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A6X942

- SH24B_MOUSE

UniProt

A6X942 - SH24B_MOUSE

Protein

SH2 domain-containing protein 4B

Gene

Sh2d4b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH2 domain-containing protein 4B
    Gene namesi
    Name:Sh2d4b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1925182. Sh2d4b.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431SH2 domain-containing protein 4BPRO_0000308601Add
    BLAST

    Proteomic databases

    PRIDEiA6X942.

    PTM databases

    PhosphoSiteiA6X942.

    Expressioni

    Gene expression databases

    BgeeiA6X942.
    CleanExiMM_SH2D4B.
    GenevestigatoriA6X942.

    Structurei

    3D structure databases

    ProteinModelPortaliA6X942.
    SMRiA6X942. Positions 285-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini325 – 41793SH2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi92 – 223132Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG77708.
    GeneTreeiENSGT00570000079047.
    HOGENOMiHOG000031527.
    HOVERGENiHBG057918.
    InParanoidiB2RSQ7.
    OMAiVRWFKEE.
    OrthoDBiEOG71P2BD.
    PhylomeDBiA6X942.
    TreeFamiTF336893.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    [Graphical view]
    PfamiPF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A6X942-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLQQILQDMY IDPELLAELS DVQKHILFYK MREEQLRRWR EREAWDALAQ    50
    AEGLRPAKVK RASNKHLQWL LGADGEVWVW VMGEGPGDKP YEEISEELIA 100
    ERARLQAQKE AEELWRQKEA EITKKFRDAL ANEKARILAE KWKVEMEDRK 150
    AAKILEERIH EEFKRKEEEE RRRGEEQIRL QEEQRAKELY WTLKQAQLHS 200
    QASENEEREW EEQLRRSKAA DEERSRRAQR ARDEYRRHSL RAIQKGTVAG 250
    LSTMFQELGQ NHEQEARLYH QLPDTSPPSP LTGPDRTWER PLRPLSREVI 300
    VRWFKEEQLP RRAGFERNTK SIAPWFHGII SRESAEDLLE NMTEGAFLVR 350
    VSEKIWGYTL SYRLQRGFKH FLVDASGDFY SFLGVDPNRH ATLTDLIDFH 400
    KEEIITVSGG ELLQEPCGQR DSPPDYHLLF E 431
    Length:431
    Mass (Da):51,120
    Last modified:August 21, 2007 - v1
    Checksum:i091871DEC7A439EA
    GO
    Isoform 2 (identifier: A6X942-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-253: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:178
    Mass (Da):20,725
    Checksum:i062C90621B678F94
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 253253Missing in isoform 2. 1 PublicationVSP_029013Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050671 mRNA. Translation: BAC34372.1.
    AK134033 mRNA. Translation: BAE21988.1.
    CT025537 Genomic DNA. Translation: CAO77722.1.
    CT025537 Genomic DNA. Translation: CAO77723.1.
    BC138964 mRNA. Translation: AAI38965.1.
    CCDSiCCDS26955.1. [A6X942-1]
    RefSeqiNP_808484.2. NM_177816.3. [A6X942-1]
    XP_006519203.1. XM_006519140.1. [A6X942-2]
    XP_006519204.1. XM_006519141.1. [A6X942-2]
    UniGeneiMm.235694.

    Genome annotation databases

    EnsembliENSMUST00000070328; ENSMUSP00000064708; ENSMUSG00000037833. [A6X942-2]
    ENSMUST00000096000; ENSMUSP00000093699; ENSMUSG00000037833. [A6X942-1]
    GeneIDi328381.
    KEGGimmu:328381.
    UCSCiuc007tcd.1. mouse. [A6X942-2]
    uc007tce.1. mouse. [A6X942-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050671 mRNA. Translation: BAC34372.1 .
    AK134033 mRNA. Translation: BAE21988.1 .
    CT025537 Genomic DNA. Translation: CAO77722.1 .
    CT025537 Genomic DNA. Translation: CAO77723.1 .
    BC138964 mRNA. Translation: AAI38965.1 .
    CCDSi CCDS26955.1. [A6X942-1 ]
    RefSeqi NP_808484.2. NM_177816.3. [A6X942-1 ]
    XP_006519203.1. XM_006519140.1. [A6X942-2 ]
    XP_006519204.1. XM_006519141.1. [A6X942-2 ]
    UniGenei Mm.235694.

    3D structure databases

    ProteinModelPortali A6X942.
    SMRi A6X942. Positions 285-424.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A6X942.

    Proteomic databases

    PRIDEi A6X942.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070328 ; ENSMUSP00000064708 ; ENSMUSG00000037833 . [A6X942-2 ]
    ENSMUST00000096000 ; ENSMUSP00000093699 ; ENSMUSG00000037833 . [A6X942-1 ]
    GeneIDi 328381.
    KEGGi mmu:328381.
    UCSCi uc007tcd.1. mouse. [A6X942-2 ]
    uc007tce.1. mouse. [A6X942-1 ]

    Organism-specific databases

    CTDi 387694.
    MGIi MGI:1925182. Sh2d4b.

    Phylogenomic databases

    eggNOGi NOG77708.
    GeneTreei ENSGT00570000079047.
    HOGENOMi HOG000031527.
    HOVERGENi HBG057918.
    InParanoidi B2RSQ7.
    OMAi VRWFKEE.
    OrthoDBi EOG71P2BD.
    PhylomeDBi A6X942.
    TreeFami TF336893.

    Miscellaneous databases

    NextBioi 398270.
    PROi A6X942.
    SOURCEi Search...

    Gene expression databases

    Bgeei A6X942.
    CleanExi MM_SH2D4B.
    Genevestigatori A6X942.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    [Graphical view ]
    Pfami PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiSH24B_MOUSE
    AccessioniPrimary (citable) accession number: A6X942
    Secondary accession number(s): B2RSQ7, Q8BQI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3