLSREVI 300
VRWFKEEQLP RRAGFERNTK SIAPWFHGII SRESAEDLLE NMTEGAFLVR 350
VSEKIWGYTL SYRLQRGFKH FLVDASGDFY SFLGVDPNRH ATLTDLIDFH 400
KEEIITVSGG ELLQEPCGQR DSPPDYHLLF E 431
Length:431
Mass (Da):51,120
Last modified:August 21, 2007 - v1
Checksum:i091871DEC7A439EA
GO
Isoform 2 (identifier: A6X942-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-253: Missing.

Note: No experimental confirmation available.

Show »
Length:178
Mass (Da):20,725
Checksum:i062C90621B678F94
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 253253Missing in isoform 2. VSP_029013Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050671 mRNA. Translation: BAC34372.1.
AK134033 mRNA. Translation: BAE21988.1.
CT025537 Genomic DNA. Translation: CAO77722.1.
CT025537 Genomic DNA. Translation: CAO77723.1.
BC138964 mRNA. Translation: AAI38965.1.
CCDSiCCDS26955.1. [A6X942-1]
RefSeqiNP_808484.2. NM_177816.3. [A6X942-1]
XP_006519203.1. XM_006519140.1. [A6X942-2]
XP_006519204.1. XM_006519141.1. [A6X942-2]
UniGeneiMm.235694.

Genome annotation databases

EnsembliENSMUST00000070328; ENSMUSP00000064708; ENSMUSG00000037833. [A6X942-2]
ENSMUST00000096000; ENSMUSP00000093699; ENSMUSG00000037833. [A6X942-1]
GeneIDi328381.
KEGGimmu:328381.
UCSCiuc007tcd.1. mouse. [A6X942-2]
uc007tce.1. mouse. [A6X942-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050671 mRNA. Translation: BAC34372.1 .
AK134033 mRNA. Translation: BAE21988.1 .
CT025537 Genomic DNA. Translation: CAO77722.1 .
CT025537 Genomic DNA. Translation: CAO77723.1 .
BC138964 mRNA. Translation: AAI38965.1 .
CCDSi CCDS26955.1. [A6X942-1 ]
RefSeqi NP_808484.2. NM_177816.3. [A6X942-1 ]
XP_006519203.1. XM_006519140.1. [A6X942-2 ]
XP_006519204.1. XM_006519141.1. [A6X942-2 ]
UniGenei Mm.235694.

3D structure databases

ProteinModelPortali A6X942.
SMRi A6X942. Positions 285-424.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A6X942.

Proteomic databases

PRIDEi A6X942.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070328 ; ENSMUSP00000064708 ; ENSMUSG00000037833 . [A6X942-2 ]
ENSMUST00000096000 ; ENSMUSP00000093699 ; ENSMUSG00000037833 . [A6X942-1 ]
GeneIDi 328381.
KEGGi mmu:328381.
UCSCi uc007tcd.1. mouse. [A6X942-2 ]
uc007tce.1. mouse. [A6X942-1 ]

Organism-specific databases

CTDi 387694.
MGIi MGI:1925182. Sh2d4b.

Phylogenomic databases

eggNOGi NOG77708.
GeneTreei ENSGT00570000079047.
HOGENOMi HOG000031527.
HOVERGENi HBG057918.
InParanoidi B2RSQ7.
OMAi VRWFKEE.
OrthoDBi EOG71P2BD.
PhylomeDBi A6X942.
TreeFami TF336893.

Miscellaneous databases

NextBioi 398270.
PROi A6X942.
SOURCEi Search...

Gene expression databases

Bgeei A6X942.
CleanExi MM_SH2D4B.
Genevestigatori A6X942.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR000980. SH2.
[Graphical view ]
Pfami PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
SMARTi SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiSH24B_MOUSE
AccessioniPrimary (citable) accession number: A6X942
Secondary accession number(s): B2RSQ7, Q8BQI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3